The contribution of the exposome to the burden of cardiovascular disease
Nature Reviews Cardiology, Published online: 10 May 2023; doi:10.1038/s41569-023-00873-3In this Review, Münzel and colleagues describe the exposome concept with a focus on environmental physical and chemical exposures and their effects on the burden of cardiovascular disease. Additionally, they discuss selected exposome studies and the relevance of the exposome concept for future health research and preventive medicine. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 10, 2023 Category: Cardiology Authors: Thomas M ünzel Mette S ørensen Omar Hahad Mark Nieuwenhuijsen Andreas Daiber Source Type: research
A role for lipophagy in atherosclerosis
Nature Reviews Cardiology, Published online: 09 May 2023; doi:10.1038/s41569-023-00885-zLipophagy is a type of selective autophagy that targets lipid droplets for degradation. Since the discovery of lipophagy in 2009, research has uncovered a central role for this process in cellular lipid metabolism, including in atherogenic foam cells. Therefore, increasing lipophagy might be a therapeutic target to reverse lipid build-up in atherosclerosis. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - May 9, 2023 Category: Cardiology Authors: Thomas Laval Mireille Ouimet Source Type: research
A high-salt diet promotes atherosclerosis by altering haematopoiesis
Nature Reviews Cardiology, Published online: 24 April 2023; doi:10.1038/s41569-023-00879-xExcessive salt intake is a known risk factor for cardiovascular disease commonly associated with hypertension. However, we propose that a high-salt diet can promote cardiovascular and other diseases independently of high blood pressure through inflammatory pathways that increase the production of myeloid cells. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 24, 2023 Category: Cardiology Authors: Man K. S. Lee Andrew J. Murphy Source Type: research
AI outperforms sonographers at diagnosing cardiac function on echocardiography
Nature Reviews Cardiology, Published online: 19 April 2023; doi:10.1038/s41569-023-00878-yAn artificial intelligence-guided workflow for initial evaluation of left ventricular ejection fraction in echocardiography is non-inferior to initial assessment by a sonographer, according to findings from a blinded, randomized, non-inferiority clinical trial. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 19, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
The bidirectional association between atrial fibrillation and myocardial infarction
Nature Reviews Cardiology, Published online: 17 April 2023; doi:10.1038/s41569-023-00857-3A bidirectional relationship exists between atrial fibrillation (AF) and myocardial infarction (MI) as a result of shared risk factors and both direct and indirect mechanisms. In this Review, Frederiksen and colleagues discuss the pathogenesis, prevention and management of AF in patients with MI and of MI in patients with AF. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 17, 2023 Category: Cardiology Authors: Tanja Charlotte Frederiksen Christina Catherine Dahm Sarah R. Preis Honghuang Lin Ludovic Trinquart Emelia J. Benjamin Jelena Kornej Source Type: research
Novel and future lipid-modulating therapies for the prevention of cardiovascular disease
Nature Reviews Cardiology, Published online: 13 April 2023; doi:10.1038/s41569-023-00860-8In this Review, the authors discuss current treatment regimens for lowering plasma LDL cholesterol levels to reduce the risk of cardiovascular disease, highlight treatment gaps and challenges, as well as describe opportunities raised by novel available therapies and potential future therapeutic approaches. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 13, 2023 Category: Cardiology Authors: Julia Brandts Kausik K. Ray Source Type: research
Improving the cardiovascular health care of transgender and non-binary persons
Nature Reviews Cardiology, Published online: 11 April 2023; doi:10.1038/s41569-023-00871-5Research consistently shows that gender-affirming practices improve markers of cardiovascular health. Consequently, the focus of the management of the cardiovascular health of transgender and non-binary populations should not be on their hormone therapies and surgical histories, but should instead be rooted in the routine screening of cardiovascular risk factors. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 11, 2023 Category: Cardiology Authors: Arjee Restar Carl G. Streed Jr Source Type: research
Factor XI inhibitors in patients with cardiovascular disease and a high risk of bleeding: a cautionary tale
Nature Reviews Cardiology, Published online: 05 April 2023; doi:10.1038/s41569-023-00872-4Factor XIa inhibitors are being tested in clinical trials, with the assumption that these agents are as effective as direct oral anticoagulants but cause fewer bleeding events. Findings from phase II trials of direct inhibitors of factor XIa for the prevention of first-ever and recurrent ischaemic stroke or recurrent major coronary artery events suggest fewer bleeding events but with uncertainty about efficacy. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 5, 2023 Category: Cardiology Authors: Bruna Gigante Hugo ten Cate Source Type: research
Increased degradation of desmosomal proteins in ACM
Nature Reviews Cardiology, Published online: 05 April 2023; doi:10.1038/s41569-023-00874-2Desmosomal protein degradation that occurs via a mechanism involving the ubiquitin–proteasome system might underlie the development of arrhythmogenic cardiomyopathy. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 5, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Current concepts and novel targets for antiplatelet therapy
Nature Reviews Cardiology, Published online: 04 April 2023; doi:10.1038/s41569-023-00854-6In this Review, Gawaz and colleagues discuss the pathophysiological role of platelets in acute myocardial ischaemia, vascular inflammation and atherosclerotic progression, summarize the current clinical concepts in antiplatelet therapy and describe novel therapeutic targets for antiplatelet drugs that are currently in development. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 4, 2023 Category: Cardiology Authors: Meinrad Gawaz Tobias Geisler Oliver Borst Source Type: research
Implementing LGBTQ-inclusive policies for cardiology practice and the workforce
Nature Reviews Cardiology, Published online: 31 March 2023; doi:10.1038/s41569-023-00870-6Establishing and enforcing LGBTQ-inclusive policies at the national, state and institutional level are essential for advancing health equity and ensuring the highest quality cardiology workforce. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 31, 2023 Category: Cardiology Authors: Tonia Poteat Mabel Toribio Source Type: research
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action
Nature Reviews Cardiology, Published online: 28 March 2023; doi:10.1038/s41569-023-00849-3Glucagon-like peptide 1 (GLP1) receptor agonists reduce the rate of major adverse cardiovascular events in people with type 2 diabetes mellitus. In this Review, Ussher and Drucker discuss the possible mechanisms of cardiovascular benefit of GLP1 receptor agonists and highlight the novel GLP1-based multi-agonists currently in development. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 28, 2023 Category: Cardiology Authors: John R. Ussher Daniel J. Drucker Source Type: research
Non-thermal ablation of AF is safe and effective
Nature Reviews Cardiology, Published online: 21 March 2023; doi:10.1038/s41569-023-00865-3According to findings from the PULSED AF trial, pulsed field ablation for atrial fibrillation is associated with a very low incidence of serious procedure-related adverse events and has an effectiveness consistent with that of established thermal ablation methods. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 21, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Suitability of TAVI in low-risk patients
Nature Reviews Cardiology, Published online: 21 March 2023; doi:10.1038/s41569-023-00862-6In the Evolut Low Risk study, transcatheter aortic valve implantation in low-risk patients with severe aortic stenosis compared favourably with surgical aortic valve replacement in terms of all-cause mortality or disabling stroke at 3 years. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 21, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Immediate non-inferior to staged complete revascularization
Nature Reviews Cardiology, Published online: 21 March 2023; doi:10.1038/s41569-023-00867-1Immediate complete revascularization is as safe and effective as staged complete revascularization in patients with acute coronary syndrome and multivessel disease, according to findings from the BIOVASC trial. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 21, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
