Dopamine D2 receptor within the intermediate region of the lateral septum modulate social hierarchy in male mice
In this study, we evaluated the functions of DA receptors within different subregions of the LS in social dominance using a confrontation tube test in male mice. The results showed that mice living in social groups formed linear dominance hierarchies after a few days of cohousing, and the subordinates showed increased anxiety. Fos expressions was elevated in the entire LS after a confrontation tube test in the subordinates. However, DA neurons were more activated in the dominates within the ventral tegmental area and the dorsal raphe nucleus. Quantitative real-time polymerase chain reaction results showed that D2 receptor ...
Source: Neuropharmacology - October 3, 2023 Category: Drugs & Pharmacology Authors: Bai-Lin Song Jie Zhou Yi Jiang Lai-Fu Li Ying-Juan Liu Source Type: research
Dopamine D2 receptor within the intermediate region of the lateral septum modulate social hierarchy in male mice
In this study, we evaluated the functions of DA receptors within different subregions of the LS in social dominance using a confrontation tube test in male mice. The results showed that mice living in social groups formed linear dominance hierarchies after a few days of cohousing, and the subordinates showed increased anxiety. Fos expressions was elevated in the entire LS after a confrontation tube test in the subordinates. However, DA neurons were more activated in the dominates within the ventral tegmental area and the dorsal raphe nucleus. Quantitative real-time polymerase chain reaction results showed that D2 receptor ...
Source: Neuropharmacology - October 3, 2023 Category: Drugs & Pharmacology Authors: Bai-Lin Song Jie Zhou Yi Jiang Lai-Fu Li Ying-Juan Liu Source Type: research
Dopamine D2 receptor within the intermediate region of the lateral septum modulate social hierarchy in male mice
In this study, we evaluated the functions of DA receptors within different subregions of the LS in social dominance using a confrontation tube test in male mice. The results showed that mice living in social groups formed linear dominance hierarchies after a few days of cohousing, and the subordinates showed increased anxiety. Fos expressions was elevated in the entire LS after a confrontation tube test in the subordinates. However, DA neurons were more activated in the dominates within the ventral tegmental area and the dorsal raphe nucleus. Quantitative real-time polymerase chain reaction results showed that D2 receptor ...
Source: Neuropharmacology - October 3, 2023 Category: Drugs & Pharmacology Authors: Bai-Lin Song Jie Zhou Yi Jiang Lai-Fu Li Ying-Juan Liu Source Type: research
Binge-like ethanol exposure during the brain growth spurt disrupts the function of retrosplenial cortex-projecting anterior thalamic neurons in adolescent mice
Neuropharmacology. 2023 Sep 29:109738. doi: 10.1016/j.neuropharm.2023.109738. Online ahead of print.ABSTRACTEthanol (EtOH) exposure during late pregnancy leads to enduring impairments in learning and memory that may stem from damage to components of the posterior limbic memory system, including the retrosplenial cortex (RSC) and anterior thalamic nuclei (ATN). In rodents, binge-like EtOH exposure during the first week of life (equivalent to the third trimester of human pregnancy) triggers apoptosis in these brain regions. We hypothesized that this effect induces long-lasting alterations in the function of RSC-projecting AT...
Source: Neuropharmacology - October 1, 2023 Category: Drugs & Pharmacology Authors: Clark W Bird Stefanie S Mayfield Katalina M Lopez Brooke R Dunn Angela Feng Bryce T Roberts Roberto N Almeida Glenna J Chavez C Fernando Valenzuela Source Type: research
Binge-like ethanol exposure during the brain growth spurt disrupts the function of retrosplenial cortex-projecting anterior thalamic neurons in adolescent mice
Neuropharmacology. 2023 Sep 29:109738. doi: 10.1016/j.neuropharm.2023.109738. Online ahead of print.ABSTRACTEthanol (EtOH) exposure during late pregnancy leads to enduring impairments in learning and memory that may stem from damage to components of the posterior limbic memory system, including the retrosplenial cortex (RSC) and anterior thalamic nuclei (ATN). In rodents, binge-like EtOH exposure during the first week of life (equivalent to the third trimester of human pregnancy) triggers apoptosis in these brain regions. We hypothesized that this effect induces long-lasting alterations in the function of RSC-projecting AT...
Source: Neuropharmacology - October 1, 2023 Category: Drugs & Pharmacology Authors: Clark W Bird Stefanie S Mayfield Katalina M Lopez Brooke R Dunn Angela Feng Bryce T Roberts Roberto N Almeida Glenna J Chavez C Fernando Valenzuela Source Type: research
Atomoxetine and reward size equally improve task engagement and perceptual decisions but differently affect movement execution
Neuropharmacology. 2023 Sep 27:109736. doi: 10.1016/j.neuropharm.2023.109736. Online ahead of print.ABSTRACTOur ability to engage and perform daily activities relies on balancing the associated benefits and costs. Rewards, as benefits, act as powerful motivators that help us stay focused for longer durations. The noradrenergic (NA) system is thought to play a significant role in optimizing our performance. Yet, the interplay between reward and the NA system in shaping performance remains unclear, particularly when actions are driven by external incentives (reward). To explore this interaction, we tested four female rhesus ...
Source: Neuropharmacology - September 29, 2023 Category: Drugs & Pharmacology Authors: Kristin Kaduk Tiphaine Henry Jerome Guitton Martine Meunier David Thura Fadila Hadj-Bouziane Source Type: research
Decreased myelin-related gene expression in the nucleus accumbens during spontaneous neonatal opioid withdrawal in the absence of long-term behavioral effects in adult outbred CFW mice
Neuropharmacology. 2023 Sep 27;240:109732. doi: 10.1016/j.neuropharm.2023.109732. Online ahead of print.ABSTRACTPrenatal opioid exposure is a major health concern in the United States, with the incidence of neonatal opioid withdrawal syndrome (NOWS) escalating in recent years. NOWS occurs upon cessation of in utero opioid exposure and is characterized by increased irritability, disrupted sleep patterns, high-pitched crying, and dysregulated feeding. The main pharmacological strategy for alleviating symptoms is treatment with replacement opioids. The neural mechanisms mediating NOWS and the long-term neurobehavioral effects...
Source: Neuropharmacology - September 29, 2023 Category: Drugs & Pharmacology Authors: Kristyn N Borrelli Kelly K Wingfield Emily J Yao Catalina A Zamorano Katherine D Sena Jacob A Beierle Michelle A Roos Huiping Zhang Elisha M Wachman Camron D Bryant Source Type: research
Gut-muscle-brain axis: Molecular mechanisms in neurodegenerative disorders and potential therapeutic efficacy of probiotic supplementation coupled with exercise
Neuropharmacology. 2023 Sep 27;240:109718. doi: 10.1016/j.neuropharm.2023.109718. Online ahead of print.ABSTRACTIncreased longevity is often associated with age-related conditions. The most common neurodegenerative disorders in the older population are Alzheimer's disease (AD) and Parkinson's disease (PD), associated with progressive neuronal loss leading to functional and cognitive impairments. Although symptomatic treatments are available, there is currently no cure for these conditions. Gut dysbiosis has been involved in the pathogenesis of AD and PD, thus interventions targeting the "gut-brain axis" could potentially p...
Source: Neuropharmacology - September 29, 2023 Category: Drugs & Pharmacology Authors: Ilaria Morella Massimo Negro Maurizia Dossena Riccardo Brambilla Giuseppe D'Antona Source Type: research
Atomoxetine and reward size equally improve task engagement and perceptual decisions but differently affect movement execution
Neuropharmacology. 2023 Sep 27:109736. doi: 10.1016/j.neuropharm.2023.109736. Online ahead of print.ABSTRACTOur ability to engage and perform daily activities relies on balancing the associated benefits and costs. Rewards, as benefits, act as powerful motivators that help us stay focused for longer durations. The noradrenergic (NA) system is thought to play a significant role in optimizing our performance. Yet, the interplay between reward and the NA system in shaping performance remains unclear, particularly when actions are driven by external incentives (reward). To explore this interaction, we tested four female rhesus ...
Source: Neuropharmacology - September 29, 2023 Category: Drugs & Pharmacology Authors: Kristin Kaduk Tiphaine Henry Jerome Guitton Martine Meunier David Thura Fadila Hadj-Bouziane Source Type: research
Decreased myelin-related gene expression in the nucleus accumbens during spontaneous neonatal opioid withdrawal in the absence of long-term behavioral effects in adult outbred CFW mice
Neuropharmacology. 2023 Sep 27:109732. doi: 10.1016/j.neuropharm.2023.109732. Online ahead of print.ABSTRACTPrenatal opioid exposure is a major health concern in the United States, with the incidence of neonatal opioid withdrawal syndrome (NOWS) escalating in recent years. NOWS occurs upon cessation of in utero opioid exposure and is characterized by increased irritability, disrupted sleep patterns, high-pitched crying, and dysregulated feeding. The main pharmacological strategy for alleviating symptoms is treatment with replacement opioids. The neural mechanisms mediating NOWS and the long-term neurobehavioral effects are...
Source: Neuropharmacology - September 29, 2023 Category: Drugs & Pharmacology Authors: Kristyn N Borrelli Kelly K Wingfield Emily J Yao Catalina A Zamorano Katherine D Sena Jacob A Beierle Michelle A Roos Huiping Zhang Elisha M Wachman Camron D Bryant Source Type: research
Gut-muscle-brain axis: Molecular mechanisms in neurodegenerative disorders and potential therapeutic efficacy of probiotic supplementation coupled with exercise
Neuropharmacology. 2023 Sep 27:109718. doi: 10.1016/j.neuropharm.2023.109718. Online ahead of print.ABSTRACTIncreased longevity is often associated with age-related conditions. The most common neurodegenerative disorders in the older population are Alzheimer's disease (AD) and Parkinson's disease (PD), associated with progressive neuronal loss leading to functional and cognitive impairments. Although symptomatic treatments are available, there is currently no cure for these conditions. Gut dysbiosis has been involved in the pathogenesis of AD and PD, thus interventions targeting the "gut-brain axis" could potentially preve...
Source: Neuropharmacology - September 29, 2023 Category: Drugs & Pharmacology Authors: Ilaria Morella Massimo Negro Maurizia Dossena Riccardo Brambilla Giuseppe D'Antona Source Type: research
Impact of physical activity on brain oxidative metabolism and intrinsic capacities in young swiss mice fed a high fat diet
Neuropharmacology. 2023 Sep 25:109730. doi: 10.1016/j.neuropharm.2023.109730. Online ahead of print.ABSTRACTType 2 diabetes and obesity characterized by hallmarks of insulin resistance along with an imbalance in brain oxidative metabolism would impair intrinsic capacities (ICs), a new concept for assessing mental and physical functioning. Here, we explored the impact of physical activity on antioxidant responses and oxidative metabolism in discrete brain areas of HFD or standard diet (STD) fed mice but also its consequences on specific domains of ICs. 6-week-old Swiss male mice were exposed to a STD or a HFD for 16 weeks a...
Source: Neuropharmacology - September 27, 2023 Category: Drugs & Pharmacology Authors: Cl émence Viguier S ébastien Bullich Marlene Botella Laure Fasseu Am élie Alfonso Khaoula Rekik S ébastien Gauzin Bruno P Guiard No élie Davezac Source Type: research
Pharmacological profiles and anti-inflammatory activity of pCN-diEPP and mCN-diEPP, new alpha9alpha10 nicotinic receptor ligands
Neuropharmacology. 2023 Sep 25;240:109717. doi: 10.1016/j.neuropharm.2023.109717. Online ahead of print.ABSTRACTPain due to inflammation can be reduced by targeting the noncanonical nicotinic receptors (NCNR) in cells of the immune system that regulate the synthesis and release of pro- and anti-inflammatory cytokines. Although NCNR do not generate ion channel currents, the pharmacology of ion-channel forms of the receptors can predict drugs which may be effective regulators of the cholinergic anti-inflammatory system (CAS). Agonists of α7 type receptors have been definitively associated with CAS. Receptors containing α9 ...
Source: Neuropharmacology - September 27, 2023 Category: Drugs & Pharmacology Authors: Katrin Richter Sara M Herz Clare Stokes M Imad Damaj Veronika Grau Roger L Papke Source Type: research
Pharmacological profiles and anti-inflammatory activity of pCN-diEPP and mCN-diEPP, new alpha9alpha10 nicotinic receptor ligands
Neuropharmacology. 2023 Sep 25:109717. doi: 10.1016/j.neuropharm.2023.109717. Online ahead of print.ABSTRACTPain due to inflammation can be reduced by targeting the noncanonical nicotinic receptors (NCNR) in cells of the immune system that regulate the synthesis and release of pro- and anti-inflammatory cytokines. Although NCNR do not generate ion channel currents, the pharmacology of ion-channel forms of the receptors can predict drugs which may be effective regulators of the cholinergic anti-inflammatory system (CAS). Agonists of α7 type receptors have been definitively associated with CAS. Receptors containing α9 and ...
Source: Neuropharmacology - September 27, 2023 Category: Drugs & Pharmacology Authors: Katrin Richter Sara M Herz Clare Stokes M Imad Damaj Veronika Grau Roger L Papke Source Type: research
Impact of physical activity on brain oxidative metabolism and intrinsic capacities in young swiss mice fed a high fat diet
Neuropharmacology. 2023 Sep 25:109730. doi: 10.1016/j.neuropharm.2023.109730. Online ahead of print.ABSTRACTType 2 diabetes and obesity characterized by hallmarks of insulin resistance along with an imbalance in brain oxidative metabolism would impair intrinsic capacities (ICs), a new concept for assessing mental and physical functioning. Here, we explored the impact of physical activity on antioxidant responses and oxidative metabolism in discrete brain areas of HFD or standard diet (STD) fed mice but also its consequences on specific domains of ICs. 6-week-old Swiss male mice were exposed to a STD or a HFD for 16 weeks a...
Source: Neuropharmacology - September 27, 2023 Category: Drugs & Pharmacology Authors: Cl émence Viguier S ébastien Bullich Marlene Botella Laure Fasseu Am élie Alfonso Khaoula Rekik S ébastien Gauzin Bruno P Guiard No élie Davezac Source Type: research
