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(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - July 13, 2020 Category: Nuclear Medicine Source Type: research

Acute Promyelocytic Leukemia After Radium-223 Exposure for Prostate Cancer in a Chemotherapy-Na ïve Patient
Abstract223Ra-dichloride is a bone-seeking targeted alpha ( α)-emitting approved for bone metastases in prostate cancer. Here, we report a case of therapy-related acute promyelocytic leukemia (t-APL) following administration of223Ra, showing some evidence of a causative relationship. A patient with metastatic prostate cancer received therapy with223Ra, with 6 injections of the radiopharmaceutical at a standard dose of 55  kBq/kg at 4-week intervals for a cumulative administered activity of 26.3 MBq. PET/CT with18F-methylcholine repeated 1  month after the conclusion of223Ra was negative. After 8  months, he developed ...
Source: Nuclear Medicine and Molecular Imaging - July 8, 2020 Category: Nuclear Medicine Source Type: research

Clinical Impact of F-18 FDG PET-CT on Biopsy Site Selection in Patients with Suspected Bone Metastasis of Unknown Primary Site
ConclusionF-18 FDG PET-CT significantly contributed not only to identify the primary site but also to suggest optimal biopsy sites in patients with suspected bone metastasis. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - July 5, 2020 Category: Nuclear Medicine Source Type: research

68 Ga DOTA-TOC Uptake in Non-ossifying Fibroma: a Case Report
AbstractNon-ossifying fibroma (NOF) is a common benign bone tumor with a high probability of occurrence in children and adolescents. It is commonly seen in the metaphysis of long bones, eccentrically located, and can coexist with other malignant tumors such as neuroendocrine tumors (NET). To date, plain radiographs play a major role in the diagnosis of these benign bone tumors. Herein, we report the case of a 13-year-old male patient who was diagnosed with pulmonary NET and underwent right lung lobectomy for a hilar mass which later revealed a well-differentiated NET. The follow-up68Ga DOTA-TOC PET/CT showed a focal somato...
Source: Nuclear Medicine and Molecular Imaging - July 5, 2020 Category: Nuclear Medicine Source Type: research

Physiological Uptake of Radioactive Iodine Around an Artificial Eyeball Observed with Single-Photon Emission Computed Tomography/Computed Tomography After Radioactive Iodine Treatment
In this study, scintigraphy and single-photon emission computed tomography/computed tomography images after radioactive iodine treatment revealed a physiological uptake of radioactive iodine due to lacrimal secretion around an artificial eyeball; such findings have not been reported previously. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - July 5, 2020 Category: Nuclear Medicine Source Type: research

Assessment of Suspected Malignancy or Infection in Immunocompromised Patients After Solid Organ Transplantation by [ 18 F]FDG PET/CT and [ 18 F]FDG PET/MRI
ConclusionFor immunocompromised patients with clinically unresolved symptoms, to rule out vital tumor manifestations or metabolic active inflammation, [18F]FDG-PET/MRI, CE-[18F]FDG-PET/CT, and NC-[18F]FDG-PET/CT exhibit excellent performance in diagnosing malignancy or infection. The main strength of PET/MRI is its considerably lower level of radiation exposure than that associated with PET/CT. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - July 1, 2020 Category: Nuclear Medicine Source Type: research

Association Between Colonic 18 F-FDG Uptake and Glycemic Control in Patients with Diabetes Mellitus
ConclusionsPatients with DM who did not show increased colonic FDG uptake after taking OHA were associated with higher fasting blood glucose and HbA1c levels on the day of FDG PET/CT. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - June 16, 2020 Category: Nuclear Medicine Source Type: research

Relationship of EGFR Mutation to Glucose Metabolic Activity and Asphericity of Metabolic Tumor Volume in Lung Adenocarcinoma
ConclusionIn Asian NSCLC/ADC patients, SUVmax, MTV, and ASP on FDG PET are significantly related to EGFR mutation status. Particularly, low SUVmax and ASP are independent determinants for EGFR-mt. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - June 13, 2020 Category: Nuclear Medicine Source Type: research

Computed Tomography (CT) Protocols Associated with Cardiac and Bone Single-Photon Emission Computed Tomography/CT (SPECT/CT) in Korea
ConclusionsThe results and current recommendations will be helpful for optimizing CT protocols for SPECT/CT. Optimization of SPECT/CT protocols will be required for generating the proper strategy for the specific lesions and clinical purpose. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - May 31, 2020 Category: Nuclear Medicine Source Type: research

Rodent Leukocyte Isolation and Radiolabeling for Inflammation Imaging Study
ConclusionInflamed lesions of rats were well visualized using autologous radiolabeled leukocytes. This method might provide good information for understanding inflammatory diseases. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - May 28, 2020 Category: Nuclear Medicine Source Type: research

How to Publish Good Nuclear Medicine and Molecular Imaging Scientific Papers?
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - May 15, 2020 Category: Nuclear Medicine Source Type: research

Reduction of Salivary Gland Damage During Radioiodine Therapy for Differentiated Thyroid Cancers
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - May 11, 2020 Category: Nuclear Medicine Source Type: research

Radiogenomics Based on PET Imaging
AbstractRadiogenomics or imaging genomics is a novel omics strategy of associating imaging data with genetic information, which has the potential to advance personalized medicine. Imaging features extracted from PET or PET/CT enable assessment of in vivo functional and physiological activity and provide comprehensive tumor information non-invasively. However, PET features are considered secondary to features on conventional imaging, and there has not yet been a review of the radiogenomic approach using PET features. This review article summarizes the current state of PET-based radiogenomic research for cancer, which discus...
Source: Nuclear Medicine and Molecular Imaging - May 8, 2020 Category: Nuclear Medicine Source Type: research

First In-Human Medical Imaging with a PASylated 89 Zr-Labeled Anti-HER2 Fab-Fragment in a Patient with Metastatic Breast Cancer
ConclusionThis study demonstrates that a PASylated Fab tracer shows appropriate blood clearance to allow sensitive visualization of small tumor lesions in a clinical setting. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - April 19, 2020 Category: Nuclear Medicine Source Type: research

Preclinical Voxel-Based Dosimetry in Theranostics: a Review
AbstractDue to the increasing use of preclinical targeted radionuclide therapy (TRT) studies for the development of novel theranostic agents, several studies have been performed to accurately estimate absorbed doses to mice at the voxel level using reference mouse phantoms and Monte Carlo (MC) simulations. Accurate dosimetry is important in preclinical theranostics to interpret radiobiological dose-response relationships and to translate results for clinical use. Direct MC (DMC) simulation is believed to produce more realistic voxel-level dose distribution with high precision because tissue heterogeneities and nonuniform s...
Source: Nuclear Medicine and Molecular Imaging - April 18, 2020 Category: Nuclear Medicine Source Type: research