4'-fluorocannabidiol associated with capsazepine restrains L-DOPA-induced dyskinesia in hemiparkinsonian mice: Contribution of anti-inflammatory and anti-glutamatergic mechanisms
Neuropharmacology. 2024 Mar 28:109926. doi: 10.1016/j.neuropharm.2024.109926. Online ahead of print.ABSTRACTWe tested the efficacy of 4'-fluorocannabidiol (4'-F-CBD), a semisynthetic cannabidiol derivative, and HU-910, a cannabinoid receptor 2 (CB2) agonist in resolving l-DOPA-induced dyskinesia (LID). Specifically, we were interested in studying whether these compounds could restrain striatal inflammatory responses and rescue glutamatergic disturbances characteristic of the dyskinetic state. C57BL/6 mice were rendered hemiparkinsonian by unilateral striatal lesioning with 6-OHDA. Abnormal involuntary movements were then i...
Source: Neuropharmacology - March 30, 2024 Category: Drugs & Pharmacology Authors: Maur ício Dos Santos Pereira Gabriel Henrique Dias de Abreu Leonardo Cala ça Arruda Vanderlei Rita Raisman-Vozari Francisco Silveira Guimar ães Hui-Chen Lu Patrick Pierre Michel Elaine Del Bel Source Type: research
4'-fluorocannabidiol associated with capsazepine restrains L-DOPA-induced dyskinesia in hemiparkinsonian mice: Contribution of anti-inflammatory and anti-glutamatergic mechanisms
Neuropharmacology. 2024 Mar 28:109926. doi: 10.1016/j.neuropharm.2024.109926. Online ahead of print.ABSTRACTWe tested the efficacy of 4'-fluorocannabidiol (4'-F-CBD), a semisynthetic cannabidiol derivative, and HU-910, a cannabinoid receptor 2 (CB2) agonist in resolving l-DOPA-induced dyskinesia (LID). Specifically, we were interested in studying whether these compounds could restrain striatal inflammatory responses and rescue glutamatergic disturbances characteristic of the dyskinetic state. C57BL/6 mice were rendered hemiparkinsonian by unilateral striatal lesioning with 6-OHDA. Abnormal involuntary movements were then i...
Source: Neuropharmacology - March 30, 2024 Category: Drugs & Pharmacology Authors: Maur ício Dos Santos Pereira Gabriel Henrique Dias de Abreu Leonardo Cala ça Arruda Vanderlei Rita Raisman-Vozari Francisco Silveira Guimar ães Hui-Chen Lu Patrick Pierre Michel Elaine Del Bel Source Type: research
The dopamine D2-like receptor and the Y-chromosome gene, SRY, are reciprocally regulated in the human male neuroblastoma M17 cell line
Neuropharmacology. 2024 Mar 27:109928. doi: 10.1016/j.neuropharm.2024.109928. Online ahead of print.NO ABSTRACTPMID:38552780 | DOI:10.1016/j.neuropharm.2024.109928 (Source: Neuropharmacology)
Source: Neuropharmacology - March 29, 2024 Category: Drugs & Pharmacology Authors: Dong-Hyun Kim Hannah Loke James Thompson Rachel Hill Suresh Sundram Joohyung Lee Source Type: research
The dopamine D2-like receptor and the Y-chromosome gene, SRY, are reciprocally regulated in the human male neuroblastoma M17 cell line
Neuropharmacology. 2024 Mar 27:109928. doi: 10.1016/j.neuropharm.2024.109928. Online ahead of print.NO ABSTRACTPMID:38552780 | DOI:10.1016/j.neuropharm.2024.109928 (Source: Neuropharmacology)
Source: Neuropharmacology - March 29, 2024 Category: Drugs & Pharmacology Authors: Dong-Hyun Kim Hannah Loke James Thompson Rachel Hill Suresh Sundram Joohyung Lee Source Type: research
Exploring the role of ghrelin and des-acyl ghrelin in chemotherapy-induced nausea and vomiting
This study investigated the effectiveness of ghrelin and des-acyl ghrelin (DAG) in antagonizing cisplatin-induced emesis and physiological changes indicative of nausea in Suncus murinus. Animals implanted with radiotelemetry devices were administered ghrelin (0.2, 1.0, and 5.0 μg/day), DAG (0.2, 1.0, and 5.0 μg/day), or saline (14 μL/day) intracerebroventricularly 4 days before and 3 days after treatment with cisplatin (30 mg/kg). At the end, the anti-apoptotic potentials of ghrelin and DAG were assessed by measuring Bax expression and cytochrome c activity. Neurotransmitter changes in the brain were evaluated using liq...
Source: Neuropharmacology - March 28, 2024 Category: Drugs & Pharmacology Authors: Lingqing Yang Charmaine J S Kung Zengbing Lu Julia Y H Liu Man Piu Ngan Takafumi Sakai Ichiro Sakata Sze Wa Chan Longlong Tu John A Rudd Source Type: research
Exploring the role of ghrelin and des-acyl ghrelin in chemotherapy-induced nausea and vomiting
This study investigated the effectiveness of ghrelin and des-acyl ghrelin (DAG) in antagonizing cisplatin-induced emesis and physiological changes indicative of nausea in Suncus murinus. Animals implanted with radiotelemetry devices were administered ghrelin (0.2, 1.0, and 5.0 μg/day), DAG (0.2, 1.0, and 5.0 μg/day), or saline (14 μL/day) intracerebroventricularly 4 days before and 3 days after treatment with cisplatin (30 mg/kg). At the end, the anti-apoptotic potentials of ghrelin and DAG were assessed by measuring Bax expression and cytochrome c activity. Neurotransmitter changes in the brain were evaluated using liq...
Source: Neuropharmacology - March 28, 2024 Category: Drugs & Pharmacology Authors: Lingqing Yang Charmaine J S Kung Zengbing Lu Julia Y H Liu Man Piu Ngan Takafumi Sakai Ichiro Sakata Sze Wa Chan Longlong Tu John A Rudd Source Type: research
Oxytocin and social learning in socially anxious men and women
CONCLUSION: These results suggest oxytocin-induced behavioral, physiological, and neural changes as a function of social learning in socially low and high anxious individuals. These findings challenge the amygdalocentric view of the role of emotions in social learning, instead contributing to the growing body of findings implicating the insula therein, revealing an interaction between oxytocin, sex, and emotional valence. Such discoveries raise an interesting set of questions regarding the computational goals of regions such as the insula in emotional learning and how neural activity can play a diagnostic or prognostic rol...
Source: Neuropharmacology - March 27, 2024 Category: Drugs & Pharmacology Authors: Aleya Flechsenhar Seth M Levine Laura E M üller Sabine C Herpertz Katja Bertsch Source Type: research
A longitudinal MRI and TSPO PET-based investigation of brain region-specific neuroprotection by diazepam versus midazolam following organophosphate-induced seizures
Neuropharmacology. 2024 Mar 23:109918. doi: 10.1016/j.neuropharm.2024.109918. Online ahead of print.ABSTRACTAcute poisoning with organophosphorus cholinesterase inhibitors (OPs), such as OP nerve agents and pesticides, can cause life threatening cholinergic crisis and status epilepticus (SE). Survivors often experience significant morbidity, including brain injury, acquired epilepsy, and cognitive deficits. Current medical countermeasures for acute OP poisoning include a benzodiazepine to mitigate seizures. Diazepam was long the benzodiazepine included in autoinjectors used to treat OP-induced seizures, but it is now being...
Source: Neuropharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Brad A Hobson Douglas R Rowland Yimeng Dou Naomi Saito Zachary T Harmany Donald A Bruun Danielle J Harvey Abhijit Chaudhari Joel R Garbow Pamela J Lein Source Type: research
A longitudinal MRI and TSPO PET-based investigation of brain region-specific neuroprotection by diazepam versus midazolam following organophosphate-induced seizures
Neuropharmacology. 2024 Mar 23:109918. doi: 10.1016/j.neuropharm.2024.109918. Online ahead of print.ABSTRACTAcute poisoning with organophosphorus cholinesterase inhibitors (OPs), such as OP nerve agents and pesticides, can cause life threatening cholinergic crisis and status epilepticus (SE). Survivors often experience significant morbidity, including brain injury, acquired epilepsy, and cognitive deficits. Current medical countermeasures for acute OP poisoning include a benzodiazepine to mitigate seizures. Diazepam was long the benzodiazepine included in autoinjectors used to treat OP-induced seizures, but it is now being...
Source: Neuropharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Brad A Hobson Douglas R Rowland Yimeng Dou Naomi Saito Zachary T Harmany Donald A Bruun Danielle J Harvey Abhijit Chaudhari Joel R Garbow Pamela J Lein Source Type: research
A longitudinal MRI and TSPO PET-based investigation of brain region-specific neuroprotection by diazepam versus midazolam following organophosphate-induced seizures
Neuropharmacology. 2024 Mar 23:109918. doi: 10.1016/j.neuropharm.2024.109918. Online ahead of print.ABSTRACTAcute poisoning with organophosphorus cholinesterase inhibitors (OPs), such as OP nerve agents and pesticides, can cause life threatening cholinergic crisis and status epilepticus (SE). Survivors often experience significant morbidity, including brain injury, acquired epilepsy, and cognitive deficits. Current medical countermeasures for acute OP poisoning include a benzodiazepine to mitigate seizures. Diazepam was long the benzodiazepine included in autoinjectors used to treat OP-induced seizures, but it is now being...
Source: Neuropharmacology - March 25, 2024 Category: Drugs & Pharmacology Authors: Brad A Hobson Douglas R Rowland Yimeng Dou Naomi Saito Zachary T Harmany Donald A Bruun Danielle J Harvey Abhijit Chaudhari Joel R Garbow Pamela J Lein Source Type: research
Tat-NR2B9c attenuates oxidative stress via inhibition of PSD95-NR2B-nNOS complex after subarachnoid hemorrhage in rats
Neuropharmacology. 2024 Mar 21:109905. doi: 10.1016/j.neuropharm.2024.109905. Online ahead of print.ABSTRACTOxidative stress plays important roles in the pathogenesis of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Tat-NR2B9c has shown efficacy as a neuroprotective agent in several studies. Here, we identified the neuroprotective role of Tat-NR2B9c after SAH and its related mechanisms. The results showed that Tat-NR2B9c treatment attenuated oxidative stress, therefore alleviated neuronal apoptosis and neurological deficits after SAH. Tat-NR2B9c treatment could alleviate mitochondrial vacuolization induced ...
Source: Neuropharmacology - March 23, 2024 Category: Drugs & Pharmacology Authors: Haocheng Zhang Longbiao Xu Yezhao He Zeyu Zhang Jiahao Zhang Qian Yu Yibo Liu Xiaoyu Wang Anke Zhang Kaikai Wang Yuanjian Fang Sheng Chen Source Type: research
Ginsenoside Rd enhances blood-brain barrier integrity after cerebral ischemia/reperfusion by alleviating endothelial cells ferroptosis via activation of NRG1/ErbB4-mediated PI3K/Akt/mTOR signaling pathway
In this study, we found that G-Rd could upregulate the levels of ZO-1, occludin, and claudin-5 in ipsilateral cerebral microvessels and bEnd.3 cells, reduce endothelial cells (ECs) loss and Evans blue (EB) leakage, and ultimately improve BBB integrity after CIRI. Interestingly, the expressions of ACSL4 and COX2 were upregulated, the expressions of GPX4 and xCT were downregulated, the levels of GSH was decreased, and the levels of MDA and Fe2+ were increased in ischemic tissues and bEnd.3 cells after CIRI, suggesting that ECs ferroptosis occurred after CIRI. However, G-Rd can alleviate CIRI-induced BBB disruption by inhibit...
Source: Neuropharmacology - March 23, 2024 Category: Drugs & Pharmacology Authors: Sheng Hu Yuxiang Fei Chenchen Jin Jun Yao Haiyan Ding Jianing Wang Chao Liu Source Type: research
Tat-NR2B9c attenuates oxidative stress via inhibition of PSD95-NR2B-nNOS complex after subarachnoid hemorrhage in rats
Neuropharmacology. 2024 Mar 21:109905. doi: 10.1016/j.neuropharm.2024.109905. Online ahead of print.ABSTRACTOxidative stress plays important roles in the pathogenesis of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Tat-NR2B9c has shown efficacy as a neuroprotective agent in several studies. Here, we identified the neuroprotective role of Tat-NR2B9c after SAH and its related mechanisms. The results showed that Tat-NR2B9c treatment attenuated oxidative stress, therefore alleviated neuronal apoptosis and neurological deficits after SAH. Tat-NR2B9c treatment could alleviate mitochondrial vacuolization induced ...
Source: Neuropharmacology - March 23, 2024 Category: Drugs & Pharmacology Authors: Haocheng Zhang Longbiao Xu Yezhao He Zeyu Zhang Jiahao Zhang Qian Yu Yibo Liu Xiaoyu Wang Anke Zhang Kaikai Wang Yuanjian Fang Sheng Chen Source Type: research
Ginsenoside Rd enhances blood-brain barrier integrity after cerebral ischemia/reperfusion by alleviating endothelial cells ferroptosis via activation of NRG1/ErbB4-mediated PI3K/Akt/mTOR signaling pathway
In this study, we found that G-Rd could upregulate the levels of ZO-1, occludin, and claudin-5 in ipsilateral cerebral microvessels and bEnd.3 cells, reduce endothelial cells (ECs) loss and Evans blue (EB) leakage, and ultimately improve BBB integrity after CIRI. Interestingly, the expressions of ACSL4 and COX2 were upregulated, the expressions of GPX4 and xCT were downregulated, the levels of GSH was decreased, and the levels of MDA and Fe2+ were increased in ischemic tissues and bEnd.3 cells after CIRI, suggesting that ECs ferroptosis occurred after CIRI. However, G-Rd can alleviate CIRI-induced BBB disruption by inhibit...
Source: Neuropharmacology - March 23, 2024 Category: Drugs & Pharmacology Authors: Sheng Hu Yuxiang Fei Chenchen Jin Jun Yao Haiyan Ding Jianing Wang Chao Liu Source Type: research
β2* nAChR sensitivity modulates acquisition of cocaine self-administration in male rats
We examined the interaction between nAChRs and cocaine reinforcement by expressing a hypersensitive β2 nAChR subunit (β2Leu9'Ser) in the ventral tegmental area of male Sprague Dawley rats. Compared to control rats, β2Leu9'Ser rats acquired (fixed ratio) intravenous cocaine self-administration faster and with greater likelihood. By contrast, β2Leu9'Ser rats were approximately equivalent to controls in their intake of cocaine on a progressive ratio schedule of reinforcement, suggesting differential effects of cholinergic signaling depending on experimental parameters. Like progressive ratio cocaine SA, β2Leu9'Ser rats a...
Source: Neuropharmacology - March 20, 2024 Category: Drugs & Pharmacology Authors: Noah B Walker Brenton R Tucker Leanne N Thomas Andrew E Tapp Anna I Neel Rong Chen Sara R Jones Ryan M Drenan Source Type: research
