Skull Lesions in Langerhans-Cell Histiocytosis Usually Resolve Without Treatment Skull Lesions in Langerhans-Cell Histiocytosis Usually Resolve Without Treatment
Call it a case of where Voltaire was correct to say, ' The art of medicine consists of amusing the patient while nature cures the disease. 'Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 30, 2022 Category: Consumer Health News Tags: Pediatrics News Source Type: news

What is in the Differential Diagnosis for Brown and Grey Skin Conditions?
Discussion This is the fourth in a short case series of differential diagnoses of colored skin conditions. An introduction to dermatological terminologies and information about colors can be found here. A differential diagnosis by distribution and common pattern can be found here. For red, orange and yellow conditions, a review can be found here. For green, blue and purple conditions, a review can be found here. For black and white conditions, a review can be found here. Note that any color can be a normal variant for an individual or is physiologic for a given state. Acanthosis nigricans causes dark brown-black patches or...
Source: PediatricEducation.org - May 16, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What is in the Differential Diagnosis for Red, Orange or Yellow Skin Conditions?
Discussion This is the first in a short case series of differential diagnoses of colored skin conditions. A differential diagnosis by distribution and common pattern can be found here. For green, blue and violet conditions, a review can be found here. For black and white conditions, a review can be found here. For brown and grey conditions, a review can be found here. Note that any color can be a normal variant for an individual or is physiologic for a given state. The skin is the largest organ of the body. It can be easily examined but for many clinicians continues to be difficult to describe what they are seeing. Analo...
Source: PediatricEducation.org - April 25, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Polyuria, Polydipsia and Possible Diabetes Insipidus?
Discussion The body is smart. It has mechanisms for maintaining balances within the body in a closely controlled manner but allows for a variety of states. This is very true for fluid balance in the body which is highly controlled between almost all of the major body organ systems. When fluid is low, the sensor sends signals for us to drink, and conserves fluid until we can. When the fluid is high, the kidneys excrete the excess and sends signals not to drink. Usually it works very well. While there are many pathological states that can cause polyuria and/or polydipsia, the most common reason is excessive fluid intake beca...
Source: PediatricEducation.org - March 7, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

A promising two-punch therapy for Langerhans cell histiocytosis
(Baylor College of Medicine) A novel combination therapy resulted in a significant decrease of disease burden in an animal model of LCH. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 29, 2021 Category: Cancer & Oncology Source Type: news

New NCCN guidelines for histiocytosis clarify best practices for recently-defined cancers
(National Comprehensive Cancer Network) NCCN announces the publication of new NCCN Guidelines ® for Histiocytic Neoplasms, rare disorders characterized by a buildup of white blood cells leading to tissue damage. The three most-common forms are Langerhans cell histiocytosis (LCH), Erdheim-Chester disease (ECD), and Rosai-Dorfman disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 1, 2021 Category: Cancer & Oncology Source Type: news

Is Langerhans Cell Histiocytosis a Cancer
? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - January 12, 2021 Category: General Medicine Source Type: news

What Causes Joint Pain?
DiscussionMusculoskeletal problems are common problems in pediatric practice with up to 15% of acute care visits being for this problem. Joint pain is a common concern for families but the differential diagnosis is extensive and needs thoughtful consideration. History is a key to discerning the potential diagnosis but also in guiding the physical examination and laboratory examination. Family history especially for systemic diseases should be considered. On physical examination all joints should be examined include sacroiliac and temporomandibular joints. Is this arthritis or arthralgia? Distinction between inflammatory...
Source: PediatricEducation.org - October 26, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Disease found in fossilized dinosaur tail afflicts humans to this day
(American Friends of Tel Aviv University) Researchers at Tel Aviv University have identified a benign tumor found in a fossilized dinosaur tail as part of the pathology of LCH (Langerhans cell histiocytosis), a rare and sometimes painful disease that still afflicts humans, particularly children under the age of 10. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 11, 2020 Category: International Medicine & Public Health Source Type: news

Boy, three, has experimental drug to treat a rare cancer after a doctor mistook his rash for eczema
Casper Royle, of Devon, was diagnosed with Langerhans cell histiocytosis when he was three months old. It affects just 50 British children a year. (Source: the Mail online | Health)
Source: the Mail online | Health - September 2, 2019 Category: Consumer Health News Source Type: news

Langerhans Cell Histiocytosis Cancer
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - July 11, 2018 Category: General Medicine Source Type: news

Study Demonstrates a Common Genetic Etiology for LCH, AML, and MF
Researchers examined more than 750 pedigrees of familial hematologic malignancies and found that the same genetic alteration may be responsible for Langerhans cell histiocytosis, acute myeloid leukemia, and primary idiopathic myelofibrosis. (Source: CancerNetwork)
Source: CancerNetwork - March 5, 2018 Category: Cancer & Oncology Authors: John Schieszer Tags: Blood Disorders Hematologic Malignancies News Source Type: news

Doctors treat deadly cancerous disorders with gene-guided, targeted therapy
(Cincinnati Children's Hospital Medical Center) Genomic testing of biopsies from patients with deadly, treatment-resistant cancerous blood syndromes called histiocytoses allowed doctors to identify genes fueling the ailments and use targeted molecular drugs to successfully treat them. Researchers report their data in Journal of Clinical Investigation Insight (JCI Insight). They recommend the regular use of comprehensive genomic profiling at diagnosis to positively impact clinical care. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 16, 2017 Category: Global & Universal Source Type: news

These Adorable Atlanta Children's Hospital Patients Are Pumped For The Super Bowl
Football fans across the Atlanta area are gearing up to watch the Falcons face the New England Patriots in the Super Bowl on Sunday. In fact, even the tiniest Falcons fans are getting in the spirit.  Children’s Healthcare of Atlanta (CHOA) posted photos of young patients decked out in their Falcons gear on Facebook. One special fan is 17-month-old Wyatt Keeton. Wyatt was born at 37 weeks and diagnosed with spondyloepiphyseal dysplasia, a rare form of dwarfism. He was later diagnosed with spinal cord stenosis, a condition that commonly occurs in dwarfism when a child’s head is disproportionate to his or he...
Source: Healthy Living - The Huffington Post - February 3, 2017 Category: Consumer Health News Source Type: news

The Moment You Face Your Child's Mortality
You just read that title and thought "I know my kid is mortal. I've faced this." And I would agree with you before my daughter was diagnosed with cancer. But I didn't realize what my child's mortality really was until it slapped me in the face. I knew, when I got pregnant, that I had this precious life that I had to care for. It was up to me to keep her healthy and warm and safe. It was up to me to make sure she grew up into a moderately tolerable adult. But I didn't see the forest for the trees. I was too concerned with whether she was walking or talking or behaving the way she was supposed to. I was too concerned with w...
Source: Healthy Living - The Huffington Post - September 14, 2016 Category: Consumer Health News Source Type: news