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Lesion-Wise Comparison of Pre-Therapy and Post-Therapy Effective Half-Life of Iodine-131 in Pediatric and Young Adult Patients with Differentiated Thyroid Cancer Undergoing Radioiodine Therapy
ConclusionsThere was a significant difference in pre-therapy and post-therapy effective half-life in all types of lesions. These results may have implications in calculating the correct therapeutic dose in children and in young adults. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - April 22, 2019 Category: Nuclear Medicine Source Type: research

Use of Molecular Imaging in Clinical Drug Development: a Systematic Review
ConclusionsThe present study confirmed the trend that molecular imaging has been more actively employed in recent clinical drug development studies although its adoption was rather slow and rare in phase 0 studies. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - April 15, 2019 Category: Nuclear Medicine Source Type: research

Promotion of Nuclear Medicine-Related Sciences in Developing Countries
(Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - April 7, 2019 Category: Nuclear Medicine Source Type: research

Theranostics in Bangladesh: Current Status, Challenges, and Future Perspective
AbstractBackground and Current Status of TheranosticsTherapeutic nuclear medicine (NM) in Bangladesh began in the early 1980s with the application of radioactive iodine for treatment of thyroid cancer and primary hyperthyroidism. Since then, NM practice has remarkably developed in the country with the advancement of instrumentation, radiopharmacy, and information technology. The government took the initiative to establish four PET-CT centers at different NM centers, including one at the National Institute of Nuclear Medicine and Allied Sciences (NINMAS). A further development is the installation of a cyclotron center (18-M...
Source: Nuclear Medicine and Molecular Imaging - April 1, 2019 Category: Nuclear Medicine Source Type: research

Perspective in Nuclear Theranostics Using Exosome for the Brain
AbstractOwing to its highly biocompatible property as naturally produced nanoscale particle and drug carrying ability, exosome has attracted much interest in the biomedical area. Versatile functions of exosome in biological system play an important role in elucidating mysterious and unknown biological processes and pathological disease progression. For usage of exosome as brain disease therapeutics, even though the ability of exosomes crossing blood brain barrier (BBB) is not well clearly proven, the small size and their own characteristics possessing cell-derived molecular contents may provide great and beneficial tools f...
Source: Nuclear Medicine and Molecular Imaging - March 30, 2019 Category: Nuclear Medicine Source Type: research

Ipsilateral Hyperhidrosis: Atypical Symptom of Small Lung Adenocarcinoma Evaluated by 18 F-FDG PET-CT
AbstractA 45-year-old male visited our clinic due to right palmar anhidrosis and contralateral hyperhidrosis. Chest computed tomography (CT) showed a solitary pulmonary nodule with mediastinal lymph node enlargement, but a cause for atypical palmar anhidrosis was not identified. Subsequent fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed (PET/CT) revealed a localized pleural metastasis at the right apex with direct invasion of the paravertebral sympathetic chain. The pleural metastasis, which was not seen on chest CT, evoked ipsilateral anhidrosis independent of a mass effect or direct invasio...
Source: Nuclear Medicine and Molecular Imaging - March 25, 2019 Category: Nuclear Medicine Source Type: research

Clinical Applications of Technetium-99m Quantitative Single-Photon Emission Computed Tomography/Computed Tomography
AbstractSingle-photon emission computed tomography/computed tomography (SPECT/CT) is an already established nuclear imaging modality. Co-registration of functional information (SPECT) with anatomical images (CT) paved the way to the wider application of SPECT. Recent advancements in quantitative SPECT/CT have made it possible to incorporate quantitative parameters, such as standardized uptake value (SUV) or %injected dose (%ID), in gamma camera imaging. This is indeed a paradigm shift in gamma camera imaging from qualitative to quantitative evaluation. In fact, such quantitative approaches of nuclear imaging have only been...
Source: Nuclear Medicine and Molecular Imaging - March 14, 2019 Category: Nuclear Medicine Source Type: research

Eruption of Metastatic Paraganglioma After Successful Therapy with 177 Lu/ 90 Y-DOTATOC and 177 Lu-DOTATATE
We present two cases of marked progression of metastatic paraganglioma following initial partial response to PRRT. Given their positivity on68Ga-DOTATATE PET/CT and111In-octreotide SPECT, they underwent PRRT. Imaging following treatment revealed significant improvement in size and intensity, with some foci nearly completely resolved in one patient, and disease regression with a decrease in the number and size of bone and liver lesions in the second patient. Within months, repeat imaging in both patients revealed extensive metastatic disease with new lesions, which eventually lead to their deaths. The mechanism for rapid di...
Source: Nuclear Medicine and Molecular Imaging - February 22, 2019 Category: Nuclear Medicine Source Type: research

Development of a Novel Imaging Agent for Determining Albumin Uptake in Solid Tumors
Conclusion111In-C4-DTPA bound rapidly to circulating albumin upon injection and showed time-dependent uptake in the tumors demonstrating a potential for clinical application as a companion imaging diagnostic for albumin-binding anticancer drugs. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 20, 2019 Category: Nuclear Medicine Source Type: research

Gallbladder Paraganglioma Associated with SDHD Mutation: a Potential Pitfall on 18 F-FDOPA PET Imaging
We report an unusual location of PGL in the gallbladder associated withSDHD mutation which could present as a potential pitfall on18F-FDOPA PET/CT as its normal excretion occurs through biliary system and gallbladder. This case highlights the superiority of68Ga-DOTATATE in comparison to18F-FDOPA and18F-FDG in the detection ofSDHD-related parasympathetic PGL.ClinicalTrials.gov Identifier:NCT00004847. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 19, 2019 Category: Nuclear Medicine Source Type: research

Quantitative Imaging of Alpha-Emitting Therapeutic Radiopharmaceuticals
AbstractTargeted alpha therapy (TAT) is an active area of drug development as a highly specific and highly potent therapeutic modality that can be applied to many types of late-stage cancers. In order to properly evaluate its safety and efficacy, understanding biokinetics of alpha-emitting radiopharmaceuticals is essential. Quantitative imaging of alpha-emitting radiopharmaceuticals is often possible via imaging of gammas and positrons produced during complex decay chains of these radionuclides. Analysis of the complex decay chains for alpha-emitting radionuclides (Tb-149, At-211, Bi-212 (decayed from Pb-212), Bi-213, Ra-2...
Source: Nuclear Medicine and Molecular Imaging - February 18, 2019 Category: Nuclear Medicine Source Type: research

Efforts in the Formation and Development of Nuclear Medicine in Vietnam
AbstractThe foundations of nuclear medicine in Vietnam were established from 1970. Until now, after 48  years of development, in Vietnam, we have some basic equipment including 31 SPECT, 4 SPECT/CT machines, 11 PET/CT scanners, five cyclotrons, and one nuclear reactor. Many nuclear medicine techniques in diagnosis and treatment have been routinely performed at provincial and central level health fac ilities such as tumor scintigraphy, thyroid scintigraphy, bone scintigraphy, kidney scintigraphy, cardiac scintigraphy, and radio-isotope therapy with I-131 and P-32. Selective internal radiation therapy with Y-90 microsphere ...
Source: Nuclear Medicine and Molecular Imaging - February 13, 2019 Category: Nuclear Medicine Source Type: research

Development of Predictive Models in Patients with Epiphora Using Lacrimal Scintigraphy and Machine Learning
ConclusionsML-based predictive models using different programming languages and different computing platforms were useful for classifying clinical diagnoses in patients with epiphora and were similar to a clinician ’s diagnostic ability. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 7, 2019 Category: Nuclear Medicine Source Type: research

Nuclear Theranostics in Taiwan
AbstractBoron neutron capture therapy and Y-90 radioembolization are emerging therapeutic methods for uncontrolled brain cancers and hepatic cancers, respectively. These advanced radiation therapies are heavily relied on theranostic nuclear medicine imaging before the therapy for the eligibility of patients and the prescribed-dose simulation, as well as the post-therapy scanning for assessing the treatment efficacy. In Taiwan, the Taipei Veterans General Hospital is the only institute performing the BNCT and also the leading institute performing Y-90 radioembolization. In this article, we present our single institute exper...
Source: Nuclear Medicine and Molecular Imaging - February 1, 2019 Category: Nuclear Medicine Source Type: research

Diagnostic Reference Levels for Adult Nuclear Medicine Imaging Established from the National Survey in Korea
ConclusionThe first DRLs for nuclear medicine imaging in Korean adults were confirmed. The DRLs will enable optimized radiation protection in the field of nuclear medicine imaging in Korea. (Source: Nuclear Medicine and Molecular Imaging)
Source: Nuclear Medicine and Molecular Imaging - February 1, 2019 Category: Nuclear Medicine Source Type: research