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False-Positive Gallium-68 DOTATATE PET/CT in Vertebral Hemangioma
AbstractA healthy 52-year-old man started to have few minutes spells of palpitation, tachycardia, hot flashes, and chest tightness. He had a lab work-up for carcinoid, including 5-hydroxyindoleacetic acid (5-HIAA), which was negative. Months later, his symptoms became worse which warranted further investigation to exclude carcinoid disease. Gallium-68 DOTATATE positron emission tomography combined with computed tomography (PET/CT) scanning was performed to assess the patient for carcinoid tumor. It showed foci of radiotracer avidity in the thoracic and lumber spine. Magnetic resonance imaging (MRI) for the vertebral lesion...
Source: Nuclear Medicine and Molecular Imaging - January 18, 2021 Category: Nuclear Medicine Source Type: research

Rosai-Dorfman Disease: Importance of 18 F FDG PET/CT to Determine Extension and Extranodal Involvement
We present the case of a 69-year-old woman with nasal obstruction as only complaint. Laboratory tests showed normal leukocyte count with elevated ANC  (absolute neutrophil count), normal RBC count with normal MCV (mean corpuscular volume) and MCH (mean corpuscular hemoglobin), elevated ESR (erythrocyte sedimentation rate), and normal IgG, IgA, and IgM values. Evaluation revealed a nasopharyngeal mass, which was biopsied and reported emperipol esis with positive CD68 and S-100; typical and differential findings of this disease [1,2].18F FDG PET/CT was performed to determine the extent and involvement of the disease. Con...
Source: Nuclear Medicine and Molecular Imaging - January 16, 2021 Category: Nuclear Medicine Source Type: research

Peptide Receptor Radionuclide Therapy of Pulmonary Neuroendocrine Neoplasms: a Single-Centre Experience
ConclusionsOur data furtherly support peptide receptor radionuclide therapy as a safe and effective treatment of patients affected by pulmonary neuroendocrine neoplasms allowing disease control in about 71% of patients without showing significant toxicity. Other studies are needed to confirm our results. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 12, 2021 Category: Nuclear Medicine Source Type: research

Development of GATE Monte Carlo Code for Simulation and Dosimetry of New I-125 Seeds in Eye Plaque Brachytherapy
ConclusionsOur simulation results show that although new model of the125I brachytherapy source having a slightly larger dimension than IAI-125A, it can be used for eye melanoma treatment because the COMS eye plaque loaded with IrSeed-125 could produce similar results to the IsoAid seeds, which is applicable for clinical plaque brachytherapy for uveal melanoma. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 11, 2021 Category: Nuclear Medicine Source Type: research

Nuclear Imaging for Cardiac Amyloidosis: Bone Scan, SPECT/CT, and Amyloid-Targeting PET
AbstractCardiac amyloidosis (CA) is a type of systemic amyloidosis, in which abnormal amyloid fibril is deposited in extracellular space of myocardium. Most common subtypes of CA are amyloidosis of immunoglobulin light chain (AL) and amyloidosis of transthyretin (ATTR). With increase in incidence of CA and development of new drugs, the needs of early and accurate diagnosis of CA are increasing. In CA, bone scan and SPECT/CT have long been used for diagnosis. Currently, bone scan is included in almost all practice guidelines as one of key diagnostic examinations for ATTR CA. In some specific scenarios, bone scan can be used...
Source: Nuclear Medicine and Molecular Imaging - January 7, 2021 Category: Nuclear Medicine Source Type: research

Management Impact of 68 Ga-DOTATATE PET/CT in Neuroendocrine Tumors
ConclusionOur retrospective cohort demonstrated that68Ga-DOTATATE PET/CT improves lesion detection over conventional imaging in 33.3% and impacts the therapeutic management in 23.8% of patients with NET. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 7, 2021 Category: Nuclear Medicine Source Type: research

Is There Any Need for Adjusting 131 I Activity for the Treatment of High Turnover Graves ’ Disease Compared to Normal Turnover Patients? Results from a Retrospective Cohort Study Validated by Propensity Score Analysis
ConclusionHigh turnover Graves ’ disease patients, if administered standard131I activity, the outcomes shall be poor. To improve the success rate,131I activity should be increased by 1.5 to 2 times in the high turnover patients. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 7, 2021 Category: Nuclear Medicine Source Type: research

A Review of Neuroimaging Studies in Persistent Postural-Perceptual Dizziness (PPPD)
AbstractPersistent postural-perceptual dizziness (PPPD) is a functional vestibular disease characterized by persistent dizziness, unsteadiness, and/or non-spinning vertigo, and is the most common vestibular syndrome in young adults. A stiffened postural control strategy, shift to reliance on visual over vestibular information, and hypervigilance to the environment have been suggested as possible pathophysiological mechanisms of PPPD. However, the exact mechanisms remain unclear. Recently, neuroimaging studies using magnetic resonance imaging and single photon emission computed tomography have provided pivotal insights into...
Source: Nuclear Medicine and Molecular Imaging - January 7, 2021 Category: Nuclear Medicine Source Type: research

The Influence of H2-Receptor Antagonist Administration to the 24-h Uptake of I-131 in the Thyroid Gland
ConclusionH2-receptor antagonist caused a significance reduction of 24-h I-131 uptake value in the thyroid gland. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 7, 2021 Category: Nuclear Medicine Source Type: research

99m Tc-HSA-DTPA Scintigraphy of Protein-Losing Gastroenteropathy Associated with Mixed Connective Tissue Disease Before and After Immunosuppressive Therapy
We present a female in her sixties with mixed connective tissue disease who underwent99mTc-human serum albumin diethylenetriaminepentaacetic acid (99mTc-HSA-DTPA) scintigraphy to clarify the cause of generalized edema. Scintigraphy findings directed the diagnosis to protein-losing gastroenteropathy. Various disorders are known to be associated with protein-losing gastroenteropathy; however, mixed connective tissue disease is a rare cause.99mTc-HSA-DTPA scintigraphy is helpful in the diagnosis and following the response to therapy of protein-losing gastroenteropathy. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 7, 2021 Category: Nuclear Medicine Source Type: research

Choroid Plexus as the Best Reference Region for Standardized Uptake Value Analysis on C11-Acetate PET/CT for Grading and Predicting Prognosis in Patients with Cerebral Gliomas
ConclusionOf the different reference regions used for grading cerebral gliomas, the choroid plexus was found to be the most optimal. In addition, the SUV ratio is useful to predict the overall survival in the model with the choroid plexus as a reference region. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 16, 2020 Category: Nuclear Medicine Source Type: research

Isolated Testicular Metastasis from Prostate Cancer Detected on Ga-68 PSMA PET/CT Scan
This report highlights the importance of68Ga-PSMA PET-CT scan in detecting these unusual and rare sites of metastasis from prostate cancer. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 9, 2020 Category: Nuclear Medicine Source Type: research

Perfusion Scintigraphy for the Evaluation of Patients with Raynaud ’s Phenomenon
AbstractRaynaud ’s phenomenon (RP) is a functional vascular disorder, which can be defined as transient vasospasm of the peripheral arteries and arterioles in the affected areas exposed to the cold or other stress. The diagnosis of RP is mainly based on symptoms. Perfusion scintigraphy, with or without cold stimu lation, can be used to evaluate RP. Studies with perfusion scintigraphy for RP have shown that patients with RP showed lower finger-to-palm ratio than patients without RP. Responses after cold stimulation were also different in patients with RP. Not only decreased perfusion or blood pool after cold stimulation b...
Source: Nuclear Medicine and Molecular Imaging - October 22, 2020 Category: Nuclear Medicine Source Type: research

Self-supervised PET Denoising
ConclusionThe self-supervised denoising method will be useful for reducing the PET scan time or radiation dose. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 20, 2020 Category: Nuclear Medicine Source Type: research

Predicting Vascularized Bone Graft Viability Using 1-Week Postoperative Bone SPECT/CT After Maxillofacial Reconstructive Surgery
ConclusionsThe absence of tracer uptake by the vascularized bone graft on bone SPECT/CT at 1 week after maxillary or mandibular reconstructive surgery can predict graft failure. Bone SPECT/CT can be used to predict vascularized bone graft viability postoperatively. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 19, 2020 Category: Nuclear Medicine Source Type: research