Resistance physical exercise alleviates lipopolysaccharide-triggered neuroinflammation in cortex and hippocampus of rats via purinergic signaling
In this study, we aimed to analyze the enzymes and components of the purinergic system involved in the inflammatory process triggered by the P2X7R. Rats were divided into four groups: control, exercise (EX), lipopolysaccharide (LPS), and EX + LPS. The animals in the exercise groups were subjected to a 12-week ladder-climbing resistance physical exercise and received LPS after the last session for sepsis induction. Enzymes activities (NTPDase, 5'-nucleotidase, and adenosine deaminase), purinoceptors' density (P2X7R, A1, and A2A), and the levels of inflammatory indicators (pyrin domain-containing protein 3 (NLRP3), Caspase-1...
Source: Neurotoxicology - October 27, 2023 Category: Neurology Authors: Vanessa Val éria Miron Charles Elias Assmann Vitor Bastianello Mostardeiro Nathieli Bianchin Bottari Jucimara Baldissarelli Karine Paula Reichert Ani élen Dutra da Silva Milagros Fanny Vera Castro Loren Borba de Jesus Marcylene Vieira da Silveira Tais V Source Type: research
Resistance physical exercise alleviates lipopolysaccharide-triggered neuroinflammation in cortex and hippocampus of rats via purinergic signaling
In this study, we aimed to analyze the enzymes and components of the purinergic system involved in the inflammatory process triggered by the P2X7R. Rats were divided into four groups: control, exercise (EX), lipopolysaccharide (LPS), and EX + LPS. The animals in the exercise groups were subjected to a 12-week ladder-climbing resistance physical exercise and received LPS after the last session for sepsis induction. Enzymes activities (NTPDase, 5'-nucleotidase, and adenosine deaminase), purinoceptors' density (P2X7R, A1, and A2A), and the levels of inflammatory indicators (pyrin domain-containing protein 3 (NLRP3), Caspase-1...
Source: Neurotoxicology - October 27, 2023 Category: Neurology Authors: Vanessa Val éria Miron Charles Elias Assmann Vitor Bastianello Mostardeiro Nathieli Bianchin Bottari Jucimara Baldissarelli Karine Paula Reichert Ani élen Dutra da Silva Milagros Fanny Vera Castro Loren Borba de Jesus Marcylene Vieira da Silveira Tais V Source Type: research
Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays
Neurotoxicology. 2023 Oct 20:S0161-813X(23)00133-X. doi: 10.1016/j.neuro.2023.10.007. Online ahead of print.ABSTRACTThere is a need to assess compounds reliably and quickly for neurotoxicity (NT) and developmental neurotoxicity (DNT). Adverse outcome pathways (AOPs) enable the mapping of molecular events to an apical endpoint in a chemical agnostic manner and have begun to be applied in NT and DNT testing frameworks. We assessed the status of NT/DNT AOPs in the AOP-Wiki (ca. 2/1/23; https://aopwiki.org/), to characterize the state of AOP development, identify strengths and knowledge gaps, elucidate areas for improvement, a...
Source: Neurotoxicology - October 22, 2023 Category: Neurology Authors: Emily M Pitzer Timothy J Shafer David W Herr Source Type: research
Net Effects Explains the Benefits to Children from Maternal Fish Consumption Despite Methylmercury in Fish
Neurotoxicology. 2023 Oct 20:S0161-813X(23)00136-5. doi: 10.1016/j.neuro.2023.10.010. Online ahead of print.ABSTRACTIn 2001 the U.S. Food and Drug Administration (FDA) issued precautionary advice to pregnant women to limit fish consumption over concerns that the methylmercury content might harm their children's neurodevelopment. This concern was based largely on results from an epidemiological study of mothers primarily exposed to methylmercury from consuming pilot whale. Subsequently, FDA and the World Health Organization/Food and Agriculture Organization (WHO/FAO) undertook independent assessments of fish consumption tha...
Source: Neurotoxicology - October 22, 2023 Category: Neurology Authors: Philip Spiller Edwin van Wijngaarden Heather R Adams J J Strain Emeir M McSorley Maria S Mulhern Marie C Conway Allison J Yeates Clark Carrington P Michael Bolger Kara M Morgan Caroline M Taylor Nicholas V C Ralston Michael A Crawford Joseph R Hibbeln J T Source Type: research
Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays
Neurotoxicology. 2023 Oct 20:S0161-813X(23)00133-X. doi: 10.1016/j.neuro.2023.10.007. Online ahead of print.ABSTRACTThere is a need to assess compounds reliably and quickly for neurotoxicity (NT) and developmental neurotoxicity (DNT). Adverse outcome pathways (AOPs) enable the mapping of molecular events to an apical endpoint in a chemical agnostic manner and have begun to be applied in NT and DNT testing frameworks. We assessed the status of NT/DNT AOPs in the AOP-Wiki (ca. 2/1/23; https://aopwiki.org/), to characterize the state of AOP development, identify strengths and knowledge gaps, elucidate areas for improvement, a...
Source: Neurotoxicology - October 22, 2023 Category: Neurology Authors: Emily M Pitzer Timothy J Shafer David W Herr Source Type: research
Net Effects Explains the Benefits to Children from Maternal Fish Consumption Despite Methylmercury in Fish
Neurotoxicology. 2023 Oct 20:S0161-813X(23)00136-5. doi: 10.1016/j.neuro.2023.10.010. Online ahead of print.ABSTRACTIn 2001 the U.S. Food and Drug Administration (FDA) issued precautionary advice to pregnant women to limit fish consumption over concerns that the methylmercury content might harm their children's neurodevelopment. This concern was based largely on results from an epidemiological study of mothers primarily exposed to methylmercury from consuming pilot whale. Subsequently, FDA and the World Health Organization/Food and Agriculture Organization (WHO/FAO) undertook independent assessments of fish consumption tha...
Source: Neurotoxicology - October 22, 2023 Category: Neurology Authors: Philip Spiller Edwin van Wijngaarden Heather R Adams J J Strain Emeir M McSorley Maria S Mulhern Marie C Conway Allison J Yeates Clark Carrington P Michael Bolger Kara M Morgan Caroline M Taylor Nicholas V C Ralston Michael A Crawford Joseph R Hibbeln J T Source Type: research
Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays
Neurotoxicology. 2023 Oct 20:S0161-813X(23)00133-X. doi: 10.1016/j.neuro.2023.10.007. Online ahead of print.ABSTRACTThere is a need to assess compounds reliably and quickly for neurotoxicity (NT) and developmental neurotoxicity (DNT). Adverse outcome pathways (AOPs) enable the mapping of molecular events to an apical endpoint in a chemical agnostic manner and have begun to be applied in NT and DNT testing frameworks. We assessed the status of NT/DNT AOPs in the AOP-Wiki (ca. 2/1/23; https://aopwiki.org/), to characterize the state of AOP development, identify strengths and knowledge gaps, elucidate areas for improvement, a...
Source: Neurotoxicology - October 22, 2023 Category: Neurology Authors: Emily M Pitzer Timothy J Shafer David W Herr Source Type: research
Net Effects Explains the Benefits to Children from Maternal Fish Consumption Despite Methylmercury in Fish
Neurotoxicology. 2023 Oct 20:S0161-813X(23)00136-5. doi: 10.1016/j.neuro.2023.10.010. Online ahead of print.ABSTRACTIn 2001 the U.S. Food and Drug Administration (FDA) issued precautionary advice to pregnant women to limit fish consumption over concerns that the methylmercury content might harm their children's neurodevelopment. This concern was based largely on results from an epidemiological study of mothers primarily exposed to methylmercury from consuming pilot whale. Subsequently, FDA and the World Health Organization/Food and Agriculture Organization (WHO/FAO) undertook independent assessments of fish consumption tha...
Source: Neurotoxicology - October 22, 2023 Category: Neurology Authors: Philip Spiller Edwin van Wijngaarden Heather R Adams J J Strain Emeir M McSorley Maria S Mulhern Marie C Conway Allison J Yeates Clark Carrington P Michael Bolger Kara M Morgan Caroline M Taylor Nicholas V C Ralston Michael A Crawford Joseph R Hibbeln J T Source Type: research
Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays
Neurotoxicology. 2023 Oct 20:S0161-813X(23)00133-X. doi: 10.1016/j.neuro.2023.10.007. Online ahead of print.ABSTRACTThere is a need to assess compounds reliably and quickly for neurotoxicity (NT) and developmental neurotoxicity (DNT). Adverse outcome pathways (AOPs) enable the mapping of molecular events to an apical endpoint in a chemical agnostic manner and have begun to be applied in NT and DNT testing frameworks. We assessed the status of NT/DNT AOPs in the AOP-Wiki (ca. 2/1/23; https://aopwiki.org/), to characterize the state of AOP development, identify strengths and knowledge gaps, elucidate areas for improvement, a...
Source: Neurotoxicology - October 22, 2023 Category: Neurology Authors: Emily M Pitzer Timothy J Shafer David W Herr Source Type: research
Net Effects Explains the Benefits to Children from Maternal Fish Consumption Despite Methylmercury in Fish
Neurotoxicology. 2023 Oct 20:S0161-813X(23)00136-5. doi: 10.1016/j.neuro.2023.10.010. Online ahead of print.ABSTRACTIn 2001 the U.S. Food and Drug Administration (FDA) issued precautionary advice to pregnant women to limit fish consumption over concerns that the methylmercury content might harm their children's neurodevelopment. This concern was based largely on results from an epidemiological study of mothers primarily exposed to methylmercury from consuming pilot whale. Subsequently, FDA and the World Health Organization/Food and Agriculture Organization (WHO/FAO) undertook independent assessments of fish consumption tha...
Source: Neurotoxicology - October 22, 2023 Category: Neurology Authors: Philip Spiller Edwin van Wijngaarden Heather R Adams J J Strain Emeir M McSorley Maria S Mulhern Marie C Conway Allison J Yeates Clark Carrington P Michael Bolger Kara M Morgan Caroline M Taylor Nicholas V C Ralston Michael A Crawford Joseph R Hibbeln J T Source Type: research
Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays
Neurotoxicology. 2023 Oct 20:S0161-813X(23)00133-X. doi: 10.1016/j.neuro.2023.10.007. Online ahead of print.ABSTRACTThere is a need to assess compounds reliably and quickly for neurotoxicity (NT) and developmental neurotoxicity (DNT). Adverse outcome pathways (AOPs) enable the mapping of molecular events to an apical endpoint in a chemical agnostic manner and have begun to be applied in NT and DNT testing frameworks. We assessed the status of NT/DNT AOPs in the AOP-Wiki (ca. 2/1/23; https://aopwiki.org/), to characterize the state of AOP development, identify strengths and knowledge gaps, elucidate areas for improvement, a...
Source: Neurotoxicology - October 22, 2023 Category: Neurology Authors: Emily M Pitzer Timothy J Shafer David W Herr Source Type: research
Net Effects Explains the Benefits to Children from Maternal Fish Consumption Despite Methylmercury in Fish
Neurotoxicology. 2023 Oct 20:S0161-813X(23)00136-5. doi: 10.1016/j.neuro.2023.10.010. Online ahead of print.ABSTRACTIn 2001 the U.S. Food and Drug Administration (FDA) issued precautionary advice to pregnant women to limit fish consumption over concerns that the methylmercury content might harm their children's neurodevelopment. This concern was based largely on results from an epidemiological study of mothers primarily exposed to methylmercury from consuming pilot whale. Subsequently, FDA and the World Health Organization/Food and Agriculture Organization (WHO/FAO) undertook independent assessments of fish consumption tha...
Source: Neurotoxicology - October 22, 2023 Category: Neurology Authors: Philip Spiller Edwin van Wijngaarden Heather R Adams J J Strain Emeir M McSorley Maria S Mulhern Marie C Conway Allison J Yeates Clark Carrington P Michael Bolger Kara M Morgan Caroline M Taylor Nicholas V C Ralston Michael A Crawford Joseph R Hibbeln J T Source Type: research
Nano polystyrene induced changes in anxiety and learning behaviour are mediated through oxidative stress and gene disturbance in mouse brain regions
Neurotoxicology. 2023 Oct 19:S0161-813X(23)00135-3. doi: 10.1016/j.neuro.2023.10.009. Online ahead of print.ABSTRACTIt is widely reported now that nanoplastic particles have potential neurotoxic effects and may disturb central nervous system (CNS) function. However, the mechanism behind these toxic effects still needs to be elucidated. In the current study, we investigated the effects of polystyrene nanoplastics (PS-NPs) on changes in learning, memory, and anxiety-related behavior in mice based on some selected biochemical, molecular, and histopathological changes in three important brain regions (Cortex, Hypothalamus, and...
Source: Neurotoxicology - October 21, 2023 Category: Neurology Authors: Anju Sharma Manjyot Kaur Kirti Sharma Suresh Kumar Bunkar Placheril John Pradeep Bhatnagar Source Type: research
KEAP1 polymorphisms and neurodevelopmental outcomes in children with exposure to prenatal MeHg from the Seychelles Child Development Study Nutrition Cohort 2
CONCLUSION: No associations between NFE2L2 and KEAP1 polymorphisms and MeHg concentration were identified. However, at 7 years, KEAP1 polymorphisms were associated with differences in neurodevelopmental outcomes in children from a population with high fish intake.PMID:37858899 | DOI:10.1016/j.neuro.2023.10.008 (Source: Neurotoxicology)
Source: Neurotoxicology - October 20, 2023 Category: Neurology Authors: Helena Korres de Paula Tanzy M Love Daniela Pineda Gene E Watson Sally W Thurston Alison J Yeates Maria S Mulhern Emeir M McSorley J J Strain Conrad F Shamlaye G J Myers Matthew D Rand Edwin van Wijngaarden Karin Broberg Source Type: research
KEAP1 polymorphisms and neurodevelopmental outcomes in children with exposure to prenatal MeHg from the Seychelles Child Development Study Nutrition Cohort 2
CONCLUSION: No associations between NFE2L2 and KEAP1 polymorphisms and MeHg concentration were identified. However, at 7 years, KEAP1 polymorphisms were associated with differences in neurodevelopmental outcomes in children from a population with high fish intake.PMID:37858899 | DOI:10.1016/j.neuro.2023.10.008 (Source: Neurotoxicology)
Source: Neurotoxicology - October 20, 2023 Category: Neurology Authors: Helena Korres de Paula Tanzy M Love Daniela Pineda Gene E Watson Sally W Thurston Alison J Yeates Maria S Mulhern Emeir M McSorley J J Strain Conrad F Shamlaye G J Myers Matthew D Rand Edwin van Wijngaarden Karin Broberg Source Type: research
