Characterizing cannabis-prevalent terpenes for neuroprotection reveal a role for α and β-pinenes in mitigating amyloid β-evoked neurotoxicity and aggregation in vitro
CONCLUSIONS: The outcomes of this study underline a neuroprotective role of α-pinene and β-pinene against Aβ-mediated neurotoxicity associated with an inhibition of Aβ1-42 fibrilization and density. This demonstrates the bioactive potential of selected terpenes for consideration in the development of medicinal cannabis formulations targeting neurodegenerative diseases.PMID:38070653 | DOI:10.1016/j.neuro.2023.12.004 (Source: Neurotoxicology)
Source: Neurotoxicology - December 9, 2023 Category: Neurology Authors: John Staton Laws Scott D Smid Source Type: research
Necroptosis involved in sevoflurane-induced cognitive dysfunction in aged mice by activating NMDA receptors increasing intracellular calcium
Neurotoxicology. 2023 Dec 7:S0161-813X(23)00171-7. doi: 10.1016/j.neuro.2023.12.006. Online ahead of print.ABSTRACTPerioperative neurocognitive disorders are a common surgical and postanesthesia complication. Necroptosis contributes to the emergence of various neurological disorders. We conjecture that cognitive impairment is associated with necroptosis of hippocampal neurons, which is mediated by NMDA receptors leading to cytoplasmic calcium imbalance. C57BL/6J male mice ( 18 months) were randomly divided into the C ( control group), S ( sevoflurane group), S+M ( sevoflurane plus the NMDA receptor antagonist memantine gro...
Source: Neurotoxicology - December 9, 2023 Category: Neurology Authors: Xiang Liu Jiaxu Yu Xiaona Tan Qi Zhang Junfang Niu Zhiyong Hou Qiujun Wang Source Type: research
Morphological Hallmarks of Dopaminergic Neurodegeneration are Associated With Altered Neuron Function in Caenorhabditis elegans
Neurotoxicology. 2023 Dec 7:S0161-813X(23)00152-3. doi: 10.1016/j.neuro.2023.12.005. Online ahead of print.ABSTRACTCaenorhabditis elegans (C. elegans) is an excellent model system to study neurodegenerative diseases, such as Parkinson's disease, as it enables analysis of both neuron morphology and function in live animals. Multiple structural changes in neurons, such as cephalic dendrite morphological abnormalities, have been considered hallmarks of neurodegeneration in this model, but their relevance to changes in neuron function are not entirely clear. We sought to test whether hallmark morphological changes associated w...
Source: Neurotoxicology - December 9, 2023 Category: Neurology Authors: Andrew S Clark Javier Huayta Katherine S Morton Joel N Meyer Adriana San-Miguel Source Type: research
Characterizing cannabis-prevalent terpenes for neuroprotection reveal a role for α and β-pinenes in mitigating amyloid β-evoked neurotoxicity and aggregation in vitro
CONCLUSIONS: The outcomes of this study underline a neuroprotective role of α-pinene and β-pinene against Aβ-mediated neurotoxicity associated with an inhibition of Aβ1-42 fibrilization and density. This demonstrates the bioactive potential of selected terpenes for consideration in the development of medicinal cannabis formulations targeting neurodegenerative diseases.PMID:38070653 | DOI:10.1016/j.neuro.2023.12.004 (Source: Neurotoxicology)
Source: Neurotoxicology - December 9, 2023 Category: Neurology Authors: John Staton Laws Scott D Smid Source Type: research
Necroptosis involved in sevoflurane-induced cognitive dysfunction in aged mice by activating NMDA receptors increasing intracellular calcium
Neurotoxicology. 2023 Dec 7:S0161-813X(23)00171-7. doi: 10.1016/j.neuro.2023.12.006. Online ahead of print.ABSTRACTPerioperative neurocognitive disorders are a common surgical and postanesthesia complication. Necroptosis contributes to the emergence of various neurological disorders. We conjecture that cognitive impairment is associated with necroptosis of hippocampal neurons, which is mediated by NMDA receptors leading to cytoplasmic calcium imbalance. C57BL/6J male mice ( 18 months) were randomly divided into the C ( control group), S ( sevoflurane group), S+M ( sevoflurane plus the NMDA receptor antagonist memantine gro...
Source: Neurotoxicology - December 9, 2023 Category: Neurology Authors: Xiang Liu Jiaxu Yu Xiaona Tan Qi Zhang Junfang Niu Zhiyong Hou Qiujun Wang Source Type: research
Morphological Hallmarks of Dopaminergic Neurodegeneration are Associated With Altered Neuron Function in Caenorhabditis elegans
Neurotoxicology. 2023 Dec 7:S0161-813X(23)00152-3. doi: 10.1016/j.neuro.2023.12.005. Online ahead of print.ABSTRACTCaenorhabditis elegans (C. elegans) is an excellent model system to study neurodegenerative diseases, such as Parkinson's disease, as it enables analysis of both neuron morphology and function in live animals. Multiple structural changes in neurons, such as cephalic dendrite morphological abnormalities, have been considered hallmarks of neurodegeneration in this model, but their relevance to changes in neuron function are not entirely clear. We sought to test whether hallmark morphological changes associated w...
Source: Neurotoxicology - December 9, 2023 Category: Neurology Authors: Andrew S Clark Javier Huayta Katherine S Morton Joel N Meyer Adriana San-Miguel Source Type: research
Predicted Versus Observed Activity of PCB Mixtures Toward the Ryanodine Receptor
Neurotoxicology. 2023 Dec 6:S0161-813X(23)00167-5. doi: 10.1016/j.neuro.2023.12.003. Online ahead of print.ABSTRACTNon-dioxin-like polychlorinated biphenyls (NDL PCBs) alter the activity of the ryanodine receptor (RyR), and this activity is linked to developmental neurotoxicity. Most work to date has focused on the activity of single congeners rather than relevant mixtures. The current study assessed the RyR activity of single congeners or binary, tertiary, and complex PCB mixtures. Observed mixture activity was then compared to the expected activity calculated using the concentration addition (CA) model or a RyR-specific ...
Source: Neurotoxicology - December 8, 2023 Category: Neurology Authors: Justin A Griffin Xueshu Li Hans-Joachim Lehmler Erika B Holland Source Type: research
Preferential potentiation of AMPA-mediated currents in brainstem hypoglossal motoneurons by subchronic exposure of mice expressing the human superoxide dismutase 1 G93A gene mutation to neurotoxicant methylmercury in vivo
Neurotoxicology. 2023 Dec 6:S0161-813X(23)00168-7. doi: 10.1016/j.neuro.2023.12.002. Online ahead of print.ABSTRACTThe exact causes of Amyotrophic lateral sclerosis (ALS), a progressive and fatal neurological disorder due to loss of upper and/or lower motoneurons, remain elusive. Gene-environment interactions are believed to be an important factor in the development of ALS. We previously showed that in vivo exposure of mice overexpressing the human superoxide dismutase 1 (hSOD1) gene mutation (hSOD1G93A; G93A), a mouse model for ALS, to environmental neurotoxicant methylmercury (MeHg) accelerated the onset of ALS-like phen...
Source: Neurotoxicology - December 8, 2023 Category: Neurology Authors: Yukun Yuan Jordan M Bailey Gretchen M Rivera-Lopez William D Atchison Source Type: research
Mohamed Bahie Abou-Donia: Pioneer in organophosphorus-induced neurotoxicity
Neurotoxicology. 2023 Dec 4:S0161-813X(23)00151-1. doi: 10.1016/j.neuro.2023.12.001. Online ahead of print.NO ABSTRACTPMID:38056506 | DOI:10.1016/j.neuro.2023.12.001 (Source: Neurotoxicology)
Source: Neurotoxicology - December 6, 2023 Category: Neurology Source Type: research
Mohamed Bahie Abou-Donia: Pioneer in organophosphorus-induced neurotoxicity
Neurotoxicology. 2023 Dec 4:S0161-813X(23)00151-1. doi: 10.1016/j.neuro.2023.12.001. Online ahead of print.NO ABSTRACTPMID:38056506 | DOI:10.1016/j.neuro.2023.12.001 (Source: Neurotoxicology)
Source: Neurotoxicology - December 6, 2023 Category: Neurology Source Type: research
Mohamed Bahie Abou-Donia: Pioneer in organophosphorus-induced neurotoxicity
Neurotoxicology. 2023 Dec 4:S0161-813X(23)00151-1. doi: 10.1016/j.neuro.2023.12.001. Online ahead of print.NO ABSTRACTPMID:38056506 | DOI:10.1016/j.neuro.2023.12.001 (Source: Neurotoxicology)
Source: Neurotoxicology - December 6, 2023 Category: Neurology Source Type: research
Preventive and therapeutic effects of azithromycin on acrylamide-induced neurotoxicity in rats
CONCLUSIONS: Administration of azithromycin had both preventive and therapeutic effects on ACR-induced neurotoxicity through its antioxidant and antiapoptotic properties.PMID:38043637 | DOI:10.1016/j.neuro.2023.11.011 (Source: Neurotoxicology)
Source: Neurotoxicology - December 3, 2023 Category: Neurology Authors: Homa Fazeli Kakhki Mahboobeh Ghasemzadeh Rahbardar Bibi Marjan Razavi Mahmoud Reza Heidari Hossein Hosseinzadeh Source Type: research
Preventive and therapeutic effects of azithromycin on acrylamide-induced neurotoxicity in rats
CONCLUSIONS: Administration of azithromycin had both preventive and therapeutic effects on ACR-induced neurotoxicity through its antioxidant and antiapoptotic properties.PMID:38043637 | DOI:10.1016/j.neuro.2023.11.011 (Source: Neurotoxicology)
Source: Neurotoxicology - December 3, 2023 Category: Neurology Authors: Homa Fazeli Kakhki Mahboobeh Ghasemzadeh Rahbardar Bibi Marjan Razavi Mahmoud Reza Heidari Hossein Hosseinzadeh Source Type: research
Preventive and therapeutic effects of azithromycin on acrylamide-induced neurotoxicity in rats
CONCLUSIONS: Administration of azithromycin had both preventive and therapeutic effects on ACR-induced neurotoxicity through its antioxidant and antiapoptotic properties.PMID:38043637 | DOI:10.1016/j.neuro.2023.11.011 (Source: Neurotoxicology)
Source: Neurotoxicology - December 3, 2023 Category: Neurology Authors: Homa Fazeli Kakhki Mahboobeh Ghasemzadeh Rahbardar Bibi Marjan Razavi Mahmoud Reza Heidari Hossein Hosseinzadeh Source Type: research
α-Pyrrolidinononanophenone derivatives induce differentiated SH-SY5Y neuroblastoma cells apoptosis via reduction of antioxidant capacity: Involvement of NO depletion and inactivation of Nrf2/HO1 signaling pathway
In this study, to clarify the detailed action mechanisms by I-α-PNP, we investigated the mechanism of reactive oxygen species (ROS) -dependent apoptosis by I-α-PNP in differentiated SH-SY5Y with a focus on the antioxidant activities. Treatment with I-α-PNP elicits overproduction of ROS such as H2O2, hydroxyl radical, and 4-hydroxy-2-nonenal, and pretreatment with antioxidant N-acetyl-L-cysteine is attenuated the SH-SY5Y cells apoptosis by I-α-PNP. These results suggested that the overproduction of ROS is related to SH-SY5Y cell apoptosis by I-α-PNP. In addition, I-α-PNP markedly decreased antioxidant capacity in diff...
Source: Neurotoxicology - December 1, 2023 Category: Neurology Authors: Yuji Sakai Daisuke Egawa Junta Hattori Yoshifumi Morikawa Koichi Suenami Tomohiro Takayama Atsushi Nagai Tomomi Michiue Akira Ikari Toshiyuki Matsunaga Source Type: research
