P2X receptor- and postsynaptic NMDA receptor-mediated long-lasting facilitation of inhibitory synapses in the rat insular cortex
Neuropharmacology. 2023 Dec 15:109817. doi: 10.1016/j.neuropharm.2023.109817. Online ahead of print.ABSTRACTAdenosine triphosphate (ATP) changes the efficacy of synaptic transmission. Despite recent progress in terms of the roles of purinergic receptors in cerebrocortical excitatory synaptic transmission, their contribution to inhibitory synaptic transmission is unknown. To elucidate the effects of α,β-methylene ATP (αβ-mATP), a selective agonist of P2X receptors (P2XRs), on inhibitory synaptic transmission in the insular cortex (IC), we performed whole-cell patch-clamp recording from IC pyramidal neurons (PNs) and fas...
Source: Neuropharmacology - December 17, 2023 Category: Drugs & Pharmacology Authors: Kiyofumi Yamamoto Satoshi Kosukegawa Masayuki Kobayashi Source Type: research
Defective autophagy contributes to bupivacaine-induced aggravation of painful diabetic neuropathy in db/db mice
Neuropharmacology. 2023 Dec 15:109814. doi: 10.1016/j.neuropharm.2023.109814. Online ahead of print.ABSTRACTCurrent evidence suggests that hyperactivated or impaired autophagy can lead to neuronal death. The effect of local anesthetics on painful diabetic neuropathy (PDN) and the role of autophagy in the above pathological process remain unclear, warranting further studies. So, PDN models were established by assessing the paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) in leptin gene-mutation (db/db) mice. Wild type (WT) and PDN mice received intrathecal 0.75% bupivacaine or/with intraperitoneal drug treatm...
Source: Neuropharmacology - December 17, 2023 Category: Drugs & Pharmacology Authors: Keke Fan Qinming Liao Pengfei Yuan Rui Xu Zhongjie Liu Source Type: research
A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging
Neuropharmacology. 2023 Dec 4:109800. doi: 10.1016/j.neuropharm.2023.109800. Online ahead of print.ABSTRACTThe prefrontal cortex (PFC) is a hub for cognitive behaviors and is a key target for neuroadaptations in alcohol use disorders. Recent advances in genetically encoded sensors and functional microscopy allow multimodal in-vivo PFC activity recordings at subcellular and cellular scales. While these methods could enable a deeper understanding of the relationship between alcohol and PFC function/dysfunction, they typically require animals to be head-fixed. Here, we present a method in mice for binge-like ethanol consumpti...
Source: Neuropharmacology - December 6, 2023 Category: Drugs & Pharmacology Authors: Anagha Kalelkar Grayson Sipe Ana Raquel Castro E Costa Ilka M Lorenzo My Nguyen Ivan Linares-Garcia Elena Vazey Rafiq Huda Source Type: research
A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging
Neuropharmacology. 2023 Dec 4:109800. doi: 10.1016/j.neuropharm.2023.109800. Online ahead of print.ABSTRACTThe prefrontal cortex (PFC) is a hub for cognitive behaviors and is a key target for neuroadaptations in alcohol use disorders. Recent advances in genetically encoded sensors and functional microscopy allow multimodal in-vivo PFC activity recordings at subcellular and cellular scales. While these methods could enable a deeper understanding of the relationship between alcohol and PFC function/dysfunction, they typically require animals to be head-fixed. Here, we present a method in mice for binge-like ethanol consumpti...
Source: Neuropharmacology - December 6, 2023 Category: Drugs & Pharmacology Authors: Anagha Kalelkar Grayson Sipe Ana Raquel Castro E Costa Ilka M Lorenzo My Nguyen Ivan Linares-Garcia Elena Vazey Rafiq Huda Source Type: research
A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging
Neuropharmacology. 2023 Dec 4:109800. doi: 10.1016/j.neuropharm.2023.109800. Online ahead of print.ABSTRACTThe prefrontal cortex (PFC) is a hub for cognitive behaviors and is a key target for neuroadaptations in alcohol use disorders. Recent advances in genetically encoded sensors and functional microscopy allow multimodal in-vivo PFC activity recordings at subcellular and cellular scales. While these methods could enable a deeper understanding of the relationship between alcohol and PFC function/dysfunction, they typically require animals to be head-fixed. Here, we present a method in mice for binge-like ethanol consumpti...
Source: Neuropharmacology - December 6, 2023 Category: Drugs & Pharmacology Authors: Anagha Kalelkar Grayson Sipe Ana Raquel Castro E Costa Ilka M Lorenzo My Nguyen Ivan Linares-Garcia Elena Vazey Rafiq Huda Source Type: research
A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging
Neuropharmacology. 2023 Dec 4:109800. doi: 10.1016/j.neuropharm.2023.109800. Online ahead of print.ABSTRACTThe prefrontal cortex (PFC) is a hub for cognitive behaviors and is a key target for neuroadaptations in alcohol use disorders. Recent advances in genetically encoded sensors and functional microscopy allow multimodal in-vivo PFC activity recordings at subcellular and cellular scales. While these methods could enable a deeper understanding of the relationship between alcohol and PFC function/dysfunction, they typically require animals to be head-fixed. Here, we present a method in mice for binge-like ethanol consumpti...
Source: Neuropharmacology - December 6, 2023 Category: Drugs & Pharmacology Authors: Anagha Kalelkar Grayson Sipe Ana Raquel Castro E Costa Ilka M Lorenzo My Nguyen Ivan Linares-Garcia Elena Vazey Rafiq Huda Source Type: research
A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging
Neuropharmacology. 2023 Dec 4:109800. doi: 10.1016/j.neuropharm.2023.109800. Online ahead of print.ABSTRACTThe prefrontal cortex (PFC) is a hub for cognitive behaviors and is a key target for neuroadaptations in alcohol use disorders. Recent advances in genetically encoded sensors and functional microscopy allow multimodal in-vivo PFC activity recordings at subcellular and cellular scales. While these methods could enable a deeper understanding of the relationship between alcohol and PFC function/dysfunction, they typically require animals to be head-fixed. Here, we present a method in mice for binge-like ethanol consumpti...
Source: Neuropharmacology - December 6, 2023 Category: Drugs & Pharmacology Authors: Anagha Kalelkar Grayson Sipe Ana Raquel Castro E Costa Ilka M Lorenzo My Nguyen Ivan Linares-Garcia Elena Vazey Rafiq Huda Source Type: research
A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging
Neuropharmacology. 2023 Dec 4:109800. doi: 10.1016/j.neuropharm.2023.109800. Online ahead of print.ABSTRACTThe prefrontal cortex (PFC) is a hub for cognitive behaviors and is a key target for neuroadaptations in alcohol use disorders. Recent advances in genetically encoded sensors and functional microscopy allow multimodal in-vivo PFC activity recordings at subcellular and cellular scales. While these methods could enable a deeper understanding of the relationship between alcohol and PFC function/dysfunction, they typically require animals to be head-fixed. Here, we present a method in mice for binge-like ethanol consumpti...
Source: Neuropharmacology - December 6, 2023 Category: Drugs & Pharmacology Authors: Anagha Kalelkar Grayson Sipe Ana Raquel Castro E Costa Ilka M Lorenzo My Nguyen Ivan Linares-Garcia Elena Vazey Rafiq Huda Source Type: research
A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging
Neuropharmacology. 2023 Dec 4:109800. doi: 10.1016/j.neuropharm.2023.109800. Online ahead of print.ABSTRACTThe prefrontal cortex (PFC) is a hub for cognitive behaviors and is a key target for neuroadaptations in alcohol use disorders. Recent advances in genetically encoded sensors and functional microscopy allow multimodal in-vivo PFC activity recordings at subcellular and cellular scales. While these methods could enable a deeper understanding of the relationship between alcohol and PFC function/dysfunction, they typically require animals to be head-fixed. Here, we present a method in mice for binge-like ethanol consumpti...
Source: Neuropharmacology - December 6, 2023 Category: Drugs & Pharmacology Authors: Anagha Kalelkar Grayson Sipe Ana Raquel Castro E Costa Ilka M Lorenzo My Nguyen Ivan Linares-Garcia Elena Vazey Rafiq Huda Source Type: research
A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging
Neuropharmacology. 2023 Dec 4:109800. doi: 10.1016/j.neuropharm.2023.109800. Online ahead of print.ABSTRACTThe prefrontal cortex (PFC) is a hub for cognitive behaviors and is a key target for neuroadaptations in alcohol use disorders. Recent advances in genetically encoded sensors and functional microscopy allow multimodal in-vivo PFC activity recordings at subcellular and cellular scales. While these methods could enable a deeper understanding of the relationship between alcohol and PFC function/dysfunction, they typically require animals to be head-fixed. Here, we present a method in mice for binge-like ethanol consumpti...
Source: Neuropharmacology - December 6, 2023 Category: Drugs & Pharmacology Authors: Anagha Kalelkar Grayson Sipe Ana Raquel Castro E Costa Ilka M Lorenzo My Nguyen Ivan Linares-Garcia Elena Vazey Rafiq Huda Source Type: research
A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging
Neuropharmacology. 2023 Dec 4:109800. doi: 10.1016/j.neuropharm.2023.109800. Online ahead of print.ABSTRACTThe prefrontal cortex (PFC) is a hub for cognitive behaviors and is a key target for neuroadaptations in alcohol use disorders. Recent advances in genetically encoded sensors and functional microscopy allow multimodal in-vivo PFC activity recordings at subcellular and cellular scales. While these methods could enable a deeper understanding of the relationship between alcohol and PFC function/dysfunction, they typically require animals to be head-fixed. Here, we present a method in mice for binge-like ethanol consumpti...
Source: Neuropharmacology - December 6, 2023 Category: Drugs & Pharmacology Authors: Anagha Kalelkar Grayson Sipe Ana Raquel Castro E Costa Ilka M Lorenzo My Nguyen Ivan Linares-Garcia Elena Vazey Rafiq Huda Source Type: research
Chemogenetic inhibition of locus coeruleus to rostromedial tegmental nucleus noradrenergic pathway increases light cycle ethanol drinking in male and female mice and blunts ethanol-induced CTA
Neuropharmacology. 2023 Dec 2:109809. doi: 10.1016/j.neuropharm.2023.109809. Online ahead of print.ABSTRACTWe recently showed that chemogenetic activation of the locus coeruleus (LC) to the rostromedial tegmental nucleus (RMTg) noradrenergic (NE) pathway significantly blunted binge-like ethanol drinking and induced aversive-like behaviors in mice. The aim of the present study is to determine if silencing this TH + LC → RMTg noradrenergic pathway promotes increased levels of binge-like ethanol intake and reduced ethanol-induced conditioned taste aversion (CTA). To this end, both male and female TH-ires-cre mice on a C57BL...
Source: Neuropharmacology - December 4, 2023 Category: Drugs & Pharmacology Authors: Ana Paula S Dornellas Todd E Thiele Montserrat Navarro Source Type: research
Chemogenetic inhibition of locus coeruleus to rostromedial tegmental nucleus noradrenergic pathway increases light cycle ethanol drinking in male and female mice and blunts ethanol-induced CTA
Neuropharmacology. 2023 Dec 2:109809. doi: 10.1016/j.neuropharm.2023.109809. Online ahead of print.ABSTRACTWe recently showed that chemogenetic activation of the locus coeruleus (LC) to the rostromedial tegmental nucleus (RMTg) noradrenergic (NE) pathway significantly blunted binge-like ethanol drinking and induced aversive-like behaviors in mice. The aim of the present study is to determine if silencing this TH + LC → RMTg noradrenergic pathway promotes increased levels of binge-like ethanol intake and reduced ethanol-induced conditioned taste aversion (CTA). To this end, both male and female TH-ires-cre mice on a C57BL...
Source: Neuropharmacology - December 4, 2023 Category: Drugs & Pharmacology Authors: Ana Paula S Dornellas Todd E Thiele Montserrat Navarro Source Type: research
Network-based analysis on the genes and their interactions reveals link between schizophrenia and Alzheimer's disease
In this study, we obtained 331 SCZ-related genes, 650 AD-related genes, 65 shared genes between SCZ and AD. Enrichment analysis shown that these 65 shared genes were mainly involved in cognition, neural development, synaptic transmission, drug reactions, metabolic processes and immune related processes, suggesting a complex mechanism for the co-existence of SCZ and AD. In addition, we performed pathway enrichment analysis and found a total of 57 common pathways between SCZ and AD, which could be largely grouped into three modules: immune module, neurodevelopment module and cancer module. We eventually identified the potent...
Source: Neuropharmacology - December 3, 2023 Category: Drugs & Pharmacology Authors: Pan Guo Chao Meng Shuyue Zhang Yingzi Cai Junkai Huang Jianbo Shu Ju Wang Chunquan Cai Source Type: research
Network-based analysis on the genes and their interactions reveals link between schizophrenia and Alzheimer's disease
In this study, we obtained 331 SCZ-related genes, 650 AD-related genes, 65 shared genes between SCZ and AD. Enrichment analysis shown that these 65 shared genes were mainly involved in cognition, neural development, synaptic transmission, drug reactions, metabolic processes and immune related processes, suggesting a complex mechanism for the co-existence of SCZ and AD. In addition, we performed pathway enrichment analysis and found a total of 57 common pathways between SCZ and AD, which could be largely grouped into three modules: immune module, neurodevelopment module and cancer module. We eventually identified the potent...
Source: Neuropharmacology - December 3, 2023 Category: Drugs & Pharmacology Authors: Pan Guo Chao Meng Shuyue Zhang Yingzi Cai Junkai Huang Jianbo Shu Ju Wang Chunquan Cai Source Type: research
