Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis
Nature Reviews Cardiology, Published online: 17 February 2023; doi:10.1038/s41569-023-00848-4Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 17, 2023 Category: Cardiology Authors: Karan Sud Navneet Narula Elena Aikawa Eloisa Arbustini Philippe Pibarot Giampaolo Merlini Robert S. Rosenson Surya V. Seshan Edgar Argulian Amir Ahmadi Fang Zhou Andre L. Moreira Nancy C ôté Sotirios Tsimikas Valentin Fuster Sam Gandy Robert O. Bonow Ol Source Type: research
Size matters: HDL particle populations and the risk of infection
Nature Reviews Cardiology, Published online: 15 February 2023; doi:10.1038/s41569-023-00844-8Low plasma levels of HDL cholesterol are a risk factor for infection and hospitalization for infectious disease. Recent work suggests that inadequate levels of HDL particles of specific sizes — small and medium — account for this risk. In this Comment, we discuss the mechanistic implications of these observations and the methodologies used to quantify HDL size. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 15, 2023 Category: Cardiology Authors: Jay W. Heinecke W. Sean Davidson Source Type: research
The role of aldehyde dehydrogenase 2 in cardiovascular disease
Nature Reviews Cardiology, Published online: 13 February 2023; doi:10.1038/s41569-023-00839-5Aldehyde dehydrogenase 2 (ALDH2), a key enzyme for the detoxification of alcohol-derived acetaldehyde, has been implicated in the pathogenesis of various types of cardiovascular disease. In this Review, Xu and colleagues present the latest evidence showing a link between the inactivating ALDH2 rs671 polymorphism and an increased or decreased risk of cardiovascular disease such as coronary artery disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 13, 2023 Category: Cardiology Authors: Jian Zhang Yunyun Guo Xiangkai Zhao Jiaojiao Pang Chang Pan Jiali Wang Shujian Wei Xiao Yu Cheng Zhang Yuguo Chen Huiyong Yin Feng Xu Source Type: research
A wearable ultrasonic device to image cardiac function
Nature Reviews Cardiology, Published online: 07 February 2023; doi:10.1038/s41569-023-00843-9Researchers have engineered a wearable device that adheres to the skin and uses ultrasound imaging and a deep learning model to produce a dynamic, real-time assessment of cardiac function. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 7, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Implementing an earlier and more intensive follow-up in acute heart failure: the STRONG-HF and COACH trials
Nature Reviews Cardiology, Published online: 06 February 2023; doi:10.1038/s41569-023-00841-xThe STRONG-HF and COACH trials have shown a reduction in morbidity and mortality in patients with acute decompensated heart failure, for whom therapeutical options are currently limited, using two different approaches that have in common the aim of more effective treatment optimization through a better transition phase from in-hospital to outpatient care. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 6, 2023 Category: Cardiology Authors: Giuseppe M. C. Rosano Gianluigi Savarese Source Type: research
Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome
Nature Reviews Cardiology, Published online: 02 February 2023; doi:10.1038/s41569-023-00842-wThe post-acute sequelae of COVID-19 present major problems for many patients, their physicians and the health-care system. They are unrelated to the severity of the initial infection, are often highly symptomatic and can occur after vaccination. Many sequelae involve cardiovascular autonomic dysfunction, with postural orthostatic tachycardia syndrome in 30% of individuals. Prognosis is unknown, and treatment is still unsatisfactory. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 2, 2023 Category: Cardiology Authors: Artur Fedorowski Richard Sutton Source Type: research
Physicians in the era of technology-enabled diagnostics
Nature Reviews Cardiology, Published online: 24 January 2023; doi:10.1038/s41569-023-00836-8Health-care delivery is evolving, with an increased availability of consumer and medical technology-enabled diagnostic devices powered by artificial intelligence. Physicians need to evolve by deprioritizing old skills in favour of new skills in statistics and medical decision-making psychology. Technology moves fast; physicians will need to pivot and adapt quickly. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 24, 2023 Category: Cardiology Authors: Rashmee U. Shah Source Type: research
Base editing of CaMKIIδ shows promise as cardiac therapy
Nature Reviews Cardiology, Published online: 24 January 2023; doi:10.1038/s41569-023-00838-6CRISPR–Cas9 base editing of the oxidative activation sites of CaMKIIδ protects the heart from ischaemia–reperfusion damage in mice. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 24, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Microbial metabolites reduce SBP in patients with resistant hypertension
Nature Reviews Cardiology, Published online: 23 January 2023; doi:10.1038/s41569-023-00840-yIn treatment-naive patients with essential hypertension, supplementation with prebiotic acetylated and butyrylated high amylose maize starch significantly reduces systolic blood pressure levels compared with placebo. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 23, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Cardiac-resident macrophages protect against sepsis-induced cardiomyopathy
Nature Reviews Cardiology, Published online: 23 January 2023; doi:10.1038/s41569-023-00837-7A subpopulation of cardiac-resident macrophages protect the heart against sepsis-induced cardiomyopathy by scavenging dysfunctional mitochondria ejected from cardiomyocytes; modulation or administration of these macrophages might be a potential therapeutic strategy. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 23, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
Cardiac splicing as a diagnostic and therapeutic target
Nature Reviews Cardiology, Published online: 18 January 2023; doi:10.1038/s41569-022-00828-0Alternative splicing determines which exons are included in mature RNA and accounts for the majority of transcriptomic diversity. In this Review, Gotthardt and colleagues discuss how alternative splicing is regulated in the heart and how it differs in cardiac development, physiological adaptation and pathological remodelling. They also summarize technological advances in the field and potential applications of splicing data in cardiovascular medicine. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 18, 2023 Category: Cardiology Authors: Michael Gotthardt Victor Badillo-Lisakowski Victoria Nicole Parikh Euan Ashley Marta Furtado Maria Carmo-Fonseca Sarah Schudy Benjamin Meder Markus Grosch Lars Steinmetz Claudia Crocini Leslie Leinwand Source Type: research
Nuclear remodelling contributes to cardiac dysfunction during ageing
Nature Reviews Cardiology, Published online: 18 January 2023; doi:10.1038/s41569-023-00832-yA new study shows that age-dependent nuclear remodelling in cardiomyocytes (via age-related loss of nuclear lamins) contributes to cardiac dysfunction through a process that is conserved in flies, mice and nonhuman primates. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 18, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Author Correction: Epidemiology and modifiable risk factors for atrial fibrillation
Nature Reviews Cardiology, Published online: 17 January 2023; doi:10.1038/s41569-023-00834-wAuthor Correction: Epidemiology and modifiable risk factors for atrial fibrillation (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 17, 2023 Category: Cardiology Authors: Adrian D. Elliott Melissa E. Middeldorp Isabelle C. Van Gelder Christine M. Albert Prashanthan Sanders Source Type: research
A machine-learning-derived, in silico marker for CAD identifies underdiagnosed patients
Nature Reviews Cardiology, Published online: 17 January 2023; doi:10.1038/s41569-023-00833-xA machine learning model trained using clinical data from electronic health records generated a novel in silico quantitative score for coronary artery disease (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 17, 2023 Category: Cardiology Authors: Karina Huynh Source Type: research
Infused ECM targets leaky vessels and heals inflamed tissues
Nature Reviews Cardiology, Published online: 17 January 2023; doi:10.1038/s41569-023-00835-9An intravascularly infused extracellular matrix preparation binds to leaky microvasculature, thereby localizing to inflamed tissues and promoting repair and regeneration, and potentially healing damaged tissues ‘from the inside out’. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 17, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research
