Neuronal exosomal miRNAs modulate mitochondrial functions and cell death in bystander neuronal cells under Parkinson's disease stress conditions

In conclusion, loss of enrichment of specific miRNAs, including miR-30a-5p and miR-181c-5p, under PD stress conditions causes mitochondrial dysfunction and neuronal death, and hence may lead to progression of PD.PMID:38401688 | DOI:10.1016/j.neuro.2024.02.005

Source: Neurotoxicology - February 24, 2024 Category: Neurology Authors: Fatema Currim Shatakshi Shukla Jyoti Singh Dhruv Gohel Minal Mane Anjali Shinde Milton Roy Shani Goyani Hitesh Vasiyani Aswathy Chandran Jean-Christophe Rochet Jason Cannon Rajesh Singh Source Type: research