GLP-1 modulated the firing activity of nigral dopaminergic neurons in both normal and parkinsonian mice
Neuropharmacology. 2024 Apr 8:109946. doi: 10.1016/j.neuropharm.2024.109946. Online ahead of print.ABSTRACTThe spontaneous firing activity of nigral dopaminergic neurons is associated with some important roles including modulation of dopamine release, expression of tyrosine hydroxylase (TH), as well as neuronal survival. The decreased neuroactivity of nigral dopaminergic neurons has been revealed in Parkinson's disease. Central glucagon-like peptide-1 (GLP-1) functions as a neurotransmitter or neuromodulator to exert multiple brain functions. Although morphological studies revealed the expression of GLP-1 receptors (GLP-1R...
Source: Neuropharmacology - April 10, 2024 Category: Drugs & Pharmacology Authors: Cui Liu Wen-Hong Liu Wu Yang Lei Chen Yan Xue Xin-Yi Chen Source Type: research
Dedication: Roland R. Griffiths (July 19, 1946 - October 16, 2023)
Neuropharmacology. 2024 Apr 5:109945. doi: 10.1016/j.neuropharm.2024.109945. Online ahead of print.NO ABSTRACTPMID:38583702 | DOI:10.1016/j.neuropharm.2024.109945 (Source: Neuropharmacology)
Source: Neuropharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: J E Henningfield S J Belouin Source Type: research
Dedication: Roland R. Griffiths (July 19, 1946 - October 16, 2023)
Neuropharmacology. 2024 Apr 5:109945. doi: 10.1016/j.neuropharm.2024.109945. Online ahead of print.NO ABSTRACTPMID:38583702 | DOI:10.1016/j.neuropharm.2024.109945 (Source: Neuropharmacology)
Source: Neuropharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: J E Henningfield S J Belouin Source Type: research
Dedication: Roland R. Griffiths (July 19, 1946 - October 16, 2023)
Neuropharmacology. 2024 Apr 5:109945. doi: 10.1016/j.neuropharm.2024.109945. Online ahead of print.NO ABSTRACTPMID:38583702 | DOI:10.1016/j.neuropharm.2024.109945 (Source: Neuropharmacology)
Source: Neuropharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: J E Henningfield S J Belouin Source Type: research
Ursolic acid molecules dock MAPK1 to modulate gut microbiota diversity to reduce neuropathic pain
Neuropharmacology. 2024 Apr 1:109939. doi: 10.1016/j.neuropharm.2024.109939. Online ahead of print.ABSTRACTTo investigate the efficacy of Ursolic acid in alleviating neuropathic pain in rats with spinal nerve ligation (SNL), the SNL rat model was surgically induced. Different concentrations of Ursolic acid and manipulated target mitogen-activated protein kinase 1 (MAPK1) were administered to the SNL rats. Fecal samples were collected from each group of rats for 16S rDNA analysis to examine the impact of gut microbiota. Molecular docking experiments were conducted to assess the binding energy between Ursolic acid and MAPK1....
Source: Neuropharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Zi-Jie Rong Min Chen Hong-Hua Cai Gui-Hua Liu Jin-Biao Chen Hao Wang Zhi-Wen Zhang Yu-Liang Huang Shuang-Fei Ni Source Type: research
The multifaceted role of Wnt canonical signalling in neurogenesis, neuroinflammation, and hyperexcitability in mesial temporal lobe epilepsy
Neuropharmacology. 2024 Apr 1;251:109942. doi: 10.1016/j.neuropharm.2024.109942. Online ahead of print.ABSTRACTEpilepsy is a neurological disorder characterised by unprovoked, repetitive seizures caused by abnormal neuronal firing. The Wnt/β-Catenin signalling pathway is involved in seizure-induced neurogenesis, aberrant neurogenesis, neuroinflammation, and hyperexcitability associated with epileptic disorder. Wnt/β-Catenin signalling is crucial for early brain development processes including neuronal patterning, synapse formation, and N-methyl-d-aspartate receptor (NMDAR) regulation. Disruption of molecular networks suc...
Source: Neuropharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: None Priya Nitin Yadav Sneha Anand Jyotirmoy Banerjee Manjari Tripathi P Sarat Chandra Aparna Banerjee Dixit Source Type: research
Exploring the effect of 6-BIO and sulindac in modulation of Wnt/ β-catenin signaling pathway in chronic phase of temporal lobe epilepsy
Neuropharmacology. 2024 Apr 2;251:109931. doi: 10.1016/j.neuropharm.2024.109931. Online ahead of print.ABSTRACTThe prospective involvement of the Wnt/β-catenin signaling pathway in epilepsy, with the proposed therapeutic uses of its modulators, has been suggested; however, comprehensive knowledge in this regard is currently limited. Despite postulations about the pathway's significance and treatment potential, a systematic investigation is required to better understand its implications in chronic epilepsy. We investigated the role of key proteins like β-catenin, GSK-3β, and their modulators sulindac and 6-BIO, in Wnt/β...
Source: Neuropharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Vipasha Gautam Kajal Rawat Arushi Sandhu Anil Kumar Parampreet Singh Kharbanda Bikash Medhi Alka Bhatia Lekha Saha Source Type: research
Pharmacological blockade of 2-AG degradation ameliorates clinical, neuroinflammatory and synaptic alterations in experimental autoimmune encephalomyelitis
In conclusion, MAGL inhibition significantly ameliorated EAE clinical disability and striatal inflammatory synaptopathy through potent anti-inflammatory effects. These findings provide new mechanistic insights into the neuroprotective role of the ECS during neuroinflammation and highlight the therapeutic potential of MAGLi-based drugs in mitigating MS-related inflammatory and neurodegenerative brain damage.PMID:38570068 | DOI:10.1016/j.neuropharm.2024.109940 (Source: Neuropharmacology)
Source: Neuropharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Livia Guadalupi Georgia Mandolesi Valentina Vanni Sara Balletta Silvia Caioli Anto Pavlovic Francesca De Vito Diego Fresegna Krizia Sanna Laura Vitiello Monica Nencini Alice Tartacca Fabrizio Mariani Valentina Rovella Sven Schippling Iris Ruf Ludovic Coll Source Type: research
Ursolic acid molecules dock MAPK1 to modulate gut microbiota diversity to reduce neuropathic pain
Neuropharmacology. 2024 Apr 1:109939. doi: 10.1016/j.neuropharm.2024.109939. Online ahead of print.ABSTRACTTo investigate the efficacy of Ursolic acid in alleviating neuropathic pain in rats with spinal nerve ligation (SNL), the SNL rat model was surgically induced. Different concentrations of Ursolic acid and manipulated target mitogen-activated protein kinase 1 (MAPK1) were administered to the SNL rats. Fecal samples were collected from each group of rats for 16S rDNA analysis to examine the impact of gut microbiota. Molecular docking experiments were conducted to assess the binding energy between Ursolic acid and MAPK1....
Source: Neuropharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Zi-Jie Rong Min Chen Hong-Hua Cai Gui-Hua Liu Jin-Biao Chen Hao Wang Zhi-Wen Zhang Yu-Liang Huang Shuang-Fei Ni Source Type: research
The multifaceted role of Wnt canonical signalling in neurogenesis, neuroinflammation, and hyperexcitability in mesial temporal lobe epilepsy
Neuropharmacology. 2024 Apr 1;251:109942. doi: 10.1016/j.neuropharm.2024.109942. Online ahead of print.ABSTRACTEpilepsy is a neurological disorder characterised by unprovoked, repetitive seizures caused by abnormal neuronal firing. The Wnt/β-Catenin signalling pathway is involved in seizure-induced neurogenesis, aberrant neurogenesis, neuroinflammation, and hyperexcitability associated with epileptic disorder. Wnt/β-Catenin signalling is crucial for early brain development processes including neuronal patterning, synapse formation, and N-methyl-d-aspartate receptor (NMDAR) regulation. Disruption of molecular networks suc...
Source: Neuropharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: None Priya Nitin Yadav Sneha Anand Jyotirmoy Banerjee Manjari Tripathi P Sarat Chandra Aparna Banerjee Dixit Source Type: research
Exploring the effect of 6-BIO and sulindac in modulation of Wnt/ β-catenin signaling pathway in chronic phase of temporal lobe epilepsy
Neuropharmacology. 2024 Apr 1:109931. doi: 10.1016/j.neuropharm.2024.109931. Online ahead of print.ABSTRACTThe prospective involvement of the Wnt/β-catenin signaling pathway in epilepsy, with the proposed therapeutic uses of its modulators, has been suggested; however, comprehensive knowledge in this regard is currently limited. Despite postulations about the pathway's significance and treatment potential, a systematic investigation is required to better understand its implications in chronic epilepsy. We investigated the role of key proteins like β-catenin, GSK-3β, and their modulators sulindac and 6-BIO, in Wnt/β-cat...
Source: Neuropharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Vipasha Gautam Kajal Rawat Arushi Sandhu Anil Kumar Parampreet Singh Kharbanda Bikash Medhi Alka Bhatia Lekha Saha Source Type: research
Pharmacological blockade of 2-AG degradation ameliorates clinical, neuroinflammatory and synaptic alterations in experimental autoimmune encephalomyelitis
In conclusion, MAGL inhibition significantly ameliorated EAE clinical disability and striatal inflammatory synaptopathy through potent anti-inflammatory effects. These findings provide new mechanistic insights into the neuroprotective role of the ECS during neuroinflammation and highlight the therapeutic potential of MAGLi-based drugs in mitigating MS-related inflammatory and neurodegenerative brain damage.PMID:38570068 | DOI:10.1016/j.neuropharm.2024.109940 (Source: Neuropharmacology)
Source: Neuropharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Livia Guadalupi Georgia Mandolesi Valentina Vanni Sara Balletta Silvia Caioli Anto Pavlovic Francesca De Vito Diego Fresegna Krizia Sanna Laura Vitiello Monica Nencini Alice Tartacca Fabrizio Mariani Valentina Rovella Sven Schippling Iris Ruf Ludovic Coll Source Type: research
Ursolic acid molecules dock MAPK1 to modulate gut microbiota diversity to reduce neuropathic pain
Neuropharmacology. 2024 Apr 1:109939. doi: 10.1016/j.neuropharm.2024.109939. Online ahead of print.ABSTRACTTo investigate the efficacy of Ursolic acid in alleviating neuropathic pain in rats with spinal nerve ligation (SNL), the SNL rat model was surgically induced. Different concentrations of Ursolic acid and manipulated target mitogen-activated protein kinase 1 (MAPK1) were administered to the SNL rats. Fecal samples were collected from each group of rats for 16S rDNA analysis to examine the impact of gut microbiota. Molecular docking experiments were conducted to assess the binding energy between Ursolic acid and MAPK1....
Source: Neuropharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Zi-Jie Rong Min Chen Hong-Hua Cai Gui-Hua Liu Jin-Biao Chen Hao Wang Zhi-Wen Zhang Yu-Liang Huang Shuang-Fei Ni Source Type: research
The multifaceted role of Wnt canonical signalling in neurogenesis, neuroinflammation, and hyperexcitability in mesial temporal lobe epilepsy
Neuropharmacology. 2024 Apr 1:109942. doi: 10.1016/j.neuropharm.2024.109942. Online ahead of print.ABSTRACTEpilepsy is a neurological disorder characterised by unprovoked, repetitive seizures caused by abnormal neuronal firing. The Wnt/β-Catenin signalling pathway is involved in seizure-induced neurogenesis, aberrant neurogenesis, neuroinflammation, and hyperexcitability associated with epileptic disorder. Wnt/β-Catenin signalling is crucial for early brain development processes including neuronal patterning, synapse formation, and N-methyl-d-aspartate receptor (NMDAR) regulation. Disruption of molecular networks such as...
Source: Neuropharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: None Priya Nitin Yadav Sneha Anand Jyotirmoy Banerjee Manjari Tripathi P Sarat Chandra Aparna Banerjee Dixit Source Type: research
Exploring the effect of 6-BIO and sulindac in modulation of Wnt/ β-catenin signaling pathway in chronic phase of temporal lobe epilepsy
Neuropharmacology. 2024 Apr 1:109931. doi: 10.1016/j.neuropharm.2024.109931. Online ahead of print.ABSTRACTThe prospective involvement of the Wnt/β-catenin signaling pathway in epilepsy, with the proposed therapeutic uses of its modulators, has been suggested; however, comprehensive knowledge in this regard is currently limited. Despite postulations about the pathway's significance and treatment potential, a systematic investigation is required to better understand its implications in chronic epilepsy. We investigated the role of key proteins like β-catenin, GSK-3β, and their modulators sulindac and 6-BIO, in Wnt/β-cat...
Source: Neuropharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Vipasha Gautam Kajal Rawat Arushi Sandhu Anil Kumar Parampreet Singh Kharbanda Bikash Medhi Alka Bhatia Lekha Saha Source Type: research
