FGF23 and klotho at the intersection of kidney and cardiovascular disease
Nature Reviews Cardiology, Published online: 13 July 2023; doi:10.1038/s41569-023-00903-0In this Review, the authors present an overview of the role of fibroblast growth factor 23 (FGF23) and klotho in normal mineral homeostasis, discuss disordered mineral homeostasis in chronic kidney disease (CKD), and explore CKD-associated FGF23 excess and klotho deficiency as novel risk factors and potential therapeutic targets for cardiovascular disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - July 13, 2023 Category: Cardiology Authors: Daniel Edmonston Alexander Grabner Myles Wolf Source Type: research
RAPID return to sinus rhythm after SVT using intranasal etripamil
Nature Reviews Cardiology, Published online: 03 July 2023; doi:10.1038/s41569-023-00908-9In the multicentre, randomized, placebo-controlled RAPID trial, use of symptom-prompted, self-administered, intranasally delivered etripamil was safe and superior to placebo for the conversion of paroxysmal superventricular tachycardia to sinus rhythm. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - July 3, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Ruxolitinib is a CaMKII inhibitor that can be repurposed to prevent arrhythmias
Nature Reviews Cardiology, Published online: 03 July 2023; doi:10.1038/s41569-023-00910-1The FDA-approved drug ruxolitinib has been identified as an inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) that has the potential to be repurposed to treat arrhythmias induced by CaMKII hyperactivity. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - July 3, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Testosterone-replacement therapy does not increase cardiac events in men with hypogonadism
Nature Reviews Cardiology, Published online: 30 June 2023; doi:10.1038/s41569-023-00909-8Testosterone-replacement therapy in men with hypogonadism and a high risk of cardiovascular disease does not increase the risk of adverse cardiac events, according to data from the TRAVERSE trial. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 30, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
IL-6R antagonism ameliorates atherosclerosis linked to Tet2-related clonal haematopoiesis
Nature Reviews Cardiology, Published online: 26 June 2023; doi:10.1038/s41569-023-00907-wLiu and colleagues demonstrate the crucial role of IL-6 signalling in the development of atherosclerosis driven by Tet2-related clonal haematopoiesis. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 26, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Low alcohol intake might lower CVD risk by reducing stress-related brain activity
Nature Reviews Cardiology, Published online: 26 June 2023; doi:10.1038/s41569-023-00906-xNew research shows that the reduced risk of major adverse cardiovascular events associated with light or moderate alcohol consumption is partly mediated by attenuation of the activity of a stress-related neural network. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 26, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Author Correction: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms
Nature Reviews Cardiology, Published online: 21 June 2023; doi:10.1038/s41569-023-00904-zAuthor Correction: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 21, 2023 Category: Cardiology Authors: Stephane Heymans Leslie T. Cooper Source Type: research
Unravelling the genetic heart–brain connection using MRI
Nature Reviews Cardiology, Published online: 19 June 2023; doi:10.1038/s41569-023-00905-yGenetic analysis of multiorgan imaging data provided novel insights into the shared biology between the heart and the brain. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 19, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Trained immunity in atherosclerotic cardiovascular disease
Nature Reviews Cardiology, Published online: 15 June 2023; doi:10.1038/s41569-023-00894-yIn this Review, Riksen and colleagues discuss the molecular and cellular mechanisms of trained immunity, the activation of these mechanisms by cardiovascular risk factors, and how trained immunity might contribute to atherosclerosis and atherosclerotic cardiovascular disease. The authors also propose potential strategies for the therapeutic modulation of trained immunity in atherosclerotic cardiovascular disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 15, 2023 Category: Cardiology Authors: Niels P. Riksen Siroon Bekkering Willem J. M. Mulder Mihai G. Netea Source Type: research
International Atherosclerosis Society guidance for implementing best practice in the care of familial hypercholesterolaemia
Nature Reviews Cardiology, Published online: 15 June 2023; doi:10.1038/s41569-023-00892-0Familial hypercholesterolaemia (FH) is a preventable cause of premature coronary artery disease and death. This guidance article from the International Atherosclerosis Society provides a comprehensive overview of FH care that includes recommendations on the detection and management of patients with FH, as well as strategies to maximize implementation. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 15, 2023 Category: Cardiology Authors: Gerald F. Watts Samuel S. Gidding Robert A. Hegele Frederick J. Raal Amy C. Sturm Laney K. Jones Mitchell N. Sarkies Khalid Al-Rasadi Dirk J. Blom Magdalena Daccord Sarah D. de Ferranti Emanuela Folco Peter Libby Pedro Mata Hapizah M. Nawawi Uma Ramaswami Source Type: research
Interplay of hypoxia-inducible factors and oxygen therapy in cardiovascular medicine
Nature Reviews Cardiology, Published online: 12 June 2023; doi:10.1038/s41569-023-00886-yThe benefits of oxygen therapy for the treatment of cardiovascular disease are unclear, and findings from preclinical studies have suggested potential adverse effects associated with its excessive use. In this Review, Eltzschig and colleagues provide an overview of studies on oxygen therapy for various cardiovascular conditions and describe alternative therapeutic strategies that target oxygen-sensing pathways. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 12, 2023 Category: Cardiology Authors: Yafen Liang Wei Ruan Yandong Jiang Richard Smalling Xiaoyi Yuan Holger K. Eltzschig Source Type: research
Sacubitril–valsartan shows benefit in heart failure with ejection fraction of >40%
Nature Reviews Cardiology, Published online: 07 June 2023; doi:10.1038/s41569-023-00897-9In a diverse population of patients with heart failure with mildly reduced or preserved ejection fraction stabilized after a recent worsening heart failure event, treatment with sacubitril–valsartan induces greater reductions in plasma NT-proBNP levels and is associated with clinical benefit compared with valsartan alone, despite a higher rate of symptomatic hypotension. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 7, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Antibody treatment to deplete transthyretin amyloid deposits in the heart
Nature Reviews Cardiology, Published online: 07 June 2023; doi:10.1038/s41569-023-00899-7An antibody-based therapy for transthyretin amyloid cardiomyopathy is safe, and initial findings from a phase I trial suggest that it might deplete amyloid deposits in the heart. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 7, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Implantable haemodynamic sensor to remotely MONITOR HF
Nature Reviews Cardiology, Published online: 06 June 2023; doi:10.1038/s41569-023-00896-wResults from the MONITOR-HF trial show that remote monitoring of pulmonary artery pressure using the implantable CardioMEMS sensor in patients with chronic heart failure improves quality of life and reduces hospitalizations. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 6, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
A fatty acid from mother’s milk drives cardiomyocyte maturation in newborn mice
Nature Reviews Cardiology, Published online: 06 June 2023; doi:10.1038/s41569-023-00898-8The essential omega-6 polyunsaturated fatty acid γ-linolenic acid present in maternal milk coordinates cardiac adaptation and survival in newborn mice, according to a new study. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - June 6, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
