Binge-like administration of alcohol mixed to energy drinks to male adolescent rats severely impacts on mesocortical dopaminergic function in adulthood: A behavioral, neurochemical and electrophysiological study
Neuropharmacology. 2023 Nov 10:109786. doi: 10.1016/j.neuropharm.2023.109786. Online ahead of print.ABSTRACTA growing body of evidence indicates that the practice of consuming alcohol mixed with energy drinks (ED) (AMED) in a binge drinking pattern is significantly diffusing among the adolescent population. This behavior, aimed at increasing the intake of alcohol, raises serious concerns about its long-term effects. Epidemiological studies suggest that AMED consumption might increase vulnerability to alcohol abuse and have a gating effect on the use of illicit drugs. The medial prefrontal cortex (mPFC) is involved in the m...
Source: Neuropharmacology - November 12, 2023 Category: Drugs & Pharmacology Authors: Laura Dazzi Fabrizio Sanna Giuseppe Talani Valentina Bassareo Francesca Biggio Paolo Follesa Maria Giuseppina Pisu Patrizia Porcu Roberta Puliga Marina Quartu Mariangela Serra Maria Pina Serra Enrico Sann Elio Acquas Source Type: research
Binge-like administration of alcohol mixed to energy drinks to male adolescent rats severely impacts on mesocortical dopaminergic function in adulthood: A behavioral, neurochemical and electrophysiological study
Neuropharmacology. 2023 Nov 10:109786. doi: 10.1016/j.neuropharm.2023.109786. Online ahead of print.ABSTRACTA growing body of evidence indicates that the practice of consuming alcohol mixed with energy drinks (ED) (AMED) in a binge drinking pattern is significantly diffusing among the adolescent population. This behavior, aimed at increasing the intake of alcohol, raises serious concerns about its long-term effects. Epidemiological studies suggest that AMED consumption might increase vulnerability to alcohol abuse and have a gating effect on the use of illicit drugs. The medial prefrontal cortex (mPFC) is involved in the m...
Source: Neuropharmacology - November 12, 2023 Category: Drugs & Pharmacology Authors: Laura Dazzi Fabrizio Sanna Giuseppe Talani Valentina Bassareo Francesca Biggio Paolo Follesa Maria Giuseppina Pisu Patrizia Porcu Roberta Puliga Marina Quartu Mariangela Serra Maria Pina Serra Enrico Sann Elio Acquas Source Type: research
Daily methocinnamox treatment dose-dependently attenuates fentanyl self-administration in rhesus monkeys
This study demonstrates that MCAM reliably and dose-dependently decreases fentanyl self-administration and prevents opioid overdose, with no evidence of any adverse effects over a broad dose range, further supporting the potential therapeutic utility of this novel antagonist.PMID:37944894 | DOI:10.1016/j.neuropharm.2023.109777 (Source: Neuropharmacology)
Source: Neuropharmacology - November 9, 2023 Category: Drugs & Pharmacology Authors: David R Maguire Charles P France Source Type: research
Daily methocinnamox treatment dose-dependently attenuates fentanyl self-administration in rhesus monkeys
This study demonstrates that MCAM reliably and dose-dependently decreases fentanyl self-administration and prevents opioid overdose, with no evidence of any adverse effects over a broad dose range, further supporting the potential therapeutic utility of this novel antagonist.PMID:37944894 | DOI:10.1016/j.neuropharm.2023.109777 (Source: Neuropharmacology)
Source: Neuropharmacology - November 9, 2023 Category: Drugs & Pharmacology Authors: David R Maguire Charles P France Source Type: research
Daily methocinnamox treatment dose-dependently attenuates fentanyl self-administration in rhesus monkeys
This study demonstrates that MCAM reliably and dose-dependently decreases fentanyl self-administration and prevents opioid overdose, with no evidence of any adverse effects over a broad dose range, further supporting the potential therapeutic utility of this novel antagonist.PMID:37944894 | DOI:10.1016/j.neuropharm.2023.109777 (Source: Neuropharmacology)
Source: Neuropharmacology - November 9, 2023 Category: Drugs & Pharmacology Authors: David R Maguire Charles P France Source Type: research
Altered brain serotonin 5-HT < sub > 1A < /sub > receptor expression and function in juvenile Fmr1 knockout mice
We examined agonist-labeled 5-HT1AR densities in male and female Fmr1 knockout mice, a mouse model of FXS, and found no difference in whole-brain 5-HT1AR expression in adult control compared to Fmr1 knockout mice. However, juvenile Fmr1 knockout mice had significantly lower whole-brain 5-HT1AR expression than age-matched controls. Consistent with these results, juvenile Fmr1 knockout mice showed significantly reduced behavioral responses elicited by the 5-HT1AR agonist (R)-8-OH-DPAT, effects blocked by the selective 5-HT1AR antagonist, WAY-100635. Also, treatment with the selective 5-HT1AR agonist, NLX-112, dose-dependentl...
Source: Neuropharmacology - November 3, 2023 Category: Drugs & Pharmacology Authors: Tanishka S Saraf Yiming Chen Richa Tyagi Clinton E Canal Source Type: research
Altered brain serotonin 5-HT < sub > 1A < /sub > receptor expression and function in juvenile Fmr1 knockout mice
We examined agonist-labeled 5-HT1AR densities in male and female Fmr1 knockout mice, a mouse model of FXS, and found no difference in whole-brain 5-HT1AR expression in adult control compared to Fmr1 knockout mice. However, juvenile Fmr1 knockout mice had significantly lower whole-brain 5-HT1AR expression than age-matched controls. Consistent with these results, juvenile Fmr1 knockout mice showed significantly reduced behavioral responses elicited by the 5-HT1AR agonist (R)-8-OH-DPAT, effects blocked by the selective 5-HT1AR antagonist, WAY-100635. Also, treatment with the selective 5-HT1AR agonist, NLX-112, dose-dependentl...
Source: Neuropharmacology - November 3, 2023 Category: Drugs & Pharmacology Authors: Tanishka S Saraf Yiming Chen Richa Tyagi Clinton E Canal Source Type: research
Altered brain serotonin 5-HT < sub > 1A < /sub > receptor expression and function in juvenile Fmr1 knockout mice
We examined agonist-labeled 5-HT1AR densities in male and female Fmr1 knockout mice, a mouse model of FXS, and found no difference in whole-brain 5-HT1AR expression in adult control compared to Fmr1 knockout mice. However, juvenile Fmr1 knockout mice had significantly lower whole-brain 5-HT1AR expression than age-matched controls. Consistent with these results, juvenile Fmr1 knockout mice showed significantly reduced behavioral responses elicited by the 5-HT1AR agonist (R)-8-OH-DPAT, effects blocked by the selective 5-HT1AR antagonist, WAY-100635. Also, treatment with the selective 5-HT1AR agonist, NLX-112, dose-dependentl...
Source: Neuropharmacology - November 3, 2023 Category: Drugs & Pharmacology Authors: Tanishka S Saraf Yiming Chen Richa Tyagi Clinton E Canal Source Type: research
Altered brain serotonin 5-HT < sub > 1A < /sub > receptor expression and function in juvenile Fmr1 knockout mice
We examined agonist-labeled 5-HT1AR densities in male and female Fmr1 knockout mice, a mouse model of FXS, and found no difference in whole-brain 5-HT1AR expression in adult control compared to Fmr1 knockout mice. However, juvenile Fmr1 knockout mice had significantly lower whole-brain 5-HT1AR expression than age-matched controls. Consistent with these results, juvenile Fmr1 knockout mice showed significantly reduced behavioral responses elicited by the 5-HT1AR agonist (R)-8-OH-DPAT, effects blocked by the selective 5-HT1AR antagonist, WAY-100635. Also, treatment with the selective 5-HT1AR agonist, NLX-112, dose-dependentl...
Source: Neuropharmacology - November 3, 2023 Category: Drugs & Pharmacology Authors: Tanishka S Saraf Yiming Chen Richa Tyagi Clinton E Canal Source Type: research
Methylone produces antidepressant-relevant actions and prosocial effects
Neuropharmacology. 2023 Oct 31;242:109787. doi: 10.1016/j.neuropharm.2023.109787. Online ahead of print.ABSTRACTMethylone (3,4-methylenedioxy-N-methylcathinone) is a rapid-acting entactogen that has been shown to have significant benefits in patients with post-traumatic stress disorder and major depressive disorder and is well tolerated in phase 1 clinical trials. A recent preclinical study reported that methylone produced robust antidepressant-like actions in naïve rats. However, its antidepressant effects on various stress-related psychopathologies and other neuropsychological actions remain unclear. In the present stud...
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Zhenlong Li Hsien-Yu Peng Chau-Shoun Lee Tzer-Bin Lin Ming-Chun Hsieh Cheng-Yuan Lai Han-Fang Wu Lih-Chyang Chen Mei-Ci Chen Dylan Chou Source Type: research
Molecular mechanisms of cholinergic neurotransmission in visceral smooth muscles with a focus on receptor-operated TRPC4 channel and impairment of gastrointestinal motility by general anaesthetics and anxiolytics
This article is part of the Special Issue featuring Ukrainian Neuroscience.PMID:37913983 | DOI:10.1016/j.neuropharm.2023.109776 (Source: Neuropharmacology)
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Alexander V Zholos Mariia I Melnyk Dariia O Dryn Source Type: research
Synergetic effect of matrine on the catalytic scFv antibody HS72 in vitro and in mice with Alzheimer disease pathology
Neuropharmacology. 2023 Oct 30:109775. doi: 10.1016/j.neuropharm.2023.109775. Online ahead of print.ABSTRACTSingle-chain variable fragment (scFv) HS72 is a catalytic antibody that specifically degrades amyloid β-protein 1-42 (Aβ42) aggregates in vitro or reduces the level or burden of Aβ42 deposits/plaques in the brains of mice with Alzheimer disease pathology. Its efficacy has been shown in protecting neural cells in vitro and improving the morphology of the cell population in the brain of mice with AD pathology (AD mice). Matrine (Mat) is a natural product capable of binding to Aβ42 or its aggregates and blocking the...
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Chuli Song He Li Tianyu Zhang Changxin Zheng Yingjiu Zhang Source Type: research
Intranasal oxytocin alleviates comorbid depressive symptoms in neuropathic pain via elevating hippocampal BDNF production in both female and male mice
Neuropharmacology. 2023 Oct 30:109769. doi: 10.1016/j.neuropharm.2023.109769. Online ahead of print.ABSTRACTThe comorbidity of pain and depression is frequently observed in patients suffering from chronic pain and depression. However, the comorbid mechanism is not well elucidated and the therapeutic medication is still inadequate. Oxytocin is a neuropeptide synthesized in the hypothalamus. It has been reported to relieve chronic pain and depressive symptoms. However, the analgesic action and mechanisms of oxytocin have mainly been investigated using peripheral or spinal administration. Because of the advantage of intranasa...
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Rongjun Liu Daofan Sun Xiuzhong Xing Qingge Chen Bo Lu Bo Meng Hui Yuan Lan Mo Liufang Sheng Jinwei Zheng Qiusheng Wang Junping Chen Xiaowei Chen Source Type: research
Corrigendum to 'The MK2 cascade regulates mGluR-dependent synaptic plasticity and reversal learning' [Neuropharmacology 155 (2019) 121-130]
Neuropharmacology. 2023 Oct 30:109760. doi: 10.1016/j.neuropharm.2023.109760. Online ahead of print.NO ABSTRACTPMID:37914554 | DOI:10.1016/j.neuropharm.2023.109760 (Source: Neuropharmacology)
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Lucia Privitera Ellen L Hogg Matthias Gaestel Mark J Wall Sonia A L Corr êa Source Type: research
Methylone produces antidepressant-relevant actions and prosocial effects
Neuropharmacology. 2023 Oct 30:109787. doi: 10.1016/j.neuropharm.2023.109787. Online ahead of print.ABSTRACTMethylone (3,4-methylenedioxy-N-methylcathinone) is a rapid-acting entactogen that has been shown to have significant benefits in patients with post-traumatic stress disorder and major depressive disorder and is well tolerated in phase 1 clinical trials. A recent preclinical study reported that methylone produced robust antidepressant-like actions in naïve rats. However, its antidepressant effects on various stress-related psychopathologies and other neuropsychological actions remain unclear. In the present study, w...
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Zhenlong Li Hsien-Yu Peng Chau-Shoun Lee Tzer-Bin Lin Ming-Chun Hsieh Cheng-Yuan Lai Han-Fang Wu Lih-Chyang Chen Mei-Ci Chen Dylan Chou Source Type: research
