Rosai-Dorfman Disease: Importance of 18 F FDG PET/CT to Determine Extension and Extranodal Involvement

We present the case of a 69-year-old woman with nasal obstruction as only complaint. Laboratory tests showed normal leukocyte count with elevated ANC  (absolute neutrophil count), normal RBC count with normal MCV (mean corpuscular volume) and MCH (mean corpuscular hemoglobin), elevated ESR (erythrocyte sedimentation rate), and normal IgG, IgA, and IgM values. Evaluation revealed a nasopharyngeal mass, which was biopsied and reported emperipol esis with positive CD68 and S-100; typical and differential findings of this disease [1,2].18F FDG PET/CT was performed to determine the extent and involvement of the disease. Considering the presence of few symptoms and no significant laboratory abnormality, treating physicians decided to start a regimen of corticosteroids (prednisolone) for a period of 4 months, after which a follow-up with18F FDG PET/CT will be performed.
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research