Smooth Muscle Cell Relaxation Worsens Aortic Dilatation and Clinical Presentation in a BAPN/Angiotensin II-Induced Aortic Dissection Model in Rats
Conclusion: SMC relaxation with ISDN increases aortic dilatation, worsens aortic prognosis, and reproduces human histological findings in a low-dose BAPN/AngII-induced aortic dissection model in rats.J Vasc Res 2022;59:369 –380 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - November 10, 2022 Category: Research Source Type: research
Smooth Muscle Cell Relaxation Worsens Aortic Dilatation and Clinical Presentation in a BAPN/Angiotensin II-Induced Aortic Dissection Model in Rats
Conclusion: SMC relaxation with ISDN increases aortic dilatation, worsens aortic prognosis, and reproduces human histological findings in a low-dose BAPN/AngII-induced aortic dissection model in rats.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - November 10, 2022 Category: Research Source Type: research
The Microvascular-Lymphatic Interface and Tissue Homeostasis: Critical Questions That Challenge Current Understanding
The objective of this review was to highlight the coordinated functional relationships between blood and lymphatic vessels in adult microvascular networks. Structural, functional, temporal, and spatial relationships will be framed in the context of maintaining tissue homeostasis, vessel permeability, and system remodeling. The integration across systems will emphasize the influence of the local environment on cellular and molecular dynamics involved in fluid flow from blood capillaries to initial lymphatic vessels in microvascular networks.J Vasc Res 2022;59:327 –342 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - October 31, 2022 Category: Research Source Type: research
The Microvascular-Lymphatic Interface and Tissue Homeostasis: Critical Questions That Challenge Current Understanding
The objective of this review was to highlight the coordinated functional relationships between blood and lymphatic vessels in adult microvascular networks. Structural, functional, temporal, and spatial relationships will be framed in the context of maintaining tissue homeostasis, vessel permeability, and system remodeling. The integration across systems will emphasize the influence of the local environment on cellular and molecular dynamics involved in fluid flow from blood capillaries to initial lymphatic vessels in microvascular networks.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - October 31, 2022 Category: Research Source Type: research
Stromal Vascular Fraction Reverses the Age-Related Impairment in Revascularization following Injury
This study highlights the effect of donor age on SVF angiogenic efficacy and demonstrates how the ex vivo mesenteric-window model can be used in conjunction with SVF therapy to investigate its contribution to angiogenesis.J Vasc Res 2022;59:343 –357 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - September 8, 2022 Category: Research Source Type: research
Stromal Vascular Fraction Reverses the Age-Related Impairment in Revascularization following Injury
This study highlights the effect of donor age on SVF angiogenic efficacy and demonstrates how the ex vivo mesenteric-window model can be used in conjunction with SVF therapy to investigate its contribution to angiogenesis.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - September 8, 2022 Category: Research Source Type: research
Connexin37 Regulates Cell Cycle in the Vasculature
Control of vascular cell growth responses is critical for development and maintenance of a healthy vasculature. Connexins – the proteins comprising gap junction channels – are key regulators of cell growth in diseases such as cancer, but their involvement in controlling cell growth in the vasculature is less well appreciated. Connexin37 (Cx37) is one of four connexin isotypes expressed in the vessel wall. Its prima ry role in blood vessels relies on its unique ability to transduce flow-sensitive signals into changes in cell cycle status of endothelial (and perhaps, mural) cells. Here, we review available evidence for C...
Source: Journal of Vascular Research - September 6, 2022 Category: Research Source Type: research
A Pilot Study Examining the Effects of Ischemic Conditioning on Walking Capacity and Lower Extremity Muscle Performance in Patients with Claudication
Conclusion: In patients with claudication, IC improved total work performed and time to fatigue at the knee but did not change walking parameters.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - September 6, 2022 Category: Research Source Type: research
Erratum
J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - August 31, 2022 Category: Research Source Type: research
Perivascular Adipose Tissue Anticontractile Function Is Mediated by Both Endothelial and Neuronal Nitric Oxide Synthase Isoforms
Conclusions: Targeting NOS isoforms may be useful in restoring PVAT anticontractile function in obesity, ameliorating increased vascular tone, and disease.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - August 10, 2022 Category: Research Source Type: research
Erratum
J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - July 22, 2022 Category: Research Source Type: research
Smooth Muscle Cell Notch2 Is Not Required for Atherosclerotic Plaque Formation in ApoE Null Mice
Conclusions: Our data show that loss of SMC Notch2 does not significantly reduce atherosclerotic lesion formation, although in early stages of plaque formation there are changes in SMC and inflammation.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - July 7, 2022 Category: Research Source Type: research
Experimental Atherosclerosis Research on Large and Small Animal Models in Vascular Surgery
Animal models have significantly advanced our understanding of the mechanisms of atherosclerosis formation and the evaluation of therapeutic options. The current focus of research is on preventive strategies and includes pharmacologic and biologic interventions directed primarily against smooth-muscle cell proliferation, endovascular devices for recanalization and/or drug delivery, and an integrated approach using both devices and pharmacobiologic agents. The experience over many decades with animal models in vascular research has established that a single, ideal, naturally available model for atherosclerosis does not exis...
Source: Journal of Vascular Research - June 27, 2022 Category: Research Source Type: research
