Vitamin D Ameliorates Angiotensin II-Induced Human Endothelial Progenitor Cell Injury via the PPAR- γ/HO-1 Pathway
Vitamin D has an important protective effect on chronic inflammatory disease. Angiotensin II (AngII) triggers vascular damage and plays a key role in vascular diseases via several mechanisms, including inflammation. Conversely, vitamin D has been shown to have an important protective effect on chronic inflammation. There is evidence showing that vitamin D can reverse the effects of AngII, but the molecular mechanisms by which this occurs are not known. Our results demonstrate that vitamin D improved the viability, migration ability, and tube formation of AngII-pretreated endothelial progenitor cells (EPCs) and inhibited th...
Source: Journal of Vascular Research - March 15, 2019 Category: Research Source Type: research
< b > < i > Panax notoginseng < /i > < /b > Saponins Ameliorate Leukocyte Adherence and Cerebrovascular Endothelial Barrier Breakdown upon Ischemia-Reperfusion in Mice
Panax notoginseng saponins (PNS) are known as clinical anti-stroke herbal medicines. The aim of this study is to describe the impact of PNS on ischemia-reperfusion-induced cerebral microvasculature barrier dysfunction which has not been investigated yet. Mice were subjected to transient middle cerebral artery occlusion and PNS were administrated to mice 3 days before and 2 days after surgery. Leukocyte adhesion, albumin leakage, tight junctions and other parameters in the cortex were measured. The PNS 45 mg/kg intervention alleviated leukocyte adhesion, inhibited endothelial barrier alterations evidenced by reduced albumin...
Source: Journal of Vascular Research - February 14, 2019 Category: Research Source Type: research
Marked Vascular Dysfunction in a Case of Peripartum Cardiomyopathy
Peripartum cardiomyopathy (PPCM) is a rare form of congestive heart failure characterized by left ventricular dysfunction that develops towards the end of pregnancy or during the early postpartum phase. Even though the majority of PPCM patients show partial or complete recovery of their heart functions, the mortality rate of PPCM remains high. Previous research has suggested that vascular dysfunction triggered by late-gestational hormones and potent anti-angiogenic factors play key roles in the pathogenesis of PPCM; however, the exact mechanisms remain elusive due to limited patient tissues for characterization. Here, we r...
Source: Journal of Vascular Research - February 14, 2019 Category: Research Source Type: research
Erratum
J Vasc Res 2019;56:16 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - February 14, 2019 Category: Research Source Type: research
Thanks to the Reviewers
J Vasc Res 2018;55:378 –379 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - February 6, 2019 Category: Research Source Type: research
Conference Calendar
J Vasc Res 2018;55:380 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - January 31, 2019 Category: Research Source Type: research
Glycyrrhizin, a High-Mobility Group Box 1 Inhibitor, Improves Lipid Metabolism and Suppresses Vascular Inflammation in Apolipoprotein E Knockout Mice
Conclusions: Our findings indicate that the attenuation of atherosclerotic lesions inApoe–/– mice by GLY might be associated with the amelioration of lipid metabolism abnormalities, inhibition of HMGB1 expression, and alterations in the Treg/Th17 ratio.J Vasc Res 2018;55:365 –377 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - January 16, 2019 Category: Research Source Type: research
Advanced Methods for the Investigation of Cell Contact Dynamics in Endothelial Cells Using Florescence-Based Live Cell Imaging
Endothelial cells of the vascular system are dynamic cells whose molecular adaptability is decisive for the adjustment of homeostasis and organ perfusion. Advanced microscopic techniques, automation processing, and image analysis software was shown to improve the understanding of vascular biology. In this work, we describe advanced methods that allow investigating the dynamics of endothelial cell contacts. The development of viral vectors has contributed significantly to the genetic manipulation of endothelial cells. We used the Gibson assembly as a quick and cheap cloning system for introducing sequences into the lentivir...
Source: Journal of Vascular Research - December 13, 2018 Category: Research Source Type: research
Vascular Remodeling Process of Heparin-Conjugated Poly( ε-Caprolactone) Scaffold in a Rat Abdominal Aorta Replacement Model
In this study, PCL scaffold was prepared by electrospinning and surface modification with heparin via hexamethylenediamine. Then the scaffolds were implanted into the infrarenal abdominal aorta of Wistar rats a nd contrast-enhanced micro-ultrasound was used to monitor the patency of grafts after implantation. These grafts were extracted from the rats at 1, 3, and 6 months for histological analysis, immunofluorescence staining, and scanning electron microscopy observation. Although some grafts experienced a neurysmal change, results showed that all implanted grafts were patent during the course of 6 months and these grafts ...
Source: Journal of Vascular Research - November 28, 2018 Category: Research Source Type: research
Conference Calendar
J Vasc Res 2018;55:328 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - November 9, 2018 Category: Research Source Type: research
Pulse Waveform Analysis in Ocular Microcirculation by Laser Speckle Flowgraphy in Patients with Left Ventricular Systolic and Diastolic Dysfunction
Conclusion: Pulse waveform analysis in the choroid has a significant correlation with LV systolic and LV diastolic function.J Vasc Res 2018;55:329 –337 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - November 8, 2018 Category: Research Source Type: research
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J Vasc Res 2018;55:328 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - November 7, 2018 Category: Research Source Type: research
Association between Atrial Fibrillation and Aortic Aneurysms: A Population-Based Cohort Study
Conclusion: There are associations between AF and AA. HF is a mutual risk factor for the development of AF and AA.J Vasc Res 2018;55:299 –307 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - October 24, 2018 Category: Research Source Type: research
Evaluation of < b > < i > Notch3 < /i > < /b > Deficiency in Diabetes-Induced Pericyte Loss in the Retina
Loss of vascular pericytes has long been associated with the onset of diabetic retinopathy; however, mechanisms contributing to pericyte dropout are not understood.Notch3 has been implicated in pericyte stability and survival, and linked to vascular integrity.Notch3 mutant mice exhibit progressive loss of retinal pericytes. Given that diabetic retinopathy is associated with pericyte loss, we sought to determine whether perturbation ofNotch3 signaling contributes to diabetes-induced pericyte dropout and capillary degeneration. We utilized a pericyte-expressed LacZ transgene (XlacZ4) to examine pericyte loss in retinas of a ...
Source: Journal of Vascular Research - October 24, 2018 Category: Research Source Type: research
Pregnancy-Induced Physiologic Adaptation of the Abdominal Aorta Is Associated with Changes in Gene Expression and Genomic Methylation
Conclusion: Physiologic changes in the aorta were accompanied by changes in gene expression and genomic methylation, suggesting an epigenetic component to maternal vascular remodeling during pregnancy.J Vasc Res 2018;55:319 –327 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - October 24, 2018 Category: Research Source Type: research
