Lifestyle Interventions for Weight Control Modified by Genetic Variation: A Review of the Evidence

Conclusion: Gene-lifestyle interaction studies on the same candidate gene in different populations have reported information which is challenging to interpret. Thus, it is difficult to arrive at a particular model for a strategy on weight management at this point in time. Most of the intervention studies focus on the effect of variants of a single candidate gene on weight loss. Further evidence from large-scale studies is necessary to assess the effect of multiple candidate genes to compute a gene score that could be used in a model intervention programme. Our review suggests that a healthy lifestyle with a balanced diet and regular physical activity will benefit individuals who carry the risk alleles of the obesity-related candidate genes. This message should be the mainstay of the recommendations and guidelines published by nutrition societies across the world.Public Health Genomics
Source: Public Health Genomics - Category: Genetics & Stem Cells Source Type: research

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In this study, LZTFL1 homologs were identified in zebrafish (ZeLZTFL1). The full-length cDNA of ZeLZTFL1 contained 897 bps encoding 298 amino acids. ZeLZTFL1 displayed conserved domains of coil–coil and leucine zipper domain. PCR results showed that ZeLZTFL1 was widely distributed in various tissues. Western blot analysis further revealed that ZeLZTFL1 was detected to be ectopically expressed in HeLa cells with correct molecular weight. Fluorescence images showed as well that ZeLZTFL1 was localized in the cytoplasm. Furthermore, luciferase reporter assay indicated ZeLZTFL1 served as a negative regulator in the hedgeh...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Obesity, a chronic multifaceted disease, predisposes its patients to increased risk of metabolic disorders such as: diabetes mellitus, cardiovascular diseaseas, dyslipidemia, etc. Recent studies reported it to be amongst the leading causes of deaths in the world. Although several treatment options for obesity abound, many of them have not been able to successfully reverse the existing obesity and metabolic dysregulation. This has therefore warranted the need for either alternative therapies or diversification of the treatment approach for obesity and its comorbidity. When the receptor for advanced glycation end products (R...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Some potential causes of shortness of breath when lying down include heart failure, obesity, and emphysema. Learn more about the causes of shortness of breath when lying down here, along with their treatment options.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Respiratory Source Type: news
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
MONDAY, June 24, 2019 -- Could America's favorite morning drink also help fight one of its biggest health issues, obesity? That's the suggestion from a British study that finds coffee stimulates the human body's " brown fat, " a heat-generating form...
Source: - Daily MedNews - Category: General Medicine Source Type: news
A study of immune and fat cells from mice found that cocoa shell extract can reduce and prevent some of the cell dysfunctions that can result from obesity.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Obesity / Weight Loss / Fitness Source Type: news
In this study, C57BL/6 J mice were parentally exposed to 100 ppb arsenic before conception. After weaning, both male and female offspring were maintained on 100 ppb arsenic and fed either a normal (LFD) or high fat diet (HFD). At 10 and 24 weeks of age, the offspring were sacrificed and kidneys collected. Exposure to arsenic led to an increase body-weight in LFD diet-fed female but not male mice. This response was not observed in HFD-fed female mice; however male mice showed significant increases in body weight in both As- and non-treated animals. Histological analysis shows that arsenic exposure significantly increa...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Scientists at the University of Nottingham used nine people to test their theory, which had already been successful in a lab. Coffee was found to increase activity in people's brown fat, which burns calories.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The objective of this article is to describe the design, implementation and evaluation of an educational initiative conducted in a Mexican locality with the aim of promoting the consumption of fruits, vegetables (FVs) and simple water (SW) among preschoolers through the influence of their mothers and teachers. We used the Intervention Mapping methodology with qualitative and quantitative components. Mothers attended eight theoretical and practical sessions and two school meetings, while teachers were offered two workshops. Our results revealed positive changes among both groups: participants took greater interest in health...
Source: Evaluation and Program Planning - Category: International Medicine & Public Health Source Type: research
By Katie Hunt, CNN (CNN) — Drinking coffee could activate the body’s fat-fighting defenses, a discovery that could have potential implications in the battle against obesity and diabetes. In a study published Monday, researchers at the University of Nottingham said that coffee may help stimulate our brown fat reserves, also known as brown adipose tissue, which play a key role in how quickly we can burn calories. There are two forms of fat cells, brown cells and white cells, and each plays a different role in our metabolism. While brown cells help generate heat, white cells are responsible for the storage of...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Coffee Source Type: news
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