Neuronal exosomal miRNAs modulate mitochondrial functions and cell death in bystander neuronal cells under Parkinson's disease stress conditions
In conclusion, loss of enrichment of specific miRNAs, including miR-30a-5p and miR-181c-5p, under PD stress conditions causes mitochondrial dysfunction and neuronal death, and hence may lead to progression of PD.PMID:38401688 | DOI:10.1016/j.neuro.2024.02.005 (Source: Neurotoxicology)
Source: Neurotoxicology - February 24, 2024 Category: Neurology Authors: Fatema Currim Shatakshi Shukla Jyoti Singh Dhruv Gohel Minal Mane Anjali Shinde Milton Roy Shani Goyani Hitesh Vasiyani Aswathy Chandran Jean-Christophe Rochet Jason Cannon Rajesh Singh Source Type: research
Neuronal exosomal miRNAs modulate mitochondrial functions and cell death in bystander neuronal cells under Parkinson's disease stress conditions
In conclusion, loss of enrichment of specific miRNAs, including miR-30a-5p and miR-181c-5p, under PD stress conditions causes mitochondrial dysfunction and neuronal death, and hence may lead to progression of PD.PMID:38401688 | DOI:10.1016/j.neuro.2024.02.005 (Source: Neurotoxicology)
Source: Neurotoxicology - February 24, 2024 Category: Neurology Authors: Fatema Currim Shatakshi Shukla Jyoti Singh Dhruv Gohel Minal Mane Anjali Shinde Milton Roy Shani Goyani Hitesh Vasiyani Aswathy Chandran Jean-Christophe Rochet Jason Cannon Rajesh Singh Source Type: research
Neuronal exosomal miRNAs modulate mitochondrial functions and cell death in bystander neuronal cells under Parkinson's disease stress conditions
In conclusion, loss of enrichment of specific miRNAs, including miR-30a-5p and miR-181c-5p, under PD stress conditions causes mitochondrial dysfunction and neuronal death, and hence may lead to progression of PD.PMID:38401688 | DOI:10.1016/j.neuro.2024.02.005 (Source: Neurotoxicology)
Source: Neurotoxicology - February 24, 2024 Category: Neurology Authors: Fatema Currim Shatakshi Shukla Jyoti Singh Dhruv Gohel Minal Mane Anjali Shinde Milton Roy Shani Goyani Hitesh Vasiyani Aswathy Chandran Jean-Christophe Rochet Jason Cannon Rajesh Singh Source Type: research
Fish consumption benefits health
Neurotoxicology. 2024 Feb 15:S0161-813X(24)00018-4. doi: 10.1016/j.neuro.2024.02.004. Online ahead of print.NO ABSTRACTPMID:38367819 | DOI:10.1016/j.neuro.2024.02.004 (Source: Neurotoxicology)
Source: Neurotoxicology - February 17, 2024 Category: Neurology Authors: Jean Golding Source Type: research
Fish consumption benefits health
Neurotoxicology. 2024 Feb 15:S0161-813X(24)00018-4. doi: 10.1016/j.neuro.2024.02.004. Online ahead of print.NO ABSTRACTPMID:38367819 | DOI:10.1016/j.neuro.2024.02.004 (Source: Neurotoxicology)
Source: Neurotoxicology - February 17, 2024 Category: Neurology Authors: Jean Golding Source Type: research
Fish consumption benefits health
Neurotoxicology. 2024 Feb 15:S0161-813X(24)00018-4. doi: 10.1016/j.neuro.2024.02.004. Online ahead of print.NO ABSTRACTPMID:38367819 | DOI:10.1016/j.neuro.2024.02.004 (Source: Neurotoxicology)
Source: Neurotoxicology - February 17, 2024 Category: Neurology Authors: Jean Golding Source Type: research
Fish consumption benefits health
Neurotoxicology. 2024 Feb 15:S0161-813X(24)00018-4. doi: 10.1016/j.neuro.2024.02.004. Online ahead of print.NO ABSTRACTPMID:38367819 | DOI:10.1016/j.neuro.2024.02.004 (Source: Neurotoxicology)
Source: Neurotoxicology - February 17, 2024 Category: Neurology Authors: Jean Golding Source Type: research
Fish consumption benefits health
Neurotoxicology. 2024 Feb 15:S0161-813X(24)00018-4. doi: 10.1016/j.neuro.2024.02.004. Online ahead of print.NO ABSTRACTPMID:38367819 | DOI:10.1016/j.neuro.2024.02.004 (Source: Neurotoxicology)
Source: Neurotoxicology - February 17, 2024 Category: Neurology Authors: Jean Golding Source Type: research
Fish consumption benefits health
Neurotoxicology. 2024 Feb 15:S0161-813X(24)00018-4. doi: 10.1016/j.neuro.2024.02.004. Online ahead of print.NO ABSTRACTPMID:38367819 | DOI:10.1016/j.neuro.2024.02.004 (Source: Neurotoxicology)
Source: Neurotoxicology - February 17, 2024 Category: Neurology Authors: Jean Golding Source Type: research
Abdominal Surgery under Ketamine Anesthesia during Second Trimester Impairs Hippocampal Learning and Memory of Offspring by Regulating Dendrite Spine Remodeling in Rats
Neurotoxicology. 2024 Feb 10:S0161-813X(24)00017-2. doi: 10.1016/j.neuro.2024.02.003. Online ahead of print.ABSTRACTRecent evidence showed that general anesthesia produces long-term neurotoxicity and cognitive dysfunction. However, it remains unclear whether maternal non-obstetric surgery under ketamine anesthesia during second trimester causes cognitive impairment in offspring. The present study assigned pregnant rats into three groups: 1) normal control group receiving no anesthesia and no surgery, 2) ketamine group receiving ketamine anesthesia for 2h on the 14th day of gestation but no surgery, and 3) surgery group rec...
Source: Neurotoxicology - February 12, 2024 Category: Neurology Authors: Mengdie Wang Namin Feng Jia Qin Shengqiang Wang Jiabao Chen Shaojie Qian Yulin Liu Foquan Luo Source Type: research
Abdominal Surgery under Ketamine Anesthesia during Second Trimester Impairs Hippocampal Learning and Memory of Offspring by Regulating Dendrite Spine Remodeling in Rats
Neurotoxicology. 2024 Feb 10:S0161-813X(24)00017-2. doi: 10.1016/j.neuro.2024.02.003. Online ahead of print.ABSTRACTRecent evidence showed that general anesthesia produces long-term neurotoxicity and cognitive dysfunction. However, it remains unclear whether maternal non-obstetric surgery under ketamine anesthesia during second trimester causes cognitive impairment in offspring. The present study assigned pregnant rats into three groups: 1) normal control group receiving no anesthesia and no surgery, 2) ketamine group receiving ketamine anesthesia for 2h on the 14th day of gestation but no surgery, and 3) surgery group rec...
Source: Neurotoxicology - February 12, 2024 Category: Neurology Authors: Mengdie Wang Namin Feng Jia Qin Shengqiang Wang Jiabao Chen Shaojie Qian Yulin Liu Foquan Luo Source Type: research
Abdominal Surgery under Ketamine Anesthesia during Second Trimester Impairs Hippocampal Learning and Memory of Offspring by Regulating Dendrite Spine Remodeling in Rats
Neurotoxicology. 2024 Feb 10:S0161-813X(24)00017-2. doi: 10.1016/j.neuro.2024.02.003. Online ahead of print.ABSTRACTRecent evidence showed that general anesthesia produces long-term neurotoxicity and cognitive dysfunction. However, it remains unclear whether maternal non-obstetric surgery under ketamine anesthesia during second trimester causes cognitive impairment in offspring. The present study assigned pregnant rats into three groups: 1) normal control group receiving no anesthesia and no surgery, 2) ketamine group receiving ketamine anesthesia for 2h on the 14th day of gestation but no surgery, and 3) surgery group rec...
Source: Neurotoxicology - February 12, 2024 Category: Neurology Authors: Mengdie Wang Namin Feng Jia Qin Shengqiang Wang Jiabao Chen Shaojie Qian Yulin Liu Foquan Luo Source Type: research
Early and transitory hypoactivity and olfactory alterations after chronic atrazine exposure in female Sprague-Dawley rats
Neurotoxicology. 2024 Feb 8;101:68-81. doi: 10.1016/j.neuro.2024.01.004. Online ahead of print.ABSTRACTSeveral studies have shown that chronic exposure to the herbicide atrazine (ATR) causes alterations in locomotor activity and markers of the dopaminergic systems of male rats. However, few studies have evaluated the sex-dependent effects of atrazine exposure. The aim of the present study was to evaluate whether chronic ATR exposure causes alterations in behavioral performance and dopaminergic systems of female rats. At weaning, two groups of rats were exposed to 1 or 10 mg ATR/kg body weight daily thorough the food, while...
Source: Neurotoxicology - February 10, 2024 Category: Neurology Authors: Jonathan S ánchez-Yépez Triana Acevedo-Huergo Maria Soledad Mendoza-Trejo Rebeca Corona Isela Hern ández-Plata Ver ónica Viñuela-Berni Magda Giordano Ver ónica M Rodríguez Source Type: research
Thymoquinone regulates microglial M1/M2 polarization after cerebral ischemia-reperfusion injury via the TLR4 signaling pathway
Neurotoxicology. 2024 Feb 5;101:54-67. doi: 10.1016/j.neuro.2024.02.002. Online ahead of print.ABSTRACTAcute ischemic stroke followed by microglia activation, and the regulation of neuroinflammatory responses after ischemic injury involves microglia polarization. microglia polarization is involved in the regulation of neuroinflammatory responses and ischemic stroke-related brain damage. Thymoquinone (TQ) is an anti-inflammatory agent following ischemic stroke onset. However, the significance of TQ in microglia polarization following acute ischemic stroke is still unclear. We predicted that TQ might have neuroprotective pro...
Source: Neurotoxicology - February 7, 2024 Category: Neurology Authors: Bingxin Zhao Sheng Zhang Nashwa Amin Jie Pan Fei Wu Guanghong Shen Mingming Tan Zongjie Shi Yu Geng Source Type: research
Absence of functional deficits in rats following systemic administration of an AAV9 vector despite moderate peripheral nerve and dorsal root ganglia findings: A clinically silent peripheral neuropathy
Neurotoxicology. 2024 Feb 3;101:46-53. doi: 10.1016/j.neuro.2024.02.001. Online ahead of print.ABSTRACTAdeno-associated virus (AAV)-based vectors are commonly used for delivering transgenes in gene therapy studies, but they are also known to cause dorsal root ganglia (DRG) and peripheral nerve toxicities in animals. However, the functional implications of these pathologic findings and their time course remain unclear. At 2, 4, 6, and 8 weeks following a single dose of an AAV9 vector carrying human frataxin transgene in rats, non-standard functional assessments, including von Frey filament, electrophysiology, and Rotarod te...
Source: Neurotoxicology - February 5, 2024 Category: Neurology Authors: Cheryl Tyszkiewicz Seo-Kyoung Hwang Jamie K DaSilva Ramesh C Kovi Kelly A Fader Madhu P Sirivelu June Liu Chris Somps Jon Cook Chang-Ning Liu Helen Wang Source Type: research
