Neuroprotective Effect of Quercetin and Nano-quercetin Against Cyclophosphamide-induced Oxidative Stress in the Rat Brain: Role of Nrf2/ HO-1/Keap-1 Signaling Pathway
Neurotoxicology. 2023 Jul 5:S0161-813X(23)00088-8. doi: 10.1016/j.neuro.2023.06.008. Online ahead of print.ABSTRACTQuercetin (Qu) is a powerful flavanol antioxidant that is naturally found in plants and is part of the flavonoid family. Qu has a wide range of biological properties, such as neuroprotective, anti-cancer, anti-diabetic, anti-inflammatory, and radical scavenging capabilities. However, the in vivo application of QU is limited by its poor water solubility and low bioavailability. These issues could be addressed by utilizing Qu nanoformulations. Cyclophosphamide (CP) is a potent chemotherapeutic agent that causes ...
Source: Neurotoxicology - July 7, 2023 Category: Neurology Authors: Dina A AbdElrazek Marwa A Ibrahim Neven H Hassan Eman I Hassanen Khaled Y Farroh H I Abass Source Type: research

Neuroprotective Effect of Quercetin and Nano-quercetin Against Cyclophosphamide-induced Oxidative Stress in the Rat Brain: Role of Nrf2/ HO-1/Keap-1 Signaling Pathway
Neurotoxicology. 2023 Jul 5:S0161-813X(23)00088-8. doi: 10.1016/j.neuro.2023.06.008. Online ahead of print.ABSTRACTQuercetin (Qu) is a powerful flavanol antioxidant that is naturally found in plants and is part of the flavonoid family. Qu has a wide range of biological properties, such as neuroprotective, anti-cancer, anti-diabetic, anti-inflammatory, and radical scavenging capabilities. However, the in vivo application of QU is limited by its poor water solubility and low bioavailability. These issues could be addressed by utilizing Qu nanoformulations. Cyclophosphamide (CP) is a potent chemotherapeutic agent that causes ...
Source: Neurotoxicology - July 7, 2023 Category: Neurology Authors: Dina A AbdElrazek Marwa A Ibrahim Neven H Hassan Eman I Hassanen Khaled Y Farroh H I Abass Source Type: research

Isochlorogenic acid B alleviates lead-induced anxiety, depression and neuroinflammation in mice by the BDNF pathway
In this study, we aimed to investigate the mechanisms of Pb-induced anxiety, depression and neuroinflammation, and the neuroprotective effect of ICAB in mouse brains. We found that ICAB supplementation significantly improved behavioral abnormalities, neuroinflammation and oxidative stress induced by Pb. ICAB attenuated Pb-induced anxiety and depression behavior in mice, as indicated by decreasing the duration of immobility in tail suspension test and increasing the crossing number, rearing number and time in center in open field test. Accordingly, ICAB inhibited oxidative stress by decreasing malondialdehyde (MDA) level an...
Source: Neurotoxicology - June 29, 2023 Category: Neurology Authors: Jia-Xue Shi Chao Cheng Hai-Nan Ruan Jun Li Chan-Min Liu Source Type: research

Isochlorogenic acid B alleviates lead-induced anxiety, depression and neuroinflammation in mice by the BDNF pathway
In this study, we aimed to investigate the mechanisms of Pb-induced anxiety, depression and neuroinflammation, and the neuroprotective effect of ICAB in mouse brains. We found that ICAB supplementation significantly improved behavioral abnormalities, neuroinflammation and oxidative stress induced by Pb. ICAB attenuated Pb-induced anxiety and depression behavior in mice, as indicated by decreasing the duration of immobility in tail suspension test and increasing the crossing number, rearing number and time in center in open field test. Accordingly, ICAB inhibited oxidative stress by decreasing malondialdehyde (MDA) level an...
Source: Neurotoxicology - June 29, 2023 Category: Neurology Authors: Jia-Xue Shi Chao Cheng Hai-Nan Ruan Jun Li Chan-Min Liu Source Type: research

Isochlorogenic acid B alleviates lead-induced anxiety, depression and neuroinflammation in mice by the BDNF pathway
In this study, we aimed to investigate the mechanisms of Pb-induced anxiety, depression and neuroinflammation, and the neuroprotective effect of ICAB in mouse brains. We found that ICAB supplementation significantly improved behavioral abnormalities, neuroinflammation and oxidative stress induced by Pb. ICAB attenuated Pb-induced anxiety and depression behavior in mice, as indicated by decreasing the duration of immobility in tail suspension test and increasing the crossing number, rearing number and time in center in open field test. Accordingly, ICAB inhibited oxidative stress by decreasing malondialdehyde (MDA) level an...
Source: Neurotoxicology - June 29, 2023 Category: Neurology Authors: Jia-Xue Shi Chao Cheng Hai-Nan Ruan Jun Li Chan-Min Liu Source Type: research

Isochlorogenic acid B alleviates lead-induced anxiety, depression and neuroinflammation in mice by the BDNF pathway
In this study, we aimed to investigate the mechanisms of Pb-induced anxiety, depression and neuroinflammation, and the neuroprotective effect of ICAB in mouse brains. We found that ICAB supplementation significantly improved behavioral abnormalities, neuroinflammation and oxidative stress induced by Pb. ICAB attenuated Pb-induced anxiety and depression behavior in mice, as indicated by decreasing the duration of immobility in tail suspension test and increasing the crossing number, rearing number and time in center in open field test. Accordingly, ICAB inhibited oxidative stress by decreasing malondialdehyde (MDA) level an...
Source: Neurotoxicology - June 29, 2023 Category: Neurology Authors: Jia-Xue Shi Chao Cheng Hai-Nan Ruan Jun Li Chan-Min Liu Source Type: research

Isochlorogenic acid B alleviates lead-induced anxiety, depression and neuroinflammation in mice by the BDNF pathway
In this study, we aimed to investigate the mechanisms of Pb-induced anxiety, depression and neuroinflammation, and the neuroprotective effect of ICAB in mouse brains. We found that ICAB supplementation significantly improved behavioral abnormalities, neuroinflammation and oxidative stress induced by Pb. ICAB attenuated Pb-induced anxiety and depression behavior in mice, as indicated by decreasing the duration of immobility in tail suspension test and increasing the crossing number, rearing number and time in center in open field test. Accordingly, ICAB inhibited oxidative stress by decreasing malondialdehyde (MDA) level an...
Source: Neurotoxicology - June 29, 2023 Category: Neurology Authors: Jia-Xue Shi Chao Cheng Hai-Nan Ruan Jun Li Chan-Min Liu Source Type: research

Isochlorogenic acid B alleviates lead-induced anxiety, depression and neuroinflammation in mice by the BDNF pathway
In this study, we aimed to investigate the mechanisms of Pb-induced anxiety, depression and neuroinflammation, and the neuroprotective effect of ICAB in mouse brains. We found that ICAB supplementation significantly improved behavioral abnormalities, neuroinflammation and oxidative stress induced by Pb. ICAB attenuated Pb-induced anxiety and depression behavior in mice, as indicated by decreasing the duration of immobility in tail suspension test and increasing the crossing number, rearing number and time in center in open field test. Accordingly, ICAB inhibited oxidative stress by decreasing malondialdehyde (MDA) level an...
Source: Neurotoxicology - June 29, 2023 Category: Neurology Authors: Jia-Xue Shi Chao Cheng Hai-Nan Ruan Jun Li Chan-Min Liu Source Type: research

Isochlorogenic acid B alleviates lead-induced anxiety, depression and neuroinflammation in mice by the BDNF pathway
In this study, we aimed to investigate the mechanisms of Pb-induced anxiety, depression and neuroinflammation, and the neuroprotective effect of ICAB in mouse brains. We found that ICAB supplementation significantly improved behavioral abnormalities, neuroinflammation and oxidative stress induced by Pb. ICAB attenuated Pb-induced anxiety and depression behavior in mice, as indicated by decreasing the duration of immobility in tail suspension test and increasing the crossing number, rearing number and time in center in open field test. Accordingly, ICAB inhibited oxidative stress by decreasing malondialdehyde (MDA) level an...
Source: Neurotoxicology - June 29, 2023 Category: Neurology Authors: Jia-Xue Shi Chao Cheng Hai-Nan Ruan Jun Li Chan-Min Liu Source Type: research

Fisetin attenuates arsenic and fluoride subacute co-exposure induced neurotoxicity via regulating TNF- α mediated activation of NLRP3 inflammasome
Neurotoxicology. 2023 Jun 16;97:133-149. doi: 10.1016/j.neuro.2023.06.006. Online ahead of print.ABSTRACTGroundwater is considered safe, however, the occurrence of contaminants like arsenic and fluoride has raised a major healthcare concern. Clinical studies suggested that arsenic and fluoride co-exposure induced neurotoxicity, however efforts to explore safe and effective management of such neurotoxicity are limited. Therefore, we investigated the ameliorative effect of Fisetin against arsenic and fluoride subacute co-exposure-induced neurotoxicity, and associated biochemical and molecular changes. Male BALB/c mice were e...
Source: Neurotoxicology - June 18, 2023 Category: Neurology Authors: Vitthal V Gopnar Debarati Rakshit Mounisha Bandakinda Uttam Kulhari Bidya Dhar Sahu Awanish Mishra Source Type: research

Fisetin attenuates arsenic and fluoride subacute co-exposure induced neurotoxicity via regulating TNF- α mediated activation of NLRP3 inflammasome
Neurotoxicology. 2023 Jun 16;97:133-149. doi: 10.1016/j.neuro.2023.06.006. Online ahead of print.ABSTRACTGroundwater is considered safe, however, the occurrence of contaminants like arsenic and fluoride has raised a major healthcare concern. Clinical studies suggested that arsenic and fluoride co-exposure induced neurotoxicity, however efforts to explore safe and effective management of such neurotoxicity are limited. Therefore, we investigated the ameliorative effect of Fisetin against arsenic and fluoride subacute co-exposure-induced neurotoxicity, and associated biochemical and molecular changes. Male BALB/c mice were e...
Source: Neurotoxicology - June 18, 2023 Category: Neurology Authors: Vitthal V Gopnar Debarati Rakshit Mounisha Bandakinda Uttam Kulhari Bidya Dhar Sahu Awanish Mishra Source Type: research

Fisetin attenuates arsenic and fluoride subacute co-exposure induced neurotoxicity via regulating TNF- α mediated activation of NLRP3 inflammasome
Neurotoxicology. 2023 Jun 16:S0161-813X(23)00086-4. doi: 10.1016/j.neuro.2023.06.006. Online ahead of print.ABSTRACTGroundwater is considered safe, however, the occurrence of contaminants like arsenic and fluoride has raised a major healthcare concern. Clinical studies suggested that arsenic and fluoride co-exposure induced neurotoxicity, however efforts to explore safe and effective management of such neurotoxicity are limited. Therefore, we investigated the ameliorative effect of Fisetin against arsenic and fluoride subacute co-exposure-induced neurotoxicity, and associated biochemical and molecular changes. Male BALB/c ...
Source: Neurotoxicology - June 18, 2023 Category: Neurology Authors: Vitthal V Gopnar Debarati Rakshit Mounisha Bandakinda Uttam Kulhari Bidya Dhar Sahu Awanish Mishra Source Type: research

Fisetin attenuates arsenic and fluoride subacute co-exposure induced neurotoxicity via regulating TNF- α mediated activation of NLRP3 inflammasome
Neurotoxicology. 2023 Jun 16:S0161-813X(23)00086-4. doi: 10.1016/j.neuro.2023.06.006. Online ahead of print.ABSTRACTGroundwater is considered safe, however, the occurrence of contaminants like arsenic and fluoride has raised a major healthcare concern. Clinical studies suggested that arsenic and fluoride co-exposure induced neurotoxicity, however efforts to explore safe and effective management of such neurotoxicity are limited. Therefore, we investigated the ameliorative effect of Fisetin against arsenic and fluoride subacute co-exposure-induced neurotoxicity, and associated biochemical and molecular changes. Male BALB/c ...
Source: Neurotoxicology - June 18, 2023 Category: Neurology Authors: Vitthal V Gopnar Debarati Rakshit Mounisha Bandakinda Uttam Kulhari Bidya Dhar Sahu Awanish Mishra Source Type: research

Fisetin attenuates arsenic and fluoride subacute co-exposure induced neurotoxicity via regulating TNF- α mediated activation of NLRP3 inflammasome
Neurotoxicology. 2023 Jun 16:S0161-813X(23)00086-4. doi: 10.1016/j.neuro.2023.06.006. Online ahead of print.ABSTRACTGroundwater is considered safe, however, the occurrence of contaminants like arsenic and fluoride has raised a major healthcare concern. Clinical studies suggested that arsenic and fluoride co-exposure induced neurotoxicity, however efforts to explore safe and effective management of such neurotoxicity are limited. Therefore, we investigated the ameliorative effect of Fisetin against arsenic and fluoride subacute co-exposure-induced neurotoxicity, and associated biochemical and molecular changes. Male BALB/c ...
Source: Neurotoxicology - June 18, 2023 Category: Neurology Authors: Vitthal V Gopnar Debarati Rakshit Mounisha Bandakinda Uttam Kulhari Bidya Dhar Sahu Awanish Mishra Source Type: research

Fisetin attenuates arsenic and fluoride subacute co-exposure induced neurotoxicity via regulating TNF- α mediated activation of NLRP3 inflammasome
Neurotoxicology. 2023 Jun 16:S0161-813X(23)00086-4. doi: 10.1016/j.neuro.2023.06.006. Online ahead of print.ABSTRACTGroundwater is considered safe, however, the occurrence of contaminants like arsenic and fluoride has raised a major healthcare concern. Clinical studies suggested that arsenic and fluoride co-exposure induced neurotoxicity, however efforts to explore safe and effective management of such neurotoxicity are limited. Therefore, we investigated the ameliorative effect of Fisetin against arsenic and fluoride subacute co-exposure-induced neurotoxicity, and associated biochemical and molecular changes. Male BALB/c ...
Source: Neurotoxicology - June 18, 2023 Category: Neurology Authors: Vitthal V Gopnar Debarati Rakshit Mounisha Bandakinda Uttam Kulhari Bidya Dhar Sahu Awanish Mishra Source Type: research