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Bilateral Ovarian Metastases of Hepatocellular Carcinoma Diagnosed with 18F-Fluorocholine PET/CT in a Patient with Endometriosis
AbstractA 47-year-old woman with history of hepatocellular carcinoma was referred for18F-fluorocholine PET/CT evaluation due to elevated alpha-fetoprotein. The examination showed several peritoneal uptakes and two nodular pelvic foci. Coelioscopic exploration allowed confirmation and resection of multiple peritoneal metastases from hepatocellular carcinoma while pelvic biopsies revealed endometriosis and endosalpingiosis. However, alpha-fetoprotein kept rising: subsequent18F-fluorodesoxyglucose PET/CT exploration found no pelvic uptake, while18F-fluorocholine PET/CT revealed intense tracer accumulation in the two pelvic ma...
Source: Nuclear Medicine and Molecular Imaging - April 14, 2023 Category: Nuclear Medicine Source Type: research

Radionuclide Therapy Videos on YouTube as An Educational Material: Has the COVID-19 Pandemic Changed the Quality, Usefulness, and Interaction Features
ConclusionRadionuclide therapy YouTube videos have high-quality content and provide useful education material. The popularity is independent of the content quality. During the pandemic, video quality and usefulness characteristics did not change, while the visibility is increased. We consider YouTube to be an appropriate educational material for patients and healthcare professionals to gain basic knowledge of radionuclide therapy. The Cov ıd-19 pandemic highlighted the power of radionuclide therapy YouTube videos as an educational material. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - April 5, 2023 Category: Nuclear Medicine Source Type: research

Molecular Imaging in Recurrent Prostate Cancer Presented as a Mixed Small Neuroendocrine Tumor/Acinar Adenocarcinoma
AbstractMolecular imaging is an important tool for evaluating patients with prostate cancer, including those with hybrid histopathology. Although rare, mixed small neuroendocrine tumor/acinar adenocarcinoma exhibit aggressive behavior that necessitates optimal therapy. Molecular imaging has been implemented previously to assess radioligand therapy eligibility in such cases. Interestingly, the uptake of radiotracers targeting prostate-specific membrane antigen (PSMA) and somatostatin receptor may be reduced and can potentially lead to false negative readings in certain tumor types with hybrid features. Therefore, physicians...
Source: Nuclear Medicine and Molecular Imaging - April 5, 2023 Category: Nuclear Medicine Source Type: research

Synchronous Pulmonary Malignancy Detected During PSMA Ligand PET/CT for Initial Staging of Prostate Cancer: a Case Report
We present a case of an 83-year-old man with underlying colorectal cancer who underwent a gallium-68 prostate specific membrane antigen-11 positron emission tomography/computed tomography (68 Ga-PSMA-11 PET/CT) for the initial staging of prostate cancer. PET / CT revealed two mildly PSMA-avid lung nodules without evidence of PSMA-avid nodal or bony metastasis. Subsequently, a wedge pulmonary resection was performed and the histopathology and immunohistochemistry of the nodules were con sistent with synchronous primary lung cancer. Because differentiating synchronous primary lung cancer from pulmonary metastasis of prostat...
Source: Nuclear Medicine and Molecular Imaging - April 5, 2023 Category: Nuclear Medicine Source Type: research

The Value of 18F-FDG PET/MRI in Detecting Lumbar Radiculopathy for Selective Percutaneous Endoscopic Discectomy: a Case Report
AbstractMagnetic resonance imaging (MRI) is the most popular imaging modality for investigating intervertebral disc herniation. However, it has a high chance for identifying incidental findings that are morphologically or structurally abnormal but not responsible for patients ’ symptoms. Although a previous study suggested that18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) may help identify neuroinflammation in lumbar radiculopathy, there is currently no direct evidence obtained from surgery. Here, we describe the case of a 32-year-old man with low back pain and right l...
Source: Nuclear Medicine and Molecular Imaging - March 29, 2023 Category: Nuclear Medicine Source Type: research

Optimization of BMI-Based Images for Overweight and Obese Patients — Implications on Image Quality, Quantification, and Radiation Dose in Whole Body 18F-FDG PET/CT Imaging
ConclusionThe optimized BMI-based approach using 1 iteration, 21 subsets, and 3  mm Hamming filter improves image quality, reduces radiation dose, and provides, at least, similar quantification compared to the BW-based approach for overweight and obese patients. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - March 20, 2023 Category: Nuclear Medicine Source Type: research

Interesting Presentation of Mycosis Fungoides in Staging on F-18 FDG PET/CT
We report an interesting case of mycosis fungoides with bilateral upper limb edema and share its findings on F-18 FDG PET/CT. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - March 17, 2023 Category: Nuclear Medicine Source Type: research

Evaluation of an Integrin αvβ3 Radiotracer, [18F]F-FPP-RGD2, for Monitoring Pharmacological Effects of Integrin αv siRNA in the NASH Liver
ConclusionThis study suggests that [18F]F-FPP-RGD2 PET imaging is a promising radiotracer for monitoring hepatic integrin αv protein levels and hepatic function in NASH pathology. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - March 7, 2023 Category: Nuclear Medicine Source Type: research

Optimal Protocol and Clinical Usefulness of 123I-MIBG Cardiac Scintigraphy for Differentiation of Parkinson ’s Disease and Dementia with Lewy Body from Non-Parkinson’s Diseases
ConclusionThis study reassured that 4-h-delayed imaging is recommended for the best diagnostic performances in123I-MIBG cardiac scintigraphy. Although it showed suboptimal diagnostic performances to differentiate PD, PDD, and DLB from non-Parkinson ’s diseases, it can be useful as an auxiliary measure for the differential diagnosis in usual clinical practice. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - March 7, 2023 Category: Nuclear Medicine Source Type: research

Incidental Detection of Papillary Thyroid Carcinoma in Tc-99  m PSMA Imaging in a Case with Negative FNA Result
We presented a case of a prostate cancer patient who went through Tc-99  m PSMA SPECT, and multifocal increased radiotracer uptake in the thyroid gland was demonstrated. Despite negative FNA results for malignancy, post-operative histopathologic examination illustrated papillary thyroid carcinoma. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 28, 2023 Category: Nuclear Medicine Source Type: research

Breast Metastasis Arising from Ileal Neuroendocrine Tumor: an Unusual Presentation
AbstractNeuroendocrine tumors (NETs) up to 80% may have metastatic disease to lymph nodes, liver, and bones upon diagnosis due to their indolent course and benign nature. However, metastasis to the breast from gastropancreatic-neuroendocrine tumors (GEP-NETs) is unusual and rarely reported. Furthermore, such metastases may mimic a primary breast carcinoma clinically and radiologically. This case report illustrates an unusual presentation of metastasis to the right breast in addition to liver, pancreas, and lymph nodal metastases in a patient with ileal NET who was operated upon 5  years back. The metastases were detected ...
Source: Nuclear Medicine and Molecular Imaging - February 28, 2023 Category: Nuclear Medicine Source Type: research

Hot Embolus Artifact Mimicking Disease Progression in Post-therapy 177Lu-DOTATATE Scan: Incremental Value of SPECT/CT
AbstractPeptide receptor radionuclide therapy (PRRT) has become an established treatment for patients with inoperable and/or metastatic, well-differentiated neuroendocrine tumors with overexpression of somatostatin receptor type 2 (SSTR-2). The post-therapy177Lu-DOTATATE whole-body scan not only assesses the biodistribution of the lesions seen on pre-therapy68 Ga-SSTR PET/CT scan but also provides a quick assessment of disease status and dosimetry during treatment. Like any other radionuclide scan, the whole-body177Lu-DOTATATE scan may also show abnormal radiotracer uptake, which may require further imaging to establish i...
Source: Nuclear Medicine and Molecular Imaging - February 18, 2023 Category: Nuclear Medicine Source Type: research

Algorithm for Reducing Overall Biological Detriment Caused by PET/CT: an Age-Based Study
ConclusionImplementation of ALGO protocols in PET can reduce the overall ACR, mainly in young and female patients. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 4, 2023 Category: Nuclear Medicine Source Type: research

Dual-Tracer Parathyroid Imaging Using Joint SPECT Reconstruction
ConclusionsThe joint reconstruction method yielded higher lesion detectability than the conventional method and holds promise for dual-tracer parathyroid SPECT imaging. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 16, 2023 Category: Nuclear Medicine Source Type: research

Applying Pix2pix to Translate Hyperemia in Blood Pool Image into Corresponding Increased Bone Uptake in Delayed Image in Three-Phase Bone Scintigraphy
ConclusionThe model based on pix2pix generated increased uptake in delayed images matching the hyperemia in the blood pool image in inflammatory arthritis and CRPS. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 3, 2023 Category: Nuclear Medicine Source Type: research