Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges

Nature Reviews Cardiology, Published online: 26 May 2023; doi:10.1038/s41569-023-00887-xIn this Review, Ritterhoff and Tian describe the metabolic reprogramming that occurs in cardiac hypertrophy and heart failure; discuss the contribution of metabolism to energy-generating and non-energy-generating functions, including signalling, protein function and gene expression regulation; and highlight the role of metabolism in non-cardiomyocytes and the potential to develop metabolic therapies for heart failure.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research