Membership of the ESM
J Vasc Res 2016;53:244 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - December 13, 2016 Category: Research Source Type: research
Conference Calendar
J Vasc Res 2016;53:243 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - December 13, 2016 Category: Research Source Type: research
Arterial Iron Content Is Increased in Patients with High Plasma Ferritin Levels
This study addresses the very fundamental question of whether there is a relation between body iron content and the level of iron accumulated in arterial tissue. The iron content in human nonatherosclerotic artery samples from patients with high and low body-iron contents estimated from the plasma ferritin concentration were determined by inductively coupled plasma mass spectroscopy in tissue extracts and by histological staining, using a modified Perls reaction to display iron deposits. We found that the arteries contained small but measurable levels of iron. The iron content was significantly higher in tissue from patien...
Source: Journal of Vascular Research - December 9, 2016 Category: Research Source Type: research
Alisol A 24-Acetate, a Triterpenoid Derived from Alisma orientale, Inhibits Ox-LDL-Induced Phenotypic Transformation and Migration of Rat Vascular Smooth Muscle Cells through Suppressing ERK1/2 Signaling
Alisol A 24-acetate, a triterpenoid extracted fromAlisma orientale, has shown antiatherosclerotic actions. The purpose of this study was to evaluate the inhibition of alisol A 24-acetate on oxidized low-density lipoprotein (Ox-LDL)-induced phenotypic transformation and migration of rat vascular smooth muscle cells (VSMCs), and to explore the underlying mechanisms. VSMCs were pretreated with alisol A 24-acetate and a specific extracellular signal-regulated kinase (ERK) inhibitor, U0126, and then stimulated with 50 mg/l Ox-LDL in vitro. The expression of VSMC phenotypic marker SM22 α was determined using immunocytochemistry...
Source: Journal of Vascular Research - December 8, 2016 Category: Research Source Type: research
Alisol A 24-Acetate, a Triterpenoid Derived from < b > < i > Alisma orientale < /i > < /b > , Inhibits Ox-LDL-Induced Phenotypic Transformation and Migration of Rat Vascular Smooth Muscle Cells through Suppressing ERK1/2 Signaling
Alisol A 24-acetate, a triterpenoid extracted fromAlisma orientale, has shown antiatherosclerotic actions. The purpose of this study was to evaluate the inhibition of alisol A 24-acetate on oxidized low-density lipoprotein (Ox-LDL)-induced phenotypic transformation and migration of rat vascular smooth muscle cells (VSMCs), and to explore the underlying mechanisms. VSMCs were pretreated with alisol A 24-acetate and a specific extracellular signal-regulated kinase (ERK) inhibitor, U0126, and then stimulated with 50 mg/l Ox-LDL in vitro. The expression of VSMC phenotypic marker SM22 α was determined using immunocytochemistry...
Source: Journal of Vascular Research - December 7, 2016 Category: Research Source Type: research
Transient Receptor Potential Vanilloid-1 Channels Contribute to the Regulation of Acid- and Base-Induced Vasomotor Responses
pH changes can influence local blood flow, but the mechanisms of how acids and bases affect vascular tone is not fully clarified. Transient receptor potential vanilloid-1 (TRPV1) channels are expressed in vessels and can be activated by pH alterations. Thus, we hypothesized that TRPV1 channels are involved in the mediation of vascular responses to acid-base changes. Vasomotor responses to HCl, NaOH, and capsaicin were measured in isolated murine carotid and tail skin arteries. The function of TRPV1 was blocked by either of three approaches:Trpv1 gene disruption, pharmacological blockade with a TRPV1 antagonist (BCTC), and ...
Source: Journal of Vascular Research - December 6, 2016 Category: Research Source Type: research
Differential Regulation of BMAL1, CLOCK, and Endothelial Signaling in the Aortic Arch and Ligated Common Carotid Artery
We examined the relationships between BMAL1 and CLOCK and 2 regulators of endothelial function, AKT1 and endothelial nitric oxide synthase (eNOS), in vascular regions of altered blood flow. We found that the aortic arch from WT mice exhibited reduced sensitivity to acetylcholine (Ach)-mediated relaxation relative to the thoracic aorta. In Clock-mutant (mut) mice the aorta exhibited a reduced sensitivity to Ach. In WT mice, the phosphorylated forms of eNOS and AKT were decreased in the aortic arch, while BMAL1 and CLOCK expression followed a similar pattern of reduction in the arch. In conditions of surgically induced flow ...
Source: Journal of Vascular Research - December 6, 2016 Category: Research Source Type: research
Efficacy of AdipoDren ® in Reducing Interleukin-1-Induced Lymphatic Endothelial Hyperpermeability
In conclusion, AdipoDren® would be useful to ameliorate condit ions of altered lymphatic vasculature and to support the physiological functionality of the lymphatic endothelium.J Vasc Res 2016;53:255-268 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - December 6, 2016 Category: Research Source Type: research
Hydroxysafflor Yellow A Promotes Angiogenesis via the Angiopoietin 1/ Tie-2 Signaling Pathway
Conclusions: These results indicate the potential utility of HSYA for the treatment of ischemic diseases.J Vasc Res 2016;53:245-254 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - November 28, 2016 Category: Research Source Type: research
Sodium Pentosan Polysulfate Reduced Renal Ischemia-Reperfusion-Induced Oxidative Stress and Inflammatory Responses in an Experimental Animal Model
Acute kidney injury (AKI) remains an independent risk factor for mortality and morbidity after vascular surgery (affecting the renal arteries) or aortic surgery (requiring suprarenal aortic clamping). These types of vascular surgery produce renal ischemia/reperfusion (I/R) injury, a common cause of AKI. The present studies aimed at monitoring the course of renal I/R injury at the cellular level and investigating the efficacy of long-term preoperative and single-shot intraoperative administration of sodium pentosan polysulfate (PPS) to protect renal tissue from acute I/R injury both in native and diabetic kidneys in rats. W...
Source: Journal of Vascular Research - November 25, 2016 Category: Research Source Type: research
Long-Term Angiotensin II Receptor Blockade Limits Hypertension, Aortic Dysfunction, and Structural Remodeling in a Rat Model of Chronic Kidney Disease
Conclusions: This study highlights the role of Ang II in driving vascular manifestations of CKD and indicates that early treatment can significantly limit pathological changes.J Vasc Res 2016;53:216-229 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - November 23, 2016 Category: Research Source Type: research
Oxidized Low-Density Lipoprotein-Induced Cyclophilin A Secretion Requires ROCK-Dependent Diphosphorylation of Myosin Light Chain
Conclusions: ox-LDL-induced CyPA secretion requires vesicle transportation, actin remodeling and ROCK-dependent diphosphorylation of MLC. VSMC-derived CyPA induced by ox-LDL may be associated with increased CyPA expression in atherosclerotic lesions.J Vasc Res 2016;53:206-215 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - November 8, 2016 Category: Research Source Type: research
Title Page
J Vasc Res 2016;53(suppl 1):I-II (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - October 28, 2016 Category: Research Source Type: research
Mechanisms of Vasodilatation 12th International Symposium. November 6-9, 2016, Rochester, Minn., USA: Abstracts
J Vasc Res 2016;53(suppl 1):1-70 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - October 28, 2016 Category: Research Source Type: research
Transplantation of Autologous Bone Marrow Mononuclear Cells Regulates Inflammation in a Rabbit Model of Carotid Artery Atherosclerosis
Objective: It is well known that inflammation plays key roles in the development of atherosclerosis and that the transplantation of bone marrow mononuclear cells (BMMNCs) can suppress inflammation in rodent models of ischemic diseases. Here, we explored whether transplantation of autologous BMMNCs could prevent the progression of atherosclerosis by the alleviation of inflammatory responses in a rabbit model of carotid artery atherosclerosis.Methods and Results: The atherosclerotic rabbit model was established by air desiccation followed by a high-cholesterol diet for 8 weeks. Then, 1 × 107 BMMNCs labeled with BrdU or an e...
Source: Journal of Vascular Research - October 27, 2016 Category: Research Source Type: research
