Pharmacological blockage of NOP receptors decreases ventral tegmental area dopamine neuronal activity through GABA < sub > B < /sub > receptor-mediated mechanism
Neuropharmacology. 2024 Feb 14:109866. doi: 10.1016/j.neuropharm.2024.109866. Online ahead of print.ABSTRACTThe Nociceptin/Orphanin FQ (N/OFQ) peptide and its receptor NOP are highly expressed within several regions of the mesolimbic system, including the ventral tegmental area (VTA). Evidence indicates that the N/OFQ-NOP receptor system is involved in reward processing and historically it has been proposed that activation of NOP receptors attenuates the motivation for substances of abuse. However, recent findings demonstrated that drug self-administration and relapse to drug-seeking are also attenuated after administratio...
Source: Neuropharmacology - February 16, 2024 Category: Drugs & Pharmacology Authors: Michele Petrella Anna Maria Borruto Lorenzo Curti None Domi Esi Domi Li Xu Estelle Barbier Alice Ilari Markus Heilig Friedbert Weiss Guido Mannaioni Alessio Masi Roberto Ciccocioppo Source Type: research
Pharmacological blockage of NOP receptors decreases ventral tegmental area dopamine neuronal activity through GABA < sub > B < /sub > receptor-mediated mechanism
Neuropharmacology. 2024 Feb 14:109866. doi: 10.1016/j.neuropharm.2024.109866. Online ahead of print.ABSTRACTThe Nociceptin/Orphanin FQ (N/OFQ) peptide and its receptor NOP are highly expressed within several regions of the mesolimbic system, including the ventral tegmental area (VTA). Evidence indicates that the N/OFQ-NOP receptor system is involved in reward processing and historically it has been proposed that activation of NOP receptors attenuates the motivation for substances of abuse. However, recent findings demonstrated that drug self-administration and relapse to drug-seeking are also attenuated after administratio...
Source: Neuropharmacology - February 16, 2024 Category: Drugs & Pharmacology Authors: Michele Petrella Anna Maria Borruto Lorenzo Curti None Domi Esi Domi Li Xu Estelle Barbier Alice Ilari Markus Heilig Friedbert Weiss Guido Mannaioni Alessio Masi Roberto Ciccocioppo Source Type: research
Pharmacological blockage of NOP receptors decreases ventral tegmental area dopamine neuronal activity through GABA < sub > B < /sub > receptor-mediated mechanism
Neuropharmacology. 2024 Feb 14:109866. doi: 10.1016/j.neuropharm.2024.109866. Online ahead of print.ABSTRACTThe Nociceptin/Orphanin FQ (N/OFQ) peptide and its receptor NOP are highly expressed within several regions of the mesolimbic system, including the ventral tegmental area (VTA). Evidence indicates that the N/OFQ-NOP receptor system is involved in reward processing and historically it has been proposed that activation of NOP receptors attenuates the motivation for substances of abuse. However, recent findings demonstrated that drug self-administration and relapse to drug-seeking are also attenuated after administratio...
Source: Neuropharmacology - February 16, 2024 Category: Drugs & Pharmacology Authors: Michele Petrella Anna Maria Borruto Lorenzo Curti None Domi Esi Domi Li Xu Estelle Barbier Alice Ilari Markus Heilig Friedbert Weiss Guido Mannaioni Alessio Masi Roberto Ciccocioppo Source Type: research
Postweaning stress affects behavior, brain and gut microbiota of adolescent mice in a sex-dependent manner
Neuropharmacology. 2024 Feb 12:109869. doi: 10.1016/j.neuropharm.2024.109869. Online ahead of print.ABSTRACTAggression is an instinctive behavior that has been reported to be influenced by early-life stress. However, the potential effects of acute stress during the postweaning period, a key stage for brain development, on defensive aggression and the associated mechanism remain poorly understood. In the present study, aggressive behaviors were evaluated in adolescent mice exposed to postweaning stress. Serum corticosterone and testosterone levels, neural dendritic spine density, and gut microbiota composition were determin...
Source: Neuropharmacology - February 14, 2024 Category: Drugs & Pharmacology Authors: Xueyong Yin Ye Zhao Shuang Wang Hao Feng Xinyue He Xincheng Li Xiaoyu Liu Hengtai Lu Di Wen Yun Shi Haishui Shi Source Type: research
Postweaning stress affects behavior, brain and gut microbiota of adolescent mice in a sex-dependent manner
Neuropharmacology. 2024 Feb 12:109869. doi: 10.1016/j.neuropharm.2024.109869. Online ahead of print.ABSTRACTAggression is an instinctive behavior that has been reported to be influenced by early-life stress. However, the potential effects of acute stress during the postweaning period, a key stage for brain development, on defensive aggression and the associated mechanism remain poorly understood. In the present study, aggressive behaviors were evaluated in adolescent mice exposed to postweaning stress. Serum corticosterone and testosterone levels, neural dendritic spine density, and gut microbiota composition were determin...
Source: Neuropharmacology - February 14, 2024 Category: Drugs & Pharmacology Authors: Xueyong Yin Ye Zhao Shuang Wang Hao Feng Xinyue He Xincheng Li Xiaoyu Liu Hengtai Lu Di Wen Yun Shi Haishui Shi Source Type: research
Postweaning stress affects behavior, brain and gut microbiota of adolescent mice in a sex-dependent manner
Neuropharmacology. 2024 Feb 12:109869. doi: 10.1016/j.neuropharm.2024.109869. Online ahead of print.ABSTRACTAggression is an instinctive behavior that has been reported to be influenced by early-life stress. However, the potential effects of acute stress during the postweaning period, a key stage for brain development, on defensive aggression and the associated mechanism remain poorly understood. In the present study, aggressive behaviors were evaluated in adolescent mice exposed to postweaning stress. Serum corticosterone and testosterone levels, neural dendritic spine density, and gut microbiota composition were determin...
Source: Neuropharmacology - February 14, 2024 Category: Drugs & Pharmacology Authors: Xueyong Yin Ye Zhao Shuang Wang Hao Feng Xinyue He Xincheng Li Xiaoyu Liu Hengtai Lu Di Wen Yun Shi Haishui Shi Source Type: research
MUFA synthesis and stearoyl-CoA desaturase as a new pharmacological target for modulation of lipid and alpha-synuclein interaction against Parkinson's disease synucleinopathy
Neuropharmacology. 2024 Feb 9:109865. doi: 10.1016/j.neuropharm.2024.109865. Online ahead of print.ABSTRACTProtein pathology spreading within the nervous system, accompanies neurodegeneration and a spectrum of motor and cognitive dysfunctions. Currently available therapies against Parkinson's disease and other synucleinopathies are mostly symptomatic and fail to slow the disease progression in the long term. Modification of α synuclein (αS) aggregation and toxicity of its pathogenic forms is one of the main goals in neuroprotective approach. Since the discovery of lipid component of Lewy bodies fatty acids became a cruci...
Source: Neuropharmacology - February 11, 2024 Category: Drugs & Pharmacology Authors: Joanna Kula Katarzyna Z Kuter Source Type: research
Impact of caloric restriction on oxidative stress and key glycolytic enzymes in the cerebral cortex, liver and kidney of old and middle-aged mice
In this study, we examined effects of aging and CR on the activities of glycolytic enzymes and parameters of oxidative stress in the cerebral cortex, liver, and kidney of middle-aged (9 months old) and old (18 months old) C57BL6/N mice. Control middle-aged and old mice were fed ad libitum (AL groups), whereas age-matched CR groups were subjected to CR (70% of individual ad libitum food intake) for 6 and 12 months, respectively. There were no significant differences in the activities of key glycolytic and antioxidant enzymes and oxidative stress indices between the cortices of middle-aged and old AL mice. The livers and kid...
Source: Neuropharmacology - February 10, 2024 Category: Drugs & Pharmacology Authors: Myroslava V Vatashchuk Viktoriia V Hurza Nadiia Stefanyshyn Maria M Bayliak Dmytro V Gospodaryov Olga Garaschuk Volodymyr I Lushchak Source Type: research
Optogenetic stimulation of corticostriatal circuits improves behavioral flexibility in mice with prenatal alcohol exposure
Neuropharmacology. 2024 Feb 7;247:109860. doi: 10.1016/j.neuropharm.2024.109860. Online ahead of print.ABSTRACTFetal alcohol spectrum disorder (FASD) is the most common preventable form of developmental and neurobehavioral disability. Animal models have demonstrated that even low to moderate prenatal alcohol exposure (PAE) is sufficient to impair behavioral flexibility in multiple domains. Previously, utilizing a moderate limited access drinking in the dark paradigm, we have shown that PAE 1) impairs touchscreen pairwise visual reversal in male adult offspring 2) leads to small but significant decreases in orbitofrontal (O...
Source: Neuropharmacology - February 9, 2024 Category: Drugs & Pharmacology Authors: Valentina Licheri Jayapriya Chandrasekaran Johnny A Kenton Clark W Bird C Fernando Valenzuela Jonathan L Brigman Source Type: research
Sleep loss disrupts decision-making ability and neuronal cytomorphology in zebrafish and the effects are mediated by noradrenaline acting on α1-adrenoceptor
Neuropharmacology. 2024 Feb 7;247:109861. doi: 10.1016/j.neuropharm.2024.109861. Online ahead of print.ABSTRACTSleep is an instinct behavior, and its significance and functions are still an enigma. It is expressed throughout one's life and its loss affects psycho-somatic and physiological processes. We had proposed that it might maintain a fundamental property of the neurons and the brain. In that context, it was shown that sleep, rapid eye movement sleep (REMS) in particular, by regulating noradrenaline (NA), maintains the brain excitability. It was also reported that sleep-loss affected memory, reaction time and decision...
Source: Neuropharmacology - February 8, 2024 Category: Drugs & Pharmacology Authors: Kumar Abhishek Birendra Nath Mallick Source Type: research
Effects of the adenosine A < sub > 2A < /sub > receptor antagonist KW6002 on the dopaminergic system, motor performance, and neuroinflammation in a rat model of Parkinson's disease
Neuropharmacology. 2024 Feb 5;247:109862. doi: 10.1016/j.neuropharm.2024.109862. Online ahead of print.ABSTRACTAdenosine A2A-receptors (A2AR) and dopamine D2-receptors (D2R) are known to work together in a synergistic manner. Inhibiting A2ARs by genetic or pharmacological means can relief symptoms and have neuroprotective effects in certain conditions. We applied PET imaging to evaluate the impact of the A2AR antagonist KW6002 on D2R availability and neuroinflammation in an animal model of Parkinson's disease. Male Wistar rats with 6-hydroxydopamine-induced damage to the right striatum were given 3 mg/kg of KW6002 daily fo...
Source: Neuropharmacology - February 7, 2024 Category: Drugs & Pharmacology Authors: Kavya Prasad Erik F J de Vries Esther van der Meiden Rodrigo Moraga-Amaro Daniel Aaron Vazquez-Matias Lara Barazzuol Rudi A J O Dierckx Aren van Waarde Source Type: research
DHEC mesylate attenuates pathologies and aberrant bisecting N-glycosylation in Alzheimer's disease models
Neuropharmacology. 2024 Feb 6;248:109863. doi: 10.1016/j.neuropharm.2024.109863. Online ahead of print.ABSTRACTTremendous progress has been made to develop the therapy of Alzheimer's disease (AD). Existing several anti-AD remedies, with certain limitations, are far from adequate. Evidence suggests that dihydroergocristine (DHEC) mesylate, one of the main components of Ergoloid mesylates, can reduce the production of amyloid-β in vitro. However, the therapeutic effect of DHEC mesylate in AD and its underlying mechanism are still largely unknown. Herein, we characterized the pharmacological effect of DHEC mesylate in AD and...
Source: Neuropharmacology - February 7, 2024 Category: Drugs & Pharmacology Authors: Yue Wang Yiming Cao Hongfei Huang Yue Xue Song Chen Xiangdong Gao Source Type: research
Sex differences in risk-based decision-making and the modulation of risk preference by dopamine-2 like receptors in rats
Neuropharmacology. 2024 Feb 5:109851. doi: 10.1016/j.neuropharm.2024.109851. Online ahead of print.ABSTRACTHeightened risk-based decision-making is observed across several neuropsychiatric disorders including schizophrenia, bipolar disorder, and Parkinson's disease, yet no treatments exist that effectively normalize this aberrant behavior. Preclinical risk-based decision-making paradigms have identified the important modulatory roles of dopamine and sex in the performance of such tasks, though specific task parameters may alter such effects (e.g., punishment and reward values). Previous work has highlighted the role of dop...
Source: Neuropharmacology - February 7, 2024 Category: Drugs & Pharmacology Authors: Samantha M Ayoub Avraham M Libster Samuel A Barnes Stephanie C Dulawa Jared W Young Source Type: research
Corrigendum to "Oxytocinergic neurons, but not oxytocin, are crucial for male penile erection" [Neuropharmacol. 235 (2023) 109576]
Neuropharmacology. 2024 Feb 6:109864. doi: 10.1016/j.neuropharm.2024.109864. Online ahead of print.NO ABSTRACTPMID:38326123 | DOI:10.1016/j.neuropharm.2024.109864 (Source: Neuropharmacology)
Source: Neuropharmacology - February 7, 2024 Category: Drugs & Pharmacology Authors: Yu-Xiang Wen Lin-Yao Fan An-Yong Yang Yan-Chufei Zhang Chang Xu Zi-Hui Wang Wen-Jiong Xie Yang Lu Xiao-Yang Zhang Jing-Ning Zhu Anyang Sun Liang Li Qi-Peng Zhang Source Type: research
Adolescent intermittent ethanol exposure decreases perineuronal nets in the hippocampus in a sex dependent manner: Modulation through pharmacological inhibition of RPTP β/ζ
Neuropharmacology. 2024 Jan 29;247:109850. doi: 10.1016/j.neuropharm.2024.109850. Online ahead of print.ABSTRACTAdolescence is a critical period for brain maturation in which this organ undergoes critical plasticity mechanisms that increase its vulnerability to the effects of alcohol. Significantly, ethanol-induced disruption of hippocampal neurogenesis has been related to cognitive decline in adulthood. During adolescence, the maturation of perineuronal nets (PNNs), extracellular matrix structures highly affected by ethanol consumption, plays a fundamental role in neurogenesis and plasticity in the hippocampus. Receptor P...
Source: Neuropharmacology - January 31, 2024 Category: Drugs & Pharmacology Authors: Milagros Gal án-Llario Esther Gramage Alba Garc ía-Guerra Abraham B Torregrosa Ani Gasparyan Daniela Navarro Francisco Navarrete Mar ía Salud García-Gutiérrez Jorge Manzanares Gonzalo Herrad ón Source Type: research
