OLFACTORY tract/BULB metal CONCENTRATION in Manganese-EXPOSED mineWORKErs
CONCLUSIONS: Our findings suggest that Mn-exposed mineworkers might have higher olfactory tract/bulb tissue Mn concentrations than non-Mn exposed mineworkers, and that concentrations might depend more on cumulative dose than recency of exposure.PMID:38582332 | DOI:10.1016/j.neuro.2024.04.001 (Source: Neurotoxicology)
Source: Neurotoxicology - April 6, 2024 Category: Neurology Authors: Luis F Gonzalez-Cuyar Gill Nelson Susan Searles Nielsen Wendy W Dlamini Amelia Keyser-Gibson C Dirk Keene Michael Paulsen Susan R Criswell Natalie Senini Lianne Sheppard Shar Samy Christopher D Simpson Marissa G Baker Brad A Racette Source Type: research
OLFACTORY tract/BULB metal CONCENTRATION in Manganese-EXPOSED mineWORKErs
CONCLUSIONS: Our findings suggest that Mn-exposed mineworkers might have higher olfactory tract/bulb tissue Mn concentrations than non-Mn exposed mineworkers, and that concentrations might depend more on cumulative dose than recency of exposure.PMID:38582332 | DOI:10.1016/j.neuro.2024.04.001 (Source: Neurotoxicology)
Source: Neurotoxicology - April 6, 2024 Category: Neurology Authors: Luis F Gonzalez-Cuyar Gill Nelson Susan Searles Nielsen Wendy W Dlamini Amelia Keyser-Gibson C Dirk Keene Michael Paulsen Susan R Criswell Natalie Senini Lianne Sheppard Shar Samy Christopher D Simpson Marissa G Baker Brad A Racette Source Type: research
OLFACTORY tract/BULB metal CONCENTRATION in Manganese-EXPOSED mineWORKErs
CONCLUSIONS: Our findings suggest that Mn-exposed mineworkers might have higher olfactory tract/bulb tissue Mn concentrations than non-Mn exposed mineworkers, and that concentrations might depend more on cumulative dose than recency of exposure.PMID:38582332 | DOI:10.1016/j.neuro.2024.04.001 (Source: Neurotoxicology)
Source: Neurotoxicology - April 6, 2024 Category: Neurology Authors: Luis F Gonzalez-Cuyar Gill Nelson Susan Searles Nielsen Wendy W Dlamini Amelia Keyser-Gibson C Dirk Keene Michael Paulsen Susan R Criswell Natalie Senini Lianne Sheppard Shar Samy Christopher D Simpson Marissa G Baker Brad A Racette Source Type: research
How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity
Neurotoxicology. 2024 Mar 27:S0161-813X(24)00031-7. doi: 10.1016/j.neuro.2024.03.005. Online ahead of print.ABSTRACTDevelopmental neurotoxicity (DNT) is not routinely evaluated in chemical risk assessment because current test paradigms for DNT require the use of mammalian models which are ethically controversial, expensive, and resource demanding. Consequently, efforts have focused on revolutionizing DNT testing through affordable novel alternative methods for risk assessment. The goal is to develop a DNT in vitro test battery amenable to high-throughput screening (HTS). Currently, the DNT in vitro test battery consists pr...
Source: Neurotoxicology - March 29, 2024 Category: Neurology Authors: Eva-Maria S Collins Ellen V S Hessel Samantha Hughes Source Type: research
How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity
Neurotoxicology. 2024 Mar 27:S0161-813X(24)00031-7. doi: 10.1016/j.neuro.2024.03.005. Online ahead of print.ABSTRACTDevelopmental neurotoxicity (DNT) is not routinely evaluated in chemical risk assessment because current test paradigms for DNT require the use of mammalian models which are ethically controversial, expensive, and resource demanding. Consequently, efforts have focused on revolutionizing DNT testing through affordable novel alternative methods for risk assessment. The goal is to develop a DNT in vitro test battery amenable to high-throughput screening (HTS). Currently, the DNT in vitro test battery consists pr...
Source: Neurotoxicology - March 29, 2024 Category: Neurology Authors: Eva-Maria S Collins Ellen V S Hessel Samantha Hughes Source Type: research
How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity
Neurotoxicology. 2024 Mar 27:S0161-813X(24)00031-7. doi: 10.1016/j.neuro.2024.03.005. Online ahead of print.ABSTRACTDevelopmental neurotoxicity (DNT) is not routinely evaluated in chemical risk assessment because current test paradigms for DNT require the use of mammalian models which are ethically controversial, expensive, and resource demanding. Consequently, efforts have focused on revolutionizing DNT testing through affordable novel alternative methods for risk assessment. The goal is to develop a DNT in vitro test battery amenable to high-throughput screening (HTS). Currently, the DNT in vitro test battery consists pr...
Source: Neurotoxicology - March 29, 2024 Category: Neurology Authors: Eva-Maria S Collins Ellen V S Hessel Samantha Hughes Source Type: research
How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity
Neurotoxicology. 2024 Mar 27:S0161-813X(24)00031-7. doi: 10.1016/j.neuro.2024.03.005. Online ahead of print.ABSTRACTDevelopmental neurotoxicity (DNT) is not routinely evaluated in chemical risk assessment because current test paradigms for DNT require the use of mammalian models which are ethically controversial, expensive, and resource demanding. Consequently, efforts have focused on revolutionizing DNT testing through affordable novel alternative methods for risk assessment. The goal is to develop a DNT in vitro test battery amenable to high-throughput screening (HTS). Currently, the DNT in vitro test battery consists pr...
Source: Neurotoxicology - March 29, 2024 Category: Neurology Authors: Eva-Maria S Collins Ellen V S Hessel Samantha Hughes Source Type: research
How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity
Neurotoxicology. 2024 Mar 27:S0161-813X(24)00031-7. doi: 10.1016/j.neuro.2024.03.005. Online ahead of print.ABSTRACTDevelopmental neurotoxicity (DNT) is not routinely evaluated in chemical risk assessment because current test paradigms for DNT require the use of mammalian models which are ethically controversial, expensive, and resource demanding. Consequently, efforts have focused on revolutionizing DNT testing through affordable novel alternative methods for risk assessment. The goal is to develop a DNT in vitro test battery amenable to high-throughput screening (HTS). Currently, the DNT in vitro test battery consists pr...
Source: Neurotoxicology - March 29, 2024 Category: Neurology Authors: Eva-Maria S Collins Ellen V S Hessel Samantha Hughes Source Type: research
How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity
Neurotoxicology. 2024 Mar 27:S0161-813X(24)00031-7. doi: 10.1016/j.neuro.2024.03.005. Online ahead of print.ABSTRACTDevelopmental neurotoxicity (DNT) is not routinely evaluated in chemical risk assessment because current test paradigms for DNT require the use of mammalian models which are ethically controversial, expensive, and resource demanding. Consequently, efforts have focused on revolutionizing DNT testing through affordable novel alternative methods for risk assessment. The goal is to develop a DNT in vitro test battery amenable to high-throughput screening (HTS). Currently, the DNT in vitro test battery consists pr...
Source: Neurotoxicology - March 29, 2024 Category: Neurology Authors: Eva-Maria S Collins Ellen V S Hessel Samantha Hughes Source Type: research
How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity
Neurotoxicology. 2024 Mar 27:S0161-813X(24)00031-7. doi: 10.1016/j.neuro.2024.03.005. Online ahead of print.ABSTRACTDevelopmental neurotoxicity (DNT) is not routinely evaluated in chemical risk assessment because current test paradigms for DNT require the use of mammalian models which are ethically controversial, expensive, and resource demanding. Consequently, efforts have focused on revolutionizing DNT testing through affordable novel alternative methods for risk assessment. The goal is to develop a DNT in vitro test battery amenable to high-throughput screening (HTS). Currently, the DNT in vitro test battery consists pr...
Source: Neurotoxicology - March 29, 2024 Category: Neurology Authors: Eva-Maria S Collins Ellen V S Hessel Samantha Hughes Source Type: research
Expression of concern "Assessment of the neuroprotective effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced toxicity in rats" [Neurotoxicology 95 (2023) 232-243]
Neurotoxicology. 2024 Mar;101:131. doi: 10.1016/j.neuro.2023.12.013. Epub 2023 Dec 21.NO ABSTRACTPMID:38548407 | DOI:10.1016/j.neuro.2023.12.013 (Source: Neurotoxicology)
Source: Neurotoxicology - March 28, 2024 Category: Neurology Source Type: research
Expression of concern "Assessment of the neuroprotective effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced toxicity in rats" [Neurotoxicology 95 (2023) 232-243]
Neurotoxicology. 2024 Mar;101:131. doi: 10.1016/j.neuro.2023.12.013. Epub 2023 Dec 21.NO ABSTRACTPMID:38548407 | DOI:10.1016/j.neuro.2023.12.013 (Source: Neurotoxicology)
Source: Neurotoxicology - March 28, 2024 Category: Neurology Source Type: research
Daytime aspartame intake results in larger influences on body weight, serum corticosterone level, serum/cerebral cytokines levels and depressive-like behaviors in mice than nighttime intake
In this study, healthy adult C57BL/6 mice were randomly divided into four groups: Control group (CON), oral gavage sham group (OGS), daytime APM intragastric group (DAI) and nighttime APM intragastric group (NAI). DAI and NAI groups were given 80 mg/kg body weight daily for 4 weeks. We found that DAI and NAI groups had significantly increased mean body weight, higher serum corticosterone levels, up-regulated pro-inflammatory responses in serum and brain, and exacerbated depressive-like behaviors than the CON and the two APM intake groups. Moreover, all these changes induced by APM intake were more significant in the DAI gr...
Source: Neurotoxicology - March 18, 2024 Category: Neurology Authors: Haiyuan Ma Jiapeng Deng Jing Liu Xiaobao Jin Junhua Yang Source Type: research
Daytime Aspartame Intake Results in Larger Influences on Body Weight, Serum Corticosterone Level, Serum/Cerebral Cytokines Levels and Depressive-Like Behaviors in Mice than Nighttime Intake
In this study, healthy adult C57BL/6 mice were randomly divided into four groups: Control group (CON), oral gavage sham group (OGS), daytime APM intragastric group (DAI) and nighttime APM intragastric group (NAI). DAI and NAI groups were given 80mg/kg body weight daily for 4 weeks. We found that DAI and NAI groups had significantly increased mean body weight, higher serum corticosterone levels, up-regulated pro-inflammatory responses in serum and brain, and exacerbated depressive-like behaviors than the CON and the two APM intake groups. Moreover, all these changes induced by APM intake were more significant in the DAI gro...
Source: Neurotoxicology - March 18, 2024 Category: Neurology Authors: Haiyuan Ma Jiapeng Deng Jing Liu Xiaobao Jin Junhua Yang Source Type: research
Daytime Aspartame Intake Results in Larger Influences on Body Weight, Serum Corticosterone Level, Serum/Cerebral Cytokines Levels and Depressive-Like Behaviors in Mice than Nighttime Intake
In this study, healthy adult C57BL/6 mice were randomly divided into four groups: Control group (CON), oral gavage sham group (OGS), daytime APM intragastric group (DAI) and nighttime APM intragastric group (NAI). DAI and NAI groups were given 80mg/kg body weight daily for 4 weeks. We found that DAI and NAI groups had significantly increased mean body weight, higher serum corticosterone levels, up-regulated pro-inflammatory responses in serum and brain, and exacerbated depressive-like behaviors than the CON and the two APM intake groups. Moreover, all these changes induced by APM intake were more significant in the DAI gro...
Source: Neurotoxicology - March 18, 2024 Category: Neurology Authors: Haiyuan Ma Jiapeng Deng Jing Liu Xiaobao Jin Junhua Yang Source Type: research
