Self-monitoring strategy reduces postpartum hypertension and cardiac remodelling
Nature Reviews Cardiology, Published online: 28 November 2023; doi:10.1038/s41569-023-00966-zIn women with elevated levels of blood pressure during pregnancy, the use of a physician-guided remote telemonitoring programme during the postpartum period improves BP control, according to findings from the POP-HT trial. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 28, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Aspirin exclusion in patients with an LVAD
Nature Reviews Cardiology, Published online: 27 November 2023; doi:10.1038/s41569-023-00965-0Data from the ARIES-HM3 trial show that excluding aspirin from the antithrombotic regimen in patients with advanced heart failure and a left ventricular assist device reduces the number of bleeding events and does not increase the risk of thromboembolism. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 27, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction
Nature Reviews Cardiology, Published online: 24 November 2023; doi:10.1038/s41569-023-00953-4Coronary microvascular obstruction and dysfunction (CMVO) is common in patients with ST-segment elevation myocardial infarction (STEMI) despite prompt reperfusion. In this Review, the authors discuss the mechanisms of CMVO as well as strategies to reduce its incidence and improve prognosis. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 24, 2023 Category: Cardiology Authors: Mattia Galli Giampaolo Niccoli Gianluigi De Maria Salvatore Brugaletta Rocco A. Montone Rocco Vergallo Stefano Benenati Giulia Magniani Domenico D ’Amario Italo Porto Francesco Burzotta Antonio Abbate Dominick J. Angiolillo Filippo Crea Source Type: research
Long non-coding RNAs in cardiac hypertrophy and heart failure: functions, mechanisms and clinical prospects
Nature Reviews Cardiology, Published online: 20 November 2023; doi:10.1038/s41569-023-00952-5In this Review, Mably and Wang summarize the expression, functions and molecular mechanisms of long non-coding RNAs (lncRNAs) in cardiac hypertrophy and failure. The authors also discuss lncRNAs as novel targets for the diagnosis and treatment of these conditions. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 20, 2023 Category: Cardiology Authors: John D. Mably Da-Zhi Wang Source Type: research
Revealing the structure of the cardiac myosin filament
Nature Reviews Cardiology, Published online: 14 November 2023; doi:10.1038/s41569-023-00960-5Two new studies using cryo-electron microscopy describe the structure and conformation of myosin in the cardiac thick filaments and how it interacts with other thick-filament proteins, such as titin and cardiac myosin-binding protein C, in mammalian hearts. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 14, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Explaining how a cardiac reflex causes syncope
Nature Reviews Cardiology, Published online: 14 November 2023; doi:10.1038/s41569-023-00961-4Activation of a specific set of vagal sensory neurons connecting the ventricular wall of the heart to the area postrema in the brainstem causes mice to faint. This finding defines a cardiac reflex that recapitulates characteristics of human syncope. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 14, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Disrupting a cell-specific miRNA–CXCR4 interaction is atheroprotective in mice
Nature Reviews Cardiology, Published online: 13 November 2023; doi:10.1038/s41569-023-00959-yAn approach that increases the expression of the chemokine receptor CXCR4 in vascular cells by targeting a microRNA-based repressive pathway attenuates atherosclerosis in mice and promotes atheroprotective functions in human and mouse vascular cells in vitro. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 13, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Lipoprotein(a), platelet function and cardiovascular disease
Nature Reviews Cardiology, Published online: 08 November 2023; doi:10.1038/s41569-023-00947-2In this Review, Tsimikas and co-workers re-examine the role of lipoprotein(a) in the regulation of platelet function and propose areas for future research to define its clinical relevance for cardiovascular disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 8, 2023 Category: Cardiology Authors: Harpreet S. Bhatia Richard C. Becker Gregor Leibundgut Mitul Patel Paul Lacaze Andrew Tonkin Jagat Narula Sotirios Tsimikas Source Type: research
Drug-eluting resorbable scaffolds are superior to angioplasty for infrapopliteal artery disease
Nature Reviews Cardiology, Published online: 06 November 2023; doi:10.1038/s41569-023-00956-1In the LIFE-BTK trial, treatment with an everolimus-eluting resorbable scaffold was superior to angioplasty in improving clinical outcomes in patients with chronic limb-threatening ischaemia due to infrapopliteal artery disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 6, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Patisiran is beneficial for the treatment of TTR cardiac amyloidosis
Nature Reviews Cardiology, Published online: 06 November 2023; doi:10.1038/s41569-023-00955-2Treatment with the small interfering RNA patisiran preserves functional capacity and improves health status and quality of life in patients with transthyretin cardiac amyloidosis, according to data from the 12-month double-blind period of the ongoing APOLLO-B trial. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 6, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
Nature Reviews Cardiology, Published online: 03 November 2023; doi:10.1038/s41569-023-00946-3The NLRP3 inflammasome can sense cardiac ischaemic and non-ischaemic injury, amplify the inflammatory response and induce inflammatory cell death. In this Review, Toldo and Abbate describe the role of the NLRP3 inflammasome in numerous cardiac pathologies and summarize evidence on the use of agents targeting the NLRP3 inflammasome and related cytokines. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 3, 2023 Category: Cardiology Authors: Stefano Toldo Antonio Abbate Source Type: research
Long-term outcomes and device failure after TAVI
Nature Reviews Cardiology, Published online: 03 November 2023; doi:10.1038/s41569-023-00954-3Transcatheter aortic valve implantation (TAVI) has become an important treatment option for aortic stenosis, even among younger patients, with similar rates of efficacy as compared with surgical valve replacement. However, complications including device failure persist; these can be addressed by surgical explantation and repeat TAVI. Ongoing research emphasizes the long-term potential of TAVI as an alternative to surgical intervention for aortic stenosis. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 3, 2023 Category: Cardiology Authors: Marco Barbanti John G. Webb Source Type: research
2023 World Heart Federation guidelines for the echocardiographic diagnosis of rheumatic heart disease
Nature Reviews Cardiology, Published online: 02 November 2023; doi:10.1038/s41569-023-00940-9A panel of experts from the World Heart Federation provide a revised set of guidelines for the echocardiographic detection of rheumatic heart disease (RHD) in patients living in RHD-endemic regions. The guidelines provide updated screening and confirmatory criteria, as well as a new stage-based classification of RHD based on risk of disease progression, which will improve the diagnosis and subsequent management of patients with RHD. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 2, 2023 Category: Cardiology Authors: Joselyn Rwebembera James Marangou Julius Chacha Mwita Ana Olga Mocumbi Cleonice Mota Emmy Okello Bruno Nascimento Lene Thorup Andrea Beaton Joseph Kado Alexander Kaethner Raman Krishna Kumar John Lawrenson Eloi Marijon Mariana Mirabel Maria Carmo Pereira Source Type: research
Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention
Nature Reviews Cardiology, Published online: 25 October 2023; doi:10.1038/s41569-023-00943-6In this Perspective article, Garg and colleagues discuss the evidence linking abnormal aortic flow patterns with adverse cardiovascular outcomes and describe how changes in aortic flow can be targeted by novel aortic valve interventions. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 25, 2023 Category: Cardiology Authors: Pankaj Garg Michael Markl Janarthanan Sathananthan Stephanie L. Sellers Chris Meduri Jo ão Cavalcante Source Type: research
Defining iron deficiency in patients with heart failure
Nature Reviews Cardiology, Published online: 24 October 2023; doi:10.1038/s41569-023-00951-6For patients with heart failure and reduced left ventricular ejection fraction, intravenous iron is likely to deliver clinical and prognostic benefits for those with anaemia and transferrin saturation (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 24, 2023 Category: Cardiology Authors: John G. F. Cleland Source Type: research
