Requisite role of dorsal raph é in contextual cocaine-memory reconsolidation
Neuropharmacology. 2024 Jan 2:109832. doi: 10.1016/j.neuropharm.2023.109832. Online ahead of print.ABSTRACTMemory reconsolidation is a process by which labile drug memories are restabilized in long-term memory stores, permitting their enduring control over drug-seeking behaviors. In the present study, we investigated the involvement of the dorsal raphé nuclei (DRN) in cocaine-memory reconsolidation. Sprague-Dawley rats (male, female) were trained to self-administer cocaine in a distinct environmental context to establish contextual drug memories. They then received extinction training in a different context. Next, the rat...
Source: Neuropharmacology - January 4, 2024 Category: Drugs & Pharmacology Authors: J L Ritchie S Qi R J Christian M J Greenwood H I Grenz S E Swatzell P J Krych R A Fuchs Source Type: research
Cannabidiol as a potential cessation therapeutic: Effects on intravenous nicotine self-administration and withdrawal symptoms in mice
Neuropharmacology. 2024 Jan 2:109833. doi: 10.1016/j.neuropharm.2023.109833. Online ahead of print.ABSTRACTCigarette smoking remains a leading cause of preventable disease and death worldwide. Due to the devastating negative health effects of smoking, many users attempt to quit, but few are successful in the long-term. Thus, there is a critical need for novel therapeutic approaches. In these investigations, we sought to examine whether cannabidiol (CBD) has the potential to be repurposed as a nicotine cessation therapeutic. In the first study, male and female mice were trained to respond for intravenous nicotine infusions ...
Source: Neuropharmacology - January 4, 2024 Category: Drugs & Pharmacology Authors: S N Cheeks B Buzzi A Valdez A Mogul M I Damaj C D Fowler Source Type: research
Requisite role of dorsal raph é in contextual cocaine-memory reconsolidation
Neuropharmacology. 2024 Jan 2:109832. doi: 10.1016/j.neuropharm.2023.109832. Online ahead of print.ABSTRACTMemory reconsolidation is a process by which labile drug memories are restabilized in long-term memory stores, permitting their enduring control over drug-seeking behaviors. In the present study, we investigated the involvement of the dorsal raphé nuclei (DRN) in cocaine-memory reconsolidation. Sprague-Dawley rats (male, female) were trained to self-administer cocaine in a distinct environmental context to establish contextual drug memories. They then received extinction training in a different context. Next, the rat...
Source: Neuropharmacology - January 4, 2024 Category: Drugs & Pharmacology Authors: J L Ritchie S Qi R J Christian M J Greenwood H I Grenz S E Swatzell P J Krych R A Fuchs Source Type: research
The anterior cingulate cortex and its interface with the dorsal periaqueductal grey regulating nitric oxide-mediated panic-like behaviour and defensive antinociception
Neuropharmacology. 2023 Dec 30;245:109831. doi: 10.1016/j.neuropharm.2023.109831. Online ahead of print.ABSTRACTThe anterior cingulate cortex (ACC) Cg1 (24b) area modulates glutamate-mediated unconditioned fear and antinociception organised by hypothalamus. However, it remains unknown whether 24b area also modulates these latter defensive responses through connections with the dorsal periaqueductal grey matter (dPAG), a midbrain structure implicated in the genesis of innate fear-induced defence. The aim of this work is to examine the correlation between the behavioural effects of intra-ACC microinjections of vehicle, NMDA ...
Source: Neuropharmacology - December 31, 2023 Category: Drugs & Pharmacology Authors: Luiz Luciano Falconi-Sobrinho Tayllon Dos Anjos-Garcia Mac ário Arosti Rebelo Paloma Molina Hernandes Rafael Carvalho Almada Jose Eduardo Tanus-Santos Norberto Cysne Coimbra Source Type: research
Activation of 5-HT < sub > 5A < /sub > receptor in the ventrolateral orbital cortex produces antinociceptive effects in rat models of neuropathic and inflammatory pain
Neuropharmacology. 2023 Dec 29;245:109830. doi: 10.1016/j.neuropharm.2023.109830. Online ahead of print.ABSTRACTThe ventrolateral orbital cortex (VLO) is identified as an integral component of the endogenous analgesic system comprising a spinal cord - thalamic nucleus submedius - VLO - periaqueductal gray (PAG) - spinal cord loop. The present study investigates the effects of 5-HT5A receptor activation in the VLO on allodynia induced by spared nerve injury and formalin-evoked flinching behavior and spinal c-Fos expression in male SD rats, and further examines whether GABAergic modulation is involved in the effects evoked b...
Source: Neuropharmacology - December 31, 2023 Category: Drugs & Pharmacology Authors: Yu-Long Zhao Jia-Liang Xu Hui-Yuan Yi Sani Sa'idu Baba Yi-Xiao Guo Xue-Mei Hou Xiao-Cui Yuan Xu-Hui Li Yu-Ying Wang Ling-Li Liang Fu-Quan Huo Source Type: research
The anterior cingulate cortex and its interface with the dorsal periaqueductal grey regulating nitric oxide-mediated panic-like behaviour and defensive antinociception
Neuropharmacology. 2023 Dec 29:109831. doi: 10.1016/j.neuropharm.2023.109831. Online ahead of print.ABSTRACTThe anterior cingulate cortex (ACC) Cg1 (24b) area modulates glutamate-mediated unconditioned fear and antinociception organised by hypothalamus. However, it remains unknown whether 24b area also modulates these latter defensive responses through connections with dorsal periaqueductal grey matter (dPAG), a midbrain structure implicated in the genesis of innate fear-induced defence. The aim of this work is to examine the correlation between the behavioural effects of intra-ACC microinjections of vehicle, NMDA (1 nmol)...
Source: Neuropharmacology - December 31, 2023 Category: Drugs & Pharmacology Authors: Luiz Luciano Falconi-Sobrinho Tayllon Dos Anjos-Garcia Mac ário Arosti Rebelo Paloma Molina Hernandes Rafael Carvalho Almada Jose Eduardo Tanus-Santos Norberto Cysne Coimbra Source Type: research
Activation of 5-HT < sub > 5A < /sub > receptor in the ventrolateral orbital cortex produces antinociceptive effects in rat models of neuropathic and inflammatory pain
Neuropharmacology. 2023 Dec 29:109830. doi: 10.1016/j.neuropharm.2023.109830. Online ahead of print.ABSTRACTThe ventrolateral orbital cortex (VLO) is identified as an integral component of the endogenous analgesic system comprising a spinal cord - thalamic nucleus submedius - VLO - periaqueductal gray (PAG) - spinal cord loop. The present study investigates the effects of 5-HT5A receptor activation in the VLO on allodynia induced by spared nerve injury and formalin-evoked flinching behavior and spinal c-Fos expression in male SD rats, and further examines whether GABAergic modulation is involved in the effects evoked by VL...
Source: Neuropharmacology - December 31, 2023 Category: Drugs & Pharmacology Authors: Yu-Long Zhao Jia-Liang Xu Hui-Yuan Yi Sani Sa'idu Baba Yi-Xiao Guo Xue-Mei Hou Xiao-Cui Yuan Xu-Hui Li Yu-Ying Wang Ling-Li Liang Fu-Quan Huo Source Type: research
Sex specific effects of buprenorphine on adult hippocampal neurogenesis and behavioral outcomes during the acute phase after pediatric traumatic brain injury in mice
In conclusion, this study elucidates the effects of BPN on adult hippocampal neurogenesis and behavioral outcomes at the acute phase after pediatric TBI.PMID:38159797 | DOI:10.1016/j.neuropharm.2023.109829 (Source: Neuropharmacology)
Source: Neuropharmacology - December 30, 2023 Category: Drugs & Pharmacology Authors: Ivan Davila-Valencia Mark Saad Grace Olthoff Megan Faulkner Maysoun Charara Abigail Farnum Robert C Dysko Zhi Zhang Source Type: research
Mitotherapy prevents peripheral neuropathy induced by oxaliplatin in mice
Neuropharmacology. 2023 Dec 27:109828. doi: 10.1016/j.neuropharm.2023.109828. Online ahead of print.ABSTRACTOxaliplatin (OXA) is an antineoplastic agent used for the treatment of cisplatin-resistant tumours, presenting lower incidence of nephrotoxicity and myelotoxicity than other platinum-based drugs. However, OXA treatment is highly associated with painful peripheral neuropathy, a well-known and relevant side effect caused by mitochondrial dysfunction. The transfer of functional exogenous mitochondria (mitotherapy) is a promising therapeutic strategy for mitochondrial diseases. We investigated the effect of mitotherapy o...
Source: Neuropharmacology - December 29, 2023 Category: Drugs & Pharmacology Authors: Jo ão R L C B Maia Loreena K A Machado Gabriel G Fernandes Louise C Vitorino Let ícia S Antônio Suzana Maria B Ara újo Lilian C Colodeti Fabr ícia L Fontes-Dantas Julianna D Zeidler Georgia N Saraiva Andrea T Da Poian Claudia P Figueiredo Giselle F P Source Type: research
Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones
Neuropharmacology. 2023 Dec 27;245:109827. doi: 10.1016/j.neuropharm.2023.109827. Online ahead of print.ABSTRACTSubstitutions to the phenethylamine structure give rise to numerous amphetamines and cathinones, contributing to an ever-growing number of abused novel psychoactive substances. Understanding how various substitutions affect the pharmacology of phenethylamines may help lawmakers and scientists predict the effects of newly emerging drugs. Here, we established structure-activity relationships for locomotor stimulant and monoamine transporter effects of 12 phenethylamines with combinations of para-chloro, β-keto, N-...
Source: Neuropharmacology - December 28, 2023 Category: Drugs & Pharmacology Authors: Lauren R Fitzgerald Brenda M Gannon Donna Walther Antonio Landavazo Takato Hiranita Bruce E Blough Michael H Baumann William E Fantegrossi Source Type: research
Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones
Neuropharmacology. 2023 Dec 26:109827. doi: 10.1016/j.neuropharm.2023.109827. Online ahead of print.ABSTRACTSubstitutions to the phenethylamine structure give rise to numerous amphetamines and cathinones, contributing to an ever-growing number of abused novel psychoactive substances. Understanding how various substitutions affect the pharmacology of phenethylamines may help lawmakers and scientists predict the effects of newly emerging drugs. Here, we established structure-activity relationships for locomotor stimulant and monoamine transporter effects of 12 phenethylamines with combinations of para-chloro, β-keto, N-meth...
Source: Neuropharmacology - December 28, 2023 Category: Drugs & Pharmacology Authors: Lauren R Fitzgerald Brenda M Gannon Donna Walther Antonio Landavazo Takato Hiranita Bruce E Blough Michael H Baumann William E Fantegrossi Source Type: research
Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones
Neuropharmacology. 2023 Dec 26:109827. doi: 10.1016/j.neuropharm.2023.109827. Online ahead of print.ABSTRACTSubstitutions to the phenethylamine structure give rise to numerous amphetamines and cathinones, contributing to an ever-growing number of abused novel psychoactive substances. Understanding how various substitutions affect the pharmacology of phenethylamines may help lawmakers and scientists predict the effects of newly emerging drugs. Here, we established structure-activity relationships for locomotor stimulant and monoamine transporter effects of 12 phenethylamines with combinations of para-chloro, β-keto, N-meth...
Source: Neuropharmacology - December 28, 2023 Category: Drugs & Pharmacology Authors: Lauren R Fitzgerald Brenda M Gannon Donna Walther Antonio Landavazo Takato Hiranita Bruce E Blough Michael H Baumann William E Fantegrossi Source Type: research
Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones
Neuropharmacology. 2023 Dec 26:109827. doi: 10.1016/j.neuropharm.2023.109827. Online ahead of print.ABSTRACTSubstitutions to the phenethylamine structure give rise to numerous amphetamines and cathinones, contributing to an ever-growing number of abused novel psychoactive substances. Understanding how various substitutions affect the pharmacology of phenethylamines may help lawmakers and scientists predict the effects of newly emerging drugs. Here, we established structure-activity relationships for locomotor stimulant and monoamine transporter effects of 12 phenethylamines with combinations of para-chloro, β-keto, N-meth...
Source: Neuropharmacology - December 28, 2023 Category: Drugs & Pharmacology Authors: Lauren R Fitzgerald Brenda M Gannon Donna Walther Antonio Landavazo Takato Hiranita Bruce E Blough Michael H Baumann William E Fantegrossi Source Type: research
Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones
Neuropharmacology. 2023 Dec 26:109827. doi: 10.1016/j.neuropharm.2023.109827. Online ahead of print.ABSTRACTSubstitutions to the phenethylamine structure give rise to numerous amphetamines and cathinones, contributing to an ever-growing number of abused novel psychoactive substances. Understanding how various substitutions affect the pharmacology of phenethylamines may help lawmakers and scientists predict the effects of newly emerging drugs. Here, we established structure-activity relationships for locomotor stimulant and monoamine transporter effects of 12 phenethylamines with combinations of para-chloro, β-keto, N-meth...
Source: Neuropharmacology - December 28, 2023 Category: Drugs & Pharmacology Authors: Lauren R Fitzgerald Brenda M Gannon Donna Walther Antonio Landavazo Takato Hiranita Bruce E Blough Michael H Baumann William E Fantegrossi Source Type: research
P2Y < sub > 13 < /sub > receptor involved in HIV-1 gp120 induced neuropathy in superior cervical ganglia through NLRP3 inflammasome activation
Neuropharmacology. 2023 Dec 22;245:109818. doi: 10.1016/j.neuropharm.2023.109818. Online ahead of print.ABSTRACTCardiac autonomic neuropathy resulting from human immunodeficiency virus (HIV) infection is common; however, its mechanism remains unknown. The current work attempted to explore the function and mechanism of the P2Y13 receptor in HIV-glycoprotein 120 (gp120)-induced neuropathy in cervical sympathetic ganglion. The superior cervical ganglion (SCG) of the male SD rat was coated with HIV-gp120 to establish a model of autonomic neuropathy. In each group, we measured heart rate, blood pressure, heart rate variability,...
Source: Neuropharmacology - December 24, 2023 Category: Drugs & Pharmacology Authors: Sui Yin Xuexuan Yang Honglei Li Chenxi Li Changyi Li Chengxu Chen Shang Ye Lifang Zou Shangdong Liang Shuangmei Liu Source Type: research
