Pharmacological profiles and anti-inflammatory activity of pCN-diEPP and mCN-diEPP, new alpha9alpha10 nicotinic receptor ligands
Neuropharmacology. 2023 Sep 25:109717. doi: 10.1016/j.neuropharm.2023.109717. Online ahead of print.ABSTRACTPain due to inflammation can be reduced by targeting the noncanonical nicotinic receptors (NCNR) in cells of the immune system that regulate the synthesis and release of pro- and anti-inflammatory cytokines. Although NCNR do not generate ion channel currents, the pharmacology of ion-channel forms of the receptors can predict drugs which may be effective regulators of the cholinergic anti-inflammatory system (CAS). Agonists of α7 type receptors have been definitively associated with CAS. Receptors containing α9 and ...
Source: Neuropharmacology - September 27, 2023 Category: Drugs & Pharmacology Authors: Katrin Richter Sara M Herz Clare Stokes M Imad Damaj Veronika Grau Roger L Papke Source Type: research
Impact of physical activity on brain oxidative metabolism and intrinsic capacities in young swiss mice fed a high fat diet
Neuropharmacology. 2023 Sep 25:109730. doi: 10.1016/j.neuropharm.2023.109730. Online ahead of print.ABSTRACTType 2 diabetes and obesity characterized by hallmarks of insulin resistance along with an imbalance in brain oxidative metabolism would impair intrinsic capacities (ICs), a new concept for assessing mental and physical functioning. Here, we explored the impact of physical activity on antioxidant responses and oxidative metabolism in discrete brain areas of HFD or standard diet (STD) fed mice but also its consequences on specific domains of ICs. 6-week-old Swiss male mice were exposed to a STD or a HFD for 16 weeks a...
Source: Neuropharmacology - September 27, 2023 Category: Drugs & Pharmacology Authors: Cl émence Viguier S ébastien Bullich Marlene Botella Laure Fasseu Am élie Alfonso Khaoula Rekik S ébastien Gauzin Bruno P Guiard No élie Davezac Source Type: research
Effects and mechanisms of salidroside on the behavior of SPS-induced PTSD rats
In conclusion, our results demonstrated that Sal could attenuate SPS-induced PTSD-like behaviors by inhibiting hippocampal neuronal apoptosis, enhancing hippocampal synaptic plasticity, and reducing neuroinflammatory responses. These findings may provide a foundation for the potential clinical application of Sal in the treatment of PTSD.PMID:37742716 | DOI:10.1016/j.neuropharm.2023.109728 (Source: Neuropharmacology)
Source: Neuropharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Xing-Dong Chen Jing-Xiang Wei Hai-Yan Wang Yu-Yuan Peng Can Tang Yang Ding Sen Li Zai-Yun Long Xiu-Min Lu Yong-Tang Wang Source Type: research
Enhanced methamphetamine sensitisation in a rat model of the brain-derived neurotrophic factor Val66Met variant: Sex differences and dopamine receptor gene expression
Neuropharmacology. 2023 Sep 22:109719. doi: 10.1016/j.neuropharm.2023.109719. Online ahead of print.ABSTRACTBrain-derived neurotrophic factor (BDNF) and the Val66Met polymorphism may play a role in the development of psychosis and schizophrenia. The aim of this study was to investigate long-term effects of methamphetamine (Meth) on psychosis-like behaviour and dopamine receptor and dopamine transporter gene expression in a novel rat model of the BDNF Val66Met polymorphism. At the end of a 7-day subchronic Meth treatment, female rats with the Met/Met genotype selectively showed locomotor hyperactivity sensitisation to the a...
Source: Neuropharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Emily J Jaehne Hayette Semaan Adam Grosman Xiangjun Xu Quenten Schwarz Maarten van den Buuse Source Type: research
Effects and mechanisms of salidroside on the behavior of SPS-induced PTSD rats
In conclusion, our results demonstrated that Sal could attenuate SPS-induced PTSD-like behaviors by inhibiting hippocampal neuronal apoptosis, enhancing hippocampal synaptic plasticity, and reducing neuroinflammatory responses. These findings may provide a foundation for the potential clinical application of Sal in the treatment of PTSD.PMID:37742716 | DOI:10.1016/j.neuropharm.2023.109728 (Source: Neuropharmacology)
Source: Neuropharmacology - September 24, 2023 Category: Drugs & Pharmacology Authors: Xing-Dong Chen Jing-Xiang Wei Hai-Yan Wang Yu-Yuan Peng Can Tang Yang Ding Sen Li Zai-Yun Long Xiu-Min Lu Yong-Tang Wang Source Type: research
