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The Presence of Residual Vascular and Adipose Tissue Inflammation on 18F-FDG PET in Patients with Chronic Coronary Artery Disease
ConclusionPatients with a chronic CAD had a higher aortic root and subcutaneous adipose tissue18F-FDG uptake compared to control patients, which suggests residual inflammatory risk. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - December 26, 2022 Category: Nuclear Medicine Source Type: research

Hyperfunctioning Intrathyroidal Parathyroid: a Misleading Preoperative Diagnosis
We present three patients with primary hyperparathyroidism related to hyperfunctioning intrathyroidal parathyroid retrospectively selected among 732 cases from own Institutional parathyroid PET/CT registry from 2018 to 2022. Intrathyroidal parathyroids showed intense18F-fluorocholine uptake but a variable echographic pattern, inconstant99mTc-MIBI uptake, and atypic iodine-contrast enhancement. Although rare, the possibility of an intrathyroidal parathyroid should be considered when no hyperfunctioning gland is found on preoperative imaging and thorough bilateral neck exploration. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 19, 2022 Category: Nuclear Medicine Source Type: research

Diagnosis of Fungal Infection (Candida albicans) After Heart Transplantation in a Pediatric Case with Fever of Unknown Origin: Role of 99mTc-UBI SPECT/CT and 18F-FDG PET/CT
AbstractThe diagnosis of patients with fever of unknown origin (FUO) in pediatric heart transplantation is a challenging medical problem. The physician should differentiate between rejections, infections, malignancy, adrenal insufficiency, and drug fever. Immunosuppressive therapy in these patients exposes them to a high risk of developing a post-transplantation fungal infection. In this case, we discuss the diagnostic contribution of the99mTc-UBI scan and18F-FDG PET scan for diagnosis of fungal infection causing FUO in these patients. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - November 2, 2022 Category: Nuclear Medicine Source Type: research

FDG PET/CT Maximum Tumor Dissemination to Predict Recurrence in Patients with Diffuse Large B-Cell Lymphoma
ConclusionsDmax at the time of diagnosis and the EOT response assessed by FDG PET/CT provide useful prognostic information additive to the IPI in patients with DLBCL. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 27, 2022 Category: Nuclear Medicine Source Type: research

Diagnosis of Seronegative Rheumatoid Arthritis by 68  Ga-FAPI PET/CT
AbstractEarly diagnosis of rheumatoid arthritis with the initiation of disease-modifying antirheumatic drugs is important to prevent future disability. Seronegative rheumatoid arthritis lacks the classical immunological markers, thus imposing clinical diagnostic difficulty. In this case, we reported68 Ga-FAPI PET/CT findings of seronegative rheumatoid arthritis in a 60-year-old lady. This case illustrates how68 Ga-FAPI PET/CT aids in the diagnosis of seronegative rheumatoid arthritis. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 20, 2022 Category: Nuclear Medicine Source Type: research

Kinetic Evaluation of the Hypoxia Radiotracers [18F]FMISO and [18F]FAZA in Dogs with Spontaneous Tumors Using Dynamic PET/CT Imaging
ConclusionsOur results showed that [18F]FAZA provided a promising alternative radiotracer to [18F]FMISO with detecting the presence of tumor hypoxia at an earlier time (60  min), consistent with its favorable faster kinetics. The strong correlation between TMRmax over the 90 –150 min and 120–150 min timeframes with [18F]FMISO and [18F]FAZA, respectively, with kinetic parameters associated with tumor hypoxia for each radiotracer, suggests that a static scan measurement (TMRmax) is a good alternative to quantify tumor hypoxia. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 11, 2022 Category: Nuclear Medicine Source Type: research

The Complementary Role of PET to Pathology in Differentiating the Primary Origin of a Malignant Skin Nodule from Liver or Lung
We present a case of malignant abdominal wall nodule initially diagnosed as metastasis from hepatocellular carcinoma through excisional biopsy and immunohistochemical (IHC) staining. Dual-tracer positron emission tomography/computed tomography (PET/CT) with11C-acetate and18F-FDG, however, showed metabolic findings in favor of metastasis from lung origin, which was finally confirmed by ensuing a lung biopsy with additional IHC stains. This case illustrates the complementary molecular role of PET to pathology, particularly when dual-tracer or multi-tracer PET is used in conjunction with pathology methods for cross referencin...
Source: Nuclear Medicine and Molecular Imaging - October 10, 2022 Category: Nuclear Medicine Source Type: research

Preparation of Patient Doses of [177Lu]Lu-DOTATATE and [177Lu]Lu-PSMA-617 with Carrier Added (CA) and No Carrier Added (NCA) 177Lu
ConclusionRobust protocols for the preparation of clinical doses of [177Lu]Lu-DOTATATE and [177Lu]Lu-PSMA-617 were developed and used for the preparation of clinical doses. The quality of the SPECT images of both the tracers are consistent with the expected uptake in respective diseases. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 7, 2022 Category: Nuclear Medicine Source Type: research

MR Template-Based Individual Brain PET Volumes-of-Interest Generation Neither Using MR nor Using Spatial Normalization
In conclusion, we established a novel quantitative analysis method both MR-less and SN-less fashion to generate individual brain space VOIs using MR template-based VOIs for PET image quantification. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 4, 2022 Category: Nuclear Medicine Source Type: research

Neuroendocrine Tumor of Tailgut Cyst with Unexpected Metastases
AbstractNeuroendocrine tumors (NETs) originate from the neuroendocrine cells, which are found in various organs. NETs occur frequently in the gastrointestinal tract. NETs arising from tailgut cysts are uncommon. We herein report an interesting case of metastatic tailgut cyst NET, which was firstly diagnosed as plasmacytoma. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - October 1, 2022 Category: Nuclear Medicine Source Type: research

Identification and Follow-up of COVID-19 Related Matching Ventilation and Perfusion Defects on Functional Imaging Using VQ SPECT/CT
ConclusionWe confirm that the VQ scan is a safe and effective tool to identify and follow-up recovered COVID-19 patients with persistent ventilation and perfusion abnormalities suspicious of small airway disease and pulmonary microthrombosis. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 24, 2022 Category: Nuclear Medicine Source Type: research

Association of Fluorodeoxyglucose Positron Emission Tomography Radiomics Features with Clinicopathological Factors and Prognosis in Lung Squamous Cell Cancer
ConclusionUsing radiomic features in addition to CPFs to predict disease recurrence and shorter overall survival can guide precision medicine in patients with LSCC. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 23, 2022 Category: Nuclear Medicine Source Type: research

Extramedullary Hematopoiesis Visualized on FDG-PET/CT in a Patient with Beta-Thalassemia
We report an interesting case with EMH visualized on FDG-PET/CT and where FDG-PET/CT has also found the focus of a severe infection in a patient with beta-thalassemia. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 20, 2022 Category: Nuclear Medicine Source Type: research

Focal Nasopharyngeal Activity Detected on [18F]FDG PET/CT: Clinical Implications and Comparison of Metabolic Parameters for Prediction of Malignancy
ConclusionNPC is an infrequent but important cause of incidental focal nasopharyngeal uptake on [18F]FDG PET/CT. Metabolic parameters were shown to be useful to differentiate between benign and malignant nasopharyngeal lesions, and NPR showed the best diagnostic performance. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 10, 2022 Category: Nuclear Medicine Source Type: research

Voxel-Based Internal Dosimetry for 177Lu-Labeled Radiopharmaceutical Therapy Using Deep Residual Learning
ConclusionDose estimation using the deep learning –based approach was approximately equal to that in the MC simulation. Accordingly, the proposed deep learning network is useful for accurate and fast dosimetry after radiation therapy using177Lu-labeled radiopharmaceuticals. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - September 1, 2022 Category: Nuclear Medicine Source Type: research