Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT

AbstractImmunoglobulin G4 (IgG4) –related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and Chan Adv Anat Pathol 17:303–32,2010). Although this condition was initially described in relation to autoimmune pancreatitis, now it has been reported in almost every organ system of body (Zen and Nakanuma Am J Surg Pathol 34:1812 –9,2010, Masaki et al. Ann Rheuma Dis 68:1310 –5,2009). Orbital involvement by IgG4 disease can involve extraocular muscles (EOM), lacrimal glands, conjunctiva, eyelids, infraorbital nerve, orbital fat, and nasolacrimal system (McNab and McKelvie. Ophthal Plast Reconstr Surg 31:167 –78,2015, Katsura et al. Neuroradiology 54:873 –82,2012). The basis of using68Ga-DOTANOC PET/CT in IgG4 orbital disease is the known expression of somatostatin receptors in chronic inflammatory cells (Cuccurullo et al. Indian J Radiol Imaging 27:509-16,2017) and also avidity shown previously in other IgG4-related diseases (Cheng et al. Clin Nucl Med 43:773-6,2018).
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research