Iron chelation prevents nigrostriatal neurodegeneration in a chronic methamphetamine mice model
Neurotoxicology. 2023 Sep 15:S0161-813X(23)00122-5. doi: 10.1016/j.neuro.2023.09.006. Online ahead of print.ABSTRACTMethamphetamine (METH) has been established to selectively target and impair dopaminergic neurons through multiple pathways. Ferroptosis is a unique form of non-apoptotic cell death driven by cellular iron accumulation-induced lipid peroxidation. Nonetheless, it remains unclear whether METH can induce ferroptosis. In the present study, we sought to assess alterations in iron levels after chronic METH exposure and reveal the modulatory role of iron on METH-induced pathologies. Importantly, we demonstrated that...
Source: Neurotoxicology - September 17, 2023 Category: Neurology Authors: Shanshan Hu Xiaorong Huang Jian Huang Ying Qian Yingbiao Tian Ye Xiao Xiaolan Qi Xiaoxian Zhou Zhusheng Yang Zehui Chen Source Type: research
Corrigendum to "JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats" [Neurotoxicology 87 (2021) 70-85]
Neurotoxicology. 2023 Sep 10;99:10-13. doi: 10.1016/j.neuro.2023.09.003. Online ahead of print.NO ABSTRACTPMID:37699281 | DOI:10.1016/j.neuro.2023.09.003 (Source: Neurotoxicology)
Source: Neurotoxicology - September 12, 2023 Category: Neurology Authors: Maylin Wong-Guerra Yanay Montano-Peguero Jeney Ram írez-Sánchez Javier Jim énez-Martin Luis Arturo Fonseca-Fonseca Daniela Hern ández-Enseñat Yasmine Nonose Odalys Vald és Abel Mondelo-Rodriguez Yaquelin Ortiz-Miranda Gretchen Bergado Tania Carmenat Source Type: research
Corrigendum to "JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats" [Neurotoxicology 87 (2021) 70-85]
Neurotoxicology. 2023 Sep 10;99:10-13. doi: 10.1016/j.neuro.2023.09.003. Online ahead of print.NO ABSTRACTPMID:37699281 | DOI:10.1016/j.neuro.2023.09.003 (Source: Neurotoxicology)
Source: Neurotoxicology - September 12, 2023 Category: Neurology Authors: Maylin Wong-Guerra Yanay Montano-Peguero Jeney Ram írez-Sánchez Javier Jim énez-Martin Luis Arturo Fonseca-Fonseca Daniela Hern ández-Enseñat Yasmine Nonose Odalys Vald és Abel Mondelo-Rodriguez Yaquelin Ortiz-Miranda Gretchen Bergado Tania Carmenat Source Type: research
Corrigendum to "JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats" [Neurotoxicology 87 (2021) 70-85]
Neurotoxicology. 2023 Sep 10;99:10-13. doi: 10.1016/j.neuro.2023.09.003. Online ahead of print.NO ABSTRACTPMID:37699281 | DOI:10.1016/j.neuro.2023.09.003 (Source: Neurotoxicology)
Source: Neurotoxicology - September 12, 2023 Category: Neurology Authors: Maylin Wong-Guerra Yanay Montano-Peguero Jeney Ram írez-Sánchez Javier Jim énez-Martin Luis Arturo Fonseca-Fonseca Daniela Hern ández-Enseñat Yasmine Nonose Odalys Vald és Abel Mondelo-Rodriguez Yaquelin Ortiz-Miranda Gretchen Bergado Tania Carmenat Source Type: research
Corrigendum to "JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats" [Neurotoxicology 87 (2021) 70-85]
Neurotoxicology. 2023 Sep 10;99:10-13. doi: 10.1016/j.neuro.2023.09.003. Online ahead of print.NO ABSTRACTPMID:37699281 | DOI:10.1016/j.neuro.2023.09.003 (Source: Neurotoxicology)
Source: Neurotoxicology - September 12, 2023 Category: Neurology Authors: Maylin Wong-Guerra Yanay Montano-Peguero Jeney Ram írez-Sánchez Javier Jim énez-Martin Luis Arturo Fonseca-Fonseca Daniela Hern ández-Enseñat Yasmine Nonose Odalys Vald és Abel Mondelo-Rodriguez Yaquelin Ortiz-Miranda Gretchen Bergado Tania Carmenat Source Type: research
Corrigendum to "JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats" [Neurotoxicology 87 (2021) 70-85]
Neurotoxicology. 2023 Sep 10;99:10-13. doi: 10.1016/j.neuro.2023.09.003. Online ahead of print.NO ABSTRACTPMID:37699281 | DOI:10.1016/j.neuro.2023.09.003 (Source: Neurotoxicology)
Source: Neurotoxicology - September 12, 2023 Category: Neurology Authors: Maylin Wong-Guerra Yanay Montano-Peguero Jeney Ram írez-Sánchez Javier Jim énez-Martin Luis Arturo Fonseca-Fonseca Daniela Hern ández-Enseñat Yasmine Nonose Odalys Vald és Abel Mondelo-Rodriguez Yaquelin Ortiz-Miranda Gretchen Bergado Tania Carmenat Source Type: research
The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish
Neurotoxicology. 2023 Sep 6:S0161-813X(23)00111-0. doi: 10.1016/j.neuro.2023.09.004. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, but the molecular mechanism of pain in PD is not fully understood, which prevents early diagnosis of PD. We aimed to determine the changes in opioidergic pathways when external pain is inflicted by inducing pain intraperitoneally in zebrafish, for which we generated a rotenone-induced PD mode...
Source: Neurotoxicology - September 8, 2023 Category: Neurology Authors: Derya Cansiz Ismail Unal Merih Beler Unsal Veli Ustundag Esin Ak Ebru Emekli-Alturfan Ahmet Ata Alturfan Source Type: research
The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish
Neurotoxicology. 2023 Sep 6:S0161-813X(23)00111-0. doi: 10.1016/j.neuro.2023.09.004. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, but the molecular mechanism of pain in PD is not fully understood, which prevents early diagnosis of PD. We aimed to determine the changes in opioidergic pathways when external pain is inflicted by inducing pain intraperitoneally in zebrafish, for which we generated a rotenone-induced PD mode...
Source: Neurotoxicology - September 8, 2023 Category: Neurology Authors: Derya Cansiz Ismail Unal Merih Beler Unsal Veli Ustundag Esin Ak Ebru Emekli-Alturfan Ahmet Ata Alturfan Source Type: research
The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish
Neurotoxicology. 2023 Sep 6:S0161-813X(23)00111-0. doi: 10.1016/j.neuro.2023.09.004. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, but the molecular mechanism of pain in PD is not fully understood, which prevents early diagnosis of PD. We aimed to determine the changes in opioidergic pathways when external pain is inflicted by inducing pain intraperitoneally in zebrafish, for which we generated a rotenone-induced PD mode...
Source: Neurotoxicology - September 8, 2023 Category: Neurology Authors: Derya Cansiz Ismail Unal Merih Beler Unsal Veli Ustundag Esin Ak Ebru Emekli-Alturfan Ahmet Ata Alturfan Source Type: research
Relationship of Mercury and Selenium in Ocean Fish Frequently Consumed in the Seychelles: A Comparison to Levels in Ocean Fish Consumed in the US
Neurotoxicology. 2023 Sep 5:S0161-813X(23)00108-0. doi: 10.1016/j.neuro.2023.09.001. Online ahead of print.ABSTRACTWe characterized mercury and selenium in the fish consumed in the Seychelles Islands to determine if their levels are similar to fish consumed in the US. A secondary aim was to examine whether fish weight and species predict mercury and selenium in fish consumed in the Seychelles. We measured total mercury (THg) and selenium (Se) content of 10 samples from each of the 19 most frequently consumed fish species in Seychelles and for each calculated the Se:Hg molar ratios and the Selenium Health Benefit Value Inde...
Source: Neurotoxicology - September 7, 2023 Category: Neurology Authors: Grazyna Zareba Donald Harrington Tom Scrimale Aubrey LeEsperance Gene E Watson Edwin van Wijngaarden Conrad F Shamlaye Tyler Nicholas Gary J Myers Sally W Thurston Source Type: research
Relationship of Mercury and Selenium in Ocean Fish Frequently Consumed in the Seychelles: A Comparison to Levels in Ocean Fish Consumed in the US
Neurotoxicology. 2023 Sep 5:S0161-813X(23)00108-0. doi: 10.1016/j.neuro.2023.09.001. Online ahead of print.ABSTRACTWe characterized mercury and selenium in the fish consumed in the Seychelles Islands to determine if their levels are similar to fish consumed in the US. A secondary aim was to examine whether fish weight and species predict mercury and selenium in fish consumed in the Seychelles. We measured total mercury (THg) and selenium (Se) content of 10 samples from each of the 19 most frequently consumed fish species in Seychelles and for each calculated the Se:Hg molar ratios and the Selenium Health Benefit Value Inde...
Source: Neurotoxicology - September 7, 2023 Category: Neurology Authors: Grazyna Zareba Donald Harrington Tom Scrimale Aubrey LeEsperance Gene E Watson Edwin van Wijngaarden Conrad F Shamlaye Tyler Nicholas Gary J Myers Sally W Thurston Source Type: research
Potential Role of Selenium in Modifying the Effect of Maternal Methylmercury Exposure on Child Neurodevelopment-A Review
Neurotoxicology. 2023 Aug 31:S0161-813X(23)00105-5. doi: 10.1016/j.neuro.2023.08.003. Online ahead of print.ABSTRACTSelenium (Se) is an essential trace element for normal neurodevelopment. It is incorporated into multiple selenoenzymes which have roles in the brain and neurological function, the synthesis of thyroid hormones, the antioxidant defense system, DNA synthesis, and reproduction. Fish is a source of both Se and neurotoxic methylmercury (MeHg). Selenium is known to ameliorate the effects of MeHg in experimental animals, but studies in children exposed to both Se and MeHg through prenatal fish consumption have been...
Source: Neurotoxicology - September 2, 2023 Category: Neurology Authors: Maria Wesolowska Alison J Yeates Emeir M McSorley Edwin van Wijngaarden Conrad F Shamlaye Gary J Myers J J Strain Maria S Mulhern Source Type: research
Potential Role of Selenium in Modifying the Effect of Maternal Methylmercury Exposure on Child Neurodevelopment-A Review
Neurotoxicology. 2023 Aug 31:S0161-813X(23)00105-5. doi: 10.1016/j.neuro.2023.08.003. Online ahead of print.ABSTRACTSelenium (Se) is an essential trace element for normal neurodevelopment. It is incorporated into multiple selenoenzymes which have roles in the brain and neurological function, the synthesis of thyroid hormones, the antioxidant defense system, DNA synthesis, and reproduction. Fish is a source of both Se and neurotoxic methylmercury (MeHg). Selenium is known to ameliorate the effects of MeHg in experimental animals, but studies in children exposed to both Se and MeHg through prenatal fish consumption have been...
Source: Neurotoxicology - September 2, 2023 Category: Neurology Authors: Maria Wesolowska Alison J Yeates Emeir M McSorley Edwin van Wijngaarden Conrad F Shamlaye Gary J Myers J J Strain Maria S Mulhern Source Type: research
Potential Role of Selenium in Modifying the Effect of Maternal Methylmercury Exposure on Child Neurodevelopment-A Review
Neurotoxicology. 2023 Aug 31:S0161-813X(23)00105-5. doi: 10.1016/j.neuro.2023.08.003. Online ahead of print.ABSTRACTSelenium (Se) is an essential trace element for normal neurodevelopment. It is incorporated into multiple selenoenzymes which have roles in the brain and neurological function, the synthesis of thyroid hormones, the antioxidant defense system, DNA synthesis, and reproduction. Fish is a source of both Se and neurotoxic methylmercury (MeHg). Selenium is known to ameliorate the effects of MeHg in experimental animals, but studies in children exposed to both Se and MeHg through prenatal fish consumption have been...
Source: Neurotoxicology - September 2, 2023 Category: Neurology Authors: Maria Wesolowska Alison J Yeates Emeir M McSorley Edwin van Wijngaarden Conrad F Shamlaye Gary J Myers J J Strain Maria S Mulhern Source Type: research
Potential Role of Selenium in Modifying the Effect of Maternal Methylmercury Exposure on Child Neurodevelopment-A Review
Neurotoxicology. 2023 Aug 31:S0161-813X(23)00105-5. doi: 10.1016/j.neuro.2023.08.003. Online ahead of print.ABSTRACTSelenium (Se) is an essential trace element for normal neurodevelopment. It is incorporated into multiple selenoenzymes which have roles in the brain and neurological function, the synthesis of thyroid hormones, the antioxidant defense system, DNA synthesis, and reproduction. Fish is a source of both Se and neurotoxic methylmercury (MeHg). Selenium is known to ameliorate the effects of MeHg in experimental animals, but studies in children exposed to both Se and MeHg through prenatal fish consumption have been...
Source: Neurotoxicology - September 2, 2023 Category: Neurology Authors: Maria Wesolowska Alison J Yeates Emeir M McSorley Edwin van Wijngaarden Conrad F Shamlaye Gary J Myers J J Strain Maria S Mulhern Source Type: research
