Antibody treatment to deplete transthyretin amyloid deposits in the heart
Nature Reviews Cardiology, Published online: 07 June 2023; doi:10.1038/s41569-023-00899-7An antibody-based therapy for transthyretin amyloid cardiomyopathy is safe, and initial findings from a phase I trial suggest that it might deplete amyloid deposits in the heart. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 7, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Implantable haemodynamic sensor to remotely MONITOR HF
Nature Reviews Cardiology, Published online: 06 June 2023; doi:10.1038/s41569-023-00896-wResults from the MONITOR-HF trial show that remote monitoring of pulmonary artery pressure using the implantable CardioMEMS sensor in patients with chronic heart failure improves quality of life and reduces hospitalizations. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 6, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
A fatty acid from mother’s milk drives cardiomyocyte maturation in newborn mice
Nature Reviews Cardiology, Published online: 06 June 2023; doi:10.1038/s41569-023-00898-8The essential omega-6 polyunsaturated fatty acid γ-linolenic acid present in maternal milk coordinates cardiac adaptation and survival in newborn mice, according to a new study. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 6, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study Group
Nature Reviews Cardiology, Published online: 05 June 2023; doi:10.1038/s41569-023-00880-4In this Consensus Statement, Dewey and the other members of the Quantitative Cardiovascular Imaging Study Group provide clinical consensus recommendations on the optimal use of different imaging techniques in various patient populations to detect and assess coronary artery stenosis and atherosclerosis. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 5, 2023 Category: Cardiology Authors: Aldo J. V ázquez Mézquita Federico Biavati Volkmar Falk Hatem Alkadhi Reza Hajhosseiny P ál Maurovich-Horvat Robert Manka Sebastian Kozerke Matthias Stuber Thorsten Derlin Keith M. Channon Ivana I šgum Adriaan Coenen Bernhard Foellmer Damini Dey Rick Source Type: research
Targeting ALK1 to block LDL transcytosis and halt atherosclerosis
Nature Reviews Cardiology, Published online: 02 June 2023; doi:10.1038/s41569-023-00895-xIn a mouse model of atherosclerosis, a selective monoclonal antibody that blocks the binding of LDL to activin receptor-like kinase 1 reduced plaque formation in the aorta. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 2, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges
Nature Reviews Cardiology, Published online: 26 May 2023; doi:10.1038/s41569-023-00887-xIn this Review, Ritterhoff and Tian describe the metabolic reprogramming that occurs in cardiac hypertrophy and heart failure; discuss the contribution of metabolism to energy-generating and non-energy-generating functions, including signalling, protein function and gene expression regulation; and highlight the role of metabolism in non-cardiomyocytes and the potential to develop metabolic therapies for heart failure. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 26, 2023 Category: Cardiology Authors: Julia Ritterhoff Rong Tian Source Type: research
Simvastatin protects against endothelial dysfunction via epigenetic mechanisms
Nature Reviews Cardiology, Published online: 26 May 2023; doi:10.1038/s41569-023-00893-zSimvastatin improves endothelial cell function by inhibiting endothelial-to-mesenchymal transition through an epigenetic regulatory mechanism, according to a new study. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 26, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Global epidemiology of acute coronary syndromes
Nature Reviews Cardiology, Published online: 25 May 2023; doi:10.1038/s41569-023-00884-0Acute coronary syndromes (ACS) are a major contributor to death from cardiovascular disease. In this Review, Timmis and colleagues present data on mortality from ACS for 122 countries and examine the regional and temporal changes in the epidemiology of ACS over the past 20 years. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 25, 2023 Category: Cardiology Authors: Adam Timmis Denis Kazakiewicz Nick Townsend Radu Huculeci Victor Aboyans Panos Vardas Source Type: research
Flow-induced reprogramming of endothelial cells in atherosclerosis
Nature Reviews Cardiology, Published online: 24 May 2023; doi:10.1038/s41569-023-00883-1In this Review, Jo and colleagues discuss blood flow-induced mechanisms involved in endothelial cell dysfunction and atherosclerosis, including the emerging concept of disturbed-flow-induced reprogramming of endothelial cells as a pro-atherogenic mechanism, and highlight the therapeutic potential of targeting of flow-sensitive genes, proteins and pathways. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 24, 2023 Category: Cardiology Authors: Ian A. Tamargo Kyung In Baek Yerin Kim Christian Park Hanjoong Jo Source Type: research
Identifying leukocyte phenotypes by scRNA-seq to predict cardiovascular risk
Nature Reviews Cardiology, Published online: 22 May 2023; doi:10.1038/s41569-023-00891-1Contemporary tools to predict cardiovascular risk lack accuracy on an individual-patient level. The use of single-cell RNA sequencing to identify specific leukocyte patterns might overcome some of these limitations, propelling us towards a precision medicine approach. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 22, 2023 Category: Cardiology Authors: Johannes Gollmer Andreas Zirlik Source Type: research
Aggregation of big tau disrupts microtubules and causes diastolic dysfunction
Nature Reviews Cardiology, Published online: 17 May 2023; doi:10.1038/s41569-023-00890-2Hyperphosphorylation of tau in the heart reduces the tyrosination of microtubules, leading to myocardial stiffness and heart failure. This novel mechanism of diastolic dysfunction parallels the aggregation of tau in the brain that leads to Alzheimer disease and might be amenable to treatment using monoclonal antibodies against tau. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 17, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Young women with AMI have worse outcomes than men up to 1 year after discharge
Nature Reviews Cardiology, Published online: 17 May 2023; doi:10.1038/s41569-023-00889-9Findings from the VIRGO study reveal that young women with acute myocardial infarction are more likely to be rehospitalized within 1 year compared with similarly aged men. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 17, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Hallmarks of cardiovascular ageing
Nature Reviews Cardiology, Published online: 16 May 2023; doi:10.1038/s41569-023-00881-3In this Review, Kroemer and colleagues describe eight molecular hallmarks of cardiovascular ageing: disabled macroautophagy, loss of proteostasis, genomic instability, epigenetic alterations, mitochondrial dysfunction, cell senescence, dysregulated neurohormonal signalling and inflammation. Therapeutically targeting these hallmarks might attenuate residual cardiovascular risk in older individuals. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 16, 2023 Category: Cardiology Authors: Mahmoud Abdellatif Peter P. Rainer Simon Sedej Guido Kroemer Source Type: research
Cardiovascular risk in diabetes mellitus: epidemiology, assessment and prevention
Nature Reviews Cardiology, Published online: 16 May 2023; doi:10.1038/s41569-023-00877-zIndividuals with type 2 diabetes mellitus are at high risk of developing cardiovascular disease (CVD). In the context of type 2 diabetes mellitus, Wong and Sattar discuss established and novel mechanisms of CVD, risk assessment and patient stratification, and strategies to reduce multiple risk factors to prevent CVD. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 16, 2023 Category: Cardiology Authors: Nathan D. Wong Naveed Sattar Source Type: research
Interventional therapies for pulmonary embolism
Nature Reviews Cardiology, Published online: 12 May 2023; doi:10.1038/s41569-023-00876-0Pulmonary embolism is the leading cause of in-hospital death and the third most frequent cause of cardiovascular death. In this Review, Mahfoud and colleagues discuss the growing range of interventional, catheter-based approaches for the treatment of pulmonary embolism as well as risk stratification and patient selection for these procedures. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 12, 2023 Category: Cardiology Authors: Felix G ötzinger Lucas Lauder Andrew S. P. Sharp Irene M. Lang Stephan Rosenkranz Stavros Konstantinides Elazer R. Edelman Michael B öhm Wissam Jaber Felix Mahfoud Source Type: research
