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Prognostic Value of Metabolic Information in Advanced Gastric Cancer Using Preoperative 18 F-FDG PET/CT
ConclusionHigh SUVmax and high MTV of the primary tumor suggest a high risk of recurrence for AGC patients. Even if SUVmax is similar, the prognosis may vary depending on MTV. Combining PET parameters results in a better prediction for prognosis. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 17, 2019 Category: Nuclear Medicine Source Type: research

Safety Profile and Therapeutic Efficacy of One Cycle of Lu177-PSMA in End-Stage Metastatic Castration-Resistant Prostate Cancer Patients with Low Performance Status
ConclusionWe concluded that Lu-177-PSMA therapy has adequate pain palliation in end-stage mCRPC patients with low performance status and it has a potential to become effective therapeutic option in properly selected patients. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 17, 2019 Category: Nuclear Medicine Source Type: research

Perspectives in TSPO PET Imaging for Neurologic Diseases
AbstractThe translocator protein (18 kDa) (TSPO) is a mitochondrial transmembrane protein, which has brought attention as a neuroinflammatory biomarker. Positron emission tomography (PET) imaging studies have been done for several decades, since neuroinflammation has been implicated as an important pathophysiology of several common neurologic disorders. However, despite numerous previous studies with positive findings, its clinical significance is not yet clear. Various attempts to overcome the limitations are ongoing, in order to bring acceptance for use in clinics. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 15, 2019 Category: Nuclear Medicine Source Type: research

Intramastoid Phosphaturic Mesenchymal Tumor Causing Hypophosphatemic Osteomalacia Detected on 68 Ga-DOTATATE PET/CT But Not on 99m Tc-Sestamibi and 18 F-FDG Scans
Abstract68Ga-DOTATATE uptake in mesenchymal tumors causing hypophosphatemic osteomalacia has been recently described. Herein, we present a case of68Ga-DOTATATE uptake in an intramastoid phosphaturic mesenchymal tumor that had not been depicted in previous99mTc-Sestamibi and18F-FDG scans. The lesion was surgically removed and the phosphorus level increased to the normal range. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 13, 2019 Category: Nuclear Medicine Source Type: research

Effect of ME Collimator Characteristic, Energy Window Width, and Reconstruction Algorithm Selection on Imaging Performance of Yttrium-90: Simulation Study
ConclusionsThe acquired optimal ME collimator and energy window along with using a suitable reconstruction algorithm lead to improved contrast and SNR of90Y bremsstrahlung images of hot spheres of the digital Jaszczak phantom. This can improve the accuracy and precision of the90Y activity distribution estimation after radioembolization in targeted radionuclide therapy. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 12, 2019 Category: Nuclear Medicine Source Type: research

Radioimmunotherapy (RIT) in Brain Tumors
AbstractAnnually, the incidence of brain tumors has slightly increased and also the patient prognosis is still disappointing, especially for high-grade neoplasms. So, researchers seek methods to improve therapeutic index as a critical aim of treatment. One of these new challenging methods is radioimmunotherapy (RIT) that involves recruiting a coupling of radionuclide component with monoclonal antibody (mAb) which are targeted against cell surface tumor –related antigens or antigens of cells within the tumor microenvironment. In the context of cancer care, precision medicine is exemplified by RIT; precision medicine can o...
Source: Nuclear Medicine and Molecular Imaging - November 11, 2019 Category: Nuclear Medicine Source Type: research

Comparative Analysis of Lung Perfusion Scan and SPECT/CT for the Evaluation of Functional Lung Capacity
ConclusionsWe suggest SPECT/CT as the primary modality of choice for the assessment of the ratio of diseased lung area. Both perfusion scan and SPECT/CT can be used for the prediction of postoperative lung function. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 10, 2019 Category: Nuclear Medicine Source Type: research

68Ga-PSMA: a One-stop Shop in Radioactive Iodine Refractory Thyroid Cancer?
We report a case of a 47-year-old female known with metastatic papillary thyroid cancer. Her treatment history included total thyroidectomy and 3 previous radio ablations with a cumulative dose of 950 mCi of131I. On follow-up, her thyroglobulin levels had demonstrated a rising trend (from 3789.0 to 4240.0 ug/L) despite a123I whole-body scan demonstrating a reduction in tracer avid lesions. She was suspected of having radio-resistant disease. The patient underwent both18F-FDG and68Ga-PSMA PET/CT imaging with both scans demonstrating congruent lesions however with far greater intensity on the68Ga-PSMA study. (Source: Nuclear...
Source: Nuclear Medicine and Molecular Imaging - November 10, 2019 Category: Nuclear Medicine Source Type: research

Radioembolization for the Treatment of Primary and Metastatic Liver Cancers
AbstractRadioembolization using90Y microspheres (glass or resin) has been introduced as an effective intraarterial therapy for unresectable primary and metastatic liver cancers. Although the basic therapeutic effect of chemoembolization results from ischemia, the therapeutic efficacy of radioembolization comes from radiation. Furthermore, compared with surgical resection and local ablation therapy, radioembolization is available with less limitation on the sites or number of liver cancers. The radioisotope90Y is a β-radiation emitter without γ-radiation, with the emission of secondary bremsstrahlung photons and small num...
Source: Nuclear Medicine and Molecular Imaging - November 7, 2019 Category: Nuclear Medicine Source Type: research

Reverse Warburg Effect-Related Mitochondrial Activity and 18 F-FDG Uptake in Invasive Ductal Carcinoma
ConclusionsThe assessment of preoperative18F-FDG uptake and post-surgical mitochondrial activity may be used for the prediction of DFS in patients with IDCB. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 27, 2019 Category: Nuclear Medicine Source Type: research

Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT
AbstractImmunoglobulin G4 (IgG4) –related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and Chan Adv Anat Pathol 17:303–32,2010). Although this condition was initially described in relation to autoimmune pancreatitis, now it has been reported in almost every organ system of body (Zen and Nakanuma Am J Surg Pathol 34:1812 –9,2010, Masaki et al. Ann Rheuma Dis 68:1310 –5,2009). Orbital involvement by IgG4 disease can involve extraocular muscles (EOM), lacrimal glands, conjuncti...
Source: Nuclear Medicine and Molecular Imaging - October 24, 2019 Category: Nuclear Medicine Source Type: research

Molecular Imaging in Breast Cancer
AbstractBreast cancer (BC) is the most common cancer among females with more than 2 million new cases diagnosed worldwide in 2018. Although the prognosis in the majority of cases in the early stages combined with appropriate treatment is positive, there are still about 30% of patients who will develop locoregional diseases and distant metastases. Molecular imaging is very important in the diagnosis, staging, follow-up, and radiotherapy planning. Additionally, it is useful in characterizing lesions, prognosis, and therapy response in BC patients. Nuclear medicine imaging modalities (SPECT and PET) are of indispensable impor...
Source: Nuclear Medicine and Molecular Imaging - October 15, 2019 Category: Nuclear Medicine Source Type: research

Amyloid PET Quantification Via End-to-End Training of a Deep Learning
ConclusionWe suggest a one-step quantification method for amyloid PET via a deep learning model. The model is highly reliable to quantify the amyloid PET regardless of multicenter images and various radiotracers. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 13, 2019 Category: Nuclear Medicine Source Type: research

Correlation of Early-Phase F-18 Florapronal PET with F-18 FDG PET in Alzheimer ’s Disease and Normal Brain
ConclusionsEarly F-18 FPN study can be used as a proxy marker for the F-18 FDG PET. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 10, 2019 Category: Nuclear Medicine Source Type: research

Postoperative Radioiodine Treatment within 9  Months from Diagnosis Significantly Reduces the Risk of Relapse in Low-Risk Differentiated Thyroid Carcinoma
ConclusionIf postoperative RAI treatment is considered in low-risk DTC, any delay in RAI administration above 9  months since diagnosis may be related to poorer long-term outcomes. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 4, 2019 Category: Nuclear Medicine Source Type: research