Flow-induced reprogramming of endothelial cells in atherosclerosis

Nature Reviews Cardiology, Published online: 24 May 2023; doi:10.1038/s41569-023-00883-1In this Review, Jo and colleagues discuss blood flow-induced mechanisms involved in endothelial cell dysfunction and atherosclerosis, including the emerging concept of disturbed-flow-induced reprogramming of endothelial cells as a pro-atherogenic mechanism, and highlight the therapeutic potential of targeting of flow-sensitive genes, proteins and pathways.

Source: Nature Reviews Cardiology - May 24, 2023 Category: Cardiology Authors: Ian A. Tamargo Kyung In Baek Yerin Kim Christian Park Hanjoong Jo Source Type: research