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Utility of Lung Perfusion SPECT/CT in Detection of Pulmonary Thromboembolic Disease: Outcome Analysis
ConclusionsIn the current COVID-19 pandemic, Q-SPECT/CT can be an alternative modality to detect pulmonary thromboembolic disease. Normal Q-SPECT/CT excludes pulmonary thromboembolic disease with high degree of certainty. However, false positive has been observed. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - January 6, 2022 Category: Nuclear Medicine Source Type: research

A Negative Correlation Between Blood Glucose Level and 68  Ga-DOTA-TOC Uptake in the Pancreas Uncinate Process
ConclusionPhysiologic68 Ga-DOTA-TOC uptake in the pancreas uncinate process was negatively correlated with BGL. Our results suggested that glycemia could affect physiologic uptake of68 Ga-DOTA-TOC. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 24, 2021 Category: Nuclear Medicine Source Type: research

F-18 FDG PET/CT in NK/T-Cell Lymphoma that Progressed from Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis
AbstractHemophagocytic lymphohistiocytosis (HLH) is a syndrome involving an uncontrolled immune response with variable triggers. HLH is rare but highly fatal, even with proper treatment; therefore, early recognition and diagnosis are crucial for management. Although the role of F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in HLH is poorly defined, it can provide valuable information on disease status and possible triggers. Herein, we report an F-18 FDG PET/CT study on a case of NK/T-cell lymphoma that progressed from Epstein-Barr virus-associated HLH. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 17, 2021 Category: Nuclear Medicine Source Type: research

A Brief History of Nuclear Medicine Physics, Instrumentation, and Data Sciences in Korea
AbstractWe review the history of nuclear medicine physics, instrumentation, and data sciences in Korea to commemorate the 60th anniversary of the Korean Society of Nuclear Medicine. In the 1970s and 1980s, the development of SPECT, nuclear stethoscope, and bone densitometry systems, as well as kidney and cardiac image analysis technology, marked the beginning of nuclear medicine physics and engineering in Korea. With the introduction of PET and cyclotron in Korea in 1994, nuclear medicine imaging research was further activated. With the support of large-scale government projects, the development of gamma camera, SPECT, and...
Source: Nuclear Medicine and Molecular Imaging - November 12, 2021 Category: Nuclear Medicine Source Type: research

Incidental Muscle Uptake of 177Lu-DOTATATE in Peripheral Vascular Disease
We present a 48-year-old male with metastatic neuroendocrine tumor who underwent lutetium-177-based somatostatin receptor-based therapy. The post-therapy scan showed a focal tracer uptake in the left calf muscle in addition to the expected tracer uptake at the primary and metastatic sites. Further, cross-sectional imaging and biochemical investigations revealed peripheral vascular disease (PVD). The incidental tracer uptake in the calf on post-therapy scan potentiates the role of somatostatin receptor scintigraphy in identifying macrophage-specific inflammatory reactions. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 12, 2021 Category: Nuclear Medicine Source Type: research

Usefulness of 99mTc-SESTAMIBI Scintigraphy in Persistent Hyperparathyroidism after Kidney Transplant
ConclusionsRegardless of relatively low and less discrete uptake in KT patients, it well depicts the largest and the most hyperfunctioning lesion. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 30, 2021 Category: Nuclear Medicine Source Type: research

Versatile Role of 18F-FDG PET/CT in a Patient with Pan-cerebellar Paraneoplastic Manifestation Due to Underlying Hodgkin ’s Lymphoma
AbstractHodgkin ’s lymphoma most commonly presents as painless lymphadenopathy and systemic B symptoms like fever, night sweats, and weight loss. But rarely, it can present with unusual paraneoplastic manifestations. In the present case, we report a 30-year-old woman who presented with sub-acute onset pan-cerebel lar symptoms. The serum neuronal antibody panel was negative. She underwent F-18 FDG PET/CT to evaluate the neoplastic etiology as the underlying cause, which demonstrated both the primary etiology and the paraneoplastic changes in the brain. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 21, 2021 Category: Nuclear Medicine Source Type: research

Increased 68  Ga-PSMA-11 Bone Marrow and Splenic Uptake in a Case of Erythroid Myelodysplasia
We describe the case of an 82-year-old man who underwent68 Ga-prostate-specific membrane antigen-11 (68 Ga-PSMA-11) positron emission tomography/computed tomography (PET/CT) for the restaging of prostate carcinoma.68 Ga-PSMA-11 PET/CT unexpectedly showed increased tracer uptake homogenously involving the axial and appendicular bone marrow and the spleen, not characteristic for metastatic prostate disease. Further investigations revealed that 2 months before the patient underwent bone marrow biopsy, which show ed the occurrence of monolinear myelodysplasia. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 20, 2021 Category: Nuclear Medicine Source Type: research

A Case of Glomus Tumor Mimicking Neuroendocrine Tumor on 68  Ga-DOTATOC PET/CT
We present the case of a 61-year-old male with a glomus tumor who underwent distal gastrectomy under the pretense of an NET grade 1 because the nodule showed focal intense uptake on preoperative68 Ga-DOTATOC PET/CT. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 13, 2021 Category: Nuclear Medicine Source Type: research

Predictors of Macrovascular Invasion and Extrahepatic Metastasis in Treatment Naive Hepatocellular Carcinoma: When Is [18F] FDG PET/CT Relevant?
ConclusionIn treatment naive HCC patients with AFP  >  93.7 ng/ml or maximum tumor size >  5.0 cm, [18F] FDG PET/CT can be valuable. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 4, 2021 Category: Nuclear Medicine Source Type: research

Comparison between Tc-99  m DTPA and Tc-99 m MAG3 Renal Scintigraphy for Prediction of Early Adverse Outcome After Kidney Transplantation
ConclusionThree parameters which, when obtained from Tc-99  m MAG3 RS, had superior predictiveness compared with Tc-99 m DTPA RS, including time to peak, 20-min to peak ratio, and 20-min to 3-min ratio. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 2, 2021 Category: Nuclear Medicine Source Type: research

Multifocal Meningiomas Mimicking Metastasis on 18F-Fluciclovine PET/CT
AbstractA 65-year-old male patient with a past medical history of prostate adenocarcinoma presented with biochemical recurrence (prostate-specific antigen level of 5.91 mg/L).18F-FACBC PET/CT was acquired to evaluate the disease recurrence and metastasis. Multifocal areas of tracer uptake localized to the dural surface of frontal convexities and cavernous sinuses were seen. Subsequent MRI confirmed lesions to be consistent with multifocal meningiomas. Focal intracranial 18F-fluciclovine radiotracer uptake especially at the skull base may present with a diagnostic challenge, and it may be difficult to differentiate between ...
Source: Nuclear Medicine and Molecular Imaging - September 23, 2021 Category: Nuclear Medicine Source Type: research

Patient-Specific Dosimetry in Radioligand Therapy (RLT) for Metastatic Prostate Cancer Using 177Lu-DKFZ-PSMA-617
ConclusionsBased on the results, the177Lu-PSMA-617 therapy is a safe method for the treatment of castration-resistant prostate cancer patients. Large inter-individual variations in organ dose were found, demonstrating the need for patient-specific dosimetry and treatment planning. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 18, 2021 Category: Nuclear Medicine Source Type: research

Radioguided Surgery in Insulinoma Using 68Ga Labeled Exendin-4: a Case Report
We present a case of a 34-year-old man with clinical suspicion of insulinoma with negative conventional imaging and successful lesion localization with68Ga-Exendin-4 PET/CT scan in the pancreatic body, who underwent laparoscopic enucleation of the lesion with the aid of a hand-held gamma detecting probe. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 10, 2021 Category: Nuclear Medicine Source Type: research

KSNM60 in Clinical Nuclear Oncology
AbstractSince the foundation of the Korean Society of Nuclear Medicine in 1961, clinical nuclear oncology has been a major part of clinical nuclear medicine in Korea. There are several important events for the development of clinical nuclear oncology in Korea. First, a scintillating type gamma camera was adopted in 1969, which enabled to perform modern oncological gamma imaging. Second, Tc-99  m generator was imported to Korea since 1979, which promoted the wide clinical use of gamma camera imaging by using various kinds of Tc-99 m labeled radiopharmaceuticals. Third, a gamma camera with single photon emission tomography...
Source: Nuclear Medicine and Molecular Imaging - August 31, 2021 Category: Nuclear Medicine Source Type: research