Perinatal morphine but not buprenorphine affects gestational and offspring neurobehavioral outcomes in mice
Neurotoxicology. 2023 Nov 17:S0161-813X(23)00147-X. doi: 10.1016/j.neuro.2023.11.008. Online ahead of print.ABSTRACTWithin the national opioid epidemic, there has been an increase in the number of infants exposed to opioids in utero. Additionally, opioid agonist medications are the standard of care for women with opioid use disorder during pregnancy. Buprenorphine (BUP), a partial µ -opioid receptor agonist, has been successful in improving gestational and neonatal outcomes. However, in utero exposure has been linked to childhood cognitive and behavioral problems. Therefore, we sought to compare offspring cognitive and be...
Source: Neurotoxicology - November 19, 2023 Category: Neurology Authors: Brittany L Smith Ally Hassler Kelsey R Lloyd Teresa M Reyes Source Type: research
Evaluating the toxic mechanism of 1,2-diacetylbenzene in neural cells/tissues: the favorable impact of silibinin
This study unraveled the toxic impact of 1,2-DAB in nerve tissues, explant cultures, and neuron-glial cultures, and explored whether herbal products can mitigate its toxicity. The effects of DAB on axonal transport were studied in retinal explant cultures grown in a micro-patterned dish. The mitochondrial movement in the axons was captured using time-lapse video recordings. The results showed that 1,2-DAB, but not 1,3-DAB inhibited axonal outgrowth and mitochondrial movement in a dose-dependent manner. The toxicity of 1,2-DAB was further studied in spinal cord tissues and cultures. 1,2-DAB selectively induced modifications...
Source: Neurotoxicology - November 19, 2023 Category: Neurology Authors: Li-Yu Fay Jun-Yi Chien Ching-Feng Weng Huai-Sheng Kuo Dann-Ying Liou Wei-Hao Weng Chi-Hung Lin Ya-Tzu Chen Wen-Hung Huang Wen-Cheng Huang May-Jywan Tsai Henrich Cheng Source Type: research
Kynurenine attenuates mitochondrial depolarization and neuronal cell death induced by rotenone exposure independently of AhR-mediated parkin induction in SH-SY5Y differentiated cells
Neurotoxicology. 2023 Nov 16:S0161-813X(23)00146-8. doi: 10.1016/j.neuro.2023.11.007. Online ahead of print.ABSTRACTRotenone is a pesticide commonly used in agriculture that is associated with the risk of developing Parkinson's disease (PD) by inducing mitochondrial damage. As a protective cell response to different challenges, they activate mitophagy, which involves parkin activity. Parkin is an E3 ubiquitin ligase necessary in the initial steps of mitophagy, and its overexpression protects against parkinsonian effects in different models. Recent studies have reported that the aryl hydrocarbon receptor (AHR), a ligand-dep...
Source: Neurotoxicology - November 18, 2023 Category: Neurology Authors: Rosario Garc ía-Aguilar Arturo Ortega Esther L ópez-Bayghen Leticia Ram írez-Martínez Ada Rodriguez-Campuzano F átima Murillo-González Guillermo Elizondo Libia Vega Source Type: research
Melatonin enhances the restoration of neurological impairments and cognitive deficits during drug withdrawal in methamphetamine-induced toxicity and endoplasmic reticulum stress in rats
This study aimed to investigate the restorative effect of Mel on behavioral flexibility in METH-induced cognitive deficits. Male Sprague-Dawley rats were randomly assigned to be intraperitoneally injected with saline (control) or Meth at 5mg/kg for 7 consecutive days. Then, METH injection was withdrawn and rats in each group were subcutaneously injected with saline or Mel at 10mg/kg for 14 consecutive days. The stereotypic behavioral test and attentional set-shifting task (ASST) were used to evaluate neurological functions and cognitive flexibility, respectively. Rats developed abnormal features of stereotyped behaviors an...
Source: Neurotoxicology - November 18, 2023 Category: Neurology Authors: Pongphat Komlao Natcharee Kraiwattanapirom Kitipong Promyo Zaw Myo Hein Banthit Chetsawang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
Repeated toluene and cyclohexane inhalation produces differential effects on HPA and HPT axes in adolescent male rats
Neurotoxicology. 2023 Nov 7:S0161-813X(23)00142-0. doi: 10.1016/j.neuro.2023.11.003. Online ahead of print.ABSTRACTMisused volatile solvents typically contain toluene (TOL) as the main psychoactive ingredient. Cyclohexane (CHX) can also be present and is considered a safer alternative. Solvent misuse often occurs at early stages of life, leading to permanent neurobehavioral impairment and growth retardation. However, a comprehensive examination of the effects of TOL and CHX on stress regulation and energy balance is lacking. Here, we compared the effect of a binge-pattern exposure to TOL or CHX (4,000 or 8,000 ppm) on body...
Source: Neurotoxicology - November 9, 2023 Category: Neurology Authors: P Soberanes-Ch ávez P de Gortari C Garc ía-Luna S L Cruz Source Type: research
Repeated toluene and cyclohexane inhalation produces differential effects on HPA and HPT axes in adolescent male rats
Neurotoxicology. 2023 Nov 7:S0161-813X(23)00142-0. doi: 10.1016/j.neuro.2023.11.003. Online ahead of print.ABSTRACTMisused volatile solvents typically contain toluene (TOL) as the main psychoactive ingredient. Cyclohexane (CHX) can also be present and is considered a safer alternative. Solvent misuse often occurs at early stages of life, leading to permanent neurobehavioral impairment and growth retardation. However, a comprehensive examination of the effects of TOL and CHX on stress regulation and energy balance is lacking. Here, we compared the effect of a binge-pattern exposure to TOL or CHX (4,000 or 8,000 ppm) on body...
Source: Neurotoxicology - November 9, 2023 Category: Neurology Authors: P Soberanes-Ch ávez P de Gortari C Garc ía-Luna S L Cruz Source Type: research
Repeated toluene and cyclohexane inhalation produces differential effects on HPA and HPT axes in adolescent male rats
Neurotoxicology. 2023 Nov 7:S0161-813X(23)00142-0. doi: 10.1016/j.neuro.2023.11.003. Online ahead of print.ABSTRACTMisused volatile solvents typically contain toluene (TOL) as the main psychoactive ingredient. Cyclohexane (CHX) can also be present and is considered a safer alternative. Solvent misuse often occurs at early stages of life, leading to permanent neurobehavioral impairment and growth retardation. However, a comprehensive examination of the effects of TOL and CHX on stress regulation and energy balance is lacking. Here, we compared the effect of a binge-pattern exposure to TOL or CHX (4,000 or 8,000 ppm) on body...
Source: Neurotoxicology - November 9, 2023 Category: Neurology Authors: P Soberanes-Ch ávez P de Gortari C Garc ía-Luna S L Cruz Source Type: research
Friedelin and Glutinol induce neuroprotection against ethanol induced neurotoxicity in pup's brain through reduction of TNF- α, NF-kB, Caspase-3 and PARP-1
Neurotoxicology. 2023 Nov 6:S0161-813X(23)00141-9. doi: 10.1016/j.neuro.2023.11.002. Online ahead of print.ABSTRACTEthanol administration triggers an inflammatory response that leads to a complex series of immune responses including the release of an excessive amount of inflammatory mediators particularly tumor necrosis factor (TNF-α) and nuclear factor-kB (NF-KB) which produce a large amount of reactive oxygen species. The inflammatory-induced cytotoxicity is increased when the PI3-kinase/Akt pathway is inhibited. Some studies have also shown that ethanol suppresses the PI3-kinase signaling pathway induced by receptor ac...
Source: Neurotoxicology - November 8, 2023 Category: Neurology Authors: Marva Sandhu Hafiz Muhammad Irfan Laiba Arshad Aman Ullah Shahid Ali Shah Hussain Ali Source Type: research
Friedelin and Glutinol induce neuroprotection against ethanol induced neurotoxicity in pup's brain through reduction of TNF- α, NF-kB, Caspase-3 and PARP-1
Neurotoxicology. 2023 Nov 6:S0161-813X(23)00141-9. doi: 10.1016/j.neuro.2023.11.002. Online ahead of print.ABSTRACTEthanol administration triggers an inflammatory response that leads to a complex series of immune responses including the release of an excessive amount of inflammatory mediators particularly tumor necrosis factor (TNF-α) and nuclear factor-kB (NF-KB) which produce a large amount of reactive oxygen species. The inflammatory-induced cytotoxicity is increased when the PI3-kinase/Akt pathway is inhibited. Some studies have also shown that ethanol suppresses the PI3-kinase signaling pathway induced by receptor ac...
Source: Neurotoxicology - November 8, 2023 Category: Neurology Authors: Marva Sandhu Hafiz Muhammad Irfan Laiba Arshad Aman Ullah Shahid Ali Shah Hussain Ali Source Type: research
