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Perspectives for Concepts of Individualized Radionuclide Therapy, Molecular Radiotherapy, and Theranostic Approaches
AbstractRadionuclide therapy (RNT) stands on the delivery of radiation to tumors or non-tumor target organs using radiopharmaceuticals that are designed to have specific affinity to targets. RNT is recently called molecular radiotherapy (MRT) by some advocators in order to emphasize its characteristics as radiotherapy and the relevance of dosimetry-guided optimization of treatment. Moreover, RNT requires relevant radiation protection standards because it employs unsealed radionuclides and gives therapeutic radiation doses in humans. On the basis of these radiation protection standards, the development and use of radiopharm...
Source: Nuclear Medicine and Molecular Imaging - January 29, 2019 Category: Nuclear Medicine Source Type: research

Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies
AbstractRadiometals have been commonly used in medical applications, and utilization of such metals continues to be an attractive research area. In particular, a variety of radiometals have been developed and implemented for molecular imaging. For such applications,89Zr has been one of the most interesting radiometals currently used for tumor targeting. Several chemical ligands were developed as89Zr chelators, and new coordinating methods have also been developed more recently. In addition, immuno-positron emission tomography (PET) studies using89Zr-labeled monoclonal antibodies have been performed by several scientists. I...
Source: Nuclear Medicine and Molecular Imaging - January 29, 2019 Category: Nuclear Medicine Source Type: research

Current Status and Growth of Nuclear Theranostics in Singapore
AbstractThe concept of theranostics, where individual patient-level biological information is used to choose the optimal therapy for that individual, has become more popular in the modern era of ‘personalised’ medicine. With the growth of theranostics, nuclear medicine as a specialty is uniquely poised to grow along with the ever-increasing number of concepts combining imaging and therapy. This special report summarises the status and growth of Theranostic Nuclear Medicine in Singapore. We will cover our experience with the use of radioiodine, radioiodinated metaiodobenzylguanidine, peptide receptor radionuclide therap...
Source: Nuclear Medicine and Molecular Imaging - January 25, 2019 Category: Nuclear Medicine Source Type: research

Theranostics in India: a Particularly Exquisite Concept or an Experimental Tool
AbstractThe term theranostics is a combination of a diagnostic tool that helps to define a right therapeutic tool for specific disease and paves the approach towards personalized or precision medicine. In Nuclear Medicine, a diagnostic radionuclide is labeled with the target and once expression is documented, the same target is labeled with a therapeutic radionuclide and treatment is executed. The theranostic concept was applied first time in 1964 in the treatment of thyroid cancer with I-131 (RAI). Over the years, other theranostic radiotracers became available indigenously from the Bhabha Atomic Research Centre (BARC) in...
Source: Nuclear Medicine and Molecular Imaging - January 23, 2019 Category: Nuclear Medicine Source Type: research

Tracer Accumulation in Relation to Venous Thrombus on 18 F-DOPA PET/CT in a Case of Persistent Hyperinsulinemic Hypoglycemia of Infancy
We present the findings in a 20-day-old neonate with PHHI who underwent18F-DOPA PET/CT. The scan showed diffuse uptake in the pancreas with no focal lesion, physiologic excretion into the genito-urinary system, and interestingly tracer accumulation was seen in the inferior vena cava and ilio-femoral veins which is a non-physiological site for tracer accumulation. The uptake corresponded to a large venous thrombus which was confirmed by a venous Doppler. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 23, 2019 Category: Nuclear Medicine Source Type: research