Sex-specific and ethnicity-specific differences in MINOCA
Nature Reviews Cardiology, Published online: 29 September 2023; doi:10.1038/s41569-023-00927-6Myocardial infarction with non-obstructive coronary arteries (MINOCA) has been the focus of an increasing number of studies in the past decade. In this Review, Tavella and colleagues detail the prevalence and clinical presentation of MINOCA, describe the mechanisms underlying the syndrome, and summarize the sex-specific and ethnicity-specific differences in the clinical features, pathophysiological mechanisms, treatment and prognosis of MINOCA. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 29, 2023 Category: Cardiology Authors: Sarena La John Beltrame Rosanna Tavella Source Type: research
Effects of lifestyle factors on leukocytes in cardiovascular health and disease
Nature Reviews Cardiology, Published online: 26 September 2023; doi:10.1038/s41569-023-00931-wIn this Review, Swirski and co-workers discuss how lifestyle factors modulate haematopoiesis and leukocyte migration in the context of cardiovascular homeostasis and disease, with particular focus on the role of the nervous system as the key executor connecting environmental influences to leukocyte behaviour. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 26, 2023 Category: Cardiology Authors: Henrike Janssen Laura L. Koekkoek Filip K. Swirski Source Type: research
The menopausal transition period and cardiovascular risk
Nature Reviews Cardiology, Published online: 26 September 2023; doi:10.1038/s41569-023-00926-7The menopausal transition period, which begins with irregular menstrual cycles and ends with the final menstrual period, is associated with an increase in cardiovascular risk. In this Review, Mehta and Manson describe the metabolic and cardiovascular changes that occur during the menopausal transition period and summarize the evidence on the use of targeted interventions to slow the progression of atherosclerosis. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 26, 2023 Category: Cardiology Authors: Jaya M. Mehta JoAnn E. Manson Source Type: research
Prehabilitation: evolving role in contemporary cardiac surgery
Nature Reviews Cardiology, Published online: 25 September 2023; doi:10.1038/s41569-023-00939-2The population of patients who undergo cardiac surgery is becoming older and more medically complex, and frailty is increasingly prevalent. Prehabilitation is a multicomponent programme intended to better prepare these vulnerable patients for the stresses of surgery. Nonetheless, the effectiveness, implementation and effects on long-term outcomes of prehabilitation have not been clearly established. In particular, frailty might not be easily mitigated by prehabilitation. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 25, 2023 Category: Cardiology Authors: Atilio Barbeito Daniel E. Forman Source Type: research
CHIP in HF: prognostic role and cell-intrinsic effects
Nature Reviews Cardiology, Published online: 20 September 2023; doi:10.1038/s41569-023-00942-7Two studies now report that TET2-driven clonal haematopoiesis of indeterminate potential (CHIP) is associated with poor prognosis in patients with heart failure (HF) and preserved ejection fraction and that DNMT3A CHIP driver mutations promote dysregulated gene expression profiles that are associated with inflammation in monocytes in the setting of HF. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 20, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Migraines and cardiovascular disease: mechanisms and methodological challenges
Nature Reviews Cardiology, Published online: 18 September 2023; doi:10.1038/s41569-023-00934-7The link between migraine and cardiovascular disease is complex and involves overlapping mechanisms, such as endovascular disturbances. Challenges in measuring migraine, in distinguishing between causation and prediction, and in the understanding of clinical implications highlight the need for further research to guide treatment and cardiovascular risk assessment for the millions of individuals living with migraine. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 18, 2023 Category: Cardiology Authors: Tobias Kurth Pamela M. Rist Source Type: research
Immunomodulation and immunopharmacology in heart failure
Nature Reviews Cardiology, Published online: 14 September 2023; doi:10.1038/s41569-023-00919-6In this Review, the authors discuss the clinical and experimental data on immunomodulatory effects of evidence-based treatments for heart failure and their primary mechanisms of action, and highlight potential therapeutic targets and opportunities for the development and application of novel immunomodulatory treatments for heart failure. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 14, 2023 Category: Cardiology Authors: George Markousis-Mavrogenis Lukas Baumhove Ali A. Al-Mubarak Joseph Pierre Aboumsallem Nils Bomer Adriaan A. Voors Peter van der Meer Source Type: research
Semaglutide is beneficial in patients with HFpEF and obesity
Nature Reviews Cardiology, Published online: 14 September 2023; doi:10.1038/s41569-023-00935-6In patients with heart failure (HF) with preserved ejection fraction and obesity, treatment with the glucagon-like peptide 1 receptor agonist semaglutide (2.4 mg) leads to large reductions in HF-related symptoms and physical limitations, improves exercise function and decreases body weight compared with placebo, according to the STEP-HFpEF trial. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 14, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Age-induced senescence impairs the neurovascular interface in the heart
Nature Reviews Cardiology, Published online: 13 September 2023; doi:10.1038/s41569-023-00936-5An interaction between blood vessels and nerve fibres in the heart contributes to the decline in nerve density in the ageing left ventricle, potentially increasing susceptibility to arrhythmias. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 13, 2023 Category: Cardiology Authors: Jennifer Harman Source Type: research
Complete revascularization in MI: role in older patients and optimal timing
Nature Reviews Cardiology, Published online: 13 September 2023; doi:10.1038/s41569-023-00933-8The FIRE trial showed that complete revascularization improves outcomes in older patients with myocardial infarction (MI) and multivessel disease compared with culprit-lesion-only revascularization, whereas the MULTISTARS AMI trial reported that immediate multivessel revascularization is non-inferior to staged revascularization in patients with ST-segment elevation MI. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 13, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Catheter ablation improves outcomes in patients with AF and end-stage HF
Nature Reviews Cardiology, Published online: 11 September 2023; doi:10.1038/s41569-023-00932-9In the CASTLE HTx trial, patients with symptomatic atrial fibrillation and end-stage heart failure who underwent catheter ablation and received medical therapy had improved outcomes compared with patients who received medical therapy only. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 11, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
VA-ECMO does not increase survival in MI-related cardiogenic shock
Nature Reviews Cardiology, Published online: 06 September 2023; doi:10.1038/s41569-023-00929-4New data from the ECLS-SHOCK trial and a meta-analysis indicate that the routine use of venoarterial extracorporeal membrane oxygenation does not increase survival in patients with myocardial infarction-related cardiogenic shock. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 6, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
New insights into OCT-guided PCI
Nature Reviews Cardiology, Published online: 05 September 2023; doi:10.1038/s41569-023-00930-xTwo clinical trials presented at the ESC Congress 2023 provide conflicting evidence on the use of optical coherence tomography to guide percutaneous coronary intervention. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 5, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
No benefit of colchicine to prevent AF or myocardial injury after non-cardiac surgery
Nature Reviews Cardiology, Published online: 04 September 2023; doi:10.1038/s41569-023-00928-5According to data from the COP-AF trial, anti-inflammatory therapy with colchicine does not reduce the risk of perioperative atrial fibrillation or myocardial injury in patients undergoing major non-cardiac thoracic surgery. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 4, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Circadian medicine: a critical strategy for cardiac care
Nature Reviews Cardiology, Published online: 29 August 2023; doi:10.1038/s41569-023-00925-8In patients with an acute myocardial infarction, disrupted circadian rhythms during the initial days in the cardiac intensive care unit, caused by factors such as noise, excessive night-time light and frequent patient–staff interactions, can have devastating effects on cardiac repair and long-term prognosis. Providing care that aligns with the patient’s natural circadian rhythms is critical for optimum long-term recovery. Incorporating ‘circadian medicine’ into clinical practice will provide important health-care benefits. (S...
Source: Nature Reviews Cardiology - August 29, 2023 Category: Cardiology Authors: Michael J. Sole Tami A. Martino Source Type: research
