CCK-8 enhances acid-sensing ion channel currents in rat primary sensory neurons
Neuropharmacology. 2023 Oct 9:109739. doi: 10.1016/j.neuropharm.2023.109739. Online ahead of print.ABSTRACTCholecystokinin (CCK) is a peptide that has been implicated in pain modulation. Acid-sensing ion channels (ASICs) also play an important role in pain associated with tissue acidification. However, it is still unclear whether there is an interaction between CCK signaling and ASICs during pain process. Herein, we report that a functional link between them in rat dorsal root ganglia (DRG) neurons. Pretreatment with CCK-8 concentration-dependently increased acid-evoked ASIC currents. CCK-8 increased the maximum response o...
Source: Neuropharmacology - October 11, 2023 Category: Drugs & Pharmacology Authors: Qing-Rui Qin Zhong-Qing Xu Ting-Ting Liu Xue-Mei Li Chun-Yu Qiu Wang-Ping Hu Source Type: research
Acute anxiogenic effects of escitalopram are associated with mild alterations in d-amphetamine-induced behavior and social approach evoked by playback of 50-kHz ultrasonic vocalizations
Neuropharmacology. 2023 Oct 7:109734. doi: 10.1016/j.neuropharm.2023.109734. Online ahead of print.ABSTRACTRats communicate through auditory signals in the ultrasonic range, so-called ultrasonic vocalizations (USV). Short, high-frequency 50-kHz USV are associated with positive affective states and are emitted in appetitive situations, often rewarding social interactions, such as rough-and-tumble play and mating. Exaggerated levels of 50-kHz USV emission can be observed in response to psychostimulants, most notably d-amphetamine (AMPH). There is robust evidence suggesting that 50-kHz USV serve as affiliative signals and hel...
Source: Neuropharmacology - October 9, 2023 Category: Drugs & Pharmacology Authors: Maria Willadsen Rainer K W Schwarting Markus W öhr Source Type: research
Acute anxiogenic effects of escitalopram are associated with mild alterations in d-amphetamine-induced behavior and social approach evoked by playback of 50-kHz ultrasonic vocalizations
Neuropharmacology. 2023 Oct 7:109734. doi: 10.1016/j.neuropharm.2023.109734. Online ahead of print.ABSTRACTRats communicate through auditory signals in the ultrasonic range, so-called ultrasonic vocalizations (USV). Short, high-frequency 50-kHz USV are associated with positive affective states and are emitted in appetitive situations, often rewarding social interactions, such as rough-and-tumble play and mating. Exaggerated levels of 50-kHz USV emission can be observed in response to psychostimulants, most notably d-amphetamine (AMPH). There is robust evidence suggesting that 50-kHz USV serve as affiliative signals and hel...
Source: Neuropharmacology - October 9, 2023 Category: Drugs & Pharmacology Authors: Maria Willadsen Rainer K W Schwarting Markus W öhr Source Type: research
Acute anxiogenic effects of escitalopram are associated with mild alterations in d-amphetamine-induced behavior and social approach evoked by playback of 50-kHz ultrasonic vocalizations
Neuropharmacology. 2023 Oct 7:109734. doi: 10.1016/j.neuropharm.2023.109734. Online ahead of print.ABSTRACTRats communicate through auditory signals in the ultrasonic range, so-called ultrasonic vocalizations (USV). Short, high-frequency 50-kHz USV are associated with positive affective states and are emitted in appetitive situations, often rewarding social interactions, such as rough-and-tumble play and mating. Exaggerated levels of 50-kHz USV emission can be observed in response to psychostimulants, most notably d-amphetamine (AMPH). There is robust evidence suggesting that 50-kHz USV serve as affiliative signals and hel...
Source: Neuropharmacology - October 9, 2023 Category: Drugs & Pharmacology Authors: Maria Willadsen Rainer K W Schwarting Markus W öhr Source Type: research
Corrigendum to "New paradigms in purinergic receptor ligand discovery" [Neuropharmacology 230 (2023) 109503]
Neuropharmacology. 2023 Oct 6:109731. doi: 10.1016/j.neuropharm.2023.109731. Online ahead of print.NO ABSTRACTPMID:37806912 | DOI:10.1016/j.neuropharm.2023.109731 (Source: Neuropharmacology)
Source: Neuropharmacology - October 8, 2023 Category: Drugs & Pharmacology Authors: Kenneth A Jacobson Balaram Pradhan Zhiwei Wen Asmita Pramanik Source Type: research
Restorative effect of NitroSynapsin on synaptic plasticity in an animal model of depression
Neuropharmacology. 2023 Oct 3:109729. doi: 10.1016/j.neuropharm.2023.109729. Online ahead of print.ABSTRACTIn the search for new options for the pharmacological treatment of major depressive disorder, compounds with a rapid onset of action and high efficacy but lacking a psychotomimetic effect are of particular interest. In the present study, we evaluated the antidepressant potential of NitroSynapsin (NS) at behavioural, structural, and functional levels. NS is a memantine derivative and a dual allosteric N-methyl-d-aspartate receptors (NMDAR) antagonist using targeted delivery by the aminoadamantane of a warhead nitro gro...
Source: Neuropharmacology - October 5, 2023 Category: Drugs & Pharmacology Authors: Wing Sze Tse Bart łomiej Pochwat Bernadeta Szewczyk Paulina Misztak Bartosz Bobula Krzysztof Tokarski Remigiusz Worch Marta Czarnota-Bojarska Stuart A Lipton Monika Zar ęba-Kozioł Monika Bijata Jakub Wlodarczyk Source Type: research
Restorative effect of NitroSynapsin on synaptic plasticity in an animal model of depression
Neuropharmacology. 2023 Oct 3:109729. doi: 10.1016/j.neuropharm.2023.109729. Online ahead of print.ABSTRACTIn the search for new options for the pharmacological treatment of major depressive disorder, compounds with a rapid onset of action and high efficacy but lacking a psychotomimetic effect are of particular interest. In the present study, we evaluated the antidepressant potential of NitroSynapsin (NS) at behavioural, structural, and functional levels. NS is a memantine derivative and a dual allosteric N-methyl-d-aspartate receptors (NMDAR) antagonist using targeted delivery by the aminoadamantane of a warhead nitro gro...
Source: Neuropharmacology - October 5, 2023 Category: Drugs & Pharmacology Authors: Wing Sze Tse Bart łomiej Pochwat Bernadeta Szewczyk Paulina Misztak Bartosz Bobula Krzysztof Tokarski Remigiusz Worch Marta Czarnota-Bojarska Stuart A Lipton Monika Zar ęba-Kozioł Monika Bijata Jakub Wlodarczyk Source Type: research
Restorative effect of NitroSynapsin on synaptic plasticity in an animal model of depression
Neuropharmacology. 2023 Oct 3:109729. doi: 10.1016/j.neuropharm.2023.109729. Online ahead of print.ABSTRACTIn the search for new options for the pharmacological treatment of major depressive disorder, compounds with a rapid onset of action and high efficacy but lacking a psychotomimetic effect are of particular interest. In the present study, we evaluated the antidepressant potential of NitroSynapsin (NS) at behavioural, structural, and functional levels. NS is a memantine derivative and a dual allosteric N-methyl-d-aspartate receptors (NMDAR) antagonist using targeted delivery by the aminoadamantane of a warhead nitro gro...
Source: Neuropharmacology - October 5, 2023 Category: Drugs & Pharmacology Authors: Wing Sze Tse Bart łomiej Pochwat Bernadeta Szewczyk Paulina Misztak Bartosz Bobula Krzysztof Tokarski Remigiusz Worch Marta Czarnota-Bojarska Stuart A Lipton Monika Zar ęba-Kozioł Monika Bijata Jakub Wlodarczyk Source Type: research
Dopamine D2 receptor within the intermediate region of the lateral septum modulate social hierarchy in male mice
In this study, we evaluated the functions of DA receptors within different subregions of the LS in social dominance using a confrontation tube test in male mice. The results showed that mice living in social groups formed linear dominance hierarchies after a few days of cohousing, and the subordinates showed increased anxiety. Fos expressions was elevated in the entire LS after a confrontation tube test in the subordinates. However, DA neurons were more activated in the dominates within the ventral tegmental area and the dorsal raphe nucleus. Quantitative real-time polymerase chain reaction results showed that D2 receptor ...
Source: Neuropharmacology - October 3, 2023 Category: Drugs & Pharmacology Authors: Bai-Lin Song Jie Zhou Yi Jiang Lai-Fu Li Ying-Juan Liu Source Type: research
Dopamine D2 receptor within the intermediate region of the lateral septum modulate social hierarchy in male mice
In this study, we evaluated the functions of DA receptors within different subregions of the LS in social dominance using a confrontation tube test in male mice. The results showed that mice living in social groups formed linear dominance hierarchies after a few days of cohousing, and the subordinates showed increased anxiety. Fos expressions was elevated in the entire LS after a confrontation tube test in the subordinates. However, DA neurons were more activated in the dominates within the ventral tegmental area and the dorsal raphe nucleus. Quantitative real-time polymerase chain reaction results showed that D2 receptor ...
Source: Neuropharmacology - October 3, 2023 Category: Drugs & Pharmacology Authors: Bai-Lin Song Jie Zhou Yi Jiang Lai-Fu Li Ying-Juan Liu Source Type: research
Dopamine D2 receptor within the intermediate region of the lateral septum modulate social hierarchy in male mice
In this study, we evaluated the functions of DA receptors within different subregions of the LS in social dominance using a confrontation tube test in male mice. The results showed that mice living in social groups formed linear dominance hierarchies after a few days of cohousing, and the subordinates showed increased anxiety. Fos expressions was elevated in the entire LS after a confrontation tube test in the subordinates. However, DA neurons were more activated in the dominates within the ventral tegmental area and the dorsal raphe nucleus. Quantitative real-time polymerase chain reaction results showed that D2 receptor ...
Source: Neuropharmacology - October 3, 2023 Category: Drugs & Pharmacology Authors: Bai-Lin Song Jie Zhou Yi Jiang Lai-Fu Li Ying-Juan Liu Source Type: research
Binge-like ethanol exposure during the brain growth spurt disrupts the function of retrosplenial cortex-projecting anterior thalamic neurons in adolescent mice
Neuropharmacology. 2023 Sep 29:109738. doi: 10.1016/j.neuropharm.2023.109738. Online ahead of print.ABSTRACTEthanol (EtOH) exposure during late pregnancy leads to enduring impairments in learning and memory that may stem from damage to components of the posterior limbic memory system, including the retrosplenial cortex (RSC) and anterior thalamic nuclei (ATN). In rodents, binge-like EtOH exposure during the first week of life (equivalent to the third trimester of human pregnancy) triggers apoptosis in these brain regions. We hypothesized that this effect induces long-lasting alterations in the function of RSC-projecting AT...
Source: Neuropharmacology - October 1, 2023 Category: Drugs & Pharmacology Authors: Clark W Bird Stefanie S Mayfield Katalina M Lopez Brooke R Dunn Angela Feng Bryce T Roberts Roberto N Almeida Glenna J Chavez C Fernando Valenzuela Source Type: research
Binge-like ethanol exposure during the brain growth spurt disrupts the function of retrosplenial cortex-projecting anterior thalamic neurons in adolescent mice
Neuropharmacology. 2023 Sep 29:109738. doi: 10.1016/j.neuropharm.2023.109738. Online ahead of print.ABSTRACTEthanol (EtOH) exposure during late pregnancy leads to enduring impairments in learning and memory that may stem from damage to components of the posterior limbic memory system, including the retrosplenial cortex (RSC) and anterior thalamic nuclei (ATN). In rodents, binge-like EtOH exposure during the first week of life (equivalent to the third trimester of human pregnancy) triggers apoptosis in these brain regions. We hypothesized that this effect induces long-lasting alterations in the function of RSC-projecting AT...
Source: Neuropharmacology - October 1, 2023 Category: Drugs & Pharmacology Authors: Clark W Bird Stefanie S Mayfield Katalina M Lopez Brooke R Dunn Angela Feng Bryce T Roberts Roberto N Almeida Glenna J Chavez C Fernando Valenzuela Source Type: research
Atomoxetine and reward size equally improve task engagement and perceptual decisions but differently affect movement execution
Neuropharmacology. 2023 Sep 27:109736. doi: 10.1016/j.neuropharm.2023.109736. Online ahead of print.ABSTRACTOur ability to engage and perform daily activities relies on balancing the associated benefits and costs. Rewards, as benefits, act as powerful motivators that help us stay focused for longer durations. The noradrenergic (NA) system is thought to play a significant role in optimizing our performance. Yet, the interplay between reward and the NA system in shaping performance remains unclear, particularly when actions are driven by external incentives (reward). To explore this interaction, we tested four female rhesus ...
Source: Neuropharmacology - September 29, 2023 Category: Drugs & Pharmacology Authors: Kristin Kaduk Tiphaine Henry Jerome Guitton Martine Meunier David Thura Fadila Hadj-Bouziane Source Type: research
Decreased myelin-related gene expression in the nucleus accumbens during spontaneous neonatal opioid withdrawal in the absence of long-term behavioral effects in adult outbred CFW mice
Neuropharmacology. 2023 Sep 27;240:109732. doi: 10.1016/j.neuropharm.2023.109732. Online ahead of print.ABSTRACTPrenatal opioid exposure is a major health concern in the United States, with the incidence of neonatal opioid withdrawal syndrome (NOWS) escalating in recent years. NOWS occurs upon cessation of in utero opioid exposure and is characterized by increased irritability, disrupted sleep patterns, high-pitched crying, and dysregulated feeding. The main pharmacological strategy for alleviating symptoms is treatment with replacement opioids. The neural mechanisms mediating NOWS and the long-term neurobehavioral effects...
Source: Neuropharmacology - September 29, 2023 Category: Drugs & Pharmacology Authors: Kristyn N Borrelli Kelly K Wingfield Emily J Yao Catalina A Zamorano Katherine D Sena Jacob A Beierle Michelle A Roos Huiping Zhang Elisha M Wachman Camron D Bryant Source Type: research
