β2* nAChR sensitivity modulates acquisition of cocaine self-administration in male rats
We examined the interaction between nAChRs and cocaine reinforcement by expressing a hypersensitive β2 nAChR subunit (β2Leu9'Ser) in the ventral tegmental area of male Sprague Dawley rats. Compared to control rats, β2Leu9'Ser rats acquired (fixed ratio) intravenous cocaine self-administration faster and with greater likelihood. By contrast, β2Leu9'Ser rats were approximately equivalent to controls in their intake of cocaine on a progressive ratio schedule of reinforcement, suggesting differential effects of cholinergic signaling depending on experimental parameters. Like progressive ratio cocaine SA, β2Leu9'Ser rats a...
Source: Neuropharmacology - March 20, 2024 Category: Drugs & Pharmacology Authors: Noah B Walker Brenton R Tucker Leanne N Thomas Andrew E Tapp Anna I Neel Rong Chen Sara R Jones Ryan M Drenan Source Type: research
β2* nAChR sensitivity modulates acquisition of cocaine self-administration in male rats
We examined the interaction between nAChRs and cocaine reinforcement by expressing a hypersensitive β2 nAChR subunit (β2Leu9'Ser) in the ventral tegmental area of male Sprague Dawley rats. Compared to control rats, β2Leu9'Ser rats acquired (fixed ratio) intravenous cocaine self-administration faster and with greater likelihood. By contrast, β2Leu9'Ser rats were approximately equivalent to controls in their intake of cocaine on a progressive ratio schedule of reinforcement, suggesting differential effects of cholinergic signaling depending on experimental parameters. Like progressive ratio cocaine SA, β2Leu9'Ser rats a...
Source: Neuropharmacology - March 20, 2024 Category: Drugs & Pharmacology Authors: Noah B Walker Brenton R Tucker Leanne N Thomas Andrew E Tapp Anna I Neel Rong Chen Sara R Jones Ryan M Drenan Source Type: research
Resveratrol evokes neuroprotective effects and improves foot stance following kainate-induced excitotoxic damage to the mouse spinal cord
Neuropharmacology. 2024 Mar 16;250:109906. doi: 10.1016/j.neuropharm.2024.109906. Online ahead of print.ABSTRACTExcitotoxicity, characterized by over-activation of glutamate receptors, is a major contributor to spinal cord injury (SCI) pathophysiology, resulting in neuronal death and loss of locomotor function. In our previous in vitro studies, we showed that excitotoxicity induced by the glutamate analogue kainate (KA) leads to a significant reduction in the number of neurons, providing a model for SCI. Our current objective was to assess the neuroprotective role of resveratrol (RESV), a natural polyphenol, following KA-i...
Source: Neuropharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Benjam Ãn Zylberberg Martina Poodts Julieta Roncoroni M Florencia Coronel Graciela L Mazzone Source Type: research
Neuro-modulatory impact of felodipine against experimentally-induced Parkinson's disease: Possible contribution of PINK1-Parkin mitophagy pathway
In conclusion, felodipine restored dopamine synthesis, attenuated oxidative stress, inflammation, and mitochondrial dysfunction, and improved the mitophagy process resulting in improved PD-associated motor impairment.PMID:38494124 | DOI:10.1016/j.neuropharm.2024.109909 (Source: Neuropharmacology)
Source: Neuropharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Hadeer O Abou-Hany Mohamed El-Sherbiny Sally Elshaer Eman Said Tarek Moustafa Source Type: research
Resveratrol evokes neuroprotective effects and improves foot stance following kainate-induced excitotoxic damage to the mouse spinal cord
Neuropharmacology. 2024 Mar 15:109906. doi: 10.1016/j.neuropharm.2024.109906. Online ahead of print.ABSTRACTExcitotoxicity, characterized by over-activation of glutamate receptors, is a major contributor to spinal cord injury (SCI) pathophysiology, resulting in neuronal death and loss of locomotor function. In our previous in vitro studies, we showed that excitotoxicity induced by the glutamate analogue kainate (KA) leads to a significant reduction in the number of neurons, providing a model for SCI. Our current objective was to assess the neuroprotective role of resveratrol (RESV), a natural polyphenol, following KA-induc...
Source: Neuropharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Benjam Ãn Zylberberg Martina Poodts Julieta Roncoroni M Florencia Coronel Graciela L Mazzone Source Type: research
Neuro-modulatory impact of felodipine against experimentally-induced Parkinson's disease: Possible contribution of PINK1-Parkin mitophagy pathway
In conclusion, felodipine restored dopamine synthesis, attenuated oxidative stress, inflammation, and mitochondrial dysfunction, and improved the mitophagy process resulting in improved PD-associated motor impairment.PMID:38494124 | DOI:10.1016/j.neuropharm.2024.109909 (Source: Neuropharmacology)
Source: Neuropharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Hadeer O Abou-Hany Mohamed El-Sherbiny Sally Elshaer Eman Said Tarek Moustafa Source Type: research
Resveratrol evokes neuroprotective effects and improves foot stance following kainate-induced excitotoxic damage to the mouse spinal cord
Neuropharmacology. 2024 Mar 15:109906. doi: 10.1016/j.neuropharm.2024.109906. Online ahead of print.ABSTRACTExcitotoxicity, characterized by over-activation of glutamate receptors, is a major contributor to spinal cord injury (SCI) pathophysiology, resulting in neuronal death and loss of locomotor function. In our previous in vitro studies, we showed that excitotoxicity induced by the glutamate analogue kainate (KA) leads to a significant reduction in the number of neurons, providing a model for SCI. Our current objective was to assess the neuroprotective role of resveratrol (RESV), a natural polyphenol, following KA-induc...
Source: Neuropharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Benjam Ãn Zylberberg Martina Poodts Julieta Roncoroni M Florencia Coronel Graciela L Mazzone Source Type: research
Neuro-modulatory impact of felodipine against experimentally-induced Parkinson's disease: Possible contribution of PINK1-Parkin mitophagy pathway
In conclusion, felodipine restored dopamine synthesis, attenuated oxidative stress, inflammation, and mitochondrial dysfunction, and improved the mitophagy process resulting in improved PD-associated motor impairment.PMID:38494124 | DOI:10.1016/j.neuropharm.2024.109909 (Source: Neuropharmacology)
Source: Neuropharmacology - March 17, 2024 Category: Drugs & Pharmacology Authors: Hadeer O Abou-Hany Mohamed El-Sherbiny Sally Elshaer Eman Said Tarek Moustafa Source Type: research
PGC-1 α in the hippocampus mediates depressive-like and stress-coping behaviours and regulates excitatory synapses in the dentate gyrus in mice
Neuropharmacology. 2024 Mar 14:109908. doi: 10.1016/j.neuropharm.2024.109908. Online ahead of print.ABSTRACTDecreased hippocampal synaptic plasticity is an important pathological change in stress-related mood disorders, including major depressive disorder. However, the underlying mechanism is unclear. PGC-1α, a transcriptional coactivator, is a key factor in synaptic plasticity. We investigated the relationships between changes in hippocampal PGC-1α expression and depressive-like and stress-coping behaviours, and whether they are related to hippocampal synapses. Adeno-associated virus was used to alter hippocampal PGC-1Î...
Source: Neuropharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Yuhui Deng Xin Liang Yue Li Lin Jiang Jin Wang Jing Tang Jing Li Yuhan Xie Kai Xiao Peilin Zhu Yijing Guo Yanmin Luo Yong Tang Source Type: research
Ginkgolide B can alleviate spinal glymphatic system dysfunction and provide neuroprotection in PDN rats by inhibiting matrix metalloproteinase-9
In this study, we investigated whether inhibition of MMP-9-mediated β-DG cleavage by GB is involved in the regulation of AQP4 polarity within the glymphatic system in painful diabetic neuropathy (PDN) and exerts neuroprotective effects. The PDN model was established by injecting streptozotocin (STZ). Functional changes in the glymphatic system were observed using magnetic resonance imaging (MRI). The paw withdrawal threshold (PWT) was measured to assess mechanical allodynia. The protein expressions of MMP-9, β-DG, and AQP4 were detected by Western blotting and immunofluorescence. Our findings revealed significant decreas...
Source: Neuropharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Jiang Li Shuaiying Jia Yuehan Song Wenmei Xu Jingyan Lin Source Type: research
PGC-1 α in the hippocampus mediates depressive-like and stress-coping behaviours and regulates excitatory synapses in the dentate gyrus in mice
Neuropharmacology. 2024 Mar 14:109908. doi: 10.1016/j.neuropharm.2024.109908. Online ahead of print.ABSTRACTDecreased hippocampal synaptic plasticity is an important pathological change in stress-related mood disorders, including major depressive disorder. However, the underlying mechanism is unclear. PGC-1α, a transcriptional coactivator, is a key factor in synaptic plasticity. We investigated the relationships between changes in hippocampal PGC-1α expression and depressive-like and stress-coping behaviours, and whether they are related to hippocampal synapses. Adeno-associated virus was used to alter hippocampal PGC-1Î...
Source: Neuropharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Yuhui Deng Xin Liang Yue Li Lin Jiang Jin Wang Jing Tang Jing Li Yuhan Xie Kai Xiao Peilin Zhu Yijing Guo Yanmin Luo Yong Tang Source Type: research
Ginkgolide B can alleviate spinal glymphatic system dysfunction and provide neuroprotection in PDN rats by inhibiting matrix metalloproteinase-9
In this study, we investigated whether inhibition of MMP-9-mediated β-DG cleavage by GB is involved in the regulation of AQP4 polarity within the glymphatic system in painful diabetic neuropathy (PDN) and exerts neuroprotective effects. The PDN model was established by injecting streptozotocin (STZ). Functional changes in the glymphatic system were observed using magnetic resonance imaging (MRI). The paw withdrawal threshold (PWT) was measured to assess mechanical allodynia. The protein expressions of MMP-9, β-DG, and AQP4 were detected by Western blotting and immunofluorescence. Our findings revealed significant decreas...
Source: Neuropharmacology - March 16, 2024 Category: Drugs & Pharmacology Authors: Jiang Li Shuaiying Jia Yuehan Song Wenmei Xu Jingyan Lin Source Type: research
Roles of mechanosensitive ion channel PIEZO1 in the pathogenesis of brain injury after experimental intracerebral hemorrhage
In conclusion, Piezo1 plays a crucial role in the pathogenesis of brain injury after ICH and may be a target for clinical treatment of ICH.PMID:38490299 | DOI:10.1016/j.neuropharm.2024.109896 (Source: Neuropharmacology)
Source: Neuropharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Min Qi Ran Liu Fan Zhang Zhipeng Yao Meng-Liang Zhou Xiaochun Jiang Shizhang Ling Source Type: research
Roles of mechanosensitive ion channel PIEZO1 in the pathogenesis of brain injury after experimental intracerebral hemorrhage
In conclusion, Piezo1 plays a crucial role in the pathogenesis of brain injury after ICH and may be a target for clinical treatment of ICH.PMID:38490299 | DOI:10.1016/j.neuropharm.2024.109896 (Source: Neuropharmacology)
Source: Neuropharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Min Qi Ran Liu Fan Zhang Zhipeng Yao Meng-Liang Zhou Xiaochun Jiang Shizhang Ling Source Type: research
Novel pharmacological targets for GABAergic dysfunction in ADHD
Neuropharmacology. 2024 Mar 8;249:109897. doi: 10.1016/j.neuropharm.2024.109897. Online ahead of print.ABSTRACTAttention deficit/hyperactivity disorder (ADHD) is a neurodevelopment disorder that affects approximately 5% of the population. The disorder is characterized by impulsivity, hyperactivity, and deficits in attention and cognition, although symptoms vary across patients due to the heterogenous and polygenic nature of the disorder. Stimulant medications are the standard of care treatment for ADHD patients, and their effectiveness has led to the dopaminergic hypothesis of ADHD in which deficits in dopaminergic signali...
Source: Neuropharmacology - March 10, 2024 Category: Drugs & Pharmacology Authors: Anthony S Ferranti Deborah J Luessen Colleen M Niswender Source Type: research
