Hormone therapy ameliorates ICI-related myocarditis in mice
Nature Reviews Cardiology, Published online: 16 November 2022; doi:10.1038/s41569-022-00807-5Some clinical observations suggest that female patients are more susceptible to myocarditis induced by immune-checkpoint-inhibitor therapies. A new study recapitulates this female predisposition in mice and provides mechanistic and biological plausibility, and suggests that hormone therapy could help to treat myocarditis by promoting the expression of MANF, a protein related to the unfolded protein response. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 16, 2022 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
siRNA therapy markedly reduces Lp(a) levels
Nature Reviews Cardiology, Published online: 16 November 2022; doi:10.1038/s41569-022-00813-7Olpasiran, a small interfering RNA (siRNA) that reduces lipoprotein(a) (Lp(a)) production in the liver, administered every 12 weeks induces a pronounced and sustained decrease in the plasma levels of Lp(a) in patients with established atherosclerotic cardiovascular disease, according to findings from the OCEAN(a)-DOSE trial. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 16, 2022 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Cardiac fibroblasts and mechanosensation in heart development, health and disease
Nature Reviews Cardiology, Published online: 14 November 2022; doi:10.1038/s41569-022-00799-2A growing body of evidence suggests that the mechanical functions of cardiac fibroblasts are an active and necessary component of myocardial growth and homeostasis. In this Review, Van Linthout and colleagues describe cell mechanosensation as a regulator of cardiac maturation and disease, and summarize the evidence showing that remodelling of the cardiac extracellular matrix, as a result of disease, can induce changes in the mechanical properties of the myocardium. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 14, 2022 Category: Cardiology Authors: Maurizio Pesce Georg N. Duda Giancarlo Forte Henrique Girao Angel Raya Pere Roca-Cusachs Joost P. G. Sluijter Carsten Tsch öpe Sophie Van Linthout Source Type: research
Atrial fibrillation screening perspectives after STROKESTOP and LOOP
Nature Reviews Cardiology, Published online: 14 November 2022; doi:10.1038/s41569-022-00803-9Screening for atrial fibrillation in high-risk populations could contribute to the prevention of cardioembolic stroke. Randomized trials of atrial fibrillation screening are directionally favourable but underpowered for stroke risk assessment; nevertheless, meta-analysis results are encouraging. Consumer-facing wearable devices can detect unknown atrial fibrillation at scale, although they are mostly used by individuals at low risk of stroke. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 14, 2022 Category: Cardiology Authors: Ben Freedman Renate B. Schnabel Source Type: research
Inhibiting aldosterone synthase reduces blood pressure
Nature Reviews Cardiology, Published online: 14 November 2022; doi:10.1038/s41569-022-00810-wInhibiting aldosterone synthase reduces blood pressure (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 14, 2022 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Alternative defibrillation strategies improve outcomes
Nature Reviews Cardiology, Published online: 14 November 2022; doi:10.1038/s41569-022-00808-4Alternative strategies for defibrillation improve outcomes in patients with refractory ventricular fibrillation, according to findings from the DOSE VF trial. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 14, 2022 Category: Cardiology Authors: Gregory B. Lim Source Type: research
No benefit of routine steroids in infant heart surgery
Nature Reviews Cardiology, Published online: 14 November 2022; doi:10.1038/s41569-022-00812-8No benefit of routine steroids in infant heart surgery (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 14, 2022 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Low-dose LMWH to prevent pregnancy-related VTE
Nature Reviews Cardiology, Published online: 14 November 2022; doi:10.1038/s41569-022-00811-9Low-dose LMWH to prevent pregnancy-related VTE (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 14, 2022 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Statins outperform dietary supplements for LDL-C lowering
Nature Reviews Cardiology, Published online: 14 November 2022; doi:10.1038/s41569-022-00809-3Statins outperform dietary supplements for LDL-C lowering (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 14, 2022 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Temporary mechanical circulatory support devices: practical considerations for all stakeholders
Nature Reviews Cardiology, Published online: 10 November 2022; doi:10.1038/s41569-022-00796-5Originally intended for life-saving salvage therapy, the use of temporary mechanical circulatory support (MCS) devices has become increasingly widespread. In this Review, Salter and colleagues discuss the functionality, indications, management and complications associated with temporary MCS in specific clinical scenarios. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 10, 2022 Category: Cardiology Authors: Benjamin S. Salter Caroline R. Gross Menachem M. Weiner Srinivas R. Dukkipati Gregory W. Serrao Noah Moss Anelechi C. Anyanwu Daniel Burkhoff Anuradha Lala Source Type: research
Gut bacterium protects against atherosclerosis by degrading BCAAs
Nature Reviews Cardiology, Published online: 01 November 2022; doi:10.1038/s41569-022-00802-wA synthetic Ganoderma meroterpene derivative protects against obesity-associated atherosclerosis in mice by increasing the abundance of the gut commensal bacterium Parabacteroides merdae and increasing branched-chain amino acid degradation. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 1, 2022 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Antihypertensive drugs can be taken in the morning or evening
Nature Reviews Cardiology, Published online: 01 November 2022; doi:10.1038/s41569-022-00801-xAccording to the TIME trial, patients can take standard antihypertensive medications either in the morning or in the evening, because the timing of therapy has no significant effect on major cardiovascular outcomes. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - November 1, 2022 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Gender medicine: effects of sex and gender on cardiovascular disease manifestation and outcomes
Nature Reviews Cardiology, Published online: 31 October 2022; doi:10.1038/s41569-022-00797-4In this Review, the authors summarize the evidence on the different effects of sex and gender on the pathogenesis, clinical manifestations and treatment responses of patients with ischaemic heart disease or heart failure. In addition, they highlight unexplored areas of sex-related and gender-related factors in cardiovascular disease such as in individuals with gender dysphoria. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 31, 2022 Category: Cardiology Authors: Vera Regitz-Zagrosek Catherine Gebhard Source Type: research
Epidemiology and prevention of venous thromboembolism
Nature Reviews Cardiology, Published online: 18 October 2022; doi:10.1038/s41569-022-00787-6In this Review, Lutsey and Zakai describe the epidemiology of venous thromboembolism, including incidence, risk factors and outcomes; summarize opportunities for primordial, primary and secondary prevention; and highlight the importance of reducing disparities in venous thromboembolism incidence and management, and opportunities to reduce them. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 18, 2022 Category: Cardiology Authors: Pamela L. Lutsey Neil A. Zakai Source Type: research
The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease
Nature Reviews Cardiology, Published online: 14 October 2022; doi:10.1038/s41569-022-00771-0In this Review, Bäckhed and colleagues summarize the evidence for gut microbiome alterations in cardiometabolic and cardiovascular diseases and the rationale and potential benefit motivating translational approaches to target the gut microbiota and its metabolites for prevention and treatment. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 14, 2022 Category: Cardiology Authors: Rima Mohsen Chakaroun Lisa M. Olsson Fredrik B äckhed Source Type: research
