Methylone produces antidepressant-relevant actions and prosocial effects
Neuropharmacology. 2023 Oct 30:109787. doi: 10.1016/j.neuropharm.2023.109787. Online ahead of print.ABSTRACTMethylone (3,4-methylenedioxy-N-methylcathinone) is a rapid-acting entactogen that has been shown to have significant benefits in patients with post-traumatic stress disorder and major depressive disorder and is well tolerated in phase 1 clinical trials. A recent preclinical study reported that methylone produced robust antidepressant-like actions in naïve rats. However, its antidepressant effects on various stress-related psychopathologies and other neuropsychological actions remain unclear. In the present study, w...
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Zhenlong Li Hsien-Yu Peng Chau-Shoun Lee Tzer-Bin Lin Ming-Chun Hsieh Cheng-Yuan Lai Han-Fang Wu Lih-Chyang Chen Mei-Ci Chen Dylan Chou Source Type: research
Molecular mechanisms of cholinergic neurotransmission in visceral smooth muscles with a focus on receptor-operated TRPC4 channel and impairment of gastrointestinal motility by general anaesthetics and anxiolytics
This article is part of the Special Issue featuring Ukrainian Neuroscience.PMID:37913983 | DOI:10.1016/j.neuropharm.2023.109776 (Source: Neuropharmacology)
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Alexander V Zholos Mariia I Melnyk Dariia O Dryn Source Type: research
Synergetic effect of matrine on the catalytic scFv antibody HS72 in vitro and in mice with Alzheimer disease pathology
Neuropharmacology. 2023 Oct 30:109775. doi: 10.1016/j.neuropharm.2023.109775. Online ahead of print.ABSTRACTSingle-chain variable fragment (scFv) HS72 is a catalytic antibody that specifically degrades amyloid β-protein 1-42 (Aβ42) aggregates in vitro or reduces the level or burden of Aβ42 deposits/plaques in the brains of mice with Alzheimer disease pathology. Its efficacy has been shown in protecting neural cells in vitro and improving the morphology of the cell population in the brain of mice with AD pathology (AD mice). Matrine (Mat) is a natural product capable of binding to Aβ42 or its aggregates and blocking the...
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Chuli Song He Li Tianyu Zhang Changxin Zheng Yingjiu Zhang Source Type: research
Intranasal oxytocin alleviates comorbid depressive symptoms in neuropathic pain via elevating hippocampal BDNF production in both female and male mice
Neuropharmacology. 2023 Oct 30:109769. doi: 10.1016/j.neuropharm.2023.109769. Online ahead of print.ABSTRACTThe comorbidity of pain and depression is frequently observed in patients suffering from chronic pain and depression. However, the comorbid mechanism is not well elucidated and the therapeutic medication is still inadequate. Oxytocin is a neuropeptide synthesized in the hypothalamus. It has been reported to relieve chronic pain and depressive symptoms. However, the analgesic action and mechanisms of oxytocin have mainly been investigated using peripheral or spinal administration. Because of the advantage of intranasa...
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Rongjun Liu Daofan Sun Xiuzhong Xing Qingge Chen Bo Lu Bo Meng Hui Yuan Lan Mo Liufang Sheng Jinwei Zheng Qiusheng Wang Junping Chen Xiaowei Chen Source Type: research
Corrigendum to 'The MK2 cascade regulates mGluR-dependent synaptic plasticity and reversal learning' [Neuropharmacology 155 (2019) 121-130]
Neuropharmacology. 2023 Oct 30:109760. doi: 10.1016/j.neuropharm.2023.109760. Online ahead of print.NO ABSTRACTPMID:37914554 | DOI:10.1016/j.neuropharm.2023.109760 (Source: Neuropharmacology)
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Lucia Privitera Ellen L Hogg Matthias Gaestel Mark J Wall Sonia A L Corr êa Source Type: research
Corrigendum to 'The MK2 cascade regulates mGluR-dependent synaptic plasticity and reversal learning' [Neuropharmacology 155 (2019) 121-130]
Neuropharmacology. 2023 Oct 30:109760. doi: 10.1016/j.neuropharm.2023.109760. Online ahead of print.NO ABSTRACTPMID:37914554 | DOI:10.1016/j.neuropharm.2023.109760 (Source: Neuropharmacology)
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Lucia Privitera Ellen L Hogg Matthias Gaestel Mark J Wall Sonia A L Corr êa Source Type: research
Methylone produces antidepressant-relevant actions and prosocial effects
Neuropharmacology. 2023 Oct 30:109787. doi: 10.1016/j.neuropharm.2023.109787. Online ahead of print.ABSTRACTMethylone (3,4-methylenedioxy-N-methylcathinone) is a rapid-acting entactogen that has been shown to have significant benefits in patients with post-traumatic stress disorder and major depressive disorder and is well tolerated in phase 1 clinical trials. A recent preclinical study reported that methylone produced robust antidepressant-like actions in naïve rats. However, its antidepressant effects on various stress-related psychopathologies and other neuropsychological actions remain unclear. In the present study, w...
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Zhenlong Li Hsien-Yu Peng Chau-Shoun Lee Tzer-Bin Lin Ming-Chun Hsieh Cheng-Yuan Lai Han-Fang Wu Lih-Chyang Chen Mei-Ci Chen Dylan Chou Source Type: research
Molecular mechanisms of cholinergic neurotransmission in visceral smooth muscles with a focus on receptor-operated TRPC4 channel and impairment of gastrointestinal motility by general anaesthetics and anxiolytics
This article is part of the Special Issue featuring Ukrainian Neuroscience.PMID:37913983 | DOI:10.1016/j.neuropharm.2023.109776 (Source: Neuropharmacology)
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Alexander V Zholos Mariia I Melnyk Dariia O Dryn Source Type: research
Synergetic effect of matrine on the catalytic scFv antibody HS72 in vitro and in mice with Alzheimer disease pathology
Neuropharmacology. 2023 Oct 30:109775. doi: 10.1016/j.neuropharm.2023.109775. Online ahead of print.ABSTRACTSingle-chain variable fragment (scFv) HS72 is a catalytic antibody that specifically degrades amyloid β-protein 1-42 (Aβ42) aggregates in vitro or reduces the level or burden of Aβ42 deposits/plaques in the brains of mice with Alzheimer disease pathology. Its efficacy has been shown in protecting neural cells in vitro and improving the morphology of the cell population in the brain of mice with AD pathology (AD mice). Matrine (Mat) is a natural product capable of binding to Aβ42 or its aggregates and blocking the...
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Chuli Song He Li Tianyu Zhang Changxin Zheng Yingjiu Zhang Source Type: research
Intranasal oxytocin alleviates comorbid depressive symptoms in neuropathic pain via elevating hippocampal BDNF production in both female and male mice
Neuropharmacology. 2023 Oct 30:109769. doi: 10.1016/j.neuropharm.2023.109769. Online ahead of print.ABSTRACTThe comorbidity of pain and depression is frequently observed in patients suffering from chronic pain and depression. However, the comorbid mechanism is not well elucidated and the therapeutic medication is still inadequate. Oxytocin is a neuropeptide synthesized in the hypothalamus. It has been reported to relieve chronic pain and depressive symptoms. However, the analgesic action and mechanisms of oxytocin have mainly been investigated using peripheral or spinal administration. Because of the advantage of intranasa...
Source: Neuropharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Rongjun Liu Daofan Sun Xiuzhong Xing Qingge Chen Bo Lu Bo Meng Hui Yuan Lan Mo Liufang Sheng Jinwei Zheng Qiusheng Wang Junping Chen Xiaowei Chen Source Type: research
Effects of junk-food on food-motivated behavior and nucleus accumbens glutamate plasticity; insights into the mechanism of calcium-permeable AMPA receptor recruitment
Neuropharmacology. 2023 Oct 26:109772. doi: 10.1016/j.neuropharm.2023.109772. Online ahead of print.ABSTRACTIn rats, eating obesogenic diets increase calcium-permeable AMPA receptor (CP-AMPAR) transmission in the nucleus accumbens (NAc) core, and enhances food-motivated behavior. Interestingly these diet-induced alterations in NAc transmission are pronounced and sustained in obesity-prone (OP) male rats and absent in obesity-resistant (OR) populations. However, effects of diet manipulation on food motivation, and the mechanisms underlying NAc plasticity in OPs is unknown. Using male selectively-bred OP and OR rats, we asse...
Source: Neuropharmacology - October 28, 2023 Category: Drugs & Pharmacology Authors: Tracy L Fetterly Amanda M Catalfio Carrie R Ferrario Source Type: research
Effects of junk-food on food-motivated behavior and nucleus accumbens glutamate plasticity; insights into the mechanism of calcium-permeable AMPA receptor recruitment
Neuropharmacology. 2023 Oct 26:109772. doi: 10.1016/j.neuropharm.2023.109772. Online ahead of print.ABSTRACTIn rats, eating obesogenic diets increase calcium-permeable AMPA receptor (CP-AMPAR) transmission in the nucleus accumbens (NAc) core, and enhances food-motivated behavior. Interestingly these diet-induced alterations in NAc transmission are pronounced and sustained in obesity-prone (OP) male rats and absent in obesity-resistant (OR) populations. However, effects of diet manipulation on food motivation, and the mechanisms underlying NAc plasticity in OPs is unknown. Using male selectively-bred OP and OR rats, we asse...
Source: Neuropharmacology - October 28, 2023 Category: Drugs & Pharmacology Authors: Tracy L Fetterly Amanda M Catalfio Carrie R Ferrario Source Type: research
Effects of junk-food on food-motivated behavior and nucleus accumbens glutamate plasticity; insights into the mechanism of calcium-permeable AMPA receptor recruitment
Neuropharmacology. 2023 Oct 26:109772. doi: 10.1016/j.neuropharm.2023.109772. Online ahead of print.ABSTRACTIn rats, eating obesogenic diets increase calcium-permeable AMPA receptor (CP-AMPAR) transmission in the nucleus accumbens (NAc) core, and enhances food-motivated behavior. Interestingly these diet-induced alterations in NAc transmission are pronounced and sustained in obesity-prone (OP) male rats and absent in obesity-resistant (OR) populations. However, effects of diet manipulation on food motivation, and the mechanisms underlying NAc plasticity in OPs is unknown. Using male selectively-bred OP and OR rats, we asse...
Source: Neuropharmacology - October 28, 2023 Category: Drugs & Pharmacology Authors: Tracy L Fetterly Amanda M Catalfio Carrie R Ferrario Source Type: research
Sex-dependent effect of inflammatory pain on negative affective states is prevented by kappa opioid receptors blockade in the nucleus accumbens shell
Neuropharmacology. 2023 Oct 23:109764. doi: 10.1016/j.neuropharm.2023.109764. Online ahead of print.ABSTRACTPain comorbidities include several psychological disorders, such as anxiety and anhedonia. However, the way pain affects male and female individuals and by which mechanism is not well understood. Previous research shows that pain induces alterations in the dynorphinergic pathway within the mesocorticolimbic system (MCLS), together with a relationship between corticotropin-releasing system and dynorphin release in the MCLS. Here, we analyse the sex and time course-dependent effects of pain on negative affect. Addition...
Source: Neuropharmacology - October 25, 2023 Category: Drugs & Pharmacology Authors: J D Lorente J Cuitavi L Rullo S Candeletti P Romualdi L Hip ólito Source Type: research
Sex-dependent effect of inflammatory pain on negative affective states is prevented by kappa opioid receptors blockade in the nucleus accumbens shell
Neuropharmacology. 2023 Oct 23:109764. doi: 10.1016/j.neuropharm.2023.109764. Online ahead of print.ABSTRACTPain comorbidities include several psychological disorders, such as anxiety and anhedonia. However, the way pain affects male and female individuals and by which mechanism is not well understood. Previous research shows that pain induces alterations in the dynorphinergic pathway within the mesocorticolimbic system (MCLS), together with a relationship between corticotropin-releasing system and dynorphin release in the MCLS. Here, we analyse the sex and time course-dependent effects of pain on negative affect. Addition...
Source: Neuropharmacology - October 25, 2023 Category: Drugs & Pharmacology Authors: J D Lorente J Cuitavi L Rullo S Candeletti P Romualdi L Hip ólito Source Type: research
