Immune and inflammatory mechanisms in hypertension
Nature Reviews Cardiology, Published online: 03 January 2024; doi:10.1038/s41569-023-00964-1In this Review, Guzik and colleagues discuss immune and inflammatory mechanisms of hypertension, including upstream regulators and downstream effectors as well as the complex interplay between the immune system, blood pressure regulation and end-organ damage, which can help to identify new targets for therapeutic interventions. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 3, 2024 Category: Cardiology Authors: Tomasz J. Guzik Ryszard Nosalski Pasquale Maffia Grant R. Drummond Source Type: research

Improving medication adherence in cardiovascular disease
Nature Reviews Cardiology, Published online: 03 January 2024; doi:10.1038/s41569-023-00972-1In this Review, Bosworth and colleagues describe the causes of medication non-adherence, discuss interventions that have been clinically shown to improve adherence and identify areas for future research. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 3, 2024 Category: Cardiology Authors: Adam J. Nelson Neha J. Pagidipati Hayden B. Bosworth Source Type: research

Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets
Nature Reviews Cardiology, Published online: 02 January 2024; doi:10.1038/s41569-023-00957-0Macrophages in atherosclerotic plaques can undergo apoptosis and several forms of regulated necrosis, including necroptosis, pyroptosis and ferroptosis. In this Review, De Meyer and colleagues describe the various forms of programmed macrophage death in atherosclerosis and the potential therapeutic implications. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 2, 2024 Category: Cardiology Authors: Guido R. Y. De Meyer Michelle Zurek Pauline Puylaert Wim Martinet Source Type: research

RNA-binding proteins in cardiovascular biology and disease: the beat goes on
Nature Reviews Cardiology, Published online: 02 January 2024; doi:10.1038/s41569-023-00958-zIn this Review, the authors discuss the latest insights on RNA-binding proteins and RNA biology and appraise them in the context of cardiovascular research, summarizing the progress in our understanding of the involvement of RNA-binding proteins in cardiac biology and disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 2, 2024 Category: Cardiology Authors: Mirko V ölkers Thomas Preiss Matthias W. Hentze Source Type: research

Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden
Nature Reviews Cardiology, Published online: 02 January 2024; doi:10.1038/s41569-023-00962-3Cardiovascular autonomic dysfunction (CVAD) is a malfunction of the autonomic control of circulatory homeostasis and is an important component of post-COVID-19 syndrome. In this Review, Fedorowski and colleagues define the major forms of CVAD (including postural orthostatic tachycardia syndrome), and discuss the aetiology, diagnosis and management of post-COVID-19 syndrome-associated CVAD. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 2, 2024 Category: Cardiology Authors: Artur Fedorowski Alessandra Fanciulli Satish R. Raj Robert Sheldon Cyndya A. Shibao Richard Sutton Source Type: research

Left atrial appendage occlusion
Nature Reviews Cardiology, Published online: 19 December 2023; doi:10.1038/s41569-023-00973-0Left atrial appendage occlusion (LAAO) has been rapidly adopted for stroke prevention in patients with non-valvular atrial fibrillation and a contraindication to oral anticoagulation. Ongoing and planned clinical trials on LAAO and the development of new devices might expand clinical indications and address the remaining challenges of device-related thrombus and peridevice leak. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - December 19, 2023 Category: Cardiology Authors: Jacqueline Saw Source Type: research

Bone marrow adipocytes support fatty acid metabolism during MI-mediated emergency haematopoiesis
Nature Reviews Cardiology, Published online: 19 December 2023; doi:10.1038/s41569-023-00987-8During myocardial infarction, haematopoietic stem and progenitor cells increase fatty acid oxidation, and bone marrow adipocytes can act as a local energy resource for these cells. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - December 19, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research

Author Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention
Nature Reviews Cardiology, Published online: 18 December 2023; doi:10.1038/s41569-023-00982-zAuthor Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - December 18, 2023 Category: Cardiology Authors: Makoto Araki Seung-Jung Park Harold L. Dauerman Shiro Uemura Jung-Sun Kim Carlo Di Mario Thomas W. Johnson Giulio Guagliumi Adnan Kastrati Michael Joner Niels Ramsing Holm Fernando Alfonso William Wijns Tom Adriaenssens Holger Nef Gilles Rioufol Nicolas A Source Type: research

Photoacoustic method enables deep imaging of blood flow
Nature Reviews Cardiology, Published online: 15 December 2023; doi:10.1038/s41569-023-00985-wA method named photoacoustic vector tomography now enables the quantification of haemodynamics in veins at depths of more than 5 mm below the skin surface, outperforming current pure optical modalities for deep haemodynamic imaging. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - December 15, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Levothyroxine supplementation does not improve heart transplantation from brain-dead donors
Nature Reviews Cardiology, Published online: 08 December 2023; doi:10.1038/s41569-023-00980-1The use of intravenous levothyroxine does not increase the likelihood of hearts being transplanted from haemodynamically unstable, brain-dead potential donors, suggesting that current practice recommendations should be revised. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - December 8, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Clonal expansion of CD8+ T cells in aged mice linked to pro-atherogenic phenotype
Nature Reviews Cardiology, Published online: 08 December 2023; doi:10.1038/s41569-023-00981-0In aged mice, but not young mice, with atherosclerosis, depletion of CD8+ T cells significantly reduces atherosclerotic lesion size and necrotic core area. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - December 8, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research

Not a spectator sport: improving participation of Black patients in cardiovascular clinical trials
Nature Reviews Cardiology, Published online: 07 December 2023; doi:10.1038/s41569-023-00978-9Representation of Black patients in cardiovascular clinical trials remains dismally low, reflective of systemic and structural barriers, which can lead to missed opportunities to meet community-identified needs, understand responses to medical therapies and improve cardiovascular care. Innovative, multilevel strategies focused on Black communities are warranted to increase enrolment of this population into clinical research. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - December 7, 2023 Category: Cardiology Authors: LaPrincess C. Brewer Joshua J. Joseph Source Type: research

Anticoagulation in patients with atrial high-rate episodes
Nature Reviews Cardiology, Published online: 07 December 2023; doi:10.1038/s41569-023-00963-2The risk of stroke in patients with atrial high-rate episodes (AHREs) depends on age, comorbidities and AHRE burden. Two randomized clinical trials on the use of oral anticoagulant therapy for stroke prevention in older patients with short and rare AHREs have reported conflicting findings on the efficacy of oral anticoagulation in this patient population, although both trials report a significantly increased risk of major bleeding with oral anticoagulation. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - December 7, 2023 Category: Cardiology Authors: Tatjana Potpara Carina Blomstrom-Lundqvist Source Type: research

Mosaic loss of chromosome Y and cardiovascular disease
Nature Reviews Cardiology, Published online: 06 December 2023; doi:10.1038/s41569-023-00976-xMosaic loss of chromosome Y (mLOY) refers to the condition in male individuals in which a detectable fraction of cells lose the Y chromosome. Prevalent in haematopoietic cells, this common somatic mutation is associated with decreased longevity and an increased risk of age-related diseases, including cardiovascular disease. Haematopoietic mLOY provides further insight into the sex-specific disparities that exist in disease susceptibility. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - December 6, 2023 Category: Cardiology Authors: Soichi Sano Kenneth Walsh Source Type: research

The case for eliminating racial and ethnic cardiovascular disparities in the USA
Nature Reviews Cardiology, Published online: 05 December 2023; doi:10.1038/s41569-023-00971-2Racial and ethnic disparities in cardiovascular health in the USA result in a persistent mortality gap between white and Black individuals, increase health-care costs and compromise an egalitarian society. Solutions to racial inequities require risk factor control and the implementation of evidence-based medicine and anti-racism policies. Overcoming these disparities is not only a practical necessity, but also a moral imperative. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - December 5, 2023 Category: Cardiology Authors: Keith C. Ferdinand Source Type: research