Association between Homocysteine and Arterial Stiffness in Women with a History of Preeclampsia
This study was to assess whether Hcy level was independently associated with arterial stiffness in 168 women with a PE history who were analyzed at a 5-year follow-up. Brachial-ankle pulse wave velocity (baPWV) was measured by an automatic pulse-wave analyzer and a value #x3e;1,400 cm/s was defined as high arterial stiffness. Biochemical parameters were recorded and an Hcy value #x3e;10 μmol/L was defined as having hyperhomocysteine (H-Hcy). Variables that were significantly associated with baPWV were tested for independence by multivariate logistic regression analysis. We found that body mass index (OR 1.017, 95% CI 1.00...
Source: Journal of Vascular Research - May 27, 2019 Category: Research Source Type: research
Indoxyl Sulfate-Induced Extracellular Vesicles Released from Endothelial Cells Stimulate Vascular Smooth Muscle Cell Proliferation by Inducing Transforming Growth Factor-Beta Production
Vascular access stenosis predominantly occurs as a result of neointimal hyperplasia (NH) formation at the anastomosis. Moreover, in the presence of NH, transforming growth factor-beta (TGF- β) promotes vascular smooth muscle cell (VSMC) proliferation. Extracellular vesicles (EVs) released by endothelial cells are closely associated with vascular dysfunction. Here, we investigated the effects of EVs on TGF-β signaling and VSMC proliferation. Specifically, EVs were collected from the c ulture medium of indoxyl sulfate (IS)-treated human umbilical vein endothelial cells and used (2 × 106) to stimulate human aortic smooth m...
Source: Journal of Vascular Research - May 14, 2019 Category: Research Source Type: research
Chronological Change of Vascular Reactivity to cGMP Generators in the Balloon-Injured Rat Carotid Artery
Conclusion: Balloon injury alters vascular responsiveness to cGMP generators, which seems to be associated with the form and/or expression of sGC.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - May 14, 2019 Category: Research Source Type: research
Metformin Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Activation of Adenosine Monophosphate-Activated Protein Kinase
The objective of the present study was to investigate the role of autophagy in MET-induced hypoxia PAH protection and the underlying mechanisms. To examine the effects of MET on hypoxia, we treated rats with MET (100 mg/kg/day) after 3 weeks of hypoxia. Hemodynamic changes, weight of the right ventricle/left ventricle plus septum (RV/LV+S) ratio, and lung morphological features were examined after 3 weeks. In addition, alpha smooth muscle actin ( α-SMA), p62, and PCNA were assessed by immunofluorescence and immunohistochemistry staining. BECN-1, LC3B, p62, and activation of adenosine monophosphate-activated protein kinase...
Source: Journal of Vascular Research - May 14, 2019 Category: Research Source Type: research
Digoxin Attenuates Receptor Activation of NF- κB Ligand-Induced Osteoclastogenesis in Macrophages
Conclusions: These results show that digoxin attenuates OCG. By inhibition of HIF-1 α, digoxin decreases OCG through the downregulation of the RANK/RANKL signaling pathway. Therefore, digoxin is a potential candidate for medical treatment of AAAs.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - May 14, 2019 Category: Research Source Type: research
High Sodium Intake Impairs Small Artery Vasoreactivity in vivo in Dahl Salt-Sensitive Rats
The effects of high sodium intake on the functionality of resistance arteries have been repeatedly studied in vitro, but no study has focused on salt-sensitive hypertension in vivo. We studied the in vivo reactivity of mesenteric small arteries (MSAs) to vasoactive agents in Dahl salt-sensitive (DS) rats with various sodium diets. Twenty-four male DS rats were randomized into 3 groups: LS (0.3% NaCl diet), NS (0.6% NaCl diet), and HS (8% NaCl diet). After a 12-week intervention, the diameter changes of the MSAs after noradrenaline (NA) and acetylcholine (ACh) exposure were detected by a microscope, and changes in blood per...
Source: Journal of Vascular Research - May 10, 2019 Category: Research Source Type: research
Analysis of Biological Properties of Human Adult Mesenchymal Stem Cells and Their Effect on Mouse Hind Limb Ischemia
Conclusion: An extensive AMSC biological properties study could be useful to predict the potential clinical efficacy of cells before in vivo transplantation. Thus, peripheral ischemia and possibly other pathologies could benefit from stem cell treatments as shown in our preclinical model in terms of tissue damage repair and regeneration after ischemic injury.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - May 10, 2019 Category: Research Source Type: research
Cardioprotective Effects of Dronedarone Mediated by the Influence on the Expression of Urokinase-Type Plasminogen Activator Receptor
Conclusion: In this in vitro analysis, dronedarone directly increased platelet activation but showed significant direct effects on endothelial cells and indirect effects on platelets on selected markers of atherosclerosis.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - May 10, 2019 Category: Research Source Type: research
Cigarette Smoke Extract Activates Tartrate-Resistant Acid Phosphatase-Positive Macrophage
Conclusions: These results suggest that CSE intensifies OCG in macrophages and promotes arterial aneurysmal progression.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - May 7, 2019 Category: Research Source Type: research
Conference Calendar
J Vasc Res 2019;56:54 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - May 5, 2019 Category: Research Source Type: research
Inhibition of miR-495 Improves Both Vascular Remodeling and Angiogenesis in Pulmonary Hypertension
Conclusions: Our results indicate that AAV9-TuD-miR-495 delivery improves hemodynamic and pulmonary vascular structural changes in PH mice.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - April 26, 2019 Category: Research Source Type: research
Electrical Stimulation Directs Migration, Enhances and Orients Cell Division and Upregulates the Chemokine Receptors CXCR4 and CXCR2 in Endothelial Cells
Natural direct current electric fields (DC EFs) within tissues undergoing angiogenesis have the potential to influence vessel formation, but how they affect endothelial cells is not clear. We therefore quantified behaviours of human umbilical vein endothelial cells (HUVEC) and human microvasculature endothelial cells (HMEC) stimulated by EFsin vitro. Both cell types migrated faster and toward the cathode; HUVECs responded to fields as low as 50mV/mm, but the HMEC threshold was 100 mV/mm. Mitosis was stimulated at 50 mV/mm for HMEC and at 150 mV/mm for HUVECs, but the cleavage plane was oriented orthogonal to the field vect...
Source: Journal of Vascular Research - April 17, 2019 Category: Research Source Type: research
Renovascular Hypertension Aggravates Atherosclerosis in Cholesterol-Fed Rabbits
Conclusions: These results indicate that hyper tension not only enhances atherosclerosis in large arteries including the aorta and coronary arteries but also affects hyaline arteriolosclerosis in small arteries.J Vasc Res 2019;56:28 –38 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - April 15, 2019 Category: Research Source Type: research
Title Page
J Vasc Res 2019;56:I –II (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - March 31, 2019 Category: Research Source Type: research
Abstracts
J Vasc Res 2019;56:1 –134 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - March 31, 2019 Category: Research Source Type: research
