Conference Calendar
aaaaJ Vasc Res 2018;55:I (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - October 5, 2018 Category: Research Source Type: research
Histological and Mechanical Assessment of Decellularized Porcine Biografts, and Its Biological Evaluation following Aortic Implantation during Mid-Term Follow-Up
Conclusions: This decellularization protocol enables a cost-effective preparation of biological grafts featuring reduced immunogenicity. The implanted grafts did not degenerate during the 6-month follow-up period, the lack of graft rejection suggests acceptable immunological tolerance, while recipient cells migrate into, proliferate and differentiate, thus creating the possibility for further use as an optional vascular graft.J Vasc Res 2018;55:287 –298 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - September 19, 2018 Category: Research Source Type: research
Intussusceptive Pillar Formation in Developing Porcine Glomeruli
Conclusion: This study shows ECM presence in a mature intussusceptive pillar without any perivascular cell involvement in the structure. This leads to the hypothesis that ECM deposition precedes the participation of these cells in the formation of intraluminal pillars during IA in porcine metanephric glomerular capillaries.J Vasc Res 2018;55:278 –286 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - September 17, 2018 Category: Research Source Type: research
Sterile Inflammatory Role of High Mobility Group Box 1 Protein: Biological Functions and Involvement in Disease
High mobility group box 1 protein (HMGB1), a sterile inflammatory molecule and damage-associated molecular pattern (DAMP) released from various cells during stress has been implicated in inflammation. Several reports show that there is a direct relationship between inflammation and cardiovascular diseases (CVDs) such as thrombosis, hypertension, insulin resistance, preeclampsia, etc. Here, we intend to summarize the concept of the emerging link between HMGB1 and CVDs. Furthermore, we will discuss the possible therapeutic strategies that target HMGB1 for the treatment of different CVDs.J Vasc Res 2018;55:244 –254 (Source:...
Source: Journal of Vascular Research - September 17, 2018 Category: Research Source Type: research
Carotid-Jugular Fistula Model to Study Systemic Effects and Fistula-Related Microcirculatory Changes
Conclusion: Beside hemodynamic and morphologic changes, a CJF causes a deterioration in the microcirculation of the liver rather than of the kidney, but occlusion of the CJF immediately reverses these changes.J Vasc Res 2018;55:268 –277 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - September 10, 2018 Category: Research Source Type: research
Perfusion Tissue Culture Initiates Differential Remodeling of Internal Thoracic Arteries, Radial Arteries, and Saphenous Veins
Adaptive remodeling processes are essential to the maintenance and viability of coronary artery bypass grafts where clinical outcomes depend strongly on the tissue source. In this investigation, we utilized an ex vivo perfusion bioreactor to culture porcine analogs of common human bypass grafts: the internal thoracic artery (ITA), the radial artery (RA), and the great saphenous vein (GSV), and then evaluated samples acutely (6 h) and chronically (7 days) under in situ or coronary-like perfusion conditions. Although morphologically similar, primary cells harvested from the ITA illustrated lower intimal and medial, but not a...
Source: Journal of Vascular Research - September 7, 2018 Category: Research Source Type: research
Obstructive Sleep Apnoea and Aortic Aneurysm: A Nationwide Population-Based Retrospective Study
Conclusion: When compared to those without OSA, patients with OSA do not have an increased AA risk.J Vasc Res 2018;55:235 –243 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - August 22, 2018 Category: Research Source Type: research
Thyroid Hormone Receptor Alpha Deletion in ApoE < sup > –/– < /sup > Mice Alters the Arterial Renin-Angiotensin System and Vascular Smooth Muscular Cell Cholesterol Metabolism
In conclusion, TR α deletion in ApoE–/– mice slightly increases the expression oftRAS in the aorta and aggravates the dysregulation of cholesterol content in the VSMCs.J Vasc Res 2018;55:224 –234 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - August 9, 2018 Category: Research Source Type: research
Proinflammatory Arterial Stiffness Syndrome: A Signature of Large Arterial Aging
Age-associated structural and functional remodeling of the arterial wall produces a productive environment for the initiation and progression of hypertension and atherosclerosis. Chronic aging stress induces low-grade proinflammatory signaling and causes cellular proinflammation in arterial walls, which triggers the structural phenotypic shifts characterized by endothelial dysfunction, diffuse intimal-medial thickening, and arterial stiffening. Microscopically, aged arteries exhibit an increase in arterial cell senescence, proliferation, invasion, matrix deposition, elastin fragmentation, calcification, and amyloidosis. Th...
Source: Journal of Vascular Research - August 2, 2018 Category: Research Source Type: research
Membership of the ESM
J Vasc Res ;55:188 –188 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - July 19, 2018 Category: Research Source Type: research
Conference Calendar
J Vasc Res 2018;55:187 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - July 16, 2018 Category: Research Source Type: research
Effects of Selenium in the Microcirculation of Fructose-Fed Hamsters
Conclusion: Our results indicate that dietary selenium supplementation reduces microvascular dysfunction by increasing endothelial-dependent and independent dilatation and reducing macromolecular permeability increase in fructose-fed animals.J Vasc Res 2018;55:203 –209 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - July 12, 2018 Category: Research Source Type: research
No Protective Effect of Constitutive Activation of AMPK in Endothelial Cells on Vascular Function in Aged Obese Mice but Augmented α1-Adrenergic Contractions in Renal Arteries Reversible by Weight Loss
Conclusion: Endothelium-dependent nitric oxide (NO)- and apaminplus charybdotoxin-sensitive relaxations were preserved and similar between aortic or renal arterial preparations of lean and obese CA-AMPK mice and their wild-type littermates. Despite comparable release of vasoconstrictor prostanoids, cyclooxygenase-dependent contractions were enhanced during NO synthase inhibition in carotid arterial rings of obese CA-AMPK mice. Contractions to the α1-adrenoceptor agonist phenylephrine were augmented in renal arteries of obese animals, a genotype-independent phenomenon reversible by weight loss. These data indicate a higher...
Source: Journal of Vascular Research - July 11, 2018 Category: Research Source Type: research
A Simple Method for Normalization of Aortic Contractility
Vascular contractile function changes in proliferative vascular diseases, e.g. atherosclerosis, and is documented using isolated blood vessels; yet, many laboratories differ in their approach to quantification. Some use raw values (e.g., mg, mN); others use a “percentage of control agonist” approach; and others normalize by blood vessel characteristic, e.g. length, mass, etc. A lack of uniformity limits direct comparison of contractility outcomes. To address this limitation, we developed a simple 2-step normalization method: (1) measure blood vessel segment length (mm), area (mm2) and calculate volume (mm3); then, (2) ...
Source: Journal of Vascular Research - July 5, 2018 Category: Research Source Type: research
Astragaloside IV Improves Vasodilatation Function by Regulating the PI3K/Akt/eNOS Signaling Pathway in Rat Aorta Endothelial Cells
This study investigated the vasodilator effect of AGIV on rat aortic rings and the underlying effect of AGIV via the PI3K/Akt/eNOS signaling pathway. We measured the relaxation of isolated RARs after different concentrations of AGIV treatment. Rat aorta endothelial cells were cultured with different doses of AGIV, dimethylsulfoxide, and NG-nitro L-arginine methyl ester. The expression of phosphorylated (p)-Akt and -endothelial nitric oxide synthase (p-eNOS) were tested by Western blot analysis. The messenger (m)RNA expression of eNOS was quantified by real-time polymerase chain reaction. AGIV exerted a vasodilator effect o...
Source: Journal of Vascular Research - July 4, 2018 Category: Research Source Type: research
