Harmaline Toxicity on Dorsal Striatal Neurons and its Role in Tremor
Neurotoxicology. 2023 Oct 12:S0161-813X(23)00131-6. doi: 10.1016/j.neuro.2023.10.005. Online ahead of print.ABSTRACTHarmaline is one of the β-carboline derivative compounds that is widely distributed in the food chain and human tissues. Harmine, a dehydrogenated form of harmaline, appeared to have a higher concentration in the brain, and appeared to be elevated in essential tremor (ET) and Parkinson's disease. Exogenous harmaline exposure in high concentration has myriad consequences, including inducing tremor, and causing neurodegeneration of Purkinje cells in the cerebellum. Harmaline-induced tremor is an established an...
Source: Neurotoxicology - October 14, 2023 Category: Neurology Authors: Xiping Zhan Ly V Do Li Zou Ryan Shu Zhan Michael Jones Saba Nawaz Kebreten Manaye Source Type: research
Quantitative Proteomics Reveals the Neurotoxicity of Trimethyltin Chloride on Mitochondria in the Hippocampus of Mice
In conclusion, our findings suggest that impairment of mitochondrial respiratory chain transport and promotion of apoptosis are the potential mechanisms of TMT induced hippocampus toxicity in mice.PMID:37838251 | DOI:10.1016/j.neuro.2023.10.006 (Source: Neurotoxicology)
Source: Neurotoxicology - October 14, 2023 Category: Neurology Authors: Zhenzhong Liu Li Wang Yue Wang Siya Wu Caiting Peng Yu Wang Ming Huang Li Che Rongjing Sun Xi Zhao Zuo Du Wenhu Liu Source Type: research
Harmaline Toxicity on Dorsal Striatal Neurons and its Role in Tremor
Neurotoxicology. 2023 Oct 12:S0161-813X(23)00131-6. doi: 10.1016/j.neuro.2023.10.005. Online ahead of print.ABSTRACTHarmaline is one of the β-carboline derivative compounds that is widely distributed in the food chain and human tissues. Harmine, a dehydrogenated form of harmaline, appeared to have a higher concentration in the brain, and appeared to be elevated in essential tremor (ET) and Parkinson's disease. Exogenous harmaline exposure in high concentration has myriad consequences, including inducing tremor, and causing neurodegeneration of Purkinje cells in the cerebellum. Harmaline-induced tremor is an established an...
Source: Neurotoxicology - October 14, 2023 Category: Neurology Authors: Xiping Zhan Ly V Do Li Zou Ryan Shu Zhan Michael Jones Saba Nawaz Kebreten Manaye Source Type: research
Quantitative Proteomics Reveals the Neurotoxicity of Trimethyltin Chloride on Mitochondria in the Hippocampus of Mice
In conclusion, our findings suggest that impairment of mitochondrial respiratory chain transport and promotion of apoptosis are the potential mechanisms of TMT induced hippocampus toxicity in mice.PMID:37838251 | DOI:10.1016/j.neuro.2023.10.006 (Source: Neurotoxicology)
Source: Neurotoxicology - October 14, 2023 Category: Neurology Authors: Zhenzhong Liu Li Wang Yue Wang Siya Wu Caiting Peng Yu Wang Ming Huang Li Che Rongjing Sun Xi Zhao Zuo Du Wenhu Liu Source Type: research
Harmaline Toxicity on Dorsal Striatal Neurons and its Role in Tremor
Neurotoxicology. 2023 Oct 12:S0161-813X(23)00131-6. doi: 10.1016/j.neuro.2023.10.005. Online ahead of print.ABSTRACTHarmaline is one of the β-carboline derivative compounds that is widely distributed in the food chain and human tissues. Harmine, a dehydrogenated form of harmaline, appeared to have a higher concentration in the brain, and appeared to be elevated in essential tremor (ET) and Parkinson's disease. Exogenous harmaline exposure in high concentration has myriad consequences, including inducing tremor, and causing neurodegeneration of Purkinje cells in the cerebellum. Harmaline-induced tremor is an established an...
Source: Neurotoxicology - October 14, 2023 Category: Neurology Authors: Xiping Zhan Ly V Do Li Zou Ryan Shu Zhan Michael Jones Saba Nawaz Kebreten Manaye Source Type: research
Postnatal methylmercury exposure and neurodevelopmental outcomes at 7 years of age in the Seychelles Child Development Study Nutrition Cohort 2
CONCLUSIONS: These findings are consistent with previous cross-sectional analyses of the SCDS Main Cohort. Continued follow-up of the entire NC2 cohort at later ages with repeated exposure measures is needed to further confirm these findings.PMID:37832849 | DOI:10.1016/j.neuro.2023.10.004 (Source: Neurotoxicology)
Source: Neurotoxicology - October 13, 2023 Category: Neurology Authors: Jonathan K Klus Sally W Thurston Gary J Myers Gene E Watson Matthew D Rand Tanzy M Love Alison J Yeates Maria S Mulhern Emeir M McSorley J J Strain Conrad F Shamlaye Edwin van Wijngaarden Source Type: research
Postnatal methylmercury exposure and neurodevelopmental outcomes at 7 years of age in the Seychelles Child Development Study Nutrition Cohort 2
CONCLUSIONS: These findings are consistent with previous cross-sectional analyses of the SCDS Main Cohort. Continued follow-up of the entire NC2 cohort at later ages with repeated exposure measures is needed to further confirm these findings.PMID:37832849 | DOI:10.1016/j.neuro.2023.10.004 (Source: Neurotoxicology)
Source: Neurotoxicology - October 13, 2023 Category: Neurology Authors: Jonathan K Klus Sally W Thurston Gary Myers Gene E Watson Matthew D Rand Tanzy M Love Alison J Yeates Maria S Mulhern Emeir M McSorley J J Strain Conrad Shamlaye Edwin van Wijngaarden Source Type: research
Fish consumption and its lipid modifying effects - A review of intervention studies
Neurotoxicology. 2023 Oct 10;99:82-96. doi: 10.1016/j.neuro.2023.10.003. Online ahead of print.ABSTRACTFish is an important source of nutrients, particularly the long chain n-3 polyunsaturated fatty acids (n-3 PUFAs). The incorporation of fish into the diet has been shown to have several health benefits, including lowering the risk of cardiovascular disease (CVD). Elevated plasma lipids are one of the main modifiable risk factors contributing to CVD and may be partly mediated by n-3 PUFAs. Although n-3 PUFAs in the form of supplementation have been shown to exert lipid modifying effects, the effects of fish consumption on ...
Source: Neurotoxicology - October 11, 2023 Category: Neurology Authors: James E McMullan Alison J Yeates Philip J Allsopp Maria S Mulhern J J Strain Edwin van Wijngaarden Gary J Myers Emelyn Shroff Conrad F Shamlaye Emeir M McSorley Source Type: research
Fish consumption and its lipid modifying effects - A review of intervention studies
Neurotoxicology. 2023 Oct 9:S0161-813X(23)00129-8. doi: 10.1016/j.neuro.2023.10.003. Online ahead of print.ABSTRACTFish is an important source of nutrients, particularly the long chain n-3 polyunsaturated fatty acids (n-3 PUFAs). The incorporation of fish into the diet has been shown to have several health benefits, including lowering the risk of cardiovascular disease (CVD). Elevated plasma lipids are one of the main modifiable risk factors contributing to CVD and may be partly mediated by n-3 PUFAs. Although n-3 PUFAs in the form of supplementation have been shown to exert lipid modifying effects, the effects of fish con...
Source: Neurotoxicology - October 11, 2023 Category: Neurology Authors: James E McMullan Alison J Yeates Philip J Allsopp Maria S Mulhern J J Strain Edwin van Wijngaarden Gary J Myers Emelyn Shroff Conrad F Shamlaye Emeir M McSorley Source Type: research
Childhood Exposure to Pyrethroids and Neurodevelopment in Canadian Preschoolers
CONCLUSION: There were associations between some pyrethroid pesticide metabolites and indicators of neurodevelopmental disorder, especially among boys. These associations are in agreement with previous studies and could suggest that exposure to pyrethroid pesticides represents a risk of potential toxicity for the cognitive development of children, and a risk for behavioral development. However, the cross-sectional nature of this study limits causal inferences.PMID:37802189 | DOI:10.1016/j.neuro.2023.10.001 (Source: Neurotoxicology)
Source: Neurotoxicology - October 6, 2023 Category: Neurology Authors: Patrick Ntantu Nkinsa Mandy Fisher Gina Muckle Mireille Guay Tye E Arbuckle William Fraser Khrista Boylan Linda Booij Mark Walker Maryse F Bouchard Source Type: research
Synchrotron X-ray methods in the study of mercury neurotoxicology
Neurotoxicology. 2023 Oct 4:S0161-813X(23)00128-6. doi: 10.1016/j.neuro.2023.10.002. Online ahead of print.ABSTRACTIn situ methods are valuable in all fields of research. In toxicology, the importance of dose is well known, elevating the need for in situ techniques to measure levels of toxicants and their byproducts in precise anatomically identifiable locations. More recently, additional emphasis has been placed on the value of techniques which can detect chemical form or speciation, which is equally important in the toxicology of a chemical compound. Many important but conventional methods risk losing valuable informatio...
Source: Neurotoxicology - October 6, 2023 Category: Neurology Authors: Ashley K James Bogdan F Popescu Monica Weng Gary J Myers John L O'Donoghue Gene E Watson Ingrid J Pickering Graham N George Source Type: research
Childhood Exposure to Pyrethroids and Neurodevelopment in Canadian Preschoolers
CONCLUSION: There were associations between some pyrethroid pesticide metabolites and indicators of neurodevelopmental disorder, especially among boys. These associations are in agreement with previous studies and could suggest that exposure to pyrethroid pesticides represents a risk of potential toxicity for the cognitive development of children, and a risk for behavioral development. However, the cross-sectional nature of this study limits causal inferences.PMID:37802189 | DOI:10.1016/j.neuro.2023.10.001 (Source: Neurotoxicology)
Source: Neurotoxicology - October 6, 2023 Category: Neurology Authors: Patrick Ntantu Nkinsa Mandy Fisher Gina Muckle Mireille Guay Tye E Arbuckle William Fraser Khrista Boylan Linda Booij Mark Walker Maryse F Bouchard Source Type: research
Synchrotron X-ray methods in the study of mercury neurotoxicology
Neurotoxicology. 2023 Oct 4:S0161-813X(23)00128-6. doi: 10.1016/j.neuro.2023.10.002. Online ahead of print.ABSTRACTIn situ methods are valuable in all fields of research. In toxicology, the importance of dose is well known, elevating the need for in situ techniques to measure levels of toxicants and their byproducts in precise anatomically identifiable locations. More recently, additional emphasis has been placed on the value of techniques which can detect chemical form or speciation, which is equally important in the toxicology of a chemical compound. Many important but conventional methods risk losing valuable informatio...
Source: Neurotoxicology - October 6, 2023 Category: Neurology Authors: Ashley K James Bogdan F Popescu Monica Weng Gary J Myers John L O'Donoghue Gene E Watson Ingrid J Pickering Graham N George Source Type: research
Childhood Exposure to Pyrethroids and Neurodevelopment in Canadian Preschoolers
CONCLUSION: There were associations between some pyrethroid pesticide metabolites and indicators of neurodevelopmental disorder, especially among boys. These associations are in agreement with previous studies and could suggest that exposure to pyrethroid pesticides represents a risk of potential toxicity for the cognitive development of children, and a risk for behavioral development. However, the cross-sectional nature of this study limits causal inferences.PMID:37802189 | DOI:10.1016/j.neuro.2023.10.001 (Source: Neurotoxicology)
Source: Neurotoxicology - October 6, 2023 Category: Neurology Authors: Patrick Ntantu Nkinsa Mandy Fisher Gina Muckle Mireille Guay Tye E Arbuckle William Fraser Khrista Boylan Linda Booij Mark Walker Maryse F Bouchard Source Type: research
Synchrotron X-ray methods in the study of mercury neurotoxicology
Neurotoxicology. 2023 Oct 4:S0161-813X(23)00128-6. doi: 10.1016/j.neuro.2023.10.002. Online ahead of print.ABSTRACTIn situ methods are valuable in all fields of research. In toxicology, the importance of dose is well known, elevating the need for in situ techniques to measure levels of toxicants and their byproducts in precise anatomically identifiable locations. More recently, additional emphasis has been placed on the value of techniques which can detect chemical form or speciation, which is equally important in the toxicology of a chemical compound. Many important but conventional methods risk losing valuable informatio...
Source: Neurotoxicology - October 6, 2023 Category: Neurology Authors: Ashley K James Bogdan F Popescu Monica Weng Gary J Myers John L O'Donoghue Gene E Watson Ingrid J Pickering Graham N George Source Type: research
