Serotonergic agonism and pharmacologically-induced adolescent stress cause operant-based learning deficits in mice
CONCLUSION: Whilst we revealed dissociable detrimental effects of adolescent CORT treatment and acute 5-HT1A/1B receptor agonism on discrimination and reversal learning, respectively, we did not find evidence of additive deleterious effects of these two treatments. We therefore suggest that while disrupted serotonergic signalling is likely to be involved in the cognitive phenotype of OC-spectrum disorders, distinct neuropathological pathways may be at play in mediating the role of stress as an antecedent in OCD and related illnesses.PMID:38040286 | DOI:10.1016/j.neuropharm.2023.109801 (Source: Neuropharmacology)
Source: Neuropharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: Carey Wilson Anthony J Hannan Thibault Renoir Source Type: research
Serotonergic agonism and pharmacologically-induced adolescent stress cause operant-based learning deficits in mice
CONCLUSION: Whilst we revealed dissociable detrimental effects of adolescent CORT treatment and acute 5-HT1A/1B receptor agonism on discrimination and reversal learning, respectively, we did not find evidence of additive deleterious effects of these two treatments. We therefore suggest that while disrupted serotonergic signalling is likely to be involved in the cognitive phenotype of OC-spectrum disorders, distinct neuropathological pathways may be at play in mediating the role of stress as an antecedent in OCD and related illnesses.PMID:38040286 | DOI:10.1016/j.neuropharm.2023.109801 (Source: Neuropharmacology)
Source: Neuropharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: Carey Wilson Anthony J Hannan Thibault Renoir Source Type: research
Specific inhibition of TET1 in the spinal dorsal horn alleviates inflammatory pain in mice by regulating synaptic plasticity
Neuropharmacology. 2023 Nov 25;244:109799. doi: 10.1016/j.neuropharm.2023.109799. Online ahead of print.ABSTRACTDNA demethylation mediated by ten-eleven translocation 1 (TET1) is a critical epigenetic mechanism in which gene expression is regulated via catalysis of 5-methylcytosine to 5-hydroxymethylcytosine. Previously, we demonstrated that TET1 is associated with the genesis of chronic inflammatory pain. However, how TET1 participates in enhanced nociceptive responses in chronic pain remains poorly understood. Here, we report that conditional knockout of Tet1 in dorsal horn neurons via intrathecal injection of rAAV-hSyn-...
Source: Neuropharmacology - November 26, 2023 Category: Drugs & Pharmacology Authors: Kehui Yang Runa Wei Qiaoqiao Liu Yang Tao Zixuan Wu Li Yang Qi-Hui Wang Hongjun Wang Zhiqiang Pan Source Type: research
Specific inhibition of TET1 in the spinal dorsal horn alleviates inflammatory pain in mice by regulating synaptic plasticity
Neuropharmacology. 2023 Nov 24:109799. doi: 10.1016/j.neuropharm.2023.109799. Online ahead of print.ABSTRACTDNA demethylation mediated by ten-eleven translocation 1 (TET1) is a critical epigenetic mechanism in which gene expression is regulated via catalysis of 5-methylcytosine to 5-hydroxymethylcytosine. Previously, we demonstrated that TET1 is associated with the genesis of chronic inflammatory pain. However, how TET1 participates in enhanced nociceptive responses in chronic pain remains poorly understood. Here, we report that conditional knockout of Tet1 in dorsal horn neurons via intrathecal injection of rAAV-hSyn. -Cr...
Source: Neuropharmacology - November 26, 2023 Category: Drugs & Pharmacology Authors: Kehui Yang Runa Wei Qiaoqiao Liu Yang Tao Zixuan Wu Li Yang Qi-Hui Wang Hongjun Wang Zhiqiang Pan Source Type: research
Specific inhibition of TET1 in the spinal dorsal horn alleviates inflammatory pain in mice by regulating synaptic plasticity
Neuropharmacology. 2023 Nov 24:109799. doi: 10.1016/j.neuropharm.2023.109799. Online ahead of print.ABSTRACTDNA demethylation mediated by ten-eleven translocation 1 (TET1) is a critical epigenetic mechanism in which gene expression is regulated via catalysis of 5-methylcytosine to 5-hydroxymethylcytosine. Previously, we demonstrated that TET1 is associated with the genesis of chronic inflammatory pain. However, how TET1 participates in enhanced nociceptive responses in chronic pain remains poorly understood. Here, we report that conditional knockout of Tet1 in dorsal horn neurons via intrathecal injection of rAAV-hSyn. -Cr...
Source: Neuropharmacology - November 26, 2023 Category: Drugs & Pharmacology Authors: Kehui Yang Runa Wei Qiaoqiao Liu Yang Tao Zixuan Wu Li Yang Qi-Hui Wang Hongjun Wang Zhiqiang Pan Source Type: research
Specific inhibition of TET1 in the spinal dorsal horn alleviates inflammatory pain in mice by regulating synaptic plasticity
Neuropharmacology. 2023 Nov 24:109799. doi: 10.1016/j.neuropharm.2023.109799. Online ahead of print.ABSTRACTDNA demethylation mediated by ten-eleven translocation 1 (TET1) is a critical epigenetic mechanism in which gene expression is regulated via catalysis of 5-methylcytosine to 5-hydroxymethylcytosine. Previously, we demonstrated that TET1 is associated with the genesis of chronic inflammatory pain. However, how TET1 participates in enhanced nociceptive responses in chronic pain remains poorly understood. Here, we report that conditional knockout of Tet1 in dorsal horn neurons via intrathecal injection of rAAV-hSyn. -Cr...
Source: Neuropharmacology - November 26, 2023 Category: Drugs & Pharmacology Authors: Kehui Yang Runa Wei Qiaoqiao Liu Yang Tao Zixuan Wu Li Yang Qi-Hui Wang Hongjun Wang Zhiqiang Pan Source Type: research
Increased brain nucleus accumbens functional connectivity in melancholic depression
CONCLUSION: Melancholic depression exhibited different patterns of functional connectivity of the reward circuit relative to non-melancholic patients. This study highlights the significance of the reward circuit in the neuropathology of melancholic depression.PMID:37995807 | DOI:10.1016/j.neuropharm.2023.109798 (Source: Neuropharmacology)
Source: Neuropharmacology - November 23, 2023 Category: Drugs & Pharmacology Authors: Zhaobin Chen Yangpan Ou Feng Liu Huabing Li Ping Li Guangrong Xie Xilong Cui Wenbin Guo Source Type: research
Increased brain nucleus accumbens functional connectivity in melancholic depression
CONCLUSION: Melancholic depression exhibited different patterns of functional connectivity of the reward circuit relative to non-melancholic patients. This study highlights the significance of the reward circuit in the neuropathology of melancholic depression.PMID:37995807 | DOI:10.1016/j.neuropharm.2023.109798 (Source: Neuropharmacology)
Source: Neuropharmacology - November 23, 2023 Category: Drugs & Pharmacology Authors: Zhaobin Chen Yangpan Ou Feng Liu Huabing Li Ping Li Guangrong Xie Xilong Cui Wenbin Guo Source Type: research
Increased brain nucleus accumbens functional connectivity in melancholic depression
CONCLUSION: Melancholic depression exhibited different patterns of functional connectivity of the reward circuit relative to non-melancholic patients. This study highlights the significance of the reward circuit in the neuropathology of melancholic depression.PMID:37995807 | DOI:10.1016/j.neuropharm.2023.109798 (Source: Neuropharmacology)
Source: Neuropharmacology - November 23, 2023 Category: Drugs & Pharmacology Authors: Zhaobin Chen Yangpan Ou Feng Liu Huabing Li Ping Li Guangrong Xie Xilong Cui Wenbin Guo Source Type: research
Exploring venlafaxine effects on chronic vulvar pain: Changes in mood and pain regulation networks
Neuropharmacology. 2023 Nov 18;243:109788. doi: 10.1016/j.neuropharm.2023.109788. Online ahead of print.ABSTRACTThe etiology of idiopathic pain conditions, such as Provoked vulvodynia (PV), is multifactorial. The efficiency of venlafaxine, serotonin-noradrenaline reuptake inhibitor (SNRIs) in modulating vulvar pain led to the hypothesis that PV might involve central mechanisms. Here, we investigate whether vulvar pain is associated with gene-expression changes in mood, stress and pain systems, including amygdala (Amg), medial prefrontal cortex (mPFC), and periaqueductal gray matter (PAG). Additionally, we examined the anal...
Source: Neuropharmacology - November 20, 2023 Category: Drugs & Pharmacology Authors: Yaseen Awad-Igbaria Saher Abu-Ata Yara Nakhleh-Francis Lior Lowenstein Karen Ginat Jacob Bornstein Eilam Palzur Alon Shamir Source Type: research
Exploring venlafaxine effects on chronic vulvar pain: Changes in mood and pain regulation networks
Neuropharmacology. 2023 Nov 18:109788. doi: 10.1016/j.neuropharm.2023.109788. Online ahead of print.ABSTRACTThe etiology of idiopathic pain conditions, such as Provoked vulvodynia (PV), is multifactorial. The efficiency of venlafaxine, serotonin-noradrenaline reuptake inhibitor (SNRIs) in modulating vulvar pain led to the hypothesis that PV might involve central mechanisms. Here, we investigate whether vulvar pain is associated with gene-expression changes in mood, stress and pain systems, including amygdala (Amg), medial prefrontal cortex (mPFC), and periaqueductal gray matter (PAG). Additionally, we examined the analgesi...
Source: Neuropharmacology - November 20, 2023 Category: Drugs & Pharmacology Authors: Yaseen Awad-Igbaria Saher Abu-Atta Yara Nakhleh-Francis Lior Lowenstein Karen Ginat Jacob Bornstein Eilam Palzur Alon Shamir Source Type: research
Exploring venlafaxine effects on chronic vulvar pain: Changes in mood and pain regulation networks
Neuropharmacology. 2023 Nov 18:109788. doi: 10.1016/j.neuropharm.2023.109788. Online ahead of print.ABSTRACTThe etiology of idiopathic pain conditions, such as Provoked vulvodynia (PV), is multifactorial. The efficiency of venlafaxine, serotonin-noradrenaline reuptake inhibitor (SNRIs) in modulating vulvar pain led to the hypothesis that PV might involve central mechanisms. Here, we investigate whether vulvar pain is associated with gene-expression changes in mood, stress and pain systems, including amygdala (Amg), medial prefrontal cortex (mPFC), and periaqueductal gray matter (PAG). Additionally, we examined the analgesi...
Source: Neuropharmacology - November 20, 2023 Category: Drugs & Pharmacology Authors: Yaseen Awad-Igbaria Saher Abu-Atta Yara Nakhleh-Francis Lior Lowenstein Karen Ginat Jacob Bornstein Eilam Palzur Alon Shamir Source Type: research
CREB-induced LINC00473 promotes chemoresistance to TMZ in glioblastoma by regulating O6-methylguanine-DNA-methyltransferase expression via CEBP α binding
In conclusion, a novel CREB/LINC00473/CEBPα/MGMT pathway was revealed in the GB TMZ-resistance formation. In addition, an exosome-based mechanism of chemoresistance transmission was revealed, which suggested that LINC00473 could be used as a novel therapeutic target for GB.PMID:37981063 | DOI:10.1016/j.neuropharm.2023.109790 (Source: Neuropharmacology)
Source: Neuropharmacology - November 19, 2023 Category: Drugs & Pharmacology Authors: Li-Ya Jiang Guan-Hao Wang Jing-Jiao Xu Xiao-Li Li Xiao-Yan Lin Xiang Fang Hong-Xu Zhang Mei Feng Chun-Ming Jiang Source Type: research
CREB-induced LINC00473 promotes chemoresistance to TMZ in glioblastoma by regulating O6-methylguanine-DNA-methyltransferase expression via CEBP α binding
In conclusion, a novel CREB/LINC00473/CEBPα/MGMT pathway was revealed in the GB TMZ-resistance formation. In addition, an exosome-based mechanism of chemoresistance transmission was revealed, which suggested that LINC00473 could be used as a novel therapeutic target for GB.PMID:37981063 | DOI:10.1016/j.neuropharm.2023.109790 (Source: Neuropharmacology)
Source: Neuropharmacology - November 19, 2023 Category: Drugs & Pharmacology Authors: Li-Ya Jiang Guan-Hao Wang Jing-Jiao Xu Xiao-Li Li Xiao-Yan Lin Xiang Fang Hong-Xu Zhang Mei Feng Chun-Ming Jiang Source Type: research
Mitochondrial malfunction mediates impaired cholinergic Ca < sup > 2+ < /sup > signalling and submandibular salivary gland dysfunction in diabetes
In this study, we show that diabetic animals exhibit severe xerostomia, evident by reduced saliva flow rate, diminished total protein content, and decreased amylase activity in the saliva secreted by submandibular glands. These impairments remained resistant to exogenous cholinergic stimulation. In submandibular acinar cells in diabetes, the intracellular Ca2+ signals evoked by cholinergic stimulation were reduced and delayed, caused by malfunctioning mitochondria. Upon initiation of cholinergic-evoked Ca2+ signals, mitochondria accumulate higher Ca2+ and fail to redistribute Ca2+ influx and facilitate the store-operated C...
Source: Neuropharmacology - November 16, 2023 Category: Drugs & Pharmacology Authors: Olga Kopach Tetyana Pivneva Nataliya Fedirko Nana Voitenko Source Type: research
