Patisiran is beneficial for the treatment of TTR cardiac amyloidosis
Nature Reviews Cardiology, Published online: 06 November 2023; doi:10.1038/s41569-023-00955-2Treatment with the small interfering RNA patisiran preserves functional capacity and improves health status and quality of life in patients with transthyretin cardiac amyloidosis, according to data from the 12-month double-blind period of the ongoing APOLLO-B trial. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 6, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
Nature Reviews Cardiology, Published online: 03 November 2023; doi:10.1038/s41569-023-00946-3The NLRP3 inflammasome can sense cardiac ischaemic and non-ischaemic injury, amplify the inflammatory response and induce inflammatory cell death. In this Review, Toldo and Abbate describe the role of the NLRP3 inflammasome in numerous cardiac pathologies and summarize evidence on the use of agents targeting the NLRP3 inflammasome and related cytokines. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 3, 2023 Category: Cardiology Authors: Stefano Toldo Antonio Abbate Source Type: research
Long-term outcomes and device failure after TAVI
Nature Reviews Cardiology, Published online: 03 November 2023; doi:10.1038/s41569-023-00954-3Transcatheter aortic valve implantation (TAVI) has become an important treatment option for aortic stenosis, even among younger patients, with similar rates of efficacy as compared with surgical valve replacement. However, complications including device failure persist; these can be addressed by surgical explantation and repeat TAVI. Ongoing research emphasizes the long-term potential of TAVI as an alternative to surgical intervention for aortic stenosis. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 3, 2023 Category: Cardiology Authors: Marco Barbanti John G. Webb Source Type: research
2023 World Heart Federation guidelines for the echocardiographic diagnosis of rheumatic heart disease
Nature Reviews Cardiology, Published online: 02 November 2023; doi:10.1038/s41569-023-00940-9A panel of experts from the World Heart Federation provide a revised set of guidelines for the echocardiographic detection of rheumatic heart disease (RHD) in patients living in RHD-endemic regions. The guidelines provide updated screening and confirmatory criteria, as well as a new stage-based classification of RHD based on risk of disease progression, which will improve the diagnosis and subsequent management of patients with RHD. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 2, 2023 Category: Cardiology Authors: Joselyn Rwebembera James Marangou Julius Chacha Mwita Ana Olga Mocumbi Cleonice Mota Emmy Okello Bruno Nascimento Lene Thorup Andrea Beaton Joseph Kado Alexander Kaethner Raman Krishna Kumar John Lawrenson Eloi Marijon Mariana Mirabel Maria Carmo Pereira Source Type: research
Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention
Nature Reviews Cardiology, Published online: 25 October 2023; doi:10.1038/s41569-023-00943-6In this Perspective article, Garg and colleagues discuss the evidence linking abnormal aortic flow patterns with adverse cardiovascular outcomes and describe how changes in aortic flow can be targeted by novel aortic valve interventions. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 25, 2023 Category: Cardiology Authors: Pankaj Garg Michael Markl Janarthanan Sathananthan Stephanie L. Sellers Chris Meduri Jo ão Cavalcante Source Type: research
Defining iron deficiency in patients with heart failure
Nature Reviews Cardiology, Published online: 24 October 2023; doi:10.1038/s41569-023-00951-6For patients with heart failure and reduced left ventricular ejection fraction, intravenous iron is likely to deliver clinical and prognostic benefits for those with anaemia and transferrin saturation (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 24, 2023 Category: Cardiology Authors: John G. F. Cleland Source Type: research
SARS-CoV-2 infects macrophages in coronary atherosclerotic plaques
Nature Reviews Cardiology, Published online: 18 October 2023; doi:10.1038/s41569-023-00949-0SARS-CoV-2 infects macrophages, especially lipid-laden foam cells, in coronary atherosclerotic plaques in patients with COVID-19; this infection initiates a strong proatherogenic inflammatory response, which might contribute to the ischaemic cardiovascular complications in these patients. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 18, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Sirtuin 2 protects against cardiac ageing
Nature Reviews Cardiology, Published online: 18 October 2023; doi:10.1038/s41569-023-00950-7NAD-dependent protein deacetylase sirtuin 2 is a key protective mediator against cardiac ageing, according to a study in non-human primates. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 18, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Depolarization of fibroblasts in scar tissue drives cardiac excitation
Nature Reviews Cardiology, Published online: 17 October 2023; doi:10.1038/s41569-023-00948-1In a study published in Science, Wang and colleagues show that excited cardiomyocytes couple to fibroblasts via gap-junctional and non-gap-junctional (ephaptic) coupling. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 17, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Oxidized phospholipids in cardiovascular disease
Nature Reviews Cardiology, Published online: 17 October 2023; doi:10.1038/s41569-023-00937-4In this Review, Tsimikas and Witztum discuss the role of oxidized phospholipids (OxPLs) in atherosclerosis, describe the methods for measuring OxPLs on apolipoprotein B-containing lipoproteins (OxPL–apoB) and their relationship with lipoprotein(a), and discuss the clinical applications of the OxPL–apoB measurement for improving diagnosis, prognosis, risk reclassification and therapeutic interventions in patients with atherosclerotic cardiovascular disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 17, 2023 Category: Cardiology Authors: Sotirios Tsimikas Joseph L. Witztum Source Type: research
Metabolic reprogramming unlocks the regenerative potential of the heart
Nature Reviews Cardiology, Published online: 13 October 2023; doi:10.1038/s41569-023-00945-4The metabolic maturation of mammalian cardiomyocytes that occurs during the early postnatal period shapes the epigenetic landscape of cardiomyocytes and creates a barrier for cell division, but reversing this remodelling process can restore the reparative capacity of the heart in mice, according to a study published in Nature. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 13, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Capturing and analysing the first vertebrate heartbeat
Nature Reviews Cardiology, Published online: 13 October 2023; doi:10.1038/s41569-023-00944-5In a study published in Nature, Jia and colleagues use advanced optical electrophysiology tools coupled with 3D-printed moulds to capture the very first heartbeat of zebrafish. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 13, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Socioeconomic inequalities in cardiovascular disease: a causal perspective
Nature Reviews Cardiology, Published online: 11 October 2023; doi:10.1038/s41569-023-00941-8Low socioeconomic position (SEP) is associated with an increased risk of cardiovascular disease (CVD), but whether this association is causal is uncertain. In this Review, Bann and colleagues discuss how evidence from divergent study designs can help in understanding the causal relationship between SEP and CVD and how this relationship might have been affected by the COVID-19 pandemic. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 11, 2023 Category: Cardiology Authors: David Bann Liam Wright Alun Hughes Nish Chaturvedi Source Type: research
Cardiovascular physiology and pathophysiology at high altitude
Nature Reviews Cardiology, Published online: 02 October 2023; doi:10.1038/s41569-023-00924-9Hypoxic conditions encountered at high altitude affect all physiological functions. In this Review, Richalet et al. describe the cardiovascular responses to acute and chronic exposure to hypoxia and provide recommendations that clinicians can give to patients with cardiovascular disease who wish to travel to high-altitude destinations. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 2, 2023 Category: Cardiology Authors: Jean-Paul Richalet Eric Hermand Fran çois J. Lhuissier Source Type: research
Cardiovascular benefits of fermented foods and beverages: still up for debate
Nature Reviews Cardiology, Published online: 02 October 2023; doi:10.1038/s41569-023-00938-3Despite the high consumption of fermented foods and beverages worldwide, their role in a healthy diet is still up for debate. Some fermented beverages have been demonstrated to protect against cardiovascular disease, but many aspects of the effects of fermented foods on cardiovascular health are uncertain. Better-designed studies are warranted. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 2, 2023 Category: Cardiology Authors: Ramon Estruch Rosa M. Lamuela-Ravent ós Source Type: research
