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A Review of Machine Learning Approaches for Brain Positron Emission Tomography Data Analysis
AbstractPositron emission tomography (PET) imaging has moved forward the development of medical diagnostics and research across various domains, including cardiology, neurology, infection detection, and oncology. The integration of machine learning (ML) algorithms into PET data analysis has further enhanced their capabilities of including disease diagnosis and classification, image segmentation, and quantitative analysis. ML algorithms empower researchers and clinicians to extract valuable insights from complex big PET datasets, which enabling automated pattern recognition, predictive health outcome modeling, and more effi...
Source: Nuclear Medicine and Molecular Imaging - February 6, 2024 Category: Nuclear Medicine Source Type: research

Association Between 18F-FDG PET Activity and HER2 Status in Breast Cancer Brain Metastases
ConclusionThe SUVmax ratio may help to identify the HER2 status of breast cancer brain metastases, if validated prospectively. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 1, 2024 Category: Nuclear Medicine Source Type: research

Stent-Induced [68Ga]Ga-FAPI Diffuse Expression in a Patient with Pancreatic Cancer: Navigating Non-oncologic Challenges
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 31, 2024 Category: Nuclear Medicine Source Type: research

Discordant Molecular Imaging Findings with 2-[18F]FDG and [68Ga]Ga-PSMA PET/CT in a Patient with Both Bladder and Prostate Cancer
We present a case of double primary cancer involving the bladder and prostate, where the prostatic primary showed intense [68Ga]Ga-PSMA uptake with non-avid skeletal and pulmonary metastases, which showed intense 2-[18F]FDG uptake, thus showing discordance due to different clonal origins. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 29, 2024 Category: Nuclear Medicine Source Type: research

Incidentally Detected Gallbladder Carcinoma: Can F-18 FDG PET/CT Aid in Staging and Prognostication?
ConclusionFDG-PET/CT detects residual and metastatic disease in patients with IGBC, enabling the institution of appropriate management and acting as a tool for prognostication of survival. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 25, 2024 Category: Nuclear Medicine Source Type: research

Hepatic Superscan in Medullary Thyroid Carcinoma: A Rare Presentation in [18F]FDG PET/CT
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 18, 2024 Category: Nuclear Medicine Source Type: research

Imaging Procedure and Clinical Studies of [18F]FP-CIT PET
AbstractN-3-[18F]fluoropropyl-2 β-carbomethoxy-3β-4-iodophenyl nortropane ([18F]FP-CIT) is a radiopharmaceutical for dopamine transporter (DAT) imaging using positron emission tomography (PET) to detect dopaminergic neuronal degeneration in patients with parkinsonian syndrome. [18F]FP-CIT was granted approval by the Ministry of Food and Drug Safety in 2008 as the inaugural radiopharmaceutical for PET imaging, and it has found extensive utilization across numerous institutions in Korea. This review article presents an imaging procedure for [18F]FP-CIT PET to aid nuclear medicine physicians in clinical practice and systema...
Source: Nuclear Medicine and Molecular Imaging - January 17, 2024 Category: Nuclear Medicine Source Type: research

First Local Experience of Intra-Cavitary Yttrium-90 Citrate Colloid Irradiation via Ommaya Reservoir for Refractory Cystic Craniopharyngioma: a Case Report
AbstractCraniopharyngioma is uncommon benign intracranial tumour that can be cured by surgical resection followed by conventional radiotherapy. However, its anatomical localisation makes the treatment hazardous or impossible. This case report aims to discuss the first local experience of using beta-emitting Yttrium-90 radioisotope in treating a patient with refractory cystic craniopharyngioma. A 43-year-old male who has underlying refractory cystic craniopharyngioma complicated with visual impairment and panhypopituitarism was referred to our nuclear medicine department for intra-cavitary irradiation therapy. Initially, he...
Source: Nuclear Medicine and Molecular Imaging - January 16, 2024 Category: Nuclear Medicine Source Type: research

A Key Mediator and Imaging Target in Alzheimer ’s Disease: Unlocking the Role of Reactive Astrogliosis Through MAOB
AbstractAstrocytes primarily maintain physiological brain homeostasis. However, under various pathological conditions, they can undergo morphological, transcriptomic, and functional transformations, collectively referred to as reactive astrogliosis. Recent studies have accumulated lines of evidence that reactive astrogliosis plays a crucial role in the pathology of Alzheimer ’s disease (AD). In particular, monoamine oxidase B, a mitochondrial enzyme mainly expressed in astrocytes, significantly contributes to neuronal dysfunction and neurodegeneration in AD brains. Moreover, it has been reported that reactive astrogliosi...
Source: Nuclear Medicine and Molecular Imaging - January 15, 2024 Category: Nuclear Medicine Source Type: research

Clinical Values of Whole-Body Blood Pool Scans and SPECT for Evaluation of Congenital Vascular Malformation
ConclusionThe study findings suggested that WBBPS with SPECT/CT could be helpful in detecting occult VM lesions and ruling out a lymphatic malformation diagnosis. Thus, it can be employed in the evaluation of CVMs. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 11, 2024 Category: Nuclear Medicine Source Type: research

Reassessing the Role of Ischemia Imaging: Insights from the ISCHEMIA Trial
AbstractIschemia imaging plays an important role in prognostication as well as guiding decision for revascularization with known CAD, as shown in multiple observational registries. However, results from the ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) presented conflicting results, hinting at no survival benefit after revascularization in patients with moderate to severe ischemia on nuclear imaging. More recent analysis from the trial did, however, show decrease in cardiac mortality and increase in non-cardiac mortality following early revascularization. Howe...
Source: Nuclear Medicine and Molecular Imaging - January 9, 2024 Category: Nuclear Medicine Source Type: research

Recent Updates on Applications of Artificial Intelligence for Nuclear Medicine Professionals: Bone Scintigraphy
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 9, 2024 Category: Nuclear Medicine Source Type: research

The development status of PET radiotracers for evaluating neuroinflammation
AbstractNeuroinflammation is associated with the pathophysiologies of neurodegenerative and psychiatric disorders. Evaluating neuroinflammation using positron emission tomography (PET) plays an important role in the early diagnosis and determination of proper treatment of brain diseases. To quantify neuroinflammatory responses in vivo, many PET tracers have been developed using translocator proteins, imidazole-2 binding site, cyclooxygenase, monoamine oxidase-B, adenosine, cannabinoid, purinergic P2X7, and CSF-1 receptors as biomarkers. In this review, we introduce the latest developments in PET tracers that can image neur...
Source: Nuclear Medicine and Molecular Imaging - January 8, 2024 Category: Nuclear Medicine Source Type: research

Convoluted Neural Network for Detection of Clinically Significant Prostate Cancer on 68  Ga PSMA PET/CT Delayed Imaging by Analyzing Radiomic Features
ConclusionCNN is a feasible pre-biopsy screening tool for identifying clinically significant prostate cancer and can be used as an adjunct in the initial diagnosis and early treatment planning. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 6, 2024 Category: Nuclear Medicine Source Type: research

The Role of Lung Ventilation/Perfusion Scan in the Management of Chronic Thromboembolic Pulmonary Hypertension
AbstractChronic thromboembolic pulmonary hypertension (CTEPH), which is classified as a group 4 pulmonary hypertension (PH), is a life-threatening complication of acute pulmonary embolism (PE). With the introduction of multidisciplinary approaches and innovative treatment strategies for CTEPH, it is currently regarded not as a fatal disease, but as a curable form of PH. Ventilation/perfusion (V/Q) scan is the preferred imaging method for screening for CTEPH, with superior sensitivity to CT pulmonary angiography. The findings and interpretations of V/Q scan in CTEPH may differ from those observed in acute PE. The use of V/Q...
Source: Nuclear Medicine and Molecular Imaging - November 22, 2023 Category: Nuclear Medicine Source Type: research